-
1
-
-
84871863918
-
Exposure to kynurenic acid during adolescence produces memory deficits in adulthood
-
Akagbosu C, Evans GC, Gulick D, Suckow RF, Bucci DJ, (2012). Exposure to kynurenic acid during adolescence produces memory deficits in adulthood. Schizophr Bull 38: 769-778.
-
(2012)
Schizophr Bull
, vol.38
, pp. 769-778
-
-
Akagbosu, C.1
Evans, G.C.2
Gulick, D.3
Suckow, R.F.4
Bucci, D.J.5
-
2
-
-
84862807159
-
Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I
-
Akladios FN, Nadvi NA, Park J, Hanrahan JR, Kapoor V, Gorrell MD, et al. (2012). Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorg Med Chem Lett 22: 1579-1581.
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 1579-1581
-
-
Akladios, F.N.1
Nadvi, N.A.2
Park, J.3
Hanrahan, J.R.4
Kapoor, V.5
Gorrell, M.D.6
-
3
-
-
84858445314
-
Acute elevations of brain kynurenic acid impair cognitive flexibility: Normalization by the alpha7 positive modulator galantamine
-
Alexander KS, Wu H-Q, Schwarcz R, Bruno JP, (2012). Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine. Psychopharmacology (Berl) 220: 627-637.
-
(2012)
Psychopharmacology (Berl)
, vol.220
, pp. 627-637
-
-
Alexander, K.S.1
Wu, H.-Q.2
Schwarcz, R.3
Bruno, J.P.4
-
4
-
-
2442714056
-
Targeted deletion of the kynurenine aminotransferase II gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha 7 nicotinic receptors in the hippocampus
-
Alkondon M, Pereira EFR, Yu P, Arruda EZ, Almeida LEF, Guidetti P, et al. (2004). Targeted deletion of the kynurenine aminotransferase II gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha 7 nicotinic receptors in the hippocampus. J Neurosci 24: 4635-4648.
-
(2004)
J Neurosci
, vol.24
, pp. 4635-4648
-
-
Alkondon, M.1
Pereira, E.F.R.2
Yu, P.3
Arruda, E.Z.4
Almeida, L.E.F.5
Guidetti, P.6
-
5
-
-
80052029915
-
Endogenous activation of nAChRs and NMDA receptors contributes to the excitability of CA1 stratum radiatum interneurons in rat hippocampal slices: Effects of kynurenic acid
-
Alkondon M, Pereira EFR, Albuquerque EX, (2011a). Endogenous activation of nAChRs and NMDA receptors contributes to the excitability of CA1 stratum radiatum interneurons in rat hippocampal slices: effects of kynurenic acid. Biochem Pharmacol 82: 842-851.
-
(2011)
Biochem Pharmacol
, vol.82
, pp. 842-851
-
-
Alkondon, M.1
Pereira, E.F.R.2
Albuquerque, E.X.3
-
6
-
-
79956225844
-
Age dependency of inhibition of alpha-7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain
-
Alkondon M, Pereira EFR, Eisenberg HM, Kajii Y, Schwarcz R, Albuquerque EX, (2011b). Age dependency of inhibition of alpha-7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain. J Pharmacol Exp Ther 337: 572-582.
-
(2011)
J Pharmacol Exp Ther
, vol.337
, pp. 572-582
-
-
Alkondon, M.1
Pereira, E.F.R.2
Eisenberg, H.M.3
Kajii, Y.4
Schwarcz, R.5
Albuquerque, E.X.6
-
7
-
-
60349111588
-
Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum
-
Amori L, Wu H-Q, Marinozzi M, Pellicciari R, Guidetti P, Schwarcz R, (2009). Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience 159: 196-203.
-
(2009)
Neuroscience
, vol.159
, pp. 196-203
-
-
Amori, L.1
Wu, H.-Q.2
Marinozzi, M.3
Pellicciari, R.4
Guidetti, P.5
Schwarcz, R.6
-
8
-
-
84879397612
-
-
US Patent and Trademark Offices: Alexandria, VA.
-
Andersen RJ, Pereira A, Huan X-H, Mauk G, Vottero E, Roberge M, et al. (2012). Patent US 7799776: indoleamine-2,3-dioxygenase (IDO) inhibitors. US Patent and Trademark Offices: Alexandria, VA.
-
(2012)
Patent US 7799776: indoleamine-2,3-dioxygenase (IDO) Inhibitors
-
-
Andersen, R.J.1
Pereira, A.2
Huan, X.-H.3
Mauk, G.4
Vottero, E.5
Roberge, M.6
-
9
-
-
33845206650
-
Acute psychotic symptoms in HIV-1 infected patients are associated with increased levels of kynurenic acid in cerebrospinal fluid
-
Atlas A, Gisslen M, Nordin C, Lindstrom L, Schwieler L, (2007). Acute psychotic symptoms in HIV-1 infected patients are associated with increased levels of kynurenic acid in cerebrospinal fluid. Brain Behav Immun 21: 86-91.
-
(2007)
Brain Behav Immun
, vol.21
, pp. 86-91
-
-
Atlas, A.1
Gisslen, M.2
Nordin, C.3
Lindstrom, L.4
Schwieler, L.5
-
10
-
-
84879334302
-
-
US Patent and Trademark Offices: Alexandria, VA.
-
Autier V, De Vacqueur AA, Moinet G, Mariais D, Kargar C, Kergoat M, (2010). Patent US 7727977B2: kynurenine-3-hydroxylase inhibitors for the treatment of diabetes. US Patent and Trademark Offices: Alexandria, VA.
-
(2010)
Patent US 7727977B2: kynurenine-3-hydroxylase Inhibitors for the Treatment of Diabetes
-
-
Autier, V.1
De Vacqueur, A.A.2
Moinet, G.3
Mariais, D.4
Kargar, C.5
Kergoat, M.6
-
11
-
-
77649335893
-
Linking cognitive aging to alterations in dopamine neurotransmitter functioning: Recent data and future avenues
-
Backman L, Lindenberger U, Li S-C, Nyberg L, (2010). Linking cognitive aging to alterations in dopamine neurotransmitter functioning: recent data and future avenues. Neurosci Biobehav Rev 34: 670-677.
-
(2010)
Neurosci Biobehav Rev
, vol.34
, pp. 670-677
-
-
Backman, L.1
Lindenberger, U.2
Li, S.-C.3
Nyberg, L.4
-
12
-
-
0026043565
-
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease
-
Beal MF, Ferrante RJ, Swartz KJ, Kowall NW, (1991). Chronic quinolinic acid lesions in rats closely resemble Huntington's disease. J Neurosci 11: 1649-1659.
-
(1991)
J Neurosci
, vol.11
, pp. 1649-1659
-
-
Beal, M.F.1
Ferrante, R.J.2
Swartz, K.J.3
Kowall, N.W.4
-
13
-
-
84879369538
-
-
European Patent Office: Munich, Germany.
-
Benatti L, Caccia C, Fariello R, Pellicciari R, Salvati P, (2005). Patent EP1565451: halothienoyl-cyclopropane-1-carboxylic acid derivatives. European Patent Office: Munich, Germany.
-
(2005)
Patent EP1565451: halothienoyl-cyclopropane-1-carboxylic Acid Derivatives
-
-
Benatti, L.1
Caccia, C.2
Fariello, R.3
Pellicciari, R.4
Salvati, P.5
-
14
-
-
77955069370
-
Indoleamine 2,3-dioxygenase and 3-hydroxy-kynurenine modifications are found in the neuropathology of Alzheimer's disease
-
Bonda DJ, Mailankot M, Stone JG, Garrett MR, Staniszewska M, Castellani RJ, et al. (2010). Indoleamine 2,3-dioxygenase and 3-hydroxy-kynurenine modifications are found in the neuropathology of Alzheimer's disease. Redox Rep 15: 161-168.
-
(2010)
Redox Rep
, vol.15
, pp. 161-168
-
-
Bonda, D.J.1
Mailankot, M.2
Stone, J.G.3
Garrett, M.R.4
Staniszewska, M.5
Castellani, R.J.6
-
15
-
-
0033832470
-
Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia
-
Breese CR, Lee MJ, Adams CE, Sullivan B, Logel J, Gillen KM, et al. (2000). Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia. Neuropsychopharmacology 23: 351-364.
-
(2000)
Neuropsychopharmacology
, vol.23
, pp. 351-364
-
-
Breese, C.R.1
Lee, M.J.2
Adams, C.E.3
Sullivan, B.4
Logel, J.5
Gillen, K.M.6
-
16
-
-
0028305047
-
Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities
-
Carpenedo R, Chiarugi A, Russi P, Lombardi G, Carla V, Pellicciari R, et al. (1994). Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities. Neuroscience 61: 237-244.
-
(1994)
Neuroscience
, vol.61
, pp. 237-244
-
-
Carpenedo, R.1
Chiarugi, A.2
Russi, P.3
Lombardi, G.4
Carla, V.5
Pellicciari, R.6
-
17
-
-
0034949090
-
Presynaptic kynurenate-sensitive receptors inhibit glutamate release
-
Carpenedo R, Pittaluga A, Cozzi A, Attucci S, Galli A, Raiteri M, et al. (2001). Presynaptic kynurenate-sensitive receptors inhibit glutamate release. Eur J Neurosci 13: 2141-2147.
-
(2001)
Eur J Neurosci
, vol.13
, pp. 2141-2147
-
-
Carpenedo, R.1
Pittaluga, A.2
Cozzi, A.3
Attucci, S.4
Galli, A.5
Raiteri, M.6
-
18
-
-
78649809189
-
Biochemical and structural investigations on kynurenine aminotransferase II: An example of conformation-driven species-specific Inhibition
-
Casazza V, Rossi F, Rizzi M, (2011). Biochemical and structural investigations on kynurenine aminotransferase II: an example of conformation-driven species-specific Inhibition. Curr Top Med Chem 11: 148-157.
-
(2011)
Curr Top Med Chem
, vol.11
, pp. 148-157
-
-
Casazza, V.1
Rossi, F.2
Rizzi, M.3
-
20
-
-
33748931998
-
Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain
-
Ceresoli-Borroni G, Rassoulpour A, Wu H-Q, Guidetti P, Schwarcz R, (2006). Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain. J Neural Transm 113: 1355-1365.
