A novel role of prostaglandin E2 in neuropathic pain: Blockade of microglial migration in the spinal cord

GLIA

Volumn 59, Issue 2, 2011, Pages 208-218

  Kunori, Shunji ^a,d   Matsumura, Shinji ^a   Okuda Ashitaka, Emiko ^a   Katano, Tayo ^a   Audoly, Laurent P ^b   Urade, Yoshihiro ^c   Ito, Seiji ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b PFIZER INC   (United States)

^c OSAKA BIOSCIENCE INSTITUTE   (Japan)

^d KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

MPGES 1 knockout mice; Nitric oxide; Prostaglandin EP receptor

Indexed keywords

ADENOSINE TRIPHOSPHATE; INDOMETACIN; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE SYNTHASE INHIBITOR; ONO 8713; ONO AE1 259; ONO AE1 329; ONO AE3 208; ONO AE3 240; ONO D1 004; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; S NITROSOGLUTATHIONE; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; GENETIC ANALYSIS; HUMAN; IN VITRO STUDY; IN VIVO CULTURE; MALE; MICROGLIA; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PERIPHERAL NERVE INJURY; PHARMACOLOGY; PRIORITY JOURNAL; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL MOVEMENT; CEREBRAL CORTEX; CINNAMATES; DINOPROSTONE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPERALGESIA; INDAZOLES; INTRAMOLECULAR OXIDOREDUCTASES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MICROGLIA; NEURALGIA; NEURONS; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE TYPE I; S-NITROSOGLUTATHIONE; SPINAL CORD; SPINAL NERVES;

EID: 78650248023     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.21090     Document Type: Article

References (37)

