Prostanoids and inflammatory pain

Prostaglandins and Other Lipid Mediators

Volumn 104-105, Issue , 2013, Pages 58-66

  Chen, Lihong ^a   Yang, Guangrui ^a   Grosser, Tilo ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Central sensitization; COX 2; Inflammatory pain; mPGES 1; Peripheral sensitization; PGE2; PGI2

Indexed keywords

CELECOXIB; COLLAGEN TYPE 2; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DICLOFENAC; FREUND ADJUVANT; G PROTEIN COUPLED RECEPTOR; MONOCLONAL ANTIBODY; NEUROKININ 1 RECEPTOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTANOID; ROFECOXIB; SUBSTANCE P; VALDECOXIB;

CONFERENCE PAPER; DISEASE SEVERITY; HUMAN; HYPERALGESIA; INFLAMMATORY PAIN; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; OSTEOARTHRITIS; PAIN;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; HUMANS; INFLAMMATION; INTRAMOLECULAR OXIDOREDUCTASES; PAIN; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE;

EID: 84879693426     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2012.08.006     Document Type: Conference Paper

References (130)

1. C.J. Woolf What is this thing called pain? J Clin Invest 120 11 2010 3742 3744
2. T. Rosenbaum, and S.A. Simon W.B. Liedtke, S. Heller, TRP ion channel function in sensory transduction and cellular signaling cascades Boca Raton, FL 2007
3. F.R. Nieto, E.J. Cobos, M.A. Tejada, C. Sanchez-Fernandez, R. Gonzalez-Cano, and C.M. Cendan Tetrodotoxin (TTX) as a therapeutic agent for pain Mar Drugs 10 2 2012 281 305
4. A.I. Basbaum, D.M. Bautista, G. Scherrer, and D. Julius Cellular and molecular mechanisms of pain Cell 139 2 2009 267 284
5. A. Latremoliere, and C.J. Woolf Central sensitization: a generator of pain hypersensitivity by central neural plasticity J Pain 10 9 2009 895 926
6. M. Costigan, and C.J. Woofl Pain: molecular mechanisms J Pain 1 3 2000 35 44
7. T. Grosser, S. Fries, and G.A. FitzGerald Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities J Clin Invest 116 1 2006 4 15 (Pubitemid 43121782)
8. T. Grosser, Y. Yu, and G.A. Fitzgerald Emotion recollected in tranquility: lessons learned from the COX-2 saga Annu Rev Med 61 2010 17 33
9. Y. Yu, E. Ricciotti, and R. Scalia Vascular COX-2 modulates blood pressure and thrombosis in mice Sci Transl Med 4 132 2012 132ra54
10. 2 Science 296 5567 2002 539 541 (Pubitemid 34408674)
11. C.E. Trebino, J.L. Stock, and C.P. Gibbons Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase Proc Natl Acad Sci USA 100 15 2003 9044 9049 (Pubitemid 36899220)
12. D. Kamei, K. Yamakawa, and Y. Takegoshi Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1 J Biol Chem 279 32 2004 33684 33695 (Pubitemid 39063018)
13. M. Wang, W.L. Song, Y. Cheng, and G.A. FitzGerald Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease J Intern Med 263 5 2008 500 505 (Pubitemid 351533553)
14. H.U. Zeilhofer, and K. Brune Analgesic strategies beyond the inhibition of cyclooxygenases Trends Pharmacol Sci 27 9 2006 467 474 (Pubitemid 44233693)
15. E. Ricciotti, and G.A. FitzGerald Prostaglandins and inflammation Arterioscler Thromb Vasc Biol 31 5 2011 986 1000
16. E.M. Smyth, T. Grosser, M. Wang, Y. Yu, and G.A. FitzGerald Prostanoids in health and disease J Lipid Res 50 Suppl. 2009 S423 S428
17. B.M. Peskar, N. Maricic, B. Gretzera, R. Schuligoi, and A. Schmassmann Role of cyclooxygenase-2 in gastric mucosal defense Life Sci 69 25-26 2001 2993 3003 (Pubitemid 33044694)
