Prostaglandin receptors: Advances in the study of EP3 receptor signaling

Journal of Biochemistry

Volumn 131, Issue 6, 2002, Pages 781-784

  Hatae, Noriyuki ^a   Sugimoto, Yukihiko ^a   Ichikawa, Atsushi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Calcium mobilization; EP3 receptor; G13 protein; Prostaglandin receptor

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E3 RECEPTOR; PROSTAGLANDIN RECEPTOR; RECEPTOR SUBTYPE; RHO FACTOR; UNCLASSIFIED DRUG; CALCIUM; DNA BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PROSTAGLANDIN EP3 RECEPTOR;

CALCIUM MOBILIZATION; CELL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; NERVE CELL; NONHUMAN; PROTEIN BINDING; RECEPTOR BINDING; SHORT SURVEY; SIGNAL TRANSDUCTION; ANIMAL; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; CALCIUM; DNA-BINDING PROTEINS; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; HUMANS; RECEPTORS, PROSTAGLANDIN E; SIGNAL TRANSDUCTION;

EID: 0036594073     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a003165     Document Type: Short Survey

References (27)

1. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
2. Molecular mechanisms of diverse actions of prostanoid receptors
3. Two isoforms of the EP3 receptor with different carboxyl-terminal domains
4. Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase
5. Two isoforms of prostaglandin E receptor EP3 subtype. Different COOH-terminal domains determine sensitivity to agonist-induced desensitization
6. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity
7. 2 receptor
8. Prostaglandin E-prostanoid-3 receptor activation of cyclic AMP response element-mediated gene transcription
9. Cloning and expression of three isoforms of the human EP3 prostanoid receptor
10. Prostaglandin E receptor EP3-γ isoform, with mostly full constitutive Gi activity and agonist-dependent Gs activity
11. Two isoforms of the prostaglandin E receptor EP3 subtype different in agonist-independent constitutive activity
12. Mouse prostaglandin E receptor subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells
13. Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gβγ subunit-independent manner
14. Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits
15. 2 receptors results in cooperative regulation of cyclic AMP accumulation and mitogen-activated protein kinase activity
16. 2-induced cAMP production and sensitization of sensory neurons
17. Receptor number and caveolae colocalization determine receptor coupling efficiency to adenylyl cyclase
18. 2 receptor subtype 3
19. Prostaglandin E receptor EP3 subtype induces neurite retraction via small GTPase Rho
20. Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: Requirement for two different tyrosine kinase
21. Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho
22. Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways
23. Two isoforms of prostaglandin EP3 receptor exhibiting constitutive activity and agonist-dependent activity in Rho-mediated stress fiber formation
24. Eicosanoids: Prostaglandins, thromboxanes, leukotrienes, and other derivatives of carbon-20 unsaturated fatty acids
25. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
26. Distribution of the messenger RNA for the prostaglandin E receptor subtype EP3 in the mouse nervous system
27. Formation and function of eicosanoids in the central nervous system