Linking cognitive aging to alterations in dopamine neurotransmitter functioning: Recent data and future avenues

Neuroscience and Biobehavioral Reviews

Volumn 34, Issue 5, 2010, Pages 670-677

  Bäckman, Lars ^a   Lindenberger, Ulman ^b   Li, Shu Chen ^b   Nyberg, Lars ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b MAX PLANCK INSTITUTE FOR HUMAN DEVELOPMENT   (Germany)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

Aging; Cognition; Dopamine; Multimodal imaging; Processing fluctuations; Striatum; Working memory training

Indexed keywords

DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER;

AGING; BRAIN FUNCTION; COGNITION; COGNITIVE DEFECT; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; EPISODIC MEMORY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MEMORY DISORDER; MOLECULAR IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; TASK PERFORMANCE;

AGING; COGNITION; DOPAMINE; HUMANS; NEUROPSYCHOLOGICAL TESTS;

EID: 77649335893     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2009.12.008     Document Type: Review

References (104)

1. 11C] FLB 457. J. Neurosci. 25 (2005) 2471-2477
2. 1 receptors and working memory in schizophrenia. J. Neurosci. 22 (2002) 3708-3719
3. Alexander G.E., DeLong M.R., and Strick P.L. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 9 (1986) 357-381
4. Anstey K.J. Sensorimotor and forced expiratory volume as correlates of speed, accuracy, and variability in reaction time performance in late adulthood. Aging Neuropsychol. Cognit. 6 (1999) 84-95
5. 11C] raclopride. Arch. Neurol. 50 (1993) 474-480
6. Bäckman L., and Farde L. The role of dopamine functions in cognitive aging. In: Cabeza R.R., Nyberg L., and Park D.C. (Eds). Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging (2005), Oxford University Press, New York 58-84
7. Bäckman L., Ginovart N., Dixon R.A., Robins Wahlin T.B., Wahlin A., Halldin C., and Farde L. Age-related cognitive deficits mediated by changes in the striatal dopamine system. Am. J. Psychiatry 157 (2000) 635-637
8. Bäckman L., Karlsson S., Fischer H., Karlsson P., Brehmer Y., Rieckmann A., MacDonald S.W.S., Farde L., and Nyberg L. Dopamine D1 receptors and age differences in brain activation during working memory. Neurobiol. Aging (2009) 10.1016/j.neurobiolaging.2009.10.018
9. Bäckman L., Nyberg L., Lindenberger U., Li S.C., and Farde L. The correlative triad among aging, dopamine, and cognition: current status and future prospects. Neurosci. Biobehav. Rev. 30 (2006) 791-807
10. Bäckman L., Robins-Wahlin T.B., Lundin A., Ginovart N., and Farde L. Cognitive deficits in Huntington's disease are predicted by dopaminergic PET markers and brain volumes. Brain 120 (1997) 2207-2217
11. Bäckman L., Small B.J., and Wahlin A. Aging and memory: cognitive and biological perspectives. In: Birren J.E., and Schaie K.W. (Eds). Handbook of the Psychology of Aging. 5th ed. (2001), Academic Press, San Diego 349-377
12. Badgaiyan R.D., Fischman A.J., and Alpert N.M. Striatal dopamine release in sequential learning. Neuroimage 38 (2007) 549-556
13. Bannon M.J., and Whitty C.J. Age-related and regional differences in dopamine mRNA expression in human midbrain. Neurology 48 (1997) 969-977
14. Basak C., Boot W.R., Voss M.W., and Kramer A.F. Can training in a real-time strategy video game attenuate cognitive decline in older adults. Psychol. Aging 23 (2008) 765-777
15. Brehmer Y., Li S.-C., Müller V., von Oertzen T., and Lindenberger U. Memory plasticity across the life span: uncovering children's latent potential. Dev. Psychol. 43 (2007) 465-478
16. Bruck A., Aalto S., Nurmi E., Bergman H., and Rinne J.O. Cortical 6-[F18]fluoro-l-dopa uptake and frontal cognitive functions in early Parkinson's disease. Neurobiol. Aging 26 (2005) 891-898
