Lack of modulation of Nicotinic Acetylcholine alpha-7 receptor currents by Kynurenic acid in adult hippocampal interneurons

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Dobelis, Peter ^a   Staley, Kevin J ^b   Cooper, Donald C ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; KYNURENIC ACID; NICOTINIC ACETYLCHOLINE ALPHA7 RECEPTOR; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; INTERNEURON; MALE; MOUSE; NERVE CELL MEMBRANE POTENTIAL; NEUROMODULATION; NONHUMAN; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; SPECIES DIFFERENCE; STRATUM RADIATUM;

ANIMALS; EVOKED POTENTIALS; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; INTERNEURONS; KYNURENIC ACID; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC;

MUS; RATTUS;

EID: 84864691584     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041108     Document Type: Article

References (43)

1. Wu J, Lukas RJ, (2011) Naturally-expressed nicotinic acetylcholine receptor subtypes. Biochem Pharmacol 82: 800-807.
2. Changeux JP, (2010) Nicotine addiction and nicotinic receptors: lessons from genetically modified mice. Nat Rev Neurosci 11: 389-401.
3. Albuquerque EX, Pereira EF, Alkondon M, Rogers SW, (2009) Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev 89: 73-120.
4. Lukas RJ, Changeux JP, Le Novere N, Albuquerque EX, Balfour DJ, et al. (1999) International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev 51: 397-401.
5. Frazier CJ, Buhler AV, Weiner JL, Dunwiddie TV, (1998) Synaptic potentials mediated via alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons. J Neurosci 18: 8228-8235.
6. Frazier CJ, Rollins YD, Breese CR, Leonard S, Freedman R, et al. (1998) Acetylcholine activates an alpha-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells. J Neurosci 18: 1187-1195.
7. Buhler AV, Dunwiddie TV, (2001) Regulation of the activity of hippocampal stratum oriens interneurons by alpha7 nicotinic acetylcholine receptors. Neuroscience 106: 55-67.
8. Buhler AV, Dunwiddie TV, (2002) alpha7 nicotinic acetylcholine receptors on GABAergic interneurons evoke dendritic and somatic inhibition of hippocampal neurons. J Neurophysiol 87: 548-557.
9. Alkondon M, Pereira EF, Albuquerque EX, (1998) alpha-bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices. Brain Res 810: 257-263.
10. Alkondon M, Albuquerque EX, (2001) Nicotinic acetylcholine receptor alpha7 and alpha4beta2 subtypes differentially control GABAergic input to CA1 neurons in rat hippocampus. J Neurophysiol 86: 3043-3055.
11. Sudweeks SN, Yakel JL, (2000) Functional and molecular characterization of neuronal nicotinic ACh receptors in rat CA1 hippocampal neurons. J Physiol 527 Pt 3: 515-528.
12. McQuiston AR, Madison DV, (1999) Nicotinic receptor activation excites distinct subtypes of interneurons in the rat hippocampus. J Neurosci 19: 2887-2896.
13. Alkondon M, Pereira EF, Albuquerque EX, (2003) NMDA and AMPA receptors contribute to the nicotinic cholinergic excitation of CA1 interneurons in the rat hippocampus. J Neurophysiol 90: 1613-1625.
14. Jones S, Yakel JL, (1997) Functional nicotinic ACh receptors on interneurones in the rat hippocampus. J Physiol 504 (Pt 3): 603-610.
15. McClure-Begley TD, King NM, Collins AC, Stitzel JA, Wehner JM, et al. (2009) Acetylcholine-stimulated [3H]GABA release from mouse brain synaptosomes is modulated by alpha4beta2 and alpha4alpha5beta2 nicotinic receptor subtypes. Mol Pharmacol 75: 918-926.
16. Sharma G, Vijayaraghavan S, (2003) Modulation of presynaptic store calcium induces release of glutamate and postsynaptic firing. Neuron 38: 929-939.
17. Stone TW, Darlington LG, (2002) Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov 1: 609-620.
18. Stone TW, Forrest CM, Darlington LG, (2012) Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection. FEBS J.
19. Scharfman HE, Goodman JH, Schwarcz R, (2000) Electrophysiological effects of exogenous and endogenous kynurenic acid in the rat brain: studies in vivo and in vitro. Amino Acids 19: 283-297.