-
(2006)
J Neural Transm
, vol.113
, pp. 1355-1365
-
-
Ceresoli-Borroni, G.1
Rassoulpour, A.2
Wu, H.-Q.3
Guidetti, P.4
Schwarcz, R.5
-
22
-
-
33747459300
-
Increased concentration of cerebral kynurenic acid alters stimulus processing and conditioned responding
-
Chess AC, Bucci DJ, (2006). Increased concentration of cerebral kynurenic acid alters stimulus processing and conditioned responding. Behav Brain Res 170: 326-332.
-
(2006)
Behav Brain Res
, vol.170
, pp. 326-332
-
-
Chess, A.C.1
Bucci, D.J.2
-
23
-
-
34248335693
-
Elevations of endogenous kynurenic acid produce spatial working memory deficits
-
Chess AC, Simoni MK, Alling TE, Bucci DJ, (2007). Elevations of endogenous kynurenic acid produce spatial working memory deficits. Schizophr Bull 33: 797-804.
-
(2007)
Schizophr Bull
, vol.33
, pp. 797-804
-
-
Chess, A.C.1
Simoni, M.K.2
Alling, T.E.3
Bucci, D.J.4
-
24
-
-
67349279255
-
L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning
-
Chess AC, Landers AM, Bucci DJ, (2009). L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning. Behav Brain Res 201: 325-331.
-
(2009)
Behav Brain Res
, vol.201
, pp. 325-331
-
-
Chess, A.C.1
Landers, A.M.2
Bucci, D.J.3
-
25
-
-
0029097764
-
Comparison of the neurochemical and behavioral-effects resulting from inhibition of kynurenine hydroxylase and/or kynureninase
-
Chiarugi A, Carpenedo R, Molina M, Mattoli L, Pellicciari R, Moroni F, (1995). Comparison of the neurochemical and behavioral-effects resulting from inhibition of kynurenine hydroxylase and/or kynureninase. J Neurochem 65: 1176-1183.
-
(1995)
J Neurochem
, vol.65
, pp. 1176-1183
-
-
Chiarugi, A.1
Carpenedo, R.2
Molina, M.3
Mattoli, L.4
Pellicciari, R.5
Moroni, F.6
-
26
-
-
0030035748
-
Kynurenine disposition in blood and brain of mice: Effects of selective inhibitors of kynurenine hydroxylase and of kynureninase
-
Chiarugi A, Carpenedo R, Moroni F, (1996). Kynurenine disposition in blood and brain of mice: effects of selective inhibitors of kynurenine hydroxylase and of kynureninase. J Neurochem 67: 692-698.
-
(1996)
J Neurochem
, vol.67
, pp. 692-698
-
-
Chiarugi, A.1
Carpenedo, R.2
Moroni, F.3
-
27
-
-
23344438452
-
Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition
-
Clark CJ, Mackay GM, Smythe GA, Bustamante S, Stone TW, Phillips RS, (2005). Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition. Infect Immun 73: 5249-5251.
-
(2005)
Infect Immun
, vol.73
, pp. 5249-5251
-
-
Clark, C.J.1
Mackay, G.M.2
Smythe, G.A.3
Bustamante, S.4
Stone, T.W.5
Phillips, R.S.6
-
28
-
-
0037308979
-
Induction of metabolic hypofunction and neurochemical deficits after chronic intermittent exposure to phencyclidine: Differential modulation by antipsychotic drugs
-
Cochran SM, Kennedy M, McKerchar CE, Steward LJ, Pratt JA, Morris BJ, (2003). Induction of metabolic hypofunction and neurochemical deficits after chronic intermittent exposure to phencyclidine: differential modulation by antipsychotic drugs. Neuropsychopharmacology 28: 265-275.
-
(2003)
Neuropsychopharmacology
, vol.28
, pp. 265-275
-
-
Cochran, S.M.1
Kennedy, M.2
McKerchar, C.E.3
Steward, L.J.4
Pratt, J.A.5
Morris, B.J.6
-
29
-
-
0033502043
-
Kynurenine hydroxylase inhibitors reduce ischaemic brain damage: Studies with (m-nitrobenzoyl)alanine and 3,4-dimethoxy-[N-4-(nitrophenyl)thiazol-2-yl]- benzenesulfonamide (Ro 61-8048) in models of focal or global ischaemia
-
Cozzi R, Carpenedo R, Moroni F, (1999). Kynurenine hydroxylase inhibitors reduce ischaemic brain damage: studies with (m-nitrobenzoyl)alanine and 3,4-dimethoxy-[N-4-(nitrophenyl)thiazol-2-yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global ischaemia. J Cereb Blood Flow Metab 19: 771-777.
-
(1999)
J Cereb Blood Flow Metab
, vol.19
, pp. 771-777
-
-
Cozzi, R.1
Carpenedo, R.2
Moroni, F.3
-
30
-
-
79957798755
-
Forebrain NR2B overexpression facilitating the prefrontal cortex long-term potentiation and enhancing working memory function in mice
-
AR.
-
Cui Y, Jin J, Zhang X, Xu H, Yang LG, Du D, et al. (2011). Forebrain NR2B overexpression facilitating the prefrontal cortex long-term potentiation and enhancing working memory function in mice. PLoS ONE 6, AR: e20312.
-
(2011)
PLoS ONE
, vol.6
-
-
Cui, Y.1
Jin, J.2
Zhang, X.3
Xu, H.4
Yang, L.G.5
Du, D.6
-
32
-
-
8844286003
-
Prefrontal executive and cognitive functions in rodents: Neural and neurochemical substrates
-
Dalley JW, Cardinal RN, Robbins TW, (2004). Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev 28: 771-784.
-
(2004)
Neurosci Biobehav Rev
, vol.28
, pp. 771-784
-
-
Dalley, J.W.1
Cardinal, R.N.2
Robbins, T.W.3
-
33
-
-
37249094173
-
From inflammation to sickness and depression: When the immune system subjugates the brain
-
Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW, (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9: 46-57.
-
(2008)
Nat Rev Neurosci
, vol.9
, pp. 46-57
-
-
Dantzer, R.1
O'Connor, J.C.2
Freund, G.G.3
Johnson, R.W.4
Kelley, K.W.5
-
34
-
-
35448978696
-
Altered kynurenine metabolism correlates with infarct volume in stroke
-
Darlington LG, Mackay GM, Forrest CM, Stoy N, George C, Stone TW, (2007). Altered kynurenine metabolism correlates with infarct volume in stroke. Eur J Neurosci 26: 2211-2221.
-
(2007)
Eur J Neurosci
, vol.26
, pp. 2211-2221
-
-
Darlington, L.G.1
Mackay, G.M.2
Forrest, C.M.3
Stoy, N.4
George, C.5
Stone, T.W.6
-
35
-
-
80054951143
-
On the biological significance of the 3-hydroxyanthranilic acid: Anthranilic acid ratio
-
Darlington LG, Forrest CM, Mackay GM, Stoy N, Smith RA, Smith AJ, et al. (2010). On the biological significance of the 3-hydroxyanthranilic acid: anthranilic acid ratio. Int J Tryptophan Res 3: 51-59.
-
(2010)
Int J Tryptophan Res
, vol.3
, pp. 51-59
-
-
Darlington, L.G.1
Forrest, C.M.2
Mackay, G.M.3
Stoy, N.4
Smith, R.A.5
Smith, A.J.6
-
36
-
-
84860315722
-
Social influences on neuroplasticity: Stress and interventions to promote well-being
-
Davidson RJ, McEwen BS, (2012). Social influences on neuroplasticity: stress and interventions to promote well-being. Nat Neurosci 15: 689-695.
-
(2012)
Nat Neurosci
, vol.15
, pp. 689-695
-
-
Davidson, R.J.1
McEwen, B.S.2
-
37
-
-
79955745304
-
The cholinergic system and spatial learning
-
Deiana S, Platt B, Riedel G, (2011). The cholinergic system and spatial learning. Behav Brain Res 221: 389-411.
-
(2011)
Behav Brain Res
, vol.221
, pp. 389-411
-
-
Deiana, S.1
Platt, B.2
Riedel, G.3
-
38
-
-
84879388327
-
-
European Patent Office: Munich, Germany.
-
Della Torre A, Heidempergher F, Pevarello P, Speciale C, Varasi M, (2001). Patent EP 0922044: pyrrolo(3,2c) derivatives. European Patent Office: Munich, Germany.
-
(2001)
Patent EP 0922044: pyrrolo(3,2c) Derivatives
-
-
Della Torre, A.1
Heidempergher, F.2
Pevarello, P.3
Speciale, C.4
Varasi, M.5
-
39
-
-
79551688725
-
Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling
-
DiNatale BC, Murray IA, Schroeder JC, Flaveny CA, Lahoti TS, Laurenzana EM, et al. (2010). Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci 115: 89-97.
-
(2010)
Toxicol Sci
, vol.115
, pp. 89-97
-
-
Dinatale, B.C.1
Murray, I.A.2
Schroeder, J.C.3
Flaveny, C.A.4
Lahoti, T.S.5
Laurenzana, E.M.6
-
40
-
-
84864691584
-
Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons
-
AR.
-
Dobelis P, Staley KJ, Cooper DC, (2012). Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. PLoS ONE 7, AR: e41108.
-
(2012)
PLoS ONE
, vol.7
-
-
Dobelis, P.1
Staley, K.J.2
Cooper, D.C.3
-
41
-
-
84863267354
-
Discovery of brain-penetrant, irreversible kynurenine aminotransferase II inhibitors for schizophrenia
-
Dounay AB, Anderson M, Bechle BM, Campbell BM, Claffey MM, Evdokimov A, et al. (2012). Discovery of brain-penetrant, irreversible kynurenine aminotransferase II inhibitors for schizophrenia. ACS Med Chem Lett 3: 187-192.
-
(2012)
ACS Med Chem Lett
, vol.3
, pp. 187-192
-
-
Dounay, A.B.1
Anderson, M.2
Bechle, B.M.3
Campbell, B.M.4
Claffey, M.M.5
Evdokimov, A.6
-
42
-
-
0026635895
-
Uptake of 3-hydroxykynurenine measured in rat-brain slices and in a neuronal cell-line
-
Eastman CL, Guilarte TR, Lever JR, (1992). Uptake of 3-hydroxykynurenine measured in rat-brain slices and in a neuronal cell-line. Brain Res 584: 110-116.