17. Burton C.L., Strauss E., Hultsch D.F., Moll A., and Hunter M.A. Intraindividual variability as a marker of neurological dysfunction: a comparison of Alzheimer's disease and Parkinson's disease. J. Clin. Exp. Neuropsychol. 28 (2006) 67-83
18. Bush G., Shin L.M., Holmes J., and Rosen B.R. The multi-source interference task: validation study with fMRI in individual subjects. Mol. Psychiatry 8 (2003) 60-70
19. Buschkuehl M., Jaeggi S.M., Hutchison S., Perrig-Chiello P., Dapp C., Müller M., Breil F., Hoppeler H., and Perrig W.J. Impact of working memory training on memory performance in old-old adults. Psychol. Aging 23 (2008) 743-753
20. Castellanos F.X., and Tannock R. Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat. Rev. Neurosci. 3 (2002) 617-628
21. Cervenka S., Bäckman L., Cselényi Z., Halldin C., and Farde L. Associations between dopamine D2-recptor binding and cognitive performance indicate functional compartmentalization of the human striatum. Neuroimage 40 (2008) 1287-1295
22. Craik F.I.M., and Salthouse T.A. Handbook of Aging and Cognition. 3rd ed. (2007), Psychological Press, New York
23. Cropley V.L., Fujita M., Innis R.B., and Nathan P.J. Molecular imaging of the dopaminergic system and its association with human cognitive function. Biol. Psychiatry 59 (2006) 898-907
24. Dahlin E., Nyberg L., Bäckman L., and Stigsdotter Neely A. Plasticity of executive functioning in young and old Adults: immediate training gains, transfer, and long-term maintenance. Psychol. Aging 23 (2008) 720-730
25. Dahlin E., Stigsdotter Neely A., Larsson A., Bäckman L., and Nyberg L. Transfer of learning after updating training mediated by the striatum. Science 320 (2008) 1510-1512
26. Derwinger A., Stigsdotter Neely A., Persson M., Hill R.D., and Bäckman L. Remembering numbers in old age: mnemonic training versus self-generated strategy training. Aging Neuropsychol. Cognit. 10 (2003) 202-214
27. Egelton A., Mehta M.A., Montgomery A.J., Lappin J.M., Howes O.D., Reeves S.J., Cunningham V.J., and Grasby P.M. The dopaminergic basis of human behaviors: AS review of molecular imaging studies. Neurosci. Biobehav. Rev. 33 (2009) 1109-1132
28. Erixon-Lindroth N., Farde L., Robins Wahlin T.B., Sovago J., Halldin C., and Bäckman L. The role of the striatal dopamine transporter in cognitive aging. Psychiatr. Res. Neuroimag. 138 (2005) 1-12
29. Faisal A.A., Selen L.P., and Wolpert D.M. Noise in the nervous system. Nat. Rev. Neurosci. 9 (2008) 292-303
30. 3 receptors exhibit differential activation of prefrontal cortical neurons during tasks requiring attention. Cereb. Cortex 15 (2005) 1016-1024
31. Hill R.D., Bäckman L., and Stigsdotter Neely A. Cognitive Rehabilitation in Old Age (2000), Oxford University Press, New York
32. Hultsch D.F., MacDonald S.W.S., and Dixon R.A. Variability in reaction time performance of younger and older adults. J. Gerontol. Psychol. Sci. 57 (2002) 101-115
33. Jaeggi S.M., Buschkuehl M., Jonides J., and Perrig W.J. Improving fluid intelligence with training on working memory. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 6829-6833
34. Jones S., Nyberg L., Sandblom J., Stigsdotter Neely A., Ingvar M., Petersson K.M., and Bäckman L. Cognitive and neural plasticity in aging: general and task-specific limitations. Neurosci. Biobehav. Rev. 30 (2006) 864-871
35. 3 receptor loss in extrastriatal regions of the human brain. Neurobiol. Aging 21 (2000) 683-688
36. 1 binding by cognitive processing. Neuroimage 48 (2009) 398-404
37. Kliegl R., Smith J., and Baltes P.B. Testing-the-limits and the study of adult age differences in cognitive plasticity of a mnemonic skill. Dev. Psychol. 25 (1989) 247-256
38. Knutson B., and Gibbs S.E.B. Linking nucleus accumbens dopamine and blood oxygenation. Psychopharmacology 191 (2007) 813-822