20. Scharfman HE, Hodgkins PS, Lee SC, Schwarcz R, (1999) Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices. Neurosci Lett 274: 111-114.
21. Hilmas C, Pereira EF, Alkondon M, Rassoulpour A, Schwarcz R, et al. (2001) The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. J Neurosci 21: 7463-7473.
22. Arnaiz-Cot JJ, Gonzalez JC, Sobrado M, Baldelli P, Carbone E, et al. (2008) Allosteric modulation of alpha 7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission. Eur J Neurosci 27: 1097-1110.
23. Mok MH, Fricker AC, Weil A, Kew JN, (2009) Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channels. Neuropharmacology 57: 242-249.
24. Frazier CJ, Strowbridge BW, Papke RL, (2003) Nicotinic receptors on local circuit neurons in dentate gyrus: a potential role in regulation of granule cell excitability. J Neurophysiol 89: 3018-3028.
25. Whiteaker P, Davies AR, Marks MJ, Blagbrough IS, Potter BV, et al. (1999) An autoradiographic study of the distribution of binding sites for the novel alpha7-selective nicotinic radioligand [3H]-methyllycaconitine in the mouse brain. Eur J Neurosci 11: 2689-2696.
26. Alkondon M, Pereira EF, Eisenberg HM, Kajii Y, Schwarcz R, et al. (2011) Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain. J Pharmacol Exp Ther 337: 572-582.
27. Alkondon M, Pereira EF, Albuquerque EX, (2011) Endogenous activation of nAChRs and NMDA receptors contributes to the excitability of CA1 stratum radiatum interneurons in rat hippocampal slices: effects of kynurenic acid. Biochem Pharmacol 82: 842-851.
28. Alkondon M, Pereira EF, Yu P, Arruda EZ, Almeida LE, et al. (2004) Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus. J Neurosci 24: 4635-4648.
29. El-Hajj RA, McKay SB, McKay DB, (2007) Pharmacological and immunological identification of native alpha7 nicotinic receptors: evidence for homomeric and heteromeric alpha7 receptors. Life Sci 81: 1317-1322.
30. Ramirez-Latorre J, Yu CR, Qu X, Perin F, Karlin A, et al. (1996) Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels. Nature 380: 347-351.
31. Yu CR, Role LW, (1998) Functional contribution of the alpha5 subunit to neuronal nicotinic channels expressed by chick sympathetic ganglion neurones. J Physiol 509 (Pt 3): 667-681.
32. Khiroug SS, Harkness PC, Lamb PW, Sudweeks SN, Khiroug L, et al. (2002) Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels. J Physiol 540: 425-434.
33. Girod R, Crabtree G, Ernstrom G, Ramirez-Latorre J, McGehee D, et al. (1999) Heteromeric complexes of alpha 5 and/or alpha 7 subunits. Effects of calcium and potential role in nicotine-induced presynaptic facilitation. Ann N Y Acad Sci 868: 578-590.
34. Papke RL, Porter Papke JK, (2002) Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis. Br J Pharmacol 137: 49-61.
35. Stokes C, Papke JK, Horenstein NA, Kem WR, McCormack TJ, et al. (2004) The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors. Mol Pharmacol 66: 14-24.
36. Son JH, Winzer-Serhan UH, (2008) Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs in rat hippocampal GABAergic interneurons. J Comp Neurol 511: 286-299.
37. Banerjee J, Alkondon M, Pereira EF, Albuquerque EX, (2012) Regulation of GABAergic inputs to CA1 pyramidal neurons by nicotinic receptors and kynurenic acid. J Pharmacol Exp Ther.
38. Wang J, Simonavicius N, Wu X, Swaminath G, Reagan J, et al. (2006) Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem 281: 22021-22028.
39. Guo J, Williams DJ, Puhl HL III, Ikeda SR, (2008) Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons. J Pharmacol Exp Ther 324: 342-351.
40. Moroni F, Cozzi A, Sili M, Mannaioni G, (2012) Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery. J Neural Transm 119: 133-139.
41. Conn PJ, Pin JP, (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37: 205-237.
42. Ferraguti F, Shigemoto R, (2006) Metabotropic glutamate receptors. Cell Tissue Res 326: 483-504.
43. Chalifoux JR, Carter AG, (2011) GABAB receptor modulation of synaptic function. Curr Opin Neurobiol 21: 339-344.