Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation

Journal of Clinical Investigation

Volumn 105, Issue 10, 2000, Pages 1473-1482

  McAdam, B F ^a,b   Mardini, I A ^a   Habib, A ^a,c   Burke, A ^a   Lawson, J A ^a   Kapoor, S ^a   FitzGerald, G A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c HÔPITAL LARIBOISIÈRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

11 OXOTHROMBOXANE B2; 2,3 DINOR 6 OXOPROSTAGLANDIN F1 ALPHA; ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; IBUPROFEN; ICOSANOID; ISOPROSTANE; LIPOPOLYSACCHARIDE; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN EXPERIMENT; INFLAMMATORY DISEASE; LIPID PEROXIDATION; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; URINARY EXCRETION;

EID: 0034105218     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9523     Document Type: Article

References (79)

1. FitzGerald, G.A. 1992. Prostaglandins and related compounds. In Cecil textbook of medicine. 19th edition. J.B. Wyngaarden, L. H. Smith, and J.C. Bennett, editors. W.B. Saunders Co. Philadelphia, Pennsylvania, USA. 1271-1276.
2. Dubois, R.N., et al. 1998. Cyclooxygenase in biology and disease. FASEB J. 12:1063-1073.
3. Smith, W.L. 1992. Prostanoid biosynthesis and mechanisms of action. Am. J. Physiol. 263:F181-F191.
4. Funk, C.D., Funk, L.B., Kennedy, M.E., Pong, A.S., and FitzGerald, G.A. 1991. Human platelet/crythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J. 5:2304-2312.
5. Smith, W.L., Garavito, R.M, and DeWitt, D.L. 1996. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J. Biol. Chem. 271:33157-33160.
6. Jones, D.A., Carlron, D.P., McIntyre, T.M., Zimmerman, G.A., and Prescott, S.M. 1993. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J. Biol. Chem. 268:9049-9054.
7. Kujubu, D.A., Reddy, S.T., Fletcher, B.S., and Herschman, H.R. 1993. Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells. J. Biol. Chem. 268:5425-5430.
8. Xie, W., Chipman, J.G., Robertson, D.L., Erikson, R.L., and Simmons, D.L. 1991. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl. Acad. Sci. USA. 88:2692-2696.
9. Niiro, H., et al. 1997. Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils. Blood. 89:1621-1628.
10. Masferrer, J.L., et al. 1994. In vivo glucocorticoids regulate cyclooxygenase-2 but not cyclooxygenase-1 in peritoneal macrophages. J. Pharmacol. Exp. Ther. 270:1340-1344.
11. Seibert, K., et al. 1994. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA. 91:12013-12017.
12. Masferrer, J.L., et al. 1994. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. USA. 91:3228-3232.
13. 2 production. J. Pharmacol. Exp. Ther. 283:1069-1075.
14. O'Sullivan, M.G., Huggins, E.M., Meade, E.A., DeWitt, D.L., and McCall, C.E. 1992. Lipopolysaccharide induces prostaglandin H synthase-2 in 7 alveolar macrophages. Biochem. Biophys. Res. Commun. 187:1123-1127.
15. Masferrer, J.L., Zweifel, B.S., Seibert, K., and Needleman, P. 1990. Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J. Clin. Invest. 86:1375-1379.
16. Martich, G.D., Boujoukos, A.J., and Suffredini, A.F. 1993. Response of man to endotoxin. Immunobiology. 187:403-416.
17. Cassale, T.B., Ballas, Z.K., Kaliner, M.A., and Keahey, T.M. 1990. The effects of intravenous endotoxin on various host-effector molecules. J. Allergy Clin. Immunol. 85:45-51.
18. van Deventer, S.J., et al. 1990. Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood. 76:2520-2526.
19. 2 formation is increased in human sepsis syndrome. Effects of cyclooxygenase inhibition. Am. Rev. Respir. Dis. 144:1095-1101.
20. Martich, G.D., Parker, M.M., Cunnion, R.E., and Suffredini, A.F. 1992. Effects of ibuprofen and pentoxifylline on the cardiovascular response of normal humans to endotoxin. J. Appl. Physiol. 73:925-931.
21. Revhaug, A., et al. 1998. Inhibition of cyclo-oxygenase attenuates the metabolic response to endotoxin in humans. Arch. Surg. 123:162-170.
22. Bernard, G.R., et al. 1997. The effects of ibuprofen on the physiology and survival of patients with sepsis. N. Engl. J. Med. 336:912-918.
23. 2 metabolites in humans. Thromb. Res. 47:647-656.
24. McAdam, B.F., et al. 1999. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc. Natl. Acad. Sci. USA. 96:272-277.
