Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord

Neuroscience

Volumn 101, Issue 4, 2000, Pages 1093-1108

  Maihofner C ^a   Tegeder, I ^b   Euchenhofer, C ^b   DeWitt, D ^c   Brune, K ^a   Bang, R ^a,b   Neuhuber, W ^a   Geisslinger, G ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c Michigan State University   (United States)

Author keywords

Inflammation; nNOS; Nociception; Prostaglandin; Zymosan

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN; ZYMOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LOCALIZATION; ENZYME REGULATION; GLIA CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATION; MALE; MOTONEURON; MOUSE; NOCICEPTION; NONHUMAN; PAIN; PAW EDEMA; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL CORD VENTRAL HORN;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; EDEMA; HINDLIMB; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INJECTIONS; ISOENZYMES; LUMBAR VERTEBRAE; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PAIN; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SPINAL CORD; THORACIC VERTEBRAE; TISSUE DISTRIBUTION; ZYMOSAN;

EID: 0034736189     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00361-4     Document Type: Article

References (56)

1. Oligodendrocytes isolated from adult pig brain synthesise and release prostaglandins
2. New roles for glia
3. Expression of cyclooxygenase isoforms in the rat spinal cord and their regulation during adjuvant-induced arthritis
4. Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord
5. Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation
6. GABA- and glutamate-activated currents in glial cells of the mouse corpus callosum slice
7. Unilateral injection of calcitonin gene-related peptide (CGRP) induces bilateral oedema formation and release of CGRP-like immunoreactivity in the rat hindpaw
8. Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat
9. Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase
10. Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain
11. Characterization of inducible cyclooxygenase in rat brain
12. Localization and characterization of nitric oxide synthase in the rat suprachiasmatic nucleus: evidence for a nitrergic plexus in the biological clock
13. Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta
14. Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release
15. NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway
16. Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages
17. Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat
18. Intrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate
19. Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase
20. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes
21. Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord
22. Human cyclooxygenase-2 cDNA
23. Substance P: localization in the central nervous system and in some primary sensory neurons
24. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex
25. Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse
26. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat
27. Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test
28. Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats
29. Nitric oxide synthase activity endogenously modulates NMDA receptors
30. Substance P-induced release of prostaglandins from astrocytes: regional specialisation and correlation with phosphoinositol metabolism
31. Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice
32. Nitric oxide (NO) and nociceptive processing in the spinal cord
33. The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat
34. Intraplantar zymosan as a reliable, quantifiable model of thermal and mechanical hyperalgesia in the rat
35. Involvement of glutamate receptors in allodynia induced by prostaglandins E2 and F2 alpha injected into conscious mice
36. L-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2
37. Absence of prostaglandin E2-induced hyperalgesia in NMDA receptor epsilon subunit knockout mice
38. The effect of nitric oxide on cytokine-induced release of PGE2 by human cultured astroglial cells
39. Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2
40. Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation
41. Effects of lysine clonixinate and ketorolac tromethamine on prostanoid release from various rat organs incubated ex vivo
42. Rat spinal cord neurons contain nitric oxide synthase
43. Stimulation of nitric oxide release from rat spinal cord by prostaglandin E2
44. The nitric oxide-cyclic GMP pathway is required for nociceptive signalling at specific loci within the somatosensory pathway
45. Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine
46. Peripheral noxious stimulation releases spinal PGE2 during the first phase in the formalin assay of the rat
47. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
48. Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices
49. Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy
50. Electrophysiologic characteristics of glial cells
51. New insights into the mode of action of anti-inflammatory drugs
52. Electrophysiological properties of glial cells: comparison of brain slices with primary cultures
53. Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat
54. Prostanoids synthesized by cyclo-oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability
55. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids
56. Nitric oxide synthase-like immunoreactivity in lumbar dorsal root ganglia and spinal cord of rat and monkey and effect of peripheral axotomy