-
(1992)
Brain Res
, vol.584
, pp. 110-116
-
-
Eastman, C.L.1
Guilarte, T.R.2
Lever, J.R.3
-
43
-
-
4143096940
-
Endogenous kynurenic acid disrupts prepulse inhibition
-
Erhardt S, Schwieler L, Emanuelsson C, Geyer M, (2004). Endogenous kynurenic acid disrupts prepulse inhibition. Biol Psychiatry 56: 255-260.
-
(2004)
Biol Psychiatry
, vol.56
, pp. 255-260
-
-
Erhardt, S.1
Schwieler, L.2
Emanuelsson, C.3
Geyer, M.4
-
44
-
-
71649101571
-
Blood levels of kynurenines, interleukin-23 and sHLA-G at different stages of Huntington's disease
-
Forrest CM, Mackay GM, Stoy N, Spiden SL, Taylor R, Stone TW, et al. (2010). Blood levels of kynurenines, interleukin-23 and sHLA-G at different stages of Huntington's disease. J Neurochem 112: 112-122.
-
(2010)
J Neurochem
, vol.112
, pp. 112-122
-
-
Forrest, C.M.1
Mackay, G.M.2
Stoy, N.3
Spiden, S.L.4
Taylor, R.5
Stone, T.W.6
-
45
-
-
80052679156
-
Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery
-
Forrest CM, Mackay GM, Oxford L, Millar K, Darlington LG, Higgins MJ, et al. (2011). Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery. J Neurochem 119: 136-152.
-
(2011)
J Neurochem
, vol.119
, pp. 136-152
-
-
Forrest, C.M.1
Mackay, G.M.2
Oxford, L.3
Millar, K.4
Darlington, L.G.5
Higgins, M.J.6
-
46
-
-
84861947641
-
Prenatal activation of Toll like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring
-
Forrest CM, Khalil OS, Pisar M, Smith RA, Darlington LG, Stone TW, (2012). Prenatal activation of Toll like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring. Mol Brain 5: 22.
-
(2012)
Mol Brain
, vol.5
, pp. 22
-
-
Forrest, C.M.1
Khalil, O.S.2
Pisar, M.3
Smith, R.A.4
Darlington, L.G.5
Stone, T.W.6
-
47
-
-
84875231906
-
Prenatal inhibition of the tryptophan-kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus
-
Forrest CM, Khalil OS, Pisar M, Darlington LG, Stone TW, (2013). Prenatal inhibition of the tryptophan-kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus. Brain Res 1504: 1-15.
-
(2013)
Brain Res
, vol.1504
, pp. 1-15
-
-
Forrest, C.M.1
Khalil, O.S.2
Pisar, M.3
Darlington, L.G.4
Stone, T.W.5
-
48
-
-
0026076136
-
Blood-brain-barrier transport of kynurenines - Implications for brain synthesis and metabolism
-
Fukui S, Schwarcz R, Rapoport SI, Takada Y, Smith QR, (1991). Blood-brain-barrier transport of kynurenines-implications for brain synthesis and metabolism. J Neurochem 56: 2007-2017.
-
(1991)
J Neurochem
, vol.56
, pp. 2007-2017
-
-
Fukui, S.1
Schwarcz, R.2
Rapoport, S.I.3
Takada, Y.4
Smith, Q.R.5
-
49
-
-
80052036278
-
Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia
-
Gellert L, Fuzik J, Goebloes A, Sarkoezi K, Marosi M, Kis Z, et al. (2011). Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia. Eur J Pharmacol 667: 182-187.
-
(2011)
Eur J Pharmacol
, vol.667
, pp. 182-187
-
-
Gellert, L.1
Fuzik, J.2
Goebloes, A.3
Sarkoezi, K.4
Marosi, M.5
Kis, Z.6
-
50
-
-
34547098201
-
-
US Patent and Trademark Offices: Alexandria, VA.
-
Giordani A, Pevarello P, Speciale C, Varasi M, (2000). Patent US 6048896: 4-phenyl-4-oxo-2-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity. US Patent and Trademark Offices: Alexandria, VA.
-
(2000)
Patent US 6048896: 4-phenyl-4-oxo-2-butenoic Acid Derivatives with kynurenine-3-hydroxylase Inhibiting Activity
-
-
Giordani, A.1
Pevarello, P.2
Speciale, C.3
Varasi, M.4
-
51
-
-
18144406846
-
A genomic screen in yeast implicates kynurenine-3-monooxygenase as a therapeutic target for Huntington disease
-
Giorgini F, Guidetti P, Nguyen QV, Bennett SC, Muchowski PJ, (2005). A genomic screen in yeast implicates kynurenine-3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet 37: 526-531.
-
(2005)
Nat Genet
, vol.37
, pp. 526-531
-
-
Giorgini, F.1
Guidetti, P.2
Nguyen, Q.V.3
Bennett, S.C.4
Muchowski, P.J.5
-
52
-
-
79951549282
-
The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment
-
: AR.
-
Gold AB, Herrmann N, Swardfager W, Black SE, Aviv RI, Tennen G, et al. (2011). The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment. J Neuroinflammation 8: AR 17.
-
(2011)
J Neuroinflammation
, vol.8
, pp. 17
-
-
Gold, A.B.1
Herrmann, N.2
Swardfager, W.3
Black, S.E.4
Aviv, R.I.5
Tennen, G.6
-
53
-
-
79955629703
-
Cholinergic receptor subtypes and their role in cognition, emotion and vigilance control: A review of preclinical and clinical findings
-
Graef S, Schoenknecht P, Sabri O, Hegerl U, (2011). Cholinergic receptor subtypes and their role in cognition, emotion and vigilance control: a review of preclinical and clinical findings. Psychopharmacology (Berl) 215: 205-229.
-
(2011)
Psychopharmacology (Berl)
, vol.215
, pp. 205-229
-
-
Graef, S.1
Schoenknecht, P.2
Sabri, O.3
Hegerl, U.4
-
54
-
-
0032698232
-
3-hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum
-
Guidetti P, Schwarcz R, (1999). 3-hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum. Eur J Neurosci 11: 3857-3863.
-
(1999)
Eur J Neurosci
, vol.11
, pp. 3857-3863
-
-
Guidetti, P.1
Schwarcz, R.2
-
55
-
-
0034647059
-
Early kynureninergic impairment in Huntington's disease and in a transgenic animal model
-
Guidetti P, Reddy PH, Tagle DA, Schwarcz R, (2000). Early kynureninergic impairment in Huntington's disease and in a transgenic animal model. Neurosci Lett 283: 233-235.
-
(2000)
Neurosci Lett
, vol.283
, pp. 233-235
-
-
Guidetti, P.1
Reddy, P.H.2
Tagle, D.A.3
Schwarcz, R.4
-
56
-
-
33745279104
-
Elevated brain 3-hydroxykynurenine and quinolinate in Huntington disease mice
-
Guidetti P, Bates GP, Graham RK, Hayden MR, Leavitt BR, MacDonald ME, et al. (2006). Elevated brain 3-hydroxykynurenine and quinolinate in Huntington disease mice. Neurobiol Dis 23: 190-197.
-
(2006)
Neurobiol Dis
, vol.23
, pp. 190-197
-
-
Guidetti, P.1
Bates, G.P.2
Graham, R.K.3
Hayden, M.R.4
Leavitt, B.R.5
Macdonald, M.E.6
-
57
-
-
84879386248
-
-
European Patent Office: Munich, Germany and US Patent and Trademark Offices: Alexandria, VA.
-
Guidetti P, Pellicciari R, Schwarcz R, (2008). Patent EP 1954665 and US 201110144064: inhibitors of kynurenine aminotransferase and uses therefore. European Patent Office: Munich, Germany and US Patent and Trademark Offices: Alexandria, VA.
-
(2008)
Patent EP 1954665 and US 201110144064: Inhibitors of Kynurenine Aminotransferase and Uses Therefore
-
-
Guidetti, P.1
Pellicciari, R.2
Schwarcz, R.3
-
58
-
-
0037337196
-
Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes
-
Guillemin GJ, Croitoru-Lamoury J, Dormont D, Armati PJ, Brew BJ, (2003). Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes. Glia 41: 371-381.
-
(2003)
Glia
, vol.41
, pp. 371-381
-
-
Guillemin, G.J.1
Croitoru-Lamoury, J.2
Dormont, D.3
Armati, P.J.4
Brew, B.J.5
-
59
-
-
23044462498
-
Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus
-
Guillemin GJ, Brew BJ, Noonan CE, Takikawa O, Cullen KM, (2005). Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus. Neuropathol Appl Neurobiol 31: 395-404.
-
(2005)
Neuropathol Appl Neurobiol
, vol.31
, pp. 395-404
-
-
Guillemin, G.J.1
Brew, B.J.2
Noonan, C.E.3
Takikawa, O.4
Cullen, K.M.5
-
60
-
-
77956917231
-
Synaptic versus extrasynaptic NMDA receptor signalling: Implications for neurodegenerative disorders
-
Hardingham GE, Bading H, (2011). Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat Rev Neurosci 11: 682-696.
-
(2011)
Nat Rev Neurosci
, vol.11
, pp. 682-696
-
-
Hardingham, G.E.1
Bading, H.2
-
62
-
-
84871803863
-
Discovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokinetics
-
Henderson JL, Sawant-Basak A, Tuttle JB, Dounay AB, McAllister LA, Pandit J, et al. (2013). Discovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokinetics. MedChemComm 4: 125-129.
-
(2013)
MedChemComm
, vol.4
, pp. 125-129
-
-
Henderson, J.L.1
Sawant-Basak, A.2
Tuttle, J.B.3
Dounay, A.B.4
McAllister, L.A.5
Pandit, J.6
-
63
-
-
63849154126
-
In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease
-
Heng MY, Detloff PJ, Wang PL, Tsien JZ, Albin RL, (2009). In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease. J Neurosci 29: 3200-3205.
-
(2009)
J Neurosci
, vol.29
, pp. 3200-3205
-
-
Heng, M.Y.1
Detloff, P.J.2
Wang, P.L.3
Tsien, J.Z.4
Albin, R.L.5
-
64
-
-
77249153190
-
Loss of alpha-7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease
-
Hernandez CM, Kayed R, Zheng H, Sweatt JD, Dineley KT, (2010). Loss of alpha-7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J Neurosci 30: 2442-2453.