18. R.C. Harris, and M.D. Breyer Physiological regulation of cyclooxygenase-2 in the kidney Am J Physiol Renal Physiol 281 1 2001 F1 F11
19. C.A. Rouzer, P.J. Kingsley, and H. Wang Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages J Biol Chem 279 33 2004 34256 34268 (Pubitemid 39318049)
20. M. Chen, E. Boilard, and P.A. Nigrovic Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis Arthritis Rheum 58 5 2008 1354 1365 (Pubitemid 351705925)
21. S.L. Tilley, T.M. Coffman, and B.H. Koller Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes J Clin Invest 108 1 2001 15 23 (Pubitemid 32634916)
22. N. Hatae, Y. Sugimoto, and A. Ichikawa Prostaglandin receptors: advances in the study of EP3 receptor signaling J Biochem 131 6 2002 781 784 (Pubitemid 34717580)
23. S. Narumiya, and G.A. FitzGerald Genetic and pharmacological analysis of prostanoid receptor function J Clin Invest 108 1 2001 25 30 (Pubitemid 32634917)
24. K. Seibert, Y. Zhang, and K. Leahy Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain Proc Natl Acad Sci USA 91 25 1994 12013 12017 (Pubitemid 24368594)
25. L.K. Myers, A.H. Kang, and A.E. Postlethwaite The genetic ablation of cyclooxygenase 2 prevents the development of autoimmune arthritis Arthritis Rheum 43 12 2000 2687 2693 (Pubitemid 32001734)
26. J. Guindon, A. De Lean, and P. Beaulieu Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain Pain 121 1-2 2006 85 93 (Pubitemid 43261635)
27. J.N. Francischi, C.T. Chaves, and A.C. Moura Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation Br J Pharmacol 137 6 2002 837 844 (Pubitemid 35407490)
28. I. Appleton, A. Tomlinson, J.A. Mitchell, and D.A. Willoughby Distribution of cyclooxygenase isoforms in murine chronic granulomatous inflammation. Implications for future anti-inflammatory therapy J Pathol 176 4 1995 413 420
29. C. Hay, and J. de Belleroche Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord Neuroreport 8 5 1997 1249 1251 (Pubitemid 27198607)
30. C. Maihofner, I. Tegeder, and C. Euchenhofer Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord Neuroscience 101 4 2000 1093 1108
31. 2 and cyclooxygenase expression in rats Anesth Analg 109 3 2009 943 950
32. I. Tegeder, J. Pfeilschifter, and G. Geisslinger Cyclooxygenase- independent actions of cyclooxygenase inhibitors FASEB J 15 12 2001 2057 2072 (Pubitemid 32927924)
33. T.A. Samad, K.A. Moore, and A. Sapirstein Interleukin-1beta-mediated induction of COX-2 in the CNS contributes to inflammatory pain hypersensitivity Nature 410 6827 2001 471 475 (Pubitemid 32240046)
34. C.H. Hay, and J.S. de Belleroche Dexamethasone prevents the induction of COX-2 mRNA and prostaglandins in the lumbar spinal cord following intraplantar FCA in parallel with inhibition of oedema Neuropharmacology 37 6 1998 739 744 (Pubitemid 28313898)
35. F. Amaya, T.A. Samad, L. Barrett, D.C. Broom, and C.J. Woolf Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion Pain 142 1-2 2009 59 67
36. H.L. Willingale, N.J. Gardiner, N. McLymont, S. Giblett, and B.D. Grubb Prostanoids synthesized by cyclo-oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability Br J Pharmacol 122 8 1997 1593 1604 (Pubitemid 28000185)
37. C.C. Chan, S. Boyce, and C. Brideau Rofecoxib [Vioxx, MK-0966; 4-(4′-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles J Pharmacol Exp Ther 290 2 1999 551 560 (Pubitemid 29344546)
