The role of PKA and PKCη pathways in prostaglandin E 2-mediated hypernociception

British Journal of Pharmacology

Volumn 156, Issue 5, 2009, Pages 826-834

  Sachs, D ^a   Villarreal, C F ^a   Cunha, F Q ^a   Parada, C A ^a   Ferreira, S H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

CAMP; PGE 2 and rat mechanical hypernociception; PKA; PKC

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; PROSTAGLANDIN E2; PROTEIN KINASE C EPSILON; PROTEIN KINASE C INHIBITOR; ISOENZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; HYPERALGESIA; HYPERNOCICEPTION; MALE; MUSCLE SPINDLE AFFERENT NERVE; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SPINAL GANGLION; ANIMAL; ENZYME ACTIVE SITE; METABOLISM; PAIN; PAIN ASSESSMENT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SECOND MESSENGER; STIMULATION; WISTAR RAT;

ANIMALS; CATALYTIC DOMAIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; ENZYME ACTIVATION; GANGLIA, SPINAL; ISOENZYMES; MALE; NEURONS, AFFERENT; PAIN; PAIN MEASUREMENT; PHYSICAL STIMULATION; PROTEIN KINASE C-EPSILON; RATS; RATS, WISTAR; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION;

EID: 66949113670     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2008.00093.x     Document Type: Article

References (59)