-
(2010)
J Neurosci
, vol.30
, pp. 2442-2453
-
-
Hernandez, C.M.1
Kayed, R.2
Zheng, H.3
Sweatt, J.D.4
Dineley, K.T.5
-
65
-
-
0026061120
-
Quinolinic acid in cerebrospinal-fluid and serum in HIV-1 infection - Relationship to clinical and neurological status
-
Heyes MP, Brew BJ, Martin A, Price RW, Salazar AM, Sidtis JJ, et al. (1991). Quinolinic acid in cerebrospinal-fluid and serum in HIV-1 infection-relationship to clinical and neurological status. Ann Neurol 29: 202-209.
-
(1991)
Ann Neurol
, vol.29
, pp. 202-209
-
-
Heyes, M.P.1
Brew, B.J.2
Martin, A.3
Price, R.W.4
Salazar, A.M.5
Sidtis, J.J.6
-
66
-
-
0035478066
-
The brain metabolites kynurenic acid inhibits α7-nicotinic receptor activity and increases non-α7 nicotinic receptor expression
-
Hilmas C, Pereira EFR, Alkondon M, Rassoulpour A, Schwarcz R, Albuquerque EX, (2001). The brain metabolites kynurenic acid inhibits α7-nicotinic receptor activity and increases non-α7 nicotinic receptor expression. J Neurosci 21: 7463-7473.
-
(2001)
J Neurosci
, vol.21
, pp. 7463-7473
-
-
Hilmas, C.1
Pereira, E.F.R.2
Alkondon, M.3
Rassoulpour, A.4
Schwarcz, R.5
Albuquerque, E.X.6
-
67
-
-
84255168900
-
Kynurenine 3-monooxygenase polymorphisms: Relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls
-
Holtze M, Saetre P, Engberg G, Schwieler L, Werge T, Andreassen OA, et al. (2012). Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls. J Psychiatry Neurosci 37: 53-57.
-
(2012)
J Psychiatry Neurosci
, vol.37
, pp. 53-57
-
-
Holtze, M.1
Saetre, P.2
Engberg, G.3
Schwieler, L.4
Werge, T.5
Andreassen, O.A.6
-
68
-
-
0030882268
-
Cognitive manifestations of Huntington's disease in relation to genetic structure and clinical onset
-
Jason GW, Suchowersky O, Pajurkova EM, Graham L, Klimek ML, Garber AT, et al. (1997). Cognitive manifestations of Huntington's disease in relation to genetic structure and clinical onset. Arch Neurol 54: 1081-1088.
-
(1997)
Arch Neurol
, vol.54
, pp. 1081-1088
-
-
Jason, G.W.1
Suchowersky, O.2
Pajurkova, E.M.3
Graham, L.4
Klimek, M.L.5
Garber, A.T.6
-
69
-
-
0027233551
-
Intravenous administration of l-kynurenine to rhesus-monkeys - Effect on quinolinate and kynurenate levels in serum and cerebrospinal-fluid
-
Jauch DA, Sethy VH, Weick BG, Chase TN, Schwarcz R, (1993). Intravenous administration of l-kynurenine to rhesus-monkeys-effect on quinolinate and kynurenate levels in serum and cerebrospinal-fluid. Neuropharmacology 32: 467-472.
-
(1993)
Neuropharmacology
, vol.32
, pp. 467-472
-
-
Jauch, D.A.1
Sethy, V.H.2
Weick, B.G.3
Chase, T.N.4
Schwarcz, R.5
-
70
-
-
0032903301
-
The neuropsychopharmacology of phencyclidine: From NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia
-
Jentsch JD, Roth RH, (1999). The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 20: 201-225.
-
(1999)
Neuropsychopharmacology
, vol.20
, pp. 201-225
-
-
Jentsch, J.D.1
Roth, R.H.2
-
71
-
-
84863389813
-
Influenza infection induces neuroinflammation, alters hippocampal neuron morphology, and impairs cognition in adult mice
-
Jurgens HA, Amancherla K, Johnson RW, (2012). Influenza infection induces neuroinflammation, alters hippocampal neuron morphology, and impairs cognition in adult mice. J Neurosci 32: 3958-3968.
-
(2012)
J Neurosci
, vol.32
, pp. 3958-3968
-
-
Jurgens, H.A.1
Amancherla, K.2
Johnson, R.W.3
-
72
-
-
57749185694
-
The NMDA Agonist D-Cycloserine facilitates fear memory consolidation in humans
-
Kalisch R, Holt B, Petrovic P, De Martino B, Kloppel S, Buchel C, et al. (2009). The NMDA Agonist D-Cycloserine facilitates fear memory consolidation in humans. Cerebral Cortex 19: 187-196.
-
(2009)
Cerebral Cortex
, vol.19
, pp. 187-196
-
-
Kalisch, R.1
Holt, B.2
Petrovic, P.3
De Martino, B.4
Kloppel, S.5
Buchel, C.6
-
73
-
-
84859568305
-
The kynurenine pathway and quinolinic acid: Pivotal roles in HIV associated neurocognitive disorders
-
Kandanearatchi A, Brew BJ, (2012). The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders. FEBS J 279: 1366-1374.
-
(2012)
FEBS J
, vol.279
, pp. 1366-1374
-
-
Kandanearatchi, A.1
Brew, B.J.2
-
74
-
-
77955648350
-
Psychological stress-induced, IDO1-dependent tryptophan catabolism: Implications on immunosuppression in mice and humans
-
: AR.
-
Kiank C, Zeden J-P, Drude S, Domanska G, Fusch G, Otten W, et al. (2010). Psychological stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans. PLoS ONE 5: AR e11825.
-
(2010)
PLoS ONE
, vol.5
-
-
Kiank, C.1
Zeden, J.-P.2
Drude, S.3
Domanska, G.4
Fusch, G.5
Otten, W.6
-
75
-
-
0035957946
-
Alpha-7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block a beta-amyloid-induced neurotoxicity
-
Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, et al. (2001). alpha-7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block a beta-amyloid-induced neurotoxicity. J Biol Chem 276: 13541-13546.
-
(2001)
J Biol Chem
, vol.276
, pp. 13541-13546
-
-
Kihara, T.1
Shimohama, S.2
Sawada, H.3
Honda, K.4
Nakamizo, T.5
Shibasaki, H.6
-
77
-
-
0038383769
-
L-cysteine sulphinate, endogenous sulphur-containing amino acid, inhibits rat brain kynurenic acid production via selective interference with kynurenine aminotransferase II
-
Kocki T, Luchowski P, Luchowska E, Wielosz M, Turski WA, Urbanska EM, (2003). L-cysteine sulphinate, endogenous sulphur-containing amino acid, inhibits rat brain kynurenic acid production via selective interference with kynurenine aminotransferase II. Neurosci Lett 346: 97-100.
-
(2003)
Neurosci Lett
, vol.346
, pp. 97-100
-
-
Kocki, T.1
Luchowski, P.2
Luchowska, E.3
Wielosz, M.4
Turski, W.A.5
Urbanska, E.M.6
-
78
-
-
77955421801
-
Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry
-
Konradsson-Geuken A, Wu H-Q, Gash CR, Alexander KS, Campbell A, Sozeri Y, et al. (2010). Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry. Neuroscience 169: 1848-1859.
-
(2010)
Neuroscience
, vol.169
, pp. 1848-1859
-
-
Konradsson-Geuken, A.1
Wu, H.-Q.2
Gash, C.R.3
Alexander, K.S.4
Campbell, A.5
Sozeri, Y.6
-
79
-
-
0031657598
-
Cognitive functions and corticostriatal circuits: Insights from Huntington's disease
-
Lawrence AD, Sahakian BJ, Robbins TW, (1998). Cognitive functions and corticostriatal circuits: insights from Huntington's disease. Trends Cogn Sci 2: 379-388.
-
(1998)
Trends Cogn Sci
, vol.2
, pp. 379-388
-
-
Lawrence, A.D.1
Sahakian, B.J.2
Robbins, T.W.3
-
80
-
-
0033934298
-
Visual object and visuospatial cognition in Huntington's disease: Implications for information processing in corticostriatal circuits
-
Lawrence AD, Watkins LHA, Sahakian BJ, Hodges JR, Robbins TW, (2000). Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits. Brain 123: 1349-1364.
-
(2000)
Brain
, vol.123
, pp. 1349-1364
-
-
Lawrence, A.D.1
Watkins, L.H.A.2
Sahakian, B.J.3
Hodges, J.R.4
Robbins, T.W.5
-
81
-
-
36248958212
-
Activation of rat ventral tegmental area dopamine neurons by endogenous kynurenic acid: A pharmacological analysis
-
Linderholm KR, Andersson A, Olsson S, Olsson E, Snodgrass R, Engberg G, et al. (2007). Activation of rat ventral tegmental area dopamine neurons by endogenous kynurenic acid: a pharmacological analysis. Neuropharmacology 53: 918-924.
-
(2007)
Neuropharmacology
, vol.53
, pp. 918-924
-
-
Linderholm, K.R.1
Andersson, A.2
Olsson, S.3
Olsson, E.4
Snodgrass, R.5
Engberg, G.6
-
82
-
-
33646551184
-
Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia
-
Lindsley CW, Shipe WD, Wolkenberg SE, Theberge CR, Williams DL, Sur C, et al. (2006). Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia. Curr Top Med Chem 6: 771-785.
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 771-785
-
-
Lindsley, C.W.1
Shipe, W.D.2
Wolkenberg, S.E.3
Theberge, C.R.4
Williams, D.L.5
Sur, C.6
-
83
-
-
0035689922
-
N-G-nitro-L-arginine and its methyl ester inhibit brain synthesis of kynurenic acid possibly via nitric oxide-independent mechanism
-
Luchowski P, Kocki T, Urbanska EM, (2001). N-G-nitro-L-arginine and its methyl ester inhibit brain synthesis of kynurenic acid possibly via nitric oxide-independent mechanism. Pol J Pharmacol 53: 597-604.
-
(2001)
Pol J Pharmacol
, vol.53
, pp. 597-604
-
-
Luchowski, P.1
Kocki, T.2
Urbanska, E.M.3
-
84
-
-
0037072547
-
1-methyl-4-phenylpyridinium and 3-nitropropionic acid diminish cortical synthesis of kynurenic acid via interference with kynurenine aminotransferases in rats
-
Luchowski P, Luchowska E, Turski WA, Urbanska EM, (2002). 1-methyl-4-phenylpyridinium and 3-nitropropionic acid diminish cortical synthesis of kynurenic acid via interference with kynurenine aminotransferases in rats. Neurosci Lett 330: 49-52.
