Discovery of GSK345931A: An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 2, 2009, Pages 497-501

  Hall, Adrian ^a   Brown, Susan H ^a   Budd, Christopher ^a   Clayton, Nicholas M ^a   Giblin, Gerard M P ^a   Goldsmith, Paul ^a   Hayhow, Thomas G ^a   Hurst, David N ^a   Naylor, Alan ^a   Anthony Rawlings, D ^a   Scoccitti, Tiziana ^a   Wilson, Alexander W ^a   Winchester, Wendy J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

CNS penetration; EP1 antagonist; Free concentration; Inflammatory pain; Pain

Indexed keywords

6 [2 [5 CHLORO 2 (2,4 DIFLUOROBENZYLOXY)PHENYL] 1 CYCLOPENTENYL] 2 PYRIDINECARBOXYLIC ACID; BENZENE DERIVATIVE; GSK 345931A; GW 845706X; GW 855454X; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; ROFECOXIB; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; HYPERALGESIA; INFLAMMATION; LIPOPHILICITY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PAIN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG EVALUATION, PRECLINICAL; INFLAMMATION; PAIN; PYRIDINES; RATS; RECEPTORS, PROSTAGLANDIN E; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 57749084328     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.11.032     Document Type: Article

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