Evidence for involvement of prostaglandin I2 as a major nociceptive mediator in acetic acid-induced writhing reaction: A study using IP-receptor disrupted mice

Advances in Experimental Medicine and Biology

Volumn 469, Issue , 2000, Pages 265-268

  Oh Ishi, S ^a   Ueno, A ^a   Matsumoto, H ^a   Murata, T ^a   Ushikubi, F ^a   Narumiya, S ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ACETIC ACID; ICOSANOID; INDOMETACIN; PHENYLQUINONE; PROSTACYCLIN; PROSTAGLANDIN E2;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; CHEMICAL REACTION; CONFERENCE PAPER; ENZYME IMMUNOASSAY; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN METABOLISM; STATISTICAL ANALYSIS; WRITHING TEST;

6-KETOPROSTAGLANDIN F1 ALPHA; ACETIC ACID; ANALGESICS, NON-NARCOTIC; ANIMALS; ASCITIC FLUID; DINOPROSTONE; EPOPROSTENOL; INDOMETHACIN; MALE; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; NOCICEPTORS; PAIN; PAIN MEASUREMENT; RECEPTORS, EPOPROSTENOL; RECEPTORS, PROSTAGLANDIN;

ANIMALIA;

EID: 0034465985     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (6)

1. Production of prostacyclin in mice following intraperitoneal injection of acetic acid, phenylquinone and zymosan: Its role in the writhing response
2. 2 to thromboxane and prostaglandin D2
3. Inhibition of prostaglandin biosynthesis as the mechanism of algesia of aspirin-like drugs in the dog knee joint
4. Increased thrombotic tendency, decreased inflammatory responses and hypoalgesia in prostacyclin receptor-deficient mice
5. Antagonism of pain and hyperalgesia
6. Comparison of eicosanoid production between rat polymorphonuclear leukocytes and macrophages: Detection by high-performance liquid chromatography with precolumn fluorescence labeling