39. Koepp M.J., Gunn R.N., Lawrence A.D., Cunningham V.J., Dagher A., Jones T., Brooks D.J., Bench C.J., and Grasby P.M. Evidence for striatal dopamine release during a video game. Nature 393 (1998) 266-268
40. Kramer A.F., Hahn S., and Gopher D. Task coordination and aging: explorations of executive control processes in the task switching paradigm. Acta Psychol. 101 (1999) 339-378
41. Landau S.M., Lal R., O'Neil J.P., Baker S., and Jagust W.J. Striatal dopamine and working memory. Cereb. Cortex 19 (2009) 445-454
42. Laruelle M. Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. J. Cereb. Blood Flow Metabol. 20 (2000) 423-451
43. Lawrence A.D., Weeks R.A., Brooks D.J., Andrews T.C., Watkins L.H.A., Harding A.E., Robbins T.W., and Sahakian B.J. The relationship between striatal dopamine receptor binding and cognitive performance in Huntington's disease. Brain 121 (1998) 1343-1355
44. Li S.C., Lindenberger U., Hommel B., Aschersleben G., Prinz W., and Baltes P.B. Transformations in the couplings among intellectual abilities and constituent cognitive processes across the lifespan. Psychol. Sci. 15 (2004) 155-163
45. Li S.C., Lindenberger U., Nyberg L., Heekeren H.R., and Bäckman L. Dopaminergic modulation of cognition in human aging. In: Jagust W., and D'Esposito M. (Eds). Imaging the Aging Brain (2009), Oxford University Press, New York 71-91
46. Li S.C., Lindenberger U., and Sikström S. Aging cognition: from neuromodulation to representation to cognition. Trends Cognit. Sci. 5 (2001) 479-486
47. Li S.C., Schmiedek F., Huxhold O., Rocke C., Smith J., and Lindenberger U. Working memory plasticity in old age: practice gain, transfer, and maintenance. Psychol. Aging 23 (2008) 731-742
48. Li S.C., and Sikström S. Integrative neurocomputational perspectives on cognitive aging, neuromodulation, and representation. Neurosci. Biobehav. Rev. 26 (2002) 795-808
49. Li S.C., von Oertzen T., and Lindenberger U. A neurocomputational model of stochastic resonance and aging. Neurocomputing 69 (2006) 1553-1560
50. Lindenberger U., and Ghisletta P. Cognitive and sensory decline in aging: gauging evidence for a common cause. Psychol. Aging 24 (2009) 1-16
51. Lövdèn M., Li S.C., Shing Y.L., and Lindenberger U. Within-person trial-to-trial variability precedes and predicts cognitive decline in old and very old age: longitudinal data from the Berlin Aging Study. Neuropsychologia 45 (2007) 2827-2838
52. Luciana M., and Collins P.F. Dopamine modulates working memory for spatial but not object cues in normal humans. J Cognit. Neurosci. 9 (1997) 330-347
53. Ma S.Y., Ciliax B.J., Stebbins G., Jaffar S., Joyce J.N., Cochran E.J., Kordower J.H., Mash D.C., Levey A.I., and Mufson E.J. Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra. J. Comp. Neurol. 409 (1999) 25-37
54. MacDonald S.W.S., Cervenka S., Farde L., Nyberg L., and Bäckman L. Extrastriatal dopamine D2 receptor binding modulates intraindividual variability in episodic memory and executive functioning. Neuropsychologia 47 (2009) 2299-2304
55. MacDonald S.W.S., Nyberg L., and Bäckman L. Intra-individual variability in behavior: links to brain structure, neurotransmission, and neuronal activity. Trends Neurosci. 29 (2006) 474-480
56. MacRae P.G., Spiriduso W.W., and Wilcox R.E. Reaction time and nigrostriatal dopamine function: the effects of age and practice. Brain Res. 451 (1988) 139-146
57. Martinez D., Silfstein M., Broft A., Mawlawi T., Hwang D.R., Huang Y.Y., Cooper T., Kegeles L., Zarahn E., Abi-Dargham A., Haber S.N., and Laurelle T. Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: Amphetamine-induced dopamine release in the functional subdivisions of the striatum. J. Cereb. Blood Flow Metabol. 23 (2003) 285-300
58. Mattay V.S., Fera F., Tessitore A., Hariri A.R., Berman K.F., Das S., Meyer-Kindenberg A., Goldberg T.E., Callicott J.H., and Weinberger D.R. Neurophysiological correlates of age-related changes in working-memory capacity. Neurosci. Lett. 392 (2006) 32-37