-
(2002)
Neurosci Lett
, vol.330
, pp. 49-52
-
-
Luchowski, P.1
Luchowska, E.2
Turski, W.A.3
Urbanska, E.M.4
-
85
-
-
67349157695
-
Effects of stress throughout the lifespan on the brain, behaviour and cognition
-
Lupien SJ, McEwen BS, Gunnar MR, Heim C, (2009). Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 10: 434-445.
-
(2009)
Nat Rev Neurosci
, vol.10
, pp. 434-445
-
-
Lupien, S.J.1
McEwen, B.S.2
Gunnar, M.R.3
Heim, C.4
-
86
-
-
82355163413
-
Chronic stress, cognitive functioning and mental health
-
Marin M-F, Lord C, Andrews J, Juster R-P, Sindi S, Arsenault-Lapierre G, et al. (2011). Chronic stress, cognitive functioning and mental health. Neurobiol Learn Mem 96: 583-595.
-
(2011)
Neurobiol Learn Mem
, vol.96
, pp. 583-595
-
-
Marin, M.-F.1
Lord, C.2
Andrews, J.3
Juster, R.-P.4
Sindi, S.5
Arsenault-Lapierre, G.6
-
87
-
-
75049085096
-
Differential regulation of alpha 7 nicotinic receptor gene (CHRNA7): Expression in schizophrenic smokers
-
Mexal S, Berger R, Logel J, Ross RG, Freedman R, Leonard S, (2010). Differential regulation of alpha 7 nicotinic receptor gene (CHRNA7): expression in schizophrenic smokers. J Mol Neurosci 40: 185-195.
-
(2010)
J Mol Neurosci
, vol.40
, pp. 185-195
-
-
Mexal, S.1
Berger, R.2
Logel, J.3
Ross, R.G.4
Freedman, R.5
Leonard, S.6
-
88
-
-
84856472879
-
Cognitive dysfunction in psychiatric disorders: Characteristics, causes and the quest for improved therapy
-
Millan MJ, Agid Y, Bruene M, Bullmore ET, Carter CS, Clayton NS, et al. (2012). Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov 11: 141-168.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 141-168
-
-
Millan, M.J.1
Agid, Y.2
Bruene, M.3
Bullmore, E.T.4
Carter, C.S.5
Clayton, N.S.6
-
89
-
-
0026497479
-
The effect of peripheral loading with kynurenine and probenecid on extracellular striatal kynurenic acid concentrations
-
Miller JM, Macgarvey U, Beal MF, (1992). The effect of peripheral loading with kynurenine and probenecid on extracellular striatal kynurenic acid concentrations. Neurosci Lett 146: 115-118.
-
(1992)
Neurosci Lett
, vol.146
, pp. 115-118
-
-
Miller, J.M.1
Macgarvey, U.2
Beal, M.F.3
-
90
-
-
43649090464
-
Modafinil: A review of neurochemical actions and effects on cognition
-
Minzenberg MJ, Carter CS, (2008). Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology 33: 1477-1502.
-
(2008)
Neuropsychopharmacology
, vol.33
, pp. 1477-1502
-
-
Minzenberg, M.J.1
Carter, C.S.2
-
91
-
-
79953843859
-
Long-lasting effects of inescapable-predator stress on brain tryptophan metabolism and the behavior of juvenile mice
-
Miura H, Ando Y, Noda Y, Isobe K, Ozaki N, (2011). Long-lasting effects of inescapable-predator stress on brain tryptophan metabolism and the behavior of juvenile mice. Stress 14: 262-272.
-
(2011)
Stress
, vol.14
, pp. 262-272
-
-
Miura, H.1
Ando, Y.2
Noda, Y.3
Isobe, K.4
Ozaki, N.5
-
92
-
-
84859709836
-
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment
-
Moeller M, Du Preez JL, Emsley R, Harvey BH, (2012). Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment. Neuropharmacology 62: 2499-2506.
-
(2012)
Neuropharmacology
, vol.62
, pp. 2499-2506
-
-
Moeller, M.1
Du Preez, J.L.2
Emsley, R.3
Harvey, B.H.4
-
93
-
-
67650681778
-
Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channels
-
Mok MHS, Fricker AC, Weil A, Kew JNC, (2009). Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channels. Neuropharmacology 57: 242-249.
-
(2009)
Neuropharmacology
, vol.57
, pp. 242-249
-
-
Mok, M.H.S.1
Fricker, A.C.2
Weil, A.3
Kew, J.N.C.4
-
95
-
-
84879385980
-
-
The J D Gladstone Institute: San Francisco, CA.
-
Muchowski PJ, Muchowski JM, Schwarcz R, Guidetti P, (2011). Patent US 8071631B2 and 7994338: small molecule inhibitors of kynurenine-3-monoxygenase. The J D Gladstone Institute: San Francisco, CA.
-
(2011)
Patent US 8071631B2 and 7994338: Small Molecule Inhibitors of kynurenine-3-monoxygenase
-
-
Muchowski, P.J.1
Muchowski, J.M.2
Schwarcz, R.3
Guidetti, P.4
-
96
-
-
79960523886
-
Schizophrenia genes, epigenetics and psychoneuroimmunology therapeutics: All make sense now
-
Mueller N, Dursun SM, (2011). Schizophrenia genes, epigenetics and psychoneuroimmunology therapeutics: all make sense now. J Psychopharmacol 25: 713-714.
-
(2011)
J Psychopharmacol
, vol.25
, pp. 713-714
-
-
Mueller, N.1
Dursun, S.M.2
-
97
-
-
63149187305
-
Stressful life events, chronic difficulties, and the symptoms of clinical depression
-
Muscatell KA, Slavich GM, Monroe SM, Gotlib IH, (2009). Stressful life events, chronic difficulties, and the symptoms of clinical depression. J Nerv Ment Dis 197: 154-160.
-
(2009)
J Nerv Ment Dis
, vol.197
, pp. 154-160
-
-
Muscatell, K.A.1
Slavich, G.M.2
Monroe, S.M.3
Gotlib, I.H.4
-
98
-
-
80053900888
-
Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naive and medication-free schizophrenic patients
-
Myint AM, Schwarz MJ, Verkerk R, Mueller HH, Zach J, Scharpe S, et al. (2011). Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naive and medication-free schizophrenic patients. Brain Behav Immun 25: 1576-1581.
-
(2011)
Brain Behav Immun
, vol.25
, pp. 1576-1581
-
-
Myint, A.M.1
Schwarz, M.J.2
Verkerk, R.3
Mueller, H.H.4
Zach, J.5
Scharpe, S.6
-
99
-
-
82255192967
-
Synthesis and biological effects of some kynurenic acid analogs
-
Nagy K, Plangar I, Tuka B, Gellert L, Varga D, Demeter I, et al. (2011). Synthesis and biological effects of some kynurenic acid analogs. Bioorg Med Chem 19: 7590-7596.
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 7590-7596
-
-
Nagy, K.1
Plangar, I.2
Tuka, B.3
Gellert, L.4
Varga, D.5
Demeter, I.6
-
100
-
-
78049250838
-
Animal models of cognitive dysfunction and negative symptoms of schizophrenia: Focus on NMDA receptor antagonism
-
Neill JC, Barnes S, Cook S, Grayson B, Idris NF, McLean SL, et al. (2010). Animal models of cognitive dysfunction and negative symptoms of schizophrenia: focus on NMDA receptor antagonism. Pharmacol Ther 128: 419-432.
-
(2010)
Pharmacol Ther
, vol.128
, pp. 419-432
-
-
Neill, J.C.1
Barnes, S.2
Cook, S.3
Grayson, B.4
Idris, N.F.5
McLean, S.L.6
-
101
-
-
0035179658
-
NMDA receptor regulation of memory and behavior in humans
-
Newcomer JW, Krystal JH, (2001). NMDA receptor regulation of memory and behavior in humans. Hippocampus 11: 529-542.
-
(2001)
Hippocampus
, vol.11
, pp. 529-542
-
-
Newcomer, J.W.1
Krystal, J.H.2
-
102
-
-
0033080733
-
Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis
-
Newcomer JW, Farber NB, Jevtovic-Todorovic V, Selke G, Melson AK, Hershey T, et al. (1999). Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis. Neuropsychopharmacology 20: 106-118.
-
(1999)
Neuropsychopharmacology
, vol.20
, pp. 106-118
-
-
Newcomer, J.W.1
Farber, N.B.2
Jevtovic-Todorovic, V.3
Selke, G.4
Melson, A.K.5
Hershey, T.6
-
103
-
-
28244440276
-
Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia
-
Nilsson LK, Linderholm KR, Engberg G, Paulson L, Blennow LLH, et al. (2005). Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia. Schizophr Res 80: 315-322.
-
(2005)
Schizophr Res
, vol.80
, pp. 315-322
-
-
Nilsson, L.K.1
Linderholm, K.R.2
Engberg, G.3
Paulson, L.4
Blennow, L.L.H.5
-
104
-
-
33646379643
-
Subchronic treatment with kynurenine and probenecid: Effects on prepulse inhibition and firing of midbrain dopamine neurons
-
Nilsson LK, Linderholm KR, Erhardt S, (2006). Subchronic treatment with kynurenine and probenecid: effects on prepulse inhibition and firing of midbrain dopamine neurons. J Neural Transm 113: 557-571.
-
(2006)
J Neural Transm
, vol.113
, pp. 557-571
-
-
Nilsson, L.K.1
Linderholm, K.R.2
Erhardt, S.3
-
105
-
-
0026535226
-
Neuroprotective effects of l-kynurenine on hypoxia ischemia and NMDA lesions in neonatal rats
-
Nozaki K, Beal MF, (1992). Neuroprotective effects of l-kynurenine on hypoxia ischemia and NMDA lesions in neonatal rats. J Cereb Blood Flow Metab 12: 400-407.
-
(1992)
J Cereb Blood Flow Metab
, vol.12
, pp. 400-407
-
-
Nozaki, K.1
Beal, M.F.2
-
106
-
-
65249156122
-
Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to Bacillus Calmette-Guerin
-
O'Connor JC, Andre C, Wang Y, Lawson MA, Szegedi SS, Lestage J, et al. (2009). Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to Bacillus Calmette-Guerin. J Neurosci 29: 4200-4209.
