The genetic ablation of cyclooxygenase 2 prevents the development of autoimmune arthritis

Arthritis and Rheumatism

Volumn 43, Issue 12, 2000, Pages 2687-2693

  Myers, Linda K ^a   Kang, Andrew H ^a   Postlethwaite, Arnold E ^a   Rosloniec, Edward F ^a   Morham, Scott G ^b   Shlopov, Boris V ^a   Goorha, Sarita ^a   Ballou, Leslie R ^a,c  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2 ANTIBODY; INTERLEUKIN 6; LYMPHOTOXIN; LYMPHOTOXIN BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; CELL INFILTRATION; CELL PROLIFERATION; CHONDROPATHY; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; GENE DELETION; HISTOPATHOLOGY; IMMUNE RESPONSE; INFLAMMATORY CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SPLEEN CELL; SYNOVIOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; ARTHRITIS; AUTOIMMUNE DISEASES; COLLAGEN; CYCLOOXYGENASE 2; CYTOKINES; GENE DELETION; IMMUNIZATION; IMMUNIZATION, PASSIVE; ISOENZYMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SPLEEN;

EID: 0034544685     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200012)43:12<2687::AID-ANR8>3.0.CO;2-9     Document Type: Article

References (25)

1. Role of cyclooxygenase-1 and -2 in health and disease
2. Prostaglandin endoperoxide H synthase (cyclooxygenases)-1 and -2
3. Collagen-induced arthritis: An animal model of autoimmunity
4. B cell-deficient mice do not develop type II collagen-induced arthritis (CIA)
5. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis
6. Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage: Influence of nitric oxide
7. Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis
8. The role of the B cell in the adoptive transfer of collagen-induced arthritis from DBA/1 (H-2q) to SCID (H-2d) mice
9. Collagen-induced arthritis in the BB rat: Prevention of disease by treatment with CTLA-4-Ig
10. Serum transfer of collagen-induced arthritis. II. Identification and localization of autoantibody to type II collagen in donor and recipient rats
11. Serum transfer of collagen-induced arthritis in mice
12. Induction of arthritis with monoclonal antibodies to collagen
13. 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines
14. 2 is a potent inhibitor of human interleukin 12 production
15. 2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells
16. 2 production by macrophages infected with HIV
17. 2 levels found in 14 patients undergoing autologous bone marrow or stem cell transplantation
18. Atopic dermatitis: The skin as a window into the pathogenesis of chronic allergic diseases
19. Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development
20. Collagen-induced arthritis in rats: Evaluation of early immunologic events
21. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
22. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
23. Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice
24. Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates
25. Collagen-induced arthritis in mice: Localization of an arthritogenic determinant to a fragment of the type II collagen molecule