25. FitzGerald, G.A., Pedersen, A.K., and Patrono, C. 1983. Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease. Circulation. 67:1174-1177.
26. Lawson, J.A., Rokach, J., and FitzGerald, G.A. 1999. Minireview: isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo. J. Biol. Chem. 35:24441-24444.
27. 2: a family of icosanoids produced in vivo in humans. Proc. Natl. Acad. Sci. USA. 85:304-308.
28. Harrison, K.A., and Murphy, R.C. 1995. Isoleukotrienes are biologically active free radical products of lipid peroxidation. J. Biol. Chem. 29:17273-17278.
29. 2-isoprostanes to plaque instability in human carotid atherosclerosis. J. Clin. Invest. 103:421-427.
30. Praticò, D., et al. 1998. IPF2α-I: an index of lipid peroxidation in humans. Proc. Natl. Acad. Sci. USA. 95:3449-3454.
31. 2α in human platelets. J. Biol. Chem. 270:9800-9808.
32. 2 isoprostanes, 8, 12-iso- and 5-epi-8, 12-iso-isoprostane-VI, in human urine. J. Biol. Chem. 273: 29295-29301.
33. 2 isoprostanes by HPLC/randem mass spectrometry. Proc. Natl. Acad. Sci. USA. 96:13381-13386.
34. Smith, W.L., Meade, E.A., and DeWitt, D.L. 1994. Pharmacology of prostaglandin endoperoxide synthase isozymes-1 and -2. In Platelet-dependent vascular occlusion. G.A. FitzGerald, L.K. Jennings, and C. Patrono, editors. The New York Academy of Sciences. New York, New York, USA. 136-142.
35. Catella-Lawson F., et al. 1999. Effects of specific inhibition cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. J. Pharmacol. Exp. Ther. 289:735-741.
36. Towbin, H., Staehelin, T., and Gordon, J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad Sci. USA. 76:4350-4354.
37. Creminon, C., et al. 1995. Immunological studies of human constitutive cyclooxygenase (COX-1) using enzyme immunometric assay. Biochim. Biophys. Acta. 1254:333-340.
38. Creminon, C., et al. 1995. Differential measurement of constitutive (COX-1) and inducible (COX-2) cyclooxygenase expression in human umbilical vein endothelial cells using specific immunometric enzyme immunoassays. Biochim. Biophys. Acta. 1254:341-348.
39. Christ, W.J., et al. 1995. E5531, a pure endotoxin antagonist of high potency. Science. 268:80-83.
40. Schumann, R.R., et al. 1990. Structure and function of lipopolysaccharide binding protein. Science. 249:1429-1431.
41. Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J., and Mathison, J.C. 1990. CD 14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 249:1431-1433.
42. Yang, R.B., et al. 1998. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature. 395:284-288.
43. Chow, J.C., Young, D.X., Golenbock, D.T., Christ, W.J., and Gusovsky, F. 1999. Toll-like receptor-4 mediates lipopolysacharide-induced signal transduction. J Biol. Chem. 274:10689-10692.
44. Hempel, S.L., Monick, M.M., and Hunninghake, G.W. 1994. Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes. J. Clin. Invest. 93:391-396.
45. 2α by human monocytes: discriminate production by reactive oxygen species and PG G/H S-2. J. Biol. Chem. 271:8919-8924.
46. van der Poll, T., van Deventer, S.J., Buller, H.R., Sturk, A., and ten Care. J.W. 1991. Comparison of the early dynamics of systemic prostacyclin release after administration of tumor necrosis factor and endotoxin to healthy humans. J. Infect. Dis 164:599-601.
47. Simon, L.S., et al. 1999. Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis. A randomized controlled trial JAMA. 282:1921-1928.
48. Langman, M.J., et al. 1999. Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. JAMA. 282:1929-1933.
49. Langenbach, R., et al. 1995. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 83:483-492.
50. Morham, S.G., et al. 1995. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse, Cell. 83:473-482.
51. Patrono, C. 1994. Aspirin as an antiplatelet drug. N. Engl. J. Med. 330:1287-1294.
52. Ushikubi, F., et al. 1998. Impaired febrile response in mice lacking the prostaglandin E Receptor subtype EP3. Nature. 395:281-284.
53. Murata, T., et al. 1997. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature. 388:678-682.