-
(2009)
J Neurosci
, vol.29
, pp. 4200-4209
-
-
O'Connor, J.C.1
Andre, C.2
Wang, Y.3
Lawson, M.A.4
Szegedi, S.S.5
Lestage, J.6
-
107
-
-
84857632874
-
Subchronic elevation of brain kynurenic acid augments amphetamine-induced locomotor response in mice
-
Olsson SK, Larsson MK, Erhardt S, (2012). Subchronic elevation of brain kynurenic acid augments amphetamine-induced locomotor response in mice. J Neural Transm 119: 155-163.
-
(2012)
J Neural Transm
, vol.119
, pp. 155-163
-
-
Olsson, S.K.1
Larsson, M.K.2
Erhardt, S.3
-
108
-
-
77952849225
-
The N-Methyl-D-Aspartate receptor co-agonist d-cycloserine facilitates declarative learning and hippocampal activity in humans
-
Onur O, Schlaepfer TE, Kukolja J, Bauer A, Jeung H, Patin A, et al. (2010). The N-Methyl-D-Aspartate receptor co-agonist d-cycloserine facilitates declarative learning and hippocampal activity in humans. Biol Psychiatry 67: 1205-1211.
-
(2010)
Biol Psychiatry
, vol.67
, pp. 1205-1211
-
-
Onur, O.1
Schlaepfer, T.E.2
Kukolja, J.3
Bauer, A.4
Jeung, H.5
Patin, A.6
-
109
-
-
42549112547
-
Kynurenine pathway metabolism in human blood-brain-barrier cells: Implications for immune tolerance and neurotoxicity
-
Owe-Young R, Webster NL, Mukhtar M, Pomerantz RJ, Smythe G, Walker D, et al. (2008). Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance and neurotoxicity. J Neurochem 105: 1346-1357.
-
(2008)
J Neurochem
, vol.105
, pp. 1346-1357
-
-
Owe-Young, R.1
Webster, N.L.2
Mukhtar, M.3
Pomerantz, R.J.4
Smythe, G.5
Walker, D.6
-
110
-
-
33748148270
-
Selective increases in the cytokine, TNF-alpha, in the prefrontal cortex of PCP-treated rats and human schizophrenic subjects: Influence of antipsychotic drugs
-
Paterson GJ, Ohashi Y, Reynolds GP, Pratt JA, Morris BJ, (2006). Selective increases in the cytokine, TNF-alpha, in the prefrontal cortex of PCP-treated rats and human schizophrenic subjects: influence of antipsychotic drugs. J Psychopharmacol 20: 636-642.
-
(2006)
J Psychopharmacol
, vol.20
, pp. 636-642
-
-
Paterson, G.J.1
Ohashi, Y.2
Reynolds, G.P.3
Pratt, J.A.4
Morris, B.J.5
-
111
-
-
0026783169
-
Increased brain concentrations of a neurotoxin, 3-hydroxy-kynurenine, in Huntington's disease
-
Pearson SJ, Reynolds GP, (1992). Increased brain concentrations of a neurotoxin, 3-hydroxy-kynurenine, in Huntington's disease. Neurosci Lett 144: 199-201.
-
(1992)
Neurosci Lett
, vol.144
, pp. 199-201
-
-
Pearson, S.J.1
Reynolds, G.P.2
-
112
-
-
79952280719
-
Effects of early life stress on cognitive and affective function: An integrated review of human literature
-
Pechtel P, Pizzagalli DA, (2011). Effects of early life stress on cognitive and affective function: an integrated review of human literature. Psychopharmacology (Berl) 214: 55-70.
-
(2011)
Psychopharmacology (Berl)
, vol.214
, pp. 55-70
-
-
Pechtel, P.1
Pizzagalli, D.A.2
-
113
-
-
0028343956
-
Modulation of the kynurenine pathway in search for new neuroprotective agents - Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase
-
Pellicciari R, Natalini B, Costantino G, Mahmoud M, Mattoli L, Sadeghpour BM, et al. (1994). Modulation of the kynurenine pathway in search for new neuroprotective agents-synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase. J Med Chem 37: 647-655.
-
(1994)
J Med Chem
, vol.37
, pp. 647-655
-
-
Pellicciari, R.1
Natalini, B.2
Costantino, G.3
Mahmoud, M.4
Mattoli, L.5
Sadeghpour, B.M.6
-
114
-
-
33646765763
-
Modulators of the kynurenine pathway of tryptophan metabolism: Synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylaianine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor
-
Pellicciari R, Rizzo RC, Costantino G, Marinozzi M, Amori L, Guidetti P, et al. (2006). Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl) benzoylaianine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor. ChemMedChem 1: 528-531.
-
(2006)
ChemMedChem
, vol.1
, pp. 528-531
-
-
Pellicciari, R.1
Rizzo, R.C.2
Costantino, G.3
Marinozzi, M.4
Amori, L.5
Guidetti, P.6
-
115
-
-
0019967973
-
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
-
Perkins MN, Stone TW, (1982). An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res 247: 184-187.
-
(1982)
Brain Res
, vol.247
, pp. 184-187
-
-
Perkins, M.N.1
Stone, T.W.2
-
116
-
-
33646468351
-
Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality
-
Pertovaara M, Raitala A, Lehtimaki T, Karhunen PJ, Oja SS, Jylha M, et al. (2006). Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality. Mech Ageing Dev 127: 497-499.
-
(2006)
Mech Ageing Dev
, vol.127
, pp. 497-499
-
-
Pertovaara, M.1
Raitala, A.2
Lehtimaki, T.3
Karhunen, P.J.4
Oja, S.S.5
Jylha, M.6
-
117
-
-
84879355033
-
-
US Patent and Trademark Offices: Alexandria, VA.
-
Pevarello P, Giordani A, Villa M, Speciale C, Varasi M, (2000). Patent US 6133302: 5-(3-phenyl-3-oxo-propyl)-1H-tetrazole derivatives. US Patent and Trademark Offices: Alexandria, VA.
-
(2000)
Patent US 6133302: 5-(3-phenyl-3-oxo-propyl)-1H-tetrazole Derivatives
-
-
Pevarello, P.1
Giordani, A.2
Villa, M.3
Speciale, C.4
Varasi, M.5
-
118
-
-
0142030173
-
Convergence of biological and psychological perspectives on cognitive coordination in schizophrenia
-
Phillips WA, Silverstein SM, (2003). Convergence of biological and psychological perspectives on cognitive coordination in schizophrenia. Behav Brain Sci 26: 65-100.
-
(2003)
Behav Brain Sci
, vol.26
, pp. 65-100
-
-
Phillips, W.A.1
Silverstein, S.M.2
-
119
-
-
80052710746
-
Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory
-
Pocivavsek A, Wu H-Q, Potter MC, Elmer GI, Pellicciari R, Schwarcz R, (2011). Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory. Neuropsychopharmacology 36: 2357-2367.
-
(2011)
Neuropsychopharmacology
, vol.36
, pp. 2357-2367
-
-
Pocivavsek, A.1
Wu, H.-Q.2
Potter, M.C.3
Elmer, G.I.4
Pellicciari, R.5
Schwarcz, R.6
-
120
-
-
84861234916
-
Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood
-
Pocivavsek A, Wu H-Q, Elmer GI, Bruno JP, Schwarcz R, (2012). Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood. Eur J Neurosci 35: 1605-1612.
-
(2012)
Eur J Neurosci
, vol.35
, pp. 1605-1612
-
-
Pocivavsek, A.1
Wu, H.-Q.2
Elmer, G.I.3
Bruno, J.P.4
Schwarcz, R.5
-
121
-
-
84155160658
-
The stressed synapse: The impact of stress and glucocorticoids on glutamate transmission
-
Popoli M, Yan Z, McEwen BS, Sanacora G, (2012). The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nat Rev Neurosci 13: 22-37.
-
(2012)
Nat Rev Neurosci
, vol.13
, pp. 22-37
-
-
Popoli, M.1
Yan, Z.2
McEwen, B.S.3
Sanacora, G.4
-
122
-
-
0027959683
-
Behavioural and electrophysiological correlates of the quinolinic acid rat model of Huntington's disease in rats
-
Popoli P, Pezzola A, Domenici ME, Sagratella S, Diana G, Caporali MG, et al. (1994). Behavioural and electrophysiological correlates of the quinolinic acid rat model of Huntington's disease in rats. Brain Res Bull 35: 329-335.
-
(1994)
Brain Res Bull
, vol.35
, pp. 329-335
-
-
Popoli, P.1
Pezzola, A.2
Domenici, M.E.3
Sagratella, S.4
Diana, G.5
Caporali, M.G.6
-
123
-
-
77953617514
-
Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behaviour
-
Potter MC, Elmer GI, Bergeron R, Albuquerque EX, Guidetti P, Wu H-Q, et al. (2010). Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behaviour. Neuropsychopharmacology 35: 1734-1742.
-
(2010)
Neuropsychopharmacology
, vol.35
, pp. 1734-1742
-
-
Potter, M.C.1
Elmer, G.I.2
Bergeron, R.3
Albuquerque, E.X.4
Guidetti, P.5
Wu, H.-Q.6
-
124
-
-
67651243648
-
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons
-
AR.
-
Rahman A, Kaka T, Cullen KM, Braidy N, Brew BJ, Guillemin GJ, (2009). The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLoS ONE 4: AR e6344.
-
(2009)
PLoS ONE
, vol.4
-
-
Rahman, A.1
Kaka, T.2
Cullen, K.M.3
Braidy, N.4
Brew, B.J.5
Guillemin, G.J.6
-
125
-
-
77950022119
-
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: Relationship to CNS immune responses and depression
-
Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G, et al. (2010). CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry 15: 393-403.
-
(2010)
Mol Psychiatry
, vol.15
, pp. 393-403
-
-
Raison, C.L.1
Dantzer, R.2
Kelley, K.W.3
Lawson, M.A.4
Woolwine, B.J.5
Vogt, G.6
-
126
-
-
18144402868
-
Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum
-
Rassoulpour A, Wu H-Q, Ferre S, Schwarcz R, (2005). Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum. J Neurochem 93: 762-765.
-
(2005)
J Neurochem
, vol.93
, pp. 762-765
-
-
Rassoulpour, A.1
Wu, H.-Q.2
Ferre, S.3
Schwarcz, R.4
-
127
-
-
33846879380
-
Alpha-7 nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation
-
Ren K, Thinschmidt J, Liu J, Ai L, Papke RL, King MA, et al. (2007). Alpha-7 nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation. Neuroscience 145: 314-322.