1. Aley KO, Levine JD (1999). Role of protein kinase A in the maintenance of inflammatory pain. J Neurosci 19 : 2181 2186.
2. Aley KO, Messing RO, Mochly-Rosen D, Levine JD (2000). Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C. J Neurosci 20 : 4680 4685.
3. Aley KO, Martin A, McMahon T, Mok J, Levine JD, Messing RO (2001). Nociceptor sensitization by extracellular signal-regulated kinases. J Neurosci 17 : 6933 6939.
4. Barber LA, Vasko MR (1996). Activation of protein kinase C augments peptide release from rat sensory neurons. J Neurochem 67 : 72 80.
5. Beebe SJ (1994). The cAMP-dependent protein kinases and cAMP signal transduction. Semin Cancer Biol 5 : 285 294.
6. Cesare P, Dekker LV, Sardini A, Parker PJ, McNaughton PA (1999). Specific involvement of PKC-e in sensitization of the neuronal response to painful heat. Neuron 23 : 617 624.
7. Claudino RF, Kassuya CAL, Ferreira J, Calixto JB (2006). Pharmacological and molecular characterization of the mechanisms involved in the prostaglandin E2 (PGE2)-induced edematogenic responses in mice. J Pharmacol Exp Ther 318 : 611 618.
8. Cunha FQ, Lorenzetti BB, Poole S, Ferreira SH (1991). Interleukin-8 as a mediator of sympathetic pain. Br J Pharmacol 104 : 765 767.
9. Cunha FQ, Poole S, Lorenzetti BB, Ferreira SH (1992). The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 107 : 660 664.
10. Cunha FQ, Teixeira MM, Ferreira SH (1999). Pharmacological modulation of secondary mediator systems - cyclic AMP and cyclic GMP - on inflammatory hyperalgesia. Br J Pharmacol 127 : 671 678.
11. Cunha JM, Rae GA, Ferreira SH, Cunha FQ (2004). Endothelins induce ETB receptor-mediated mechanical hypernociception in rat hindpaw: roles of cAMP and protein kinase C. Eur J Pharmacol 501 : 87 94.
12. Di Castro A, Drew LJ, Wood JN, Cesare P (2006). Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways. Proc Nat Acad Sci USA 103 : 4699 4704.
13. Dina OA, Barletta J, Chen X, Mutero A, Martin A, Messing RO et al. (2000). Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. J Neurosci 20 : 8614 8619.
14. Dina OA, Messing RO, Levine JD (2006). Ethanol withdrawal induces hyperalgesia mediated by PKCepsilon. Eur J Neurosci 24 : 197 204.
15. Distler C, Rathee PK, Lips KS, Obreja O, Neuhuber W, Kress M (2003). Fast Ca2+-induced potentiation of heat-activated ionic currents requires cAMP/PKA signaling and functional AKAP anchoring. J Neurophysiol 89 : 2499 2505.
16. Dorn GW II., Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ et al. (1999). Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. Proc Natl Acad Sci USA 96 : 12798 12803.
17. 2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J Physiol 495 : 429 440.
18. Ferreira SH (1972). Prostaglandins, aspirin-like drugs and analgesia. Nat New Biol 240 (102 200 203.
19. 2+ dependent process. Prostaglandins 18 : 179 190.
20. Ferreira SH, Lorenzetti BB, Correa FM (1978). Central and peripheral antialgesic action of aspirin-like drugs. Eur J Pharmacol 53 : 39 48.
21. Gray MO, Karliner JS, Mochly-Rosen D (1997). A selective epsilon-protein kinaseC antagonist inhibits protection of cardiac myocytes from hypoxiainduced cell death. J Biol Chem 272 : 30945 30951.
22. Handwerker HO, Neher KD (1976). Characteristics of C-fibre receptors in the cat's foot responding to stepwise increase of skin temperature to noxious levels. Pflugers Arch 365 : 221 229.
23. Huang NK, Lin YW, Huang CL, Messing RO, Chern Y (2001). Activation of protein kinase A and atypical protein kinase C by A(2A) adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells. J Biol Chem 276 : 13838 13846.
24. Hucho TB, Dina OA, Levine JD (2005). Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism. J Neurosci 25 : 6119 6126.
25. Kassuya CA, Ferreira J, Claudino RF, Calixto JB (2007). Intraplantar PGE2 causes nociceptive behaviour and mechanical allodynia: the role of prostanoid E receptors and protein kinases. Br J Pharmacol 150 : 727 737.
26. Khasar SG, Lin YH, Martin A, Dadgar J, McMahon T, Wang D et al. (1999a). A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice. Neuron 24 : 253 260.
27. Khasar SG, McCarter G, Levine JD (1999b). Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol 81 : 1104 1112.
28. Leng S, Mizumura K, Koda H, Kumazawa T (1996). Excitation and sensitization of the heat response induced by a phorbol ester in canine visceral polymodal receptors studied in vitro. Neurosci Lett 206 : 13 16. (Pubitemid 26084718)
29. Liao X, Gunstream JD, Lewin MR, Ambron RT, Walters ET (1999). Activation of protein kinase A contributes to the expression but not the induction of long-term hyperexcitability caused by axotomy of Aplysia sensory neurons. J Neurosci 19 : 1247 1256.
