Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages

Journal of Biological Chemistry

Volumn 280, Issue 17, 2005, Pages 16579-16585

  Trebino, Catherine E ^a   Eskra, James D ^a   Wachtmann, Timothy S ^a   Perez, Jose R ^a   Carty, Thomas J ^a   Audoly, Laurent P ^a,b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; INORGANIC ACIDS; METABOLISM; POLYSACCHARIDES;

EICOSANOID METABOLISM; MICROSOMAL PROSTAGLANDIN; MPGES-1; MURINE MACROPHAGES;

ENZYMES;

6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; FATTY ACID; HYDROXYHEPTADECATRIENOIC ACID; ICOSANOID; LIPOPOLYSACCHARIDE; MICROSOMAL PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN H2; SYNTHETASE; THIOGLYCOLIC ACID; THROMBOXANE B2; TRITIUM; UNCLASSIFIED DRUG; 12 HYDROXY 5,8,10 HEPTADECATRIENOIC ACID; 12-HYDROXY-5,8,10-HEPTADECATRIENOIC ACID; DAZOXIBEN; IMIDAZOLE DERIVATIVE; ISOMERASE; PROSTAGLANDIN E SYNTHASE; THIOGLYCOLIC ACID DERIVATIVE; UNSATURATED FATTY ACID;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; GENOTYPE; ICOSANOID METABOLISM; INFLAMMATION; MACROPHAGE; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; METABOLISM; PHYSIOLOGY; TIME; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALIA; MURINAE;

ANIMALS; ARACHIDONIC ACID; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSANOIDS; FATTY ACIDS, UNSATURATED; GENOTYPE; IMIDAZOLES; INFLAMMATION; INTRAMOLECULAR OXIDOREDUCTASES; KINETICS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, TRANSGENIC; MICROSOMES; PROSTAGLANDINS; THIOGLYCOLATES; THROMBOXANE B2; TIME FACTORS;

EID: 20444494334     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412075200     Document Type: Article

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