-
(2007)
Neuroscience
, vol.145
, pp. 314-322
-
-
Ren, K.1
Thinschmidt, J.2
Liu, J.3
Ai, L.4
Papke, R.L.5
King, M.A.6
-
128
-
-
67649335607
-
Neurochemistry of cognition: Serotonergic and adrenergic mechanisms
-
DOI: 10.1016/S0072-9752(07)88002-X.
-
Robert PH, Benoit M, (2008). Neurochemistry of cognition: serotonergic and adrenergic mechanisms. Handb Clin Neurol 88: 31-40. DOI: 10.1016/S0072-9752(07)88002-X.
-
(2008)
Handb Clin Neurol
, vol.88
, pp. 31-40
-
-
Robert, P.H.1
Benoit, M.2
-
129
-
-
66549100383
-
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis
-
Rodgers J, Stone TW, Barratt MP, Bradley B, Kennedy PG, (2009). Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain 132: 1259-1267.
-
(2009)
Brain
, vol.132
, pp. 1259-1267
-
-
Rodgers, J.1
Stone, T.W.2
Barratt, M.P.3
Bradley, B.4
Kennedy, P.G.5
-
130
-
-
77955359155
-
Crystal structure-based selective targeting of the pyridoxal 5′-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement
-
Rossi F, Valentina C, Garavaglia S, Sathyasaikumar KV, Schwarcz R, Kojima S, et al. (2010). Crystal structure-based selective targeting of the pyridoxal 5′-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement. J Med Chem 53: 5684-5689.
-
(2010)
J Med Chem
, vol.53
, pp. 5684-5689
-
-
Rossi, F.1
Valentina, C.2
Garavaglia, S.3
Sathyasaikumar, K.V.4
Schwarcz, R.5
Kojima, S.6
-
131
-
-
0031434549
-
Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl) benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase
-
Röver S, Cesura AM, Hugenin P, Kettler R, Szente A, (1997). Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl) benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem 40: 4378-4385.
-
(1997)
J Med Chem
, vol.40
, pp. 4378-4385
-
-
Röver, S.1
Cesura, A.M.2
Hugenin, P.3
Kettler, R.4
Szente, A.5
-
132
-
-
69249206617
-
Thalidomide inhibition of vascular remodeling and inflammatory reactivity in the quinolinic acid-injected rat striatum
-
Ryu JK, Jantaratnotai N, McLarnon JG, (2009). Thalidomide inhibition of vascular remodeling and inflammatory reactivity in the quinolinic acid-injected rat striatum. Neuroscience 163: 601-608.
-
(2009)
Neuroscience
, vol.163
, pp. 601-608
-
-
Ryu, J.K.1
Jantaratnotai, N.2
McLarnon, J.G.3
-
133
-
-
0026489478
-
Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse
-
Saito K, Markey SP, Heyes MP, (1992). Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse. Neuroscience 51: 25-39.
-
(1992)
Neuroscience
, vol.51
, pp. 25-39
-
-
Saito, K.1
Markey, S.P.2
Heyes, M.P.3
-
134
-
-
84866758042
-
Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge
-
Salazar A, Gonzalez-Rivera BL, Redus L, Parrott JM, O'Connor JC, (2012). Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge. Horm Behav 62: 202-209.
-
(2012)
Horm Behav
, vol.62
, pp. 202-209
-
-
Salazar, A.1
Gonzalez-Rivera, B.L.2
Redus, L.3
Parrott, J.M.4
O'Connor, J.C.5
-
135
-
-
29144485791
-
Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease
-
Sapko MT, Guidetti P, Yu P, Tagle DA, Pellicciari R, Schwarcz R, (2006). Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: implications for Huntington's disease. Exp Neurol 197: 31-40.
-
(2006)
Exp Neurol
, vol.197
, pp. 31-40
-
-
Sapko, M.T.1
Guidetti, P.2
Yu, P.3
Tagle, D.A.4
Pellicciari, R.5
Schwarcz, R.6
-
136
-
-
34250341330
-
Abnormal neurotransmitter release underlying behavioral and cognitive disorders: Toward concepts of dynamic and function-specific dysregulation
-
Sarter M, Bruno JP, Parikh V, (2007). Abnormal neurotransmitter release underlying behavioral and cognitive disorders: toward concepts of dynamic and function-specific dysregulation. Neuropsychopharmacology 32: 1452-1461.
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 1452-1461
-
-
Sarter, M.1
Bruno, J.P.2
Parikh, V.3
-
137
-
-
77953107292
-
Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease
-
Sathyasaikumar KV, Stachowski EK, Amori L, Guidetti P, Muchowski PJ, Schwarcz R, (2010). Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease. J Neurochem 113: 1416-1425.
-
(2010)
J Neurochem
, vol.113
, pp. 1416-1425
-
-
Sathyasaikumar, K.V.1
Stachowski, E.K.2
Amori, L.3
Guidetti, P.4
Muchowski, P.J.5
Schwarcz, R.6
-
138
-
-
80054853253
-
Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia
-
Sathyasaikumar KV, Stachowski EK, Wonodi I, Roberts RC, Rassoulpour A, McMahon RP, et al. (2011). Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia. Schizophr Bull 37: 1147-1156.
-
(2011)
Schizophr Bull
, vol.37
, pp. 1147-1156
-
-
Sathyasaikumar, K.V.1
Stachowski, E.K.2
Wonodi, I.3
Roberts, R.C.4
Rassoulpour, A.5
McMahon, R.P.6
-
139
-
-
0020702374
-
Quinolinic acid: An endogenous metabolite that produces axon-sparing lesions in rat brain
-
Schwarcz R, Whetsell WO Jr, Mangano RM, (1983). Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science 219: 316-318.
-
(1983)
Science
, vol.219
, pp. 316-318
-
-
Schwarcz, R.1
Whetsell, Jr.W.O.2
Mangano, R.M.3
-
140
-
-
0024024251
-
3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims
-
Schwarcz R, Okuno E, White RJ, Bird ED, Jnr WWO, (1988). 3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims. Proc Natl Acad Sci USA 85: 4079-4081.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 4079-4081
-
-
Schwarcz, R.1
Okuno, E.2
White, R.J.3
Bird, E.D.4
Jnr, W.W.O.5
-
141
-
-
0035477818
-
Increased cortical kynurenate content in schizophrenia
-
Schwarcz R, Rassoulpour A, Wu H-Q, Medoff D, Tamminga CA, Roberts RC, (2001). Increased cortical kynurenate content in schizophrenia. Biol Psychiatry 50: 521-530.
-
(2001)
Biol Psychiatry
, vol.50
, pp. 521-530
-
-
Schwarcz, R.1
Rassoulpour, A.2
Wu, H.-Q.3
Medoff, D.4
Tamminga, C.A.5
Roberts, R.C.6
-
142
-
-
76849100874
-
Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease
-
Schwarcz R, Guidetti P, Sathyasaikumar KV, Muchowski PJ, (2009). Of mice, rats and men: revisiting the quinolinic acid hypothesis of Huntington's disease. Prog Neurobiol 90: 230-245.
-
(2009)
Prog Neurobiol
, vol.90
, pp. 230-245
-
-
Schwarcz, R.1
Guidetti, P.2
Sathyasaikumar, K.V.3
Muchowski, P.J.4
-
143
-
-
0032191581
-
Comparison of intrastriatal injections of quinolinic acid and 3-nitropropionic acid for use in animal models of Huntington's disease
-
Shear DA, Dong J, Gundy CD, Haik-Creguer KL, Dunbar GL, (1998). Comparison of intrastriatal injections of quinolinic acid and 3-nitropropionic acid for use in animal models of Huntington's disease. Prog Neuropsychopharmacol Biol Psychiatry 22: 1217-1240.
-
(1998)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.22
, pp. 1217-1240
-
-
Shear, D.A.1
Dong, J.2
Gundy, C.D.3
Haik-Creguer, K.L.4
Dunbar, G.L.5
-
144
-
-
0025057695
-
Uptake of kynurenine into rat-brain slices
-
Speciale C, Schwarcz R, (1990). Uptake of kynurenine into rat-brain slices. J Neurochem 54: 156-163.
-
(1990)
J Neurochem
, vol.54
, pp. 156-163
-
-
Speciale, C.1
Schwarcz, R.2
-
145
-
-
0024334021
-
High-affinity uptake of l-kynurenine by a Na+-independent transporter of neutral amino-acids in astrocytes
-
Speciale C, Hares K, Schwarcz R, Brookes N, (1989). High-affinity uptake of l-kynurenine by a Na+-independent transporter of neutral amino-acids in astrocytes. J Neurosci 9: 2066-2072.
-
(1989)
J Neurosci
, vol.9
, pp. 2066-2072
-
-
Speciale, C.1
Hares, K.2
Schwarcz, R.3
Brookes, N.4
-
146
-
-
0037135022
-
Endothelium-dependent production and liberation of kynurenic acid by rat aortic rings exposed to L-kynurenine
-
Stazka J, Luchowski P, Wielosz M, Kleinrok Z, Urbanska EM, (2002). Endothelium-dependent production and liberation of kynurenic acid by rat aortic rings exposed to L-kynurenine. Eur J Pharmacol 448: 133-137.
-
(2002)
Eur J Pharmacol
, vol.448
, pp. 133-137
-
-
Stazka, J.1
Luchowski, P.2
Wielosz, M.3
Kleinrok, Z.4
Urbanska, E.M.5
-
147
-
-
22144446744
-
Homocysteine, a risk factor for atherosclerosis, biphasically changes the endothelial production of kynurenic acid
-
Stazka J, Luchowski P, Urbanska EM, (2005). Homocysteine, a risk factor for atherosclerosis, biphasically changes the endothelial production of kynurenic acid. Eur J Pharmacol 517: 217-223.
-
(2005)
Eur J Pharmacol
, vol.517
, pp. 217-223
-
-
Stazka, J.1
Luchowski, P.2
Urbanska, E.M.3
-
148
-
-
34250017113
-
Kynurenic acid blocks nicotinic synaptic transmission to hippocampal interneurons in young rats
-
Stone TW, (2007). Kynurenic acid blocks nicotinic synaptic transmission to hippocampal interneurons in young rats. Eur J Neurosci 25: 2656-2665.