30. Lorenzetti BB, Veiga FH, Canetti CA, Poole S, Cunha FQ, Ferreira SH (2002). Cytokine-induced neutrophil chemoattractant 1 (CINC-1) mediates the sympathetic component of inflammatory mechanical hypersensitivitiy in rats. Eur Cytokine Netw 13 : 456 461.
31. Malmberg AB, Brandon EP, Idzerda RL, Liu H, McKnight GS, Basbaum AI (1997). Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase. J Neurosci 17 : 7462 7470.
32. Martin HA, Basbaum AI, Kwiat GC, Goetzl EJ, Levine JD (1987). Leukotriene and prostaglandin sensitization of cutaneous highthreshold C-mechanonociceptors in the rat. Neuroscience 22 : 651 659.
33. 2-induced sensitization of the heat response of canine visceral polymodal receptors in vitro. Neurosci Lett 161 : 117 119.
34. Moita MA, Lamprecht R, Nader K, LeDoux JE (2002). A-kinase anchoring proteins in amygdala are involved in auditory fear memory. Nat Neurosci 5 : 837 838.
35. Moriyama T, Higashi T, Togashi K, Lida T, Segi E, Sugimoto Y et al. (2005). Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain 1 : 1 3.
36. Nakamura M, Ferreira SH (1987). A peripheral sympathetic component in inflammatory hyperalgesia. Eur J Pharmacol 135 : 145 153.
37. 2 of bradykinin activation of embryonic rat sensory neurones. J Physiol 480 : 485 492.
38. 2-induced mechanical hyperalgesia in the rat. Neuroscience 64 : 769 776.
39. Parada CA, Yeh JJ, Joseph EK, Levine JD (2003). Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat. Eur J Neurosci 17 : 1847 1852.
40. Parada CA, Reichling DB, Levine JD (2005). Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways. Pain 113 : 185 190.
41. Pateromichelakis S, Rood JP (1982). Prostaglandin E1-induced sensitization of A delta moderate pressure mechanoreceptors. Brain Res 232 : 89 96.
42. Rueff A, Dray A (1993). Sensitization of peripheral afferent fibers in the in vitro neonatal rat spinal cord-tail by bradykinin and prostaglandins. Neuroscience 54 : 527 535.
43. 2. J Physiol 403 : 91 104.
44. Scott JD (1991). Cyclic nucleotide-dependent protein kinases. Pharmacol Ther 50 : 123 145.
45. Smith JA, Davis CL, Burgess GM (2000). Prostaglandin E2-induced sensitization of bradykinin-evoked responses in rat dorsal root ganglion neurons is mediated by cAMP-dependent protein kinase A. Eur J Neurosci 12 : 3250 3258.
46. Souza AL, Moreira FA, Almeida KR, Bertollo CM, Costa KA, Coelho MM (2002). In vivo evidence for a role of protein kinase C in peripheral nociceptive processing. Br J Pharmacol 135 : 239 247.
47. Summer GJ, Puntillo KA, Miaskowski C, Dina OA, Green PG, Levine JD (2006). TrkA and PKC-epsilon in thermal burn-induced mechanical hyperalgesia in the rat. J Pain 12 : 884 891.
48. Sweitzer SM, Wong SM, Peters MC, Mochly-Rosen D, Yeomans DC, Kendig JJ (2004). Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats. J Pharmacol Exp Ther 309 : 616 625.
49. Taiwo YO, Levine JD (1990). Direct cutaneous hyperalgesia induced by adenosine. Neuroscience 38 : 757 762.
50. Taiwo YO, Levine JD (1991). Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. Neuroscience 44 : 131 135.
51. Taiwo YO, Levine JD (1992). Serotonin is a directly-acting hyperalgesic agent in the rat. Neuroscience 48 : 485 490.
52. Taiwo YO, Bjerknes LK, Goetzl EJ, Levine JD (1989). Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system. Neuroscience 32 : 577 580.
53. Taiwo YO, Heller PH, Levine JD (1992). Mediation of serotonin hyperalgesia by the cAMP second messenger system. Neuroscience 48 : 479 483.
54. Wang C, Li GW, Huang LY (2007). Prostaglandin E2 potentiation of P2X3 receptor mediated currents in dorsal root ganglion neurons. Mol Pain 3 : 22.
55. Wang JF, Khasar SG, Ahlgren SC, Levine JD (1996). Sensitization of C-fibres by prostaglandin E2 in the rat is inhibited by guanosine 5′-O-(2-thiodiphosphate), 2′,5′-dideoxyadenosine and Walsh inhibitor peptide. Neuroscience 71 : 259 263.
56. Yamamoto H, Kawamata T, Ninomiya T, Omote K, Namiki A (2006). Endothelin-1 enhances capsaicin-evoked intracellular Ca2+ response via activation of endothelin a receptor in a protein kinase Cepsilon-dependent manner in dorsal root ganglion neurons. Neuroscience 137 : 949 960.
57. Yao L, Fan P, Jiang Z, Gordon A, Mochly-Rosen D, Diamond I (2008). Dopamine and ethanol cause translocation of ηPKC associated with ηRACK: cross-talk between cAMP-Dependent Protein Kinase A and Protein Kinase C Signaling Pathways. Mol Pharmacol 73 : 1105 1112.
58. Yu PY, Eisner GM, Yamaguchi I, Mouradian MM, Felder RA, Jose PA (1996). Dopamine D1A receptor regulation of phospholipase C isoform. J Biol Chem 271 : 19503 19508.
59. Zhou Y, Li GD, Zhao ZQ (2003). State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury. J Neurochem 85 : 571 580.