59. Mattay V.S., Goldberg T.E., Fera F., Hariri A.R., Tessitore A., Egan M.F., Kolachana B., Callicott J.H., and Weinberger D.R. Catechol-O-methyltransferase val(258)-met genotype and individual variation in the brain response to amphetamine. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 6186-6191
60. McIntosh A.R., Kovacevic N., and Itier R.J. Increased brain signal variability accompanies lower behavioral variability in development. PLOS Comput. Biol. 4 (2008) e1000106
61. McGowan S., Lawrence A.D., Sales T., Quested D., and Graby P. Presynaptic dopaminergic dysfunction in schizophrenia: a positron emission tomographic [F18] fluorodopa study. Arch. Gen. Psychiatry 61 (2004) 134-142
62. McNab F., and Klingberg T. Prefrontal cortex and basal ganglia control access to working memory. Nat. Neurosci. 11 (2004) 103-107
63. McNab F., Varrone A., Farde L., Jucaite A., Bystritsky P., Forssberg H., and Klingberg T. Changes in cortical dopamine binding associated with cognitive training. Science 323 (2009) 800-802
64. Miyake A., Friedman N.P., Emerson M.J., Witzki A.H., Howerter A., and Wager T.D. The unity and diversity of executive functions and their contributions to complex "frontal lobe" tasks: a latent variable analysis. Cognit. Psychol. 41 (2000) 49-100
65. 11C] raclopride PET study. Neuroimage 33 (2006) 907-912
66. Mozley L.H., Gur R.C., Mozley P.D., and Gur R.E. Striatal dopamine transporters and cognitive functioning in healthy men and women. Am. J. Psychiatry 158 (2001) 1492-1499
67. Murtha S., Cismaru R., Waechter R., and Chertkow H. Increased variability accompanies frontal lobe damage in dementia. J. Int. Neuropsychol. Soc. 8 (2002) 360-372
68. Nagano-Saito A., Kato T., Arahata Y., Washimi Y., Nakamura A., Abe Y., Yamada T., Iwai K., Hatano K., Kawasumi Y., Kachi T., Dagher A., and Ito K. Cognitive- and motor-related regions in Parkinson's disease: FDOPA and FDG PET studies. Neuroimage 22 (2004) 553-561
69. Nagel, I.E., Preuschhof, C., Li, S.-C., Nyberg, L., Bäckman, L., Lindenberger, U., Heekeren, H.R., in press. Performance level modulates adult age differences in brain activation during spatial working memory. Proc. Natl. Acad. Sci. U.S.A. www.pnas.org/cgi; doi:10.1073/pnas.0908238106.
70. Nesselroade J.R., and Salthouse T.A. Methodological and theoretical implications of intraindividual variability in perceptual-motor performance. J. Gerontol. Psychol. Sci. 59 (2004) 49-55
71. 2 binding is related to frontal BOLD response during updating of long-term memory representations. Neuroimage 46 (2009) 1194-1199
72. Nyberg L., and Bäckman L. Cognitive aging: a view from brain imaging. In: Dixon R.A., Bäckman L., and Nilsson L.G. (Eds). New Frontiers in Cognitive Aging (2004), Oxford University Press, New York 135-159
73. Nyberg L., Dahlin E., Stigsdotter Neely A., and Bäckman L. Neural correlates of variable working memory load across adult age and skill: dissociative patterns within the fronto-parietal network. Scand. J. Psychol. 50 (2009) 41-46
74. Nyberg L., Sandblom J., Jones S., Stigsdotter-Neely A., Petersson K.M., Ingvar M., and Bäckman L. Neural correlates of training-related memory improvement in adulthood and aging. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 13728-13733
75. 1 receptors in schizophrenia revealed by PET. Nature 385 (1997) 634-636
76. O'Reilly R. Biologically based computational models of high-level cognition. Science 314 (2006) 91-94
77. Picton T.W., Stuss D.T., Alexander M.P., Shallice T., Binns M.A., and Gillingham S. Effects of frontal lesions on response inhibition. Cereb. Cortex 17 (2007) 826-838
78. Rabbitt P., Osman P., Moore B., and Stollery B. There are stable individual differences in performance variability, both from moment to moment and from day to day. Q. J. Exp. Psychol. 54 (2001) 981-1003