-
(2007)
Eur J Neurosci
, vol.25
, pp. 2656-2665
-
-
Stone, T.W.1
-
149
-
-
0036690151
-
Endogenous kynurenines as targets for drug discovery and development
-
Stone TW, Darlington LG, (2002). Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov 1: 609-620.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 609-620
-
-
Stone, T.W.1
Darlington, L.G.2
-
150
-
-
0019440926
-
Quinolinic acid: A potent endogenous excitant at amino acid receptors in the CNS
-
Stone TW, Perkins MN, (1981). Quinolinic acid: a potent endogenous excitant at amino acid receptors in the CNS. Eur J Pharmacol 72: 411-412.
-
(1981)
Eur J Pharmacol
, vol.72
, pp. 411-412
-
-
Stone, T.W.1
Perkins, M.N.2
-
151
-
-
84857633327
-
Involvement of kynurenines in Huntington's disease and stroke-induced brain damage
-
Stone TW, Forrest CM, Stoy N, Darlington LG, (2012). Involvement of kynurenines in Huntington's disease and stroke-induced brain damage. J Neural Transm 119: 261-274.
-
(2012)
J Neural Transm
, vol.119
, pp. 261-274
-
-
Stone, T.W.1
Forrest, C.M.2
Stoy, N.3
Darlington, L.G.4
-
153
-
-
18144386929
-
Tryptophan metabolism and oxidative stress in patients with Huntington's disease
-
Stoy N, Mackay GM, Forrest CM, Christofides J, Egerton M, Stone TW, et al. (2005). Tryptophan metabolism and oxidative stress in patients with Huntington's disease. J Neurochem 93: 611-623.
-
(2005)
J Neurochem
, vol.93
, pp. 611-623
-
-
Stoy, N.1
Mackay, G.M.2
Forrest, C.M.3
Christofides, J.4
Egerton, M.5
Stone, T.W.6
-
154
-
-
54049128810
-
Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease
-
Tadaiesky MT, Dombrowski PA, Figueiredo CP, Cargnin-Ferreira E, Da Cunha C, Takahashi RN, (2008). Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease. Neuroscience 156: 830-840.
-
(2008)
Neuroscience
, vol.156
, pp. 830-840
-
-
Tadaiesky, M.T.1
Dombrowski, P.A.2
Figueiredo, C.P.3
Cargnin-Ferreira, E.4
Da Cunha, C.5
Takahashi, R.N.6
-
155
-
-
0029066045
-
Effects of striatal excitotoxicity on Huntington-like immunoreactivity
-
Tatter SB, Galpern WR, Hoogeveen AT, Isacson O, (1995). Effects of striatal excitotoxicity on Huntington-like immunoreactivity. Neuroreport 6: 1125-1129.
-
(1995)
Neuroreport
, vol.6
, pp. 1125-1129
-
-
Tatter, S.B.1
Galpern, W.R.2
Hoogeveen, A.T.3
Isacson, O.4
-
158
-
-
73249145672
-
Effect of quinolinic acid on human astrocytes morphology and functions: Implications in Alzheimer's disease
-
AR.
-
Ting KK, Brew BJ, Guillemin GJ, (2009). Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease. J Neuroinflammation 6: AR 36.
-
(2009)
J Neuroinflammation
, vol.6
, pp. 36
-
-
Ting, K.K.1
Brew, B.J.2
Guillemin, G.J.3
-
159
-
-
81955162911
-
Administration of kynurenine during adolescence, but not during adulthood, impairs social behavior in rats
-
Trecartin KV, Bucci DJ, (2011). Administration of kynurenine during adolescence, but not during adulthood, impairs social behavior in rats. Schizophr Res 133: 156-158.
-
(2011)
Schizophr Res
, vol.133
, pp. 156-158
-
-
Trecartin, K.V.1
Bucci, D.J.2
-
160
-
-
84858164835
-
Dynamic regulation of NMDAR function in the adult brain by the stress hormone corticosterone
-
AR.
-
Tse YC, Bagot RC, Wong TP, (2012). Dynamic regulation of NMDAR function in the adult brain by the stress hormone corticosterone. Front Cell Neurosci 6: AR 9.
-
(2012)
Front Cell Neurosci
, vol.6
, pp. 9
-
-
Tse, Y.C.1
Bagot, R.C.2
Wong, T.P.3
-
161
-
-
84879395001
-
-
US Patent and Trademark Offices: Alexandria, VA.
-
Varasi M, Giordani A, Cini M, Speciale C, Bianchetti A, (2001). Patent US 6207709B1: N-substituted-2-amino-4-phenyl-4-oxo-butanoic acid compounds having kynurenine-3-hydroxy base inhibitory activity. US Patent and Trademark Offices: Alexandria, VA.
-
(2001)
Patent US 6207709B1: N-substituted-2-amino-4-phenyl-4-oxo-butanoic Acid Compounds Having kynurenine-3-hydroxy Base Inhibitory Activity
-
-
Varasi, M.1
Giordani, A.2
Cini, M.3
Speciale, C.4
Bianchetti, A.5
-
162
-
-
0024441049
-
Studies on the potential neurotoxic and convulsant effects of increased blood-levels of quinolinic acid in rats with altered blood-brain-barrier permeability
-
Vezzani A, Stasi MA, Wu HQ, Castiglioni M, Weckermann B, Samanin R, (1989). Studies on the potential neurotoxic and convulsant effects of increased blood-levels of quinolinic acid in rats with altered blood-brain-barrier permeability. Exp Neurol 106: 90-98.
-
(1989)
Exp Neurol
, vol.106
, pp. 90-98
-
-
Vezzani, A.1
Stasi, M.A.2
Wu, H.Q.3
Castiglioni, M.4
Weckermann, B.5
Samanin, R.6
-
163
-
-
33646089457
-
Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes
-
Walker DG, Link J, Lue L-F, Dalsing-Hernandez JE, Boyes BE, (2006). Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes. J Leukoc Biol 79: 596-610.
-
(2006)
J Leukoc Biol
, vol.79
, pp. 596-610
-
-
Walker, D.G.1
Link, J.2
Lue, L.-F.3
Dalsing-Hernandez, J.E.4
Boyes, B.E.5
-
164
-
-
33746823331
-
Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35
-
Wang J, Simonavicius N, Wu X, Swaminath G, Reagen J, Tian H, et al. (2006). Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem 281: 22021-22028.
-
(2006)
J Biol Chem
, vol.281
, pp. 22021-22028
-
-
Wang, J.1
Simonavicius, N.2
Wu, X.3
Swaminath, G.4
Reagen, J.5
Tian, H.6
-
165
-
-
77949261548
-
Kynurenine is an endothelium-derived relaxing factor produced during inflammation
-
Wang Y, Liu H, McKenzie G, Witting PK, Stasch J-P HM, et al. (2010). Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med 16: 279-285.
-
(2010)
Nat Med
, vol.16
, pp. 279-285
-
-
Wang, Y.1
Liu, H.2
McKenzie, G.3
Witting, P.K.4
Stasch, J.-P.H.M.5
-
166
-
-
12144286859
-
Kynurenic acid production in cultured bovine aortic endothelial cells. Homocysteine is a potent inhibitor
-
Wejksza K, Rzeski W, Parada-Turska J, Zdzisinska B, Rejdak R, Kocki T, et al. (2004). Kynurenic acid production in cultured bovine aortic endothelial cells. Homocysteine is a potent inhibitor. Naunyn Schmiedebergs Arch Pharmacol 369: 300-304.
-
(2004)
Naunyn Schmiedebergs Arch Pharmacol
, vol.369
, pp. 300-304
-
-
Wejksza, K.1
Rzeski, W.2
Parada-Turska, J.3
Zdzisinska, B.4
Rejdak, R.5
Kocki, T.6
-
167
-
-
70549088032
-
Kynurenic acid protects against the homocysteine-induced impairment of endothelial cells
-
Wejksza K, Rzeski W, Turski WA, (2009). Kynurenic acid protects against the homocysteine-induced impairment of endothelial cells. Pharmacol Res 61: 751-756.
-
(2009)
Pharmacol Res
, vol.61
, pp. 751-756
-
-
Wejksza, K.1
Rzeski, W.2
Turski, W.A.3
-
168
-
-
79960312085
-
Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes
-
Wonodi I, Stine OC, Sathyasaikumar KV, Roberts RC, Mitchell BD, Hong LE, et al. (2011). Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes. Arch Gen Psychiatry 68: 665-674.
-
(2011)
Arch Gen Psychiatry
, vol.68
, pp. 665-674
-
-
Wonodi, I.1
Stine, O.C.2
Sathyasaikumar, K.V.3
Roberts, R.C.4
Mitchell, B.D.5
Hong, L.E.6
-
169
-
-
84862789284
-
Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease
-
Xu Y, Yan J, Zhou P, Li J, Gao H, Xia Y, et al. (2012). Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 97: 1-13.
-
(2012)
Prog Neurobiol
, vol.97
, pp. 1-13
-
-
Xu, Y.1
Yan, J.2
Zhou, P.3
Li, J.4
Gao, H.5
Xia, Y.6
-
170
-
-
67650472723
-
Proinflammatory cytokine interferon-gamma increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid beta peptide 1-42: Implications for the pathogenesis of Alzheimer's disease
-
Yamada A, Akimoto H, Kagawa S, Guillemin GJ, Takikawa O, (2009). Proinflammatory cytokine interferon-gamma increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid beta peptide 1-42: implications for the pathogenesis of Alzheimer's disease. J Neurochem 110: 791-800.
-
(2009)
J Neurochem
, vol.110
, pp. 791-800
-
-
Yamada, A.1
Akimoto, H.2
Kagawa, S.3
Guillemin, G.J.4
Takikawa, O.5
-
171
-
-
84863284778
-
Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex
-
Yuen EY, Wei J, Liu W, Zhong P, Li Xiangning YZ, (2012). Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex. Neuron 73: 962-977.
-
(2012)
Neuron
, vol.73
, pp. 962-977
-
-
Yuen, E.Y.1
Wei, J.2
Liu, W.3
Zhong, P.4
Li Xiangning, Y.Z.5
-
173
-
-
59149100167
-
Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release
-
Zmarowski A, Wu H-Q, Brooks JM, Potter MC, Pellicciari R, Schwarcz R, et al. (2009). Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release. Eur J Neurosci 29: 529-538.
-
(2009)
Eur J Neurosci
, vol.29
, pp. 529-538
-
-
Zmarowski, A.1
Wu, H.-Q.2
Brooks, J.M.3
Potter, M.C.4
Pellicciari, R.5
Schwarcz, R.6
|