Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis

Brain

Volumn 132, Issue 5, 2009, Pages 1259-1267

  Rodgers, Jean ^a   Stone, Trevor W ^b   Barrett, Michael P ^a   Bradley, Barbara ^a   Kennedy, Peter G E ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Brain; Kynurenine pathway; Mice; Ro 61 8048; Trypanosomiasis

Indexed keywords

3,4 DIMETHOXY N [4 (3 NITROPHENYL) 2 THIAZOLYL]BENZENESULFONAMIDE; KYNURENINE; KYNURENINE 3 MONOOXYGENASE; MELARSOPROL; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DISEASE; FEMALE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; POST TREATMENT REACTIVE ENCEPHALOPATHY; PRIORITY JOURNAL; TRYPANOSOMA; TRYPANOSOMA RHODESIENSE; TRYPTOPHAN METABOLISM;

ANIMALS; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM PROTOZOAL INFECTIONS; FEMALE; INHIBITORY CONCENTRATION 50; KYNURENINE; MICE; MICE, INBRED STRAINS; PENTAMIDINE; SIGNAL TRANSDUCTION; SULFONAMIDES; THIAZOLES; TIME FACTORS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EID: 66549100383     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awp074     Document Type: Article

References (36)

1. Adams JH, Haller L, Boa FY, Doua F, Dago A, Konian K. Human African trypanosomiasis (T. b. gambiense): a study of 16 fatal cases of sleeping sickness with some observations on acute reactive arsenical encephalopathy. Neuropathol Appl Neurobiol 1986; 12: 81-94. (Pubitemid 16168225)
2. Clark CJ, Mackay GM, Smythe GA, Bustamante S, Stone TW, Phillips RS. Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition. Infect Immun 2005; 73: 5249-5251 (Pubitemid 41105691)
3. Eastman CL, Guilarte TR. Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line. Brain Res 1989; 495: 225-231 (Pubitemid 19213559)
4. Eastman CL, Guilarte TR. The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine. Neurochem Res 1990; 15: 1101-1107
5. Frumento G, Rotondo R, Tonetti M, Damonte G, Benatti U, Ferrara GB. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J Exp Med 2002; 196: 459-468
6. Giles GI, Collins CA, Stone TW, Jacob C. Electrochemical and in vitro evaluation of the redox-properties of kynurenine species. Biochem Biophys Res Commun 2003; 300: 719-724 (Pubitemid 36268896)
7. Gonzalez A, Varo N, Alegre E, Diaz A, Melero I. Immunosuppression routed via the kynurenine pathway: a biochemical and pathophysiologic approach. Adv Clin Chem 2008; 45: 155-197
8. Guidetti P, Schwarcz R. 3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum. Eur J Neurosci 1999; 11: 3857-3863 (Pubitemid 29537565)
9. Hirumi H, Hirumi K. Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J Parasitol 1989; 75: 985-989 (Pubitemid 20099178)
10. Jennings FW, Gichuki CW, Kennedy PG, Rodgers J, Hunter CA, Murray M, et al. The role of the polyamine inhibitor e?ornithine in the neuropathogenesis of experimental murine African trypanosomia- sis. Neuropathol Appl Neurobiol 1997; 23: 225-234 (Pubitemid 27267708)
11. Jennings FW, Whitelaw DD, Holmes PH, Chizyuka HG, Urquhart GM. The brain as a source of relapsing Trypanosoma brucei infection in mice after chemotherapy. Int J Parasitol 1979; 9: 381-384 (Pubitemid 10243646)
12. Jhamandas K, Boegman RJ, Beninger RJ, Bialik M. Quinolinate-induced cortical cholinergic damage: modulation by tryptophan metabolites. Brain Res 1990; 529: 185-191 (Pubitemid 20326855)
13. Kamleh A, Barrett MP, Wildridge D, Burchmore RJ, Scheltema RA, Watson DG. Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. Rapid Commun Mass Spectrom 2008; 22: 1912-1918
14. Kennedy PG. Human African trypanosomiasis of the CNS: current issues and challenges. J Clin Invest 2004; 113: 496-504. (Pubitemid 38542496)