38. D. Riendeau, M.D. Percival, and S. Boyce Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor Br J Pharmacol 121 1 1997 105 117 (Pubitemid 27195011)
39. A. Matsunaga, M. Kawamoto, and S. Shiraishi Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats Eur J Pharmacol 554 1 2007 12 17 (Pubitemid 44820041)
40. 2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1 J Neurosci 21 16 2001 5847 5853 (Pubitemid 32737717)
41. D.M. Dirig, P.C. Isakson, and T.L. Yaksh Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats J Pharmacol Exp Ther 285 3 1998 1031 1038 (Pubitemid 28277901)
42. D. Vardeh, D. Wang, and M. Costigan COX-2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice J Clin Invest 119 2 2009 287 294
43. R. Langenbach, S.G. Morham, and H.F. Tiano Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration Cell 83 3 1995 483 492
44. R. Langenbach, C. Loftin, C. Lee, and H. Tiano Cyclooxygenase knockout mice: models for elucidating isoform-specific functions Biochem Pharmacol 58 8 1999 1237 1246 (Pubitemid 29406158)
45. L.R. Ballou, R.M. Botting, S. Goorha, J. Zhang, and J.R. Vane Nociception in cyclooxygenase isozyme-deficient mice Proc Natl Acad Sci USA 97 18 2000 10272 10276
46. M.M. Ndengele, S. Cuzzocrea, and E. Esposito Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity FASEB J 22 9 2008 3154 3164
47. B.F. McAdam, I.A. Mardini, and A. Habib Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation J Clin Invest 105 10 2000 1473 1482 (Pubitemid 30322413)
48. 2 in activated mast cells J Biol Chem 272 6 1997 3231 3237 (Pubitemid 27066813)
49. T. Ochi, Y. Ohkubo, and S. Mutoh Role of cyclooxygenase-2, but not cyclooxygenase-1, on type II collagen-induced arthritis in DBA/1J mice Biochem Pharmacol 66 6 2003 1055 1060 (Pubitemid 37083602)
50. X. Zhu, and J.C. Eisenach Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury Anesthesiology 99 5 2003 1175 1179 (Pubitemid 37339465)
51. X. Zhu, D. Conklin, and J.C. Eisenach Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain Pain 104 1-2 2003 15 23 (Pubitemid 36835870)
52. T. Moriyama, T. Higashi, and K. Togashi Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins Mol Pain 1 2005 3
53. G.D. Nicol, M.R. Vasko, and A.R. Evans Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons J Neurophysiol 77 1 1997 167 176 (Pubitemid 27053772)
54. C.F. Villarreal, D. Sachs, F.Q. Cunha, C.A. Parada, and S.H. Ferreira The role of Na(V)1.8 sodium channel in the maintenance of chronic inflammatory hypernociception Neurosci Lett 386 2 2005 72 77 (Pubitemid 41058934)
55. B. Abrahamsen, J. Zhao, and C.O. Asante The cell and molecular basis of mechanical, cold, and inflammatory pain Science 321 5889 2008 702 705
56. F. Amaya, H. Wang, and M. Costigan The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity J Neurosci 26 50 2006 12852 12860 (Pubitemid 44954605)
57. 2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade J Physiol 495 Pt 2 1996 429 440 (Pubitemid 26331824)
58. 2-induced inhibition of potassium currents in rat sensory neurones J Physiol 516 Pt 1 1999 163 178 (Pubitemid 29164000)
59. 2-induced sensitization of rat sensory neurons in vitro J Neurosci 18 24 1998 10345 10355 (Pubitemid 29016554)
60. 2 and pain - an update Biol Pharm Bull 34 8 2011 1170 1173
61. 3 receptor currents in inflamed rats J Physiol 584 Pt 1 2007 191 203 (Pubitemid 47500548)
62. 2-induced sensitization of cultured rat sensory neurons Neurosci Lett 205 3 1996 161 164