79. Reeves S.J., Bench C., and Howard R.J. Aging and the nigrostriatal dopamine system. Int. J. Geriatr. Psychiatr. 17 (2002) 359-370
80. 2 receptor availability in spatial cognition. Neuroimage 28 (2005) 216-226
81. 2 receptor. Brain Res. 508 (1990) 349-352
82. Rönnlund M., Nyberg L., Bäckman L., and Nilsson L.G. Stability, growth, and decline in adult life-span development of declarative memory: cross-sectional and longitudinal data from a population-based study. Psychol. Aging 20 (2005) 3-18
83. Rypma B., and D'Esposito M. Isolating the neural mechanisms of age-related changes in human working memory. Nat. Neurosci. 3 (2000) 509-515
84. Salthouse T.A. Why do adult age differences increase with task complexity?. Dev. Psychol. 28 (1992) 905-918
85. Sánchez-González M.A., García-Cabezas M.A., Rico B., and Cavada C. The primate thalamus is a key target for brain dopamine. J. Neurosci. 25 (2005) 6076-6083
86. Sawaguchi T., and Goldman-Rakic P.S. D1 dopamine receptors in prefrontal cortex: involvement in working memory. Science 251 (1991) 947-950
87. Sawamoto N., Piccini P., Hotton G., Pavese N., Thielemans K., and Brooks D.J. Cognitive deficits and striato-frontal dopamine release in Parkinson's disease. Brain 131 (2008) 1294-1302
88. Schaie K.W. Intellectual Development in Adulthood: The Seattle Longitudinal Study (1996), Cambridge University Press, Cambridge, England
89. Schott B.H., Minuzzi L., Krebs R.M., Elmenhorst D., Lang M., Winz O.H., Seidenbecher C.I., Coenen H.H., Heinze H.J., Zilles K., and Düzel E. Mesolimbic fMRI activations during reward anticipation correlate with reward-related ventral striatal dopamine release. J. Neurosci. 28 (2008) 14311-14319
90. Schultz W., Studer A., Romo R., Sundström E., Jonsson G., and Scarnati E. Deficits in reaction times and movement times as correlates of hypokinesia in monkeys with MPTP-induced striatal dopamine depletion. J. Neurophysiol. 61 (1989) 651-668
91. Servan-Schreiber D., Printz H., and Cohen J.D. A network model of catecholamine effects: gain, signal-to-noise ratio, and behavior. Science 249 (1990) 892-895
92. Shipley B.A., Der G., Taylor M.D., and Deary I.J. Cognition and all-cause mortality across the entire adult age range: health and lifestyle survey. Psychosom. Med. 68 (2006) 17-24
93. Stein R.B., Gossen E.R., and Jones K.E. Neuronal variability: noise or part of the signal?. Nat. Rev. Neurosci. 6 (2005) 389-397
94. Stuss D.T., Murphy K.J., Binns M.A., and Alexander M.P. Staying on the job: the frontal lobes control individual performance variability. Brain 126 (2003) 2363-2380
95. Stuss D.T., Pogue J., Buckle L., and Bondar J. Characterization of stability of performance in patients with traumatic brain injury: variability and consistency on reaction time tests. Neuropsychology 8 (1994) 316-324
96. 2 receptors in human cognitive functions. J. Neurosci. 28 (2008) 12032-12038
97. 2 receptors in the hippocampus. Neuroimage 34 (2007) 1643-1649
98. Van Dyck C.H., Avery R.A., MacAvoy M.G., Marek K.L., Quinlan D.M., Baldwin R.M., Seibyl J.P., Innis R.B., and Arnsten A.F.T. Striatal dopamine receptors correlate with simple reaction time in elderly subjects. Neurobiol. Aging 29 (2008) 1237-1246
99. Verhaeghen P., and Marcoen A. On the mechanisms of plasticity in young and older adults after instruction in the method of loci: evidence for an amplification model. Psychol. Aging 11 (1996) 164-178
100. 1 receptor actions on prefrontal neurons engaged in working memory. Nat. Neurosci. 10 (2007) 376-384
101. Volkow N.D., Gur R.C., Wang G.J., Fowler J.S., Moberg P.J., Ding Y.S., Hitzemann R., Smith G., and Logan J. Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals. Am. J. Psychiatry 157 (1998) 344-349
102. 1 receptors in human brain: a PET study. Synapