Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype

Journal of Clinical Investigation

Volumn 115, Issue 3, 2005, Pages 673-679

  Reinold, Heiko ^a   Ahmadi, Seifollah ^a   Depner, Ulrike B ^a   Layh, Beate ^a   Heindl, Cornelia ^a   Hamza, May ^a,b   Pahl, Andreas ^a   Brune, Kay ^a   Narumiya, Shuh ^c   Müller, Ulrike ^d   Zeilhofer, Hanns Ulrich ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b African Union Organization St Abbassia   (Egypt)

^c KYOTO UNIVERSITY   (Japan)

^d MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; PROSTAGLANDIN E RECEPTOR;

ANALYSIS OF VARIANCE; ARTICLE; HYPERALGESIA; INFLAMMATION; MOUSE; NEUROTRANSMISSION; NONHUMAN; PAIN; PRIORITY JOURNAL; SENSITIZATION; SPINAL CORD DORSAL HORN; SPINE; SYNAPTIC INHIBITION;

EID: 20044385551     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI23618     Document Type: Article

References (42)

1. Brune, K., and Zeilhofer, H.U. 1999. Antipyretic (non-narcotic) analgesics. In Textbook of pain. P.D. Wall and R. Melzack, editors. Churchill Livingstone. London, United Kingdom. 1139-1153.
2. 2 production. J. Pharmacol. Exp. Ther. 283:1069-1075.
3. Cannon, G.W., et al. 2000. Rofecoxib, a specific inhibitor of cyclooxygenase 2, with clinical efficacy comparable with that of diclofenac sodium: resulrs of a one-year, randomized, clinical trial in patients with osteoarthritis of the knee and hip. Rofecoxib Phase III Protocol 035 Study Group. Arthritis Rheum. 43:978-987.
4. Bombardier, C., et al. 2000. Comparison of upper gasrrointestinal roxicity of rofecoxib and naproxen in parienrs with rheumatoid arthriris. VIGOR Study Group. N. Engl. J. Med. 343:1520-1528.
5. Graham, D.J., et al. 2004. Risk of acute cardiac events among patients treared with cyclooxygenase-2 selective and non-selective nonsteroidal antiinflammatory drugs. Pharmacoepidemiol. Drug Saf. 13(Suppl.):S287-S288.
6. Vane, J.R., Bakhle, S., and Botting, R.M. 1998. Cyclooxygenases 1 and 2. Annu. Rev. Pharmacol. Toxicol. 38:97-120.
7. Narumiya, S., Sugimoro, Y., and Ushikubi, F. 1999. Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79:1193-1226.
8. Murata, T., et al. 1997. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature. 388:678-682.
9. Minami, T., et al. 2001. Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice. Br. J. Pharmacol. 133:438-444.
10. 2 EP1 receptor mediates pain perception and regulates blood pressure. J. Clin. Invest. 107:325-331.
11. 2 to mice. Br. J. Pharmacol. 112:735-740.
12. Nakayama, Y., Omote, K., and Namiki, A. 2002. Role of prostaglandin receptor EP1 in the spinal dorsal horn in carrageenan-induced inflammatory pain. Anesthesiology. 97:1254-1262.
13. Samad, T.A., Sapirstein, A., and Woolf, C.J. 2002. Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets. Trends Mol. Med. 8:390-396.
14. 2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J. Physiol. 495:429-440.
15. Lopshire, J.C., and Nicol, G.D. 1997. Activation and recovery of the PGE2-mediated sensitization of the capsaicin response in rat sensory neurons. J. Neurophysiol. 78:3154-3164.
16. + current in nociceptors. Proc. Natl. Acad. Sci. U. S. A. 93:1108-1112.
17. Samad, T.A., et al. 2001. Interleukin-1beta-mediated inducrion of Cox-2 in the CNS contributes ro inflammatory pain hypersensiriviry. Nature. 410:471-475.
18. Malmberg, A.B., and Yaksh, T.L. 1992. Hyperalgesia mediated by spinal gluramate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science. 257:1276-1279.
19. Baba, H., Kohno, T., Moore, K.A., and Woolf, C.J. 2001. Direct activation of rat spinal dorsal horn neurons by prosraglandin E2. J. Neurosci. 21:1750-1756.
20. 2 selecrively blocks inhibirory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat. Neurosci. 5:34-40.
21. 2-mediated inflammatory pain sensitization. Science. 304:884-887.
22. Kawamura, T., et al. 1997. Expression of prostaglandin EP2 receptor mRNA in the rat spinal cord. Life Sci. 61:2111-2116.
23. Beiche, F., Klein, T., Nüsing, R., Neuhuber, W., and Goppelt-Struebe, M. 1998. Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord. J. Neuroimmunol. 89:26-34.
24. Nakamura, K., et al. 2000. Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system. J. Comp. Neurol. 421:543-569.
25. Gühring, H., et al. 2000. Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice. J. Neurosci. 20:6714-6720.
26. Zeilhofer, H.U., et al. 2005. Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice. J. Comp. Neurol. 482:123-141.
27. Narumiya, S., and FitzGerald, G.A. 2001. Genetic and pharmacological analysis of prostanoid receptor function. J. Clin. Invest. 108:25-30. doi:10.1172/JCI200113455.
28. FitzGerald, G.A. 2003. COX-2 and beyond: approaches to prostaglandin inhibition in human disease. Nat. Rev. Drug Discov. 2:879-890.
29. 2α to conscious mice. Brain Res. 510:26-32.
30. 2 or prostaglandin F2α primarily produces mechanical hyperalgesia that is mediated by nociceptive specific spinal dorsal horn neurons. Pain. 97:33-45.
31. 2 synthase-1. J. Biol. Chem. 279:24866-24872.
32. Trebino, C.E., et al. 2003. Impaired inflammarory and pain responses in mice lacking an inducible prosraglandin E synchase. Proc. Natl. Acad. Sci. U. S. A. 100:9044-9049.
33. 2-induced nociceprive transmission in the rat spinal dorsal horn. Brain Res. 1010:62-68.
34. Oida, H., et al. 1995. In siru hybridization studies of prostacyclin receptor mRNA expression in various mouse organs. Br. J. Pharmacol. 116:2828-2837.
35. 2 during inflammarion: prostaglandin E (EP1-EP4) receptors in spinal nocicepcive processing of input from the normal or inflamed knee joint. J. Neurosci. 24:642-651.
36. Omote, K., Yamamoto, H., Kawamata, T., Nakayama, Y., and Namiki, A. 2002. The effects of intrathecal administration of an antagonist for prostaglandin E receptor subtype EP1 on mechanical and thermal hyperalgesia in a rat model of postoperative pain. Anesth. Analg. 95:1708-1712.
37. Beiche, F., Scheuerer, S., Brune, K., Geisslinger, G., and Goppelt-Struebe, M. 1996. Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation. FEBS Lett. 390:165-169.
38. Akopian, A.N., et al. 1999. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat. Neurosci. 2:541-548.
39. Hizaki, H., et al. 1999. Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP2. Proc. Natl. Acad. Sci. U. S. A. 96:10501-10506.
40. Ushikubi, F., et al. 1998. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature. 395:281-284.
41. Depner, U.B., Reinscheid, R.K., Takeshima, H., Brune, K., and Zeilhofer, H.U. 2003. Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor. Eur. J. Neurosci. 17:2381-2387.
42. Ahmadi, S., et al. 2001. Modulation of synaptic transmission by nociceptin/orphanin FQ and nocistatin in the spinal cord dorsal horn of mutant mice lacking the nociceptin/orphanin FQ receptor. Mol. Pharmacol. 59:612-618.