63. 2-mediated hypernociception Br J Pharmacol 156 5 2009 826 834
64. 2-induced potentiation of bradykinin excitation in rat sensory neurons Neuroscience 66 2 1995 459 466
65. 2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture J Neurosci 14 8 1994 4987 4997
66. 2 enhancement of the capsaicin-elicited current in rat sensory neurons: whole-cell and single-channel studies J Neurosci 18 16 1998 6081 6092 (Pubitemid 28373217)
67. S.H. Ferreira Prostaglandins, aspirin-like drugs and analgesia Nat New Biol 240 102 1972 200 203
68. 2 J Immunol 155 9 1995 4437 4444
69. 2-induced sensitization of polymodal receptors in response to bradykinin and heat J Neurophysiol 75 6 1996 2361 2368 (Pubitemid 26200631)
70. 2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord Neuroscience 93 2 1999 775 781 (Pubitemid 29329481)
71. 2 production and reduced early thermal hyperalgesia in iNOS-deficient mice J Neurosci 20 17 2000 6714 6720
72. 2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats J Neurosci 15 4 1995 2768 2776
73. 2 during the first phase in the formalin assay of the rat Life Sci 60 21 1997 PL 295-300
74. 2 release in rat Neuroscience 75 2 1996 453 461 (Pubitemid 26361335)
75. 2 stimulates glutamate release from synaptosomes of rat spinal cord Neurosci Lett 196 1-2 1995 57 60
76. 2 increases calcium conductance and stimulates release of substance P in avian sensory neurons J Neurosci 12 5 1992 1917 1927
77. C.M. Hingtgen, and M.R. Vasko Prostacyclin enhances the evoked-release of substance P and calcitonin gene-related peptide from rat sensory neurons Brain Res 655 1-2 1994 51 60 (Pubitemid 24262991)
78. T. Kohno, H. Wang, and F. Amaya Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity J Neurosci 28 17 2008 4533 4540
79. 2 J Neurosci 21 5 2001 1750 1756 (Pubitemid 32182214)
80. 2-mediated inflammatory pain sensitization Science 304 5672 2004 884 887 (Pubitemid 38620190)
81. F. Kojima, M. Kapoor, and L. Yang Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice J Immunol 180 12 2008 8361 8368
82. F. Kojima, R.G. Matnani, S. Kawai, F. Ushikubi, and L.J. Crofford Potential roles of microsomal prostaglandin E synthase-1 in rheumatoid arthritis Inflamm Regen 31 2 2011 157 166
83. T. Mabuchi, H. Kojima, and T. Abe Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain Neuroreport 15 9 2004 1395 1398 (Pubitemid 38925229)
84. D. Xu, S.E. Rowland, and P. Clark MF63 [2-(6-chloro-1H-phenanthro[9,10-d] imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation J Pharmacol Exp Ther 326 3 2008 754 763
85. M.D. Guerrero, M. Aquino, I. Bruno, R. Riccio, M.C. Terencio, and M. Paya Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression Eur J Pharmacol 620 1-3 2009 112 119
86. 2 in neuropathic pain: blockade of microglial migration in the spinal cord Glia 59 2 2011 208 218
87. C. Brenneis, O. Coste, and R. Schmidt Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice J Cell Mol Med 12 2 2008 639 648 (Pubitemid 351555141)
88. M. Wang, A.M. Zukas, Y. Hui, E. Ricciotti, E. Pure, and G.A. FitzGerald Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis Proc Natl Acad Sci USA 103 39 2006 14507 14512 (Pubitemid 44484780)
89. C.E. Trebino, J.D. Eskra, T.S. Wachtmann, J.R. Perez, T.J. Carty, and L.P. Audoly Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages J Biol Chem 280 17 2005 16579 16585 (Pubitemid 41389113)