1. Abe T, Matsumura S, Katano T, Mabuchi T, Takagi K, Xu L, Yamamoto A, Hattori K, Yagi T, Watanabe M, Nakazawa T, Yamamoto T, Mishina M, Nakai Y, Ito S. 2005. Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur J Neurosci 22: 1445-1454.
2. 2 selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat Neurosci 5: 34-40.
3. Broom DC, Samad TA, Kohno T, Tegeder I, Geisslinger G, Woolf CJ. 2004. Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain. Neuroscience 124: 891-900.
4. Chen T, Koga K, Li XT, Zhou M. 2010. Spinal microglial motility is independent of neuronal activity and plasticity in adult mice. Mol Pain 6: 19.
5. Chopra B, Giblett S, Little JG, Donaldson LF, Tate S, Evans RJ, Grubb BD. 2000. Cyclooxygenase-1 is a marker for a subpopulation of putative nociceptive neurons in rat dorsal root ganglia. Eur J Neurosci 12: 911-920.
6. Dawson TM, Bredt DS, Fotuhi M, Hwang PM, Snyder SH. 1991. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci USA 88: 7797-7801.
7. Eisenach JC, Curry R, Rauck R, Pan P, Yaksh TL. 2010. Role of spinal cyclooxygenase in human postoperative and chronic pain. Anesthesiology 112: 1225-1233.
8. Engblom D, Saha S, Engström L, Westman M, Audoly LP, Jakobsson PJ, Blomqvist A. 2003. Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. Nat Neurosci 6: 1137-1138.
9. Garthwaite J. 2008. Concepts of neural nitric oxide-mediated transmission. Eur J Neurosci 27: 2783-2802.
10. Honda S, Sasaki Y, Ohsawa K, Imai Y, Nakamura Y, Inoue K, Kohsaka S. 2001. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci 21: 1975-1982.
11. Inoue K, Koizumi S, Tsuda M. 2007. The role of nucleotides in the neuron-glia communication responsible for the brain functions. J Neurochem 102: 1447-1458.
12. Ito S, Okuda-Ashitaka E, Minami T. 2001. Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin. Neurosci Res 41: 299-332.
13. Jin SX, Zhuang ZY, Woolf CJ, Ji RR. 2003. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci 23: 4017-4022.
14. Kamei D, Yamakawa K, Takegoshi Y, Mikami-Nakanishi M, Nakatani Y, Oh-Ishi S, Yasui H, Azuma Y, Hirasawa N, Ohuchi K, Kawaguchi H, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Kudo I. 2004. Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin E synthase-1. J Biol Chem 279: 33684-33695.
15. Lazarus M, Munday CJ, Eguchi N, Matsumoto S, Killian GJ, Kubata BK, Urade Y. 2003. Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs. Endocrinology 143: 2410-2419.
16. Ma W, Du W, Eisenach JC. 2002. Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. Brain Res 937: 94-99.
17. Mabuchi T, Kojima H, Abe T, Takagi K, Sakurai M, Ohmiya Y, Uematsu S, Akira S, Watanabe K, Ito S. 2004. Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain. Neuroreport 15: 1395-1398.
18. Milligan ED, Watkins LR. 2009. Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 10: 23-36.
19. α injected into conscious mice. Pain 57: 225-231.
20. 2. Eur J Neurosci 11: 1849-1856.
21. 2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem 275: 32783-32792.
22. 2 reduces extracellular ATP-induced migration in cultured rat microglia. Brain Res 1221: 1-5.
23. Narumiya S, Sugimoto Y, Ushikubi F. 1999. Prostanoid receptors: Structures, properties, and functions. Physiol Rev 79: 1193-1226.
24. Norel X, de Montpreville V, Brink C. 2004. Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: Effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. Prostaglandins Other Lipid Mediat 74: 101-112.
25. Omana-Zapata I, Bley KR. 2001. A stable prostacyclin analog enhances ectopic activity in rat sensory neurons following neuropathic injury. Brain Res 904: 85-92.
26. Parris WCV, Janicki PK, Johnson BJr, Horn JL. 1996. Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat. Can J Anaesth 43: 867-870.
27. Scholich K, Geisslinger G. 2006. Is mPGES-1 a promising target for pain therapy? Trends Pharmacol Sci 27: 399-401.
28. Scholz J, Woolf CJ. 2007. The neuropathic pain triad: Neurons, immune cells and glia. Nat Neurosci 10: 1361-1368.
29. Schwab JM, Brechtel K, Nguyen TD, Schluesener HJ. 2000. Persistent accumulation of cyclooxygenase-1 (COX-1) expressing microglia/macrophages and upregulation by endothelium following spinal cord injury. J Neuroimmunol 111: 122-130.
30. Suzumura A, Mezitis SG, Gonatas NK, Silberberg DH. 1987. MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: Induction of Ia antigen expression by γ-interferon. J Neuroimmunol 15: 263-278.
31. Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, Pandher K, Lapointe JM, Saha S, Roach ML, Carter D, Thomas NA, Durtschi BA, McNeish JD, Hambor JE, Jakobsson PJ, Carty TJ, Perez JR, Audoly LP. 2003. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci USA 100: 9044-9049.
32. Tsuda M, Inoue K, Salter MW. 2005. Neuropathic pain and spinal microglia: A big problem from molecules in 'small' glia. Trends Neurosci 28: 101-107.
33. 2 activation in primary afferent sensory neurons contributes to neuropathic pain. J Neurochem 103: 1408-1416.
34. Vane JR. 1971. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 231: 232-235.
35. Vo T, Rice ASC, Dworkin RH. 2009. Non-steroidal anti-inflammatory drugs for neuropathic pain: How do we explain continued widespread use? Pain 143: 169-171.
36. Webb SE, Pollard JW, Jones GE. 1996. Direct observation and quantification of macrophage chemoattraction to the growth factor CSF-1. J Cell Sci 109: 793-803.
37. Yaksh TL. 1999. Spinal systems and pain processing: Development of novel analgesic drugs with mechanistically defined models. Trends Pharmacol Sci 20: 329-337.