54. FitzGerald, GA, Friedman, L.A., Miyamori, I., O'Grady, J., and Lewis, P.J. 1979. A double blind placebo controlled crossover study of prostacyclin in man. Life Sci. 25:665-672.
55. Salat, A., et al. 1999. Endotoxin enhances in vitro platelet aggregability in whole blood. Thromb. Res. 93:145-148.
56. Masferrer, J. L., Zweifel, B.S., Seibert, K., and Needleman, P. 1990. Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J. Clin. invest. 86:1375-1379.
57. Habib, A., et al. 1993. Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2. J. Biol. Chem. 268:23448-23454.
58. Hurley, J.C. 1995. Endotoxemia: methods of detection and clinical correlates. Clin. Microbiol. Rev. 8:268-292.
59. Boujoukos, A.J., Martich, G.D., Supinski, E., and Suffredini, A.F. 1993. Compartmentalization of the acute cytokine response in humans after IV endotoxin administration. J. Appl. Physiol. 74:3027-3033.
60. Richardson, R.P., et al. 1989. Peripheral blood leukocyte kinetics following in vivo LPS administration to normal human subjects. Ann. Surg. 210:239-245.
61. O'Sullivan, M.G., Chilton, F.H., Huggins, E.M., Jr., and McCall, C.E. 1992. Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin II synthase. J. Biol. Chem. 267:14547-14550.
62. Jun, S.S., Chen, Z., Pace, M.C., and Shaul, P.W. 1999, Glucocorticoids downregulate cyclooxygenase-1 gene expression and prostacyclin synthesis in fetal pulmonary artery endothelium. Circ. Res. 84:193-200.
63. Schonbeck, U., Sukhova, G.K., Graber, P., Coulter, S., and Libby, 1999. Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions. Am. J. Pathol. 155:1281-1291.
64. Crofford, L.J., et al. 1994. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J. Clin. Invest. 93:1095-1101.
65. Maloney, C.G., et al. 1998. Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils. J. Immunol. 160:1402-1410.
66. 2 metabolites during leg exercise in humans. Am. J. Physiol. 255:H15-H18.
67. Roy, L., Knapp, U.K., Robertson, R.M., and Fitzgerald, G.A. 1985. Endogenous biosynthesis of prostacylin during cardiac catheterization and angiography in man. Circulation. 71:434-440.
68. FitzGerald, G.A., Smith, H., Pedersen, A.K., and Brash, A.R. 1984. Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. N. Engl. J. Med. 310:1065-1068.
69. Reilly, I.A., Doran, J.B., Smith, B., and FitzGerald, G.A. 1986. Increased thromboxane biosynthesis in a human preparation of platelet activation: biochemical and functional consequences of selective inhibition of thromboxane synthase. Circulation. 73:1300-1309.
70. Fitzgerald, D.J., Roy, L., Catella, F., and FitzGerald, G.A. 1986. Platelet activation in unstable coronary disease. N. Engl. J. Med. 315 983-989.
71. Maier, J.A., Hla, T., and Maciag, T. 1990. Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. J. Biol. Chem. 265:10805-10808.
72. Rimarachin, J.A., et al. 1994. Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells. Arterioscler. Thromb. 14:1021-1031.
73. Topper, J.N., Cai, J., Falb, D., and Gimbrone, M.A., Jr. 1996. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese-superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc. Natl. Acad. Sci. USA. 93:10417-10422.
74. Reilly, M.P., et al. 1998. Isoprostanes in the assessment of oxidant stress in vivo. In Molecular and cellular basis of inflammation. C.N. Serhan and P.A Ward, editors. Humana Press. Totowa, New Jersey, USA. 127-139.
75. Geisel, J., Cook, J.A., Ashton, S.H., Wise, W.C., and Halushka, P.V. 1994. Endotoxin tolerance is associated with decreased prostaglandin H synthases-1 and -2. Am. J. Physiol. 267:C1067-C1072.
76. Kerins, D.M., Roy, L., FitzGerald, G.A., and Fitzgerald, D.J. 1989. Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator. Circulation. 80:1718-1725.
77. F2α generation during coronary reperfusion: a potential quantitative marker of oxidant stress in vivo. Circulation. 95:2492-2499.
78. Nowak, J., Murray, J.J., Oates, J.A., and FitzGerald, G.A. 1987. Biochemical evidence of a chronic abnormality in platelet and vascular function in apparently healthy chronic cigarette smokers. Circulation. 76:6 14.
79. Reilly, M., Delanty, N., Lawson, J.A., and FitzGerald, G.A. 1996, Modulation of oxidant stress in vivo in chronic cigarette smokers. Circulation. 94:19-25.