90. H. Vanegas, and H.G. Schaible Prostaglandins and cyclooxygenases [correction of cycloxygenases] in the spinal cord Prog Neurobiol 64 4 2001 327 363 (Pubitemid 32244138)
91. A.N. Hata, and R.M. Breyer Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation Pharmacol Ther 103 2 2004 147 166 (Pubitemid 39209041)
92. K. Scholich, and G. Geisslinger Is mPGES-1 a promising target for pain therapy? Trends Pharmacol Sci 27 8 2006 399 401 (Pubitemid 44069583)
93. 2 biosynthesis J Biochem Mol Biol 38 6 2005 633 638 (Pubitemid 43240966)
94. F. Kojima, S. Kato, and S. Kawai Prostaglandin E synthase in the pathophysiology of arthritis Fundam Clin Pharmacol 19 3 2005 255 261 (Pubitemid 40769448)
95. T. Kawamura, T. Yamauchi, M. Koyama, T. Maruyama, T. Akira, and N. Nakamura Expression of prostaglandin EP2 receptor mRNA in the rat spinal cord Life Sci 61 21 1997 2111 2116 (Pubitemid 27478838)
96. H. Oida, T. Namba, and Y. Sugimoto In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs Br J Pharmacol 116 7 1995 2828 2837
97. 2 EP1 receptor mediates pain perception and regulates blood pressure J Clin Invest 107 3 2001 325 331 (Pubitemid 32157964)
98. A. Ueno, H. Matsumoto, and H. Naraba Major roles of prostanoid receptors IP and EP3 in endotoxin-induced enhancement of pain perception Biochem Pharmacol 62 2 2001 157 160 (Pubitemid 32522934)
99. H. Reinold, S. Ahmadi, and U.B. Depner Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype J Clin Invest 115 3 2005 673 679 (Pubitemid 40322241)
100. 2 receptor EP4 contributes to inflammatory pain hypersensitivity J Pharmacol Exp Ther 319 3 2006 1096 1103
101. 2 receptors in the pathogenesis of rheumatoid arthritis J Clin Invest 110 5 2002 651 658 (Pubitemid 34988789)
102. T. Johansson, S. Narumiya, and H.U. Zeilhofer Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory pain Neurosci Lett 495 2 2011 98 101
103. K. Omote, T. Kawamata, Y. Nakayama, M. Kawamata, K. Hazama, and A. Namiki The effects of peripheral administration of a novel selective antagonist for prostaglandin E receptor subtype EP1, ONO-8711, in a rat model of postoperative pain Anesth Analg 92 1 2001 233 238 (Pubitemid 32039211)
104. Y. Nakayama, K. Omote, and A. Namiki Role of prostaglandin receptor EP1 in the spinal dorsal horn in carrageenan-induced inflammatory pain Anesthesiology 97 5 2002 1254 1262 (Pubitemid 35265582)
105. A.C. Allan, A. Billinton, and S.H. Brown Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists Bioorg Med Chem Lett 21 14 2011 4343 4348
106. A. Hall, S.H. Brown, and C. Budd Discovery of GSK345931A: An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain Bioorg Med Chem Lett 19 2 2009 497 501
107. G.M. Giblin, R.A. Bit, and S.H. Brown The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl] -2-p yridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain Bioorg Med Chem Lett 17 2 2007 385 389 (Pubitemid 46084909)
108. K. Watanabe, T. Kawamori, and S. Nakatsugi Inhibitory effect of a prostaglandin E receptor subtype EP1 selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice Cancer Lett 156 1 2000 57 61 (Pubitemid 30326768)
109. 2 receptor subtype EP1 receptor antagonist: experimental study of application of nucleus pulposus Spine (Phila Pa 1976) 36 22 2011 1829 1834
110. P. Clark, S.E. Rowland, and D. Denis MF498 [N-{[4-(5,9-diethoxy-6-oxo-6, 8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbe nzyl]sulfonyl}-2-(2- methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis J Pharmacol Exp Ther 325 2 2008 425 434 (Pubitemid 351574801)
