Ginsenoside Rg3 increases nitric oxide production via increases in phosphorylation and expression of endothelial nitric oxide synthase: Essential roles of estrogen receptor-dependent PI3-kinase and AMP-activated protein kinase

Toxicology and Applied Pharmacology

Volumn 246, Issue 3, 2010, Pages 171-183

  Hien, Tran Thi ^a   Kim, Nak Doo ^b   Pokharel, Yuba Raj ^a   Oh, Seok Jeong ^c   Lee, Moo Yeol ^c   Kang, Keon Wook ^a  

^a Chosun University   (South Korea)

^b Seoul National University   (South Korea)

^c Chonnam National University   (South Korea)

Author keywords

AMP activated protein kinase; ENOS; Estrogen receptor; Ginsenoside Rg3; PI3 kinase

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTROGEN RECEPTOR; GINSENOSIDE RG 3; GLUCOCORTICOID RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; REPORTER GENE; SIGNAL TRANSDUCTION; UPREGULATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; ENDOPLASMIC RETICULUM; ENDOTHELIAL CELLS; GINSENOSIDES; HUMANS; MALE; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; UP-REGULATION;

PANAX GINSENG;

EID: 77956886889     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.05.008     Document Type: Article

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