15. Kennedy PG. Diagnostic and neuropathogenesis issues in human African trypanosomiasis. Int J Parasitol 2006; 36: 505-512
16. Kennedy PG. The continuing problem of human African trypanosomiasis (sleeping sickness). Ann Neurol 2008; 64: 116-126.
17. Kennedy PG, Rodgers J, Jennings FW, Murray M, Leeman SE, Burke JM. A substance P antagonist, RP-67,580, ameliorates a mouse menin-goencephalitic response to Trypanosoma brucei brucei. Proc Natl Acad Sci USA 1997; 94: 4167-4170 (Pubitemid 27180517)
18. Moffett JR, Namboodiri MA. Tryptophan and the immune response. Immunol Cell Biol 2003; 81: 247-265 (Pubitemid 36904332)
19. Okuda S, Nishiyama N, Saito H, Katsuki H. Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydro-xykynurenine. Proc Natl Acad Sci USA 1996; 93: 12553-12558 (Pubitemid 26367182)
20. Okuda S, Nishiyama N, Saito H, Katsuki H. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem 1998; 70: 299-307. (Pubitemid 28020856)
21. Pepin J, Milord F. African trypanosomiasis and drug-induced encephalo-pathy: risk factors and pathogenesis. Trans R Soc Trop Med Hyg 1991; 85: 222-224
22. Pepin J, Milord F. The treatment of human African trypanosomiasis. Adv Parasitol 1994; 33: 1-47. (Pubitemid 23357084)
23. Perkins MN, Stone TW. An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res 1982; 247: 184-187
24. Pfefferkorn ER. Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Natl Acad Sci USA 1984; 81: 908-912. (Pubitemid 14197611)
25. Raz B, Iten M, Grether-Buhler Y, Kaminsky R, Brun R. The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T. b. rhodesiense and T. b. gambiense) in vitro. Acta Trop 1997; 68: 139-147. (Pubitemid 27438330)
26. Sanni LA, Thomas SR, Tattam BN, Moore DE, Chaudhri G, Stocker R, et al. Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria. Am J Pathol 1998; 152: 611-619 (Pubitemid 28106408)
27. Schroten H, Spors B, Hucke C, Stins M, Kim KS, Adam R, et al. Potential role of human brain microvascular endothelial cells in the pathogenesis of brain abscess: inhibition of Staphylococcus aureus by activation of indoleamine 2,3-dioxygenase. Neuropediatrics 2001; 32: 206-210 (Pubitemid 32895903)
28. Schwarcz R, Whetsell WO Jr, Mangano RM. Quinolinic acid: an endo-genous metabolite that produces axonsparing lesions in rat brain. Science 1983; 219: 316-318 (Pubitemid 13222319)
29. Smith AJ, Stone TW, Smith RA. Neurotoxicity of tryptophan metabolites. Biochem Soc Trans 2007; 35: 1287-1289 (Pubitemid 350206480)
30. Sternberg JM, Rodgers J, Bradley B, MacLean L, Murray M, Kennedy PG. Meningoencephalitic African trypanosomiasis: brain IL-10 and IL-6 are associated with protection from neuro-in?ammatory pathology. J Neuroimmunol 2005; 167: 81-89 (Pubitemid 41242290)
31. Stone TW. Kynurenines in the CNS: from endogenous obscurity to ther-apeutic importance. Prog Neurobiol 2001; 64: 185-218. (Pubitemid 32195412)
32. Stone TW, Darlington LG. Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov 2002; 1: 609-620 (Pubitemid 37361524)
33. Stone TW, Perkins MN. Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. Eur J Pharmacol 1981; 72: 411-412 (Pubitemid 11081065)
34. Terness P, Bauer TM, Rose L, Dufter C, Watzlik A, Simon H, et al. Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxy-genase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J Exp Med 2002; 196: 447-457
35. Vincendeau P, Lesthelle S, Bertazzo A, Okomo-Assoumou MC, Allegri G, Costa CV. Importance of L-tryptophan metabolism in trypanosomiasis. Adv Exp Med Biol 1999; 467: 525-531 (Pubitemid 32202198)
36. WHO. Control and surveillance of African trypanosomiaisis. WHO technical report series, Geneva 1998; 881: 1-113.