111. J. Colucci, M. Boyd, and C. Berthelette Discovery of 4-[1-[([1-[4- (trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]be nzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain Bioorg Med Chem Lett 20 12 2010 3760 3763
112. K. Nakao, A. Murase, and H. Ohshiro CJ-023,423, a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic properties J Pharmacol Exp Ther 322 2 2007 686 694 (Pubitemid 47105812)
113. A. Murase, T. Okumura, A. Sakakibara, H. Tonai-Kachi, K. Nakao, and J. Takada Effect of prostanoid EP4 receptor antagonist, CJ-042,794, in rat models of pain and inflammation Eur J Pharmacol 580 1-2 2008 116 121
114. 2 during inflammation: prostaglandin E (EP1-EP4) receptors in spinal nociceptive processing of input from the normal or inflamed knee joint J Neurosci 24 3 2004 642 651 (Pubitemid 38166490)
115. T. Murata, F. Ushikubi, and T. Matsuoka Altered pain perception and inflammatory response in mice lacking prostacyclin receptor Nature 388 6643 1997 678 682 (Pubitemid 27366439)
116. Y. Doi, T. Minami, M. Nishizawa, T. Mabuchi, H. Mori, and S. Ito Central nociceptive role of prostacyclin (IP) receptor induced by peripheral inflammation Neuroreport 13 1 2002 93 96 (Pubitemid 34102033)
117. A.M. Pulichino, S. Rowland, and T. Wu Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis J Pharmacol Exp Ther 319 3 2006 1043 1050
118. 2 as a major nociceptive mediator in acetic acid-induced writhing reaction: a study using IP-receptor disrupted mice Adv Exp Med Biol 469 1999 265 268 (Pubitemid 32204645)
119. 2 as a mediator of allergic asthma Science 287 5460 2000 2013 2017 (Pubitemid 30158677)
120. K. Kabashima, and S. Narumiya The DP receptor, allergic inflammation and asthma Prostaglandins Leukot Essent Fatty Acids 69 2-3 2003 187 194 (Pubitemid 36976174)
121. Y. Murakami, T. Akahoshi, and I. Hayashi Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase Arthritis Rheum 48 10 2003 2931 2941 (Pubitemid 37280623)
122. 2 Arthritis Rheum 58 11 2008 3530 3540
123. N. Eguchi, T. Minami, and N. Shirafuji Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice Proc Natl Acad Sci USA 96 2 1999 726 730 (Pubitemid 29061276)
124. L. Popp, A. Haussler, and A. Olliges Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice Eur J Pain 13 7 2009 691 703
125. L. Andreeva, and H.P. Rang Effect of bradykinin and prostaglandins on the release of calcitonin gene-related peptide-like immunoreactivity from the rat spinal cord in vitro Br J Pharmacol 108 1 1993 185 190 (Pubitemid 23007429)
126. D.W. Jenkins, W. Feniuk, and P.P. Humphrey Characterization of the prostanoid receptor types involved in mediating calcitonin gene-related peptide release from cultured rat trigeminal neurones Br J Pharmacol 134 6 2001 1296 1302 (Pubitemid 33097260)
127. K. Nakae, F. Hayashi, and M. Hayashi Functional role of prostacyclin receptor in rat dorsal root ganglion neurons Neurosci Lett 388 3 2005 132 137 (Pubitemid 41208207)
128. 2-induced allodynia in conscious mice J Pharmacol Exp Ther 278 3 1996 1146 1152 (Pubitemid 27166964)
129. 2 on responses of dorsal horn neurons with knee input in normal rats and in rats with acute knee inflammation Neuroscience 156 1 2008 184 192
130. + currents in DRG neurons of adult rat Pain 152 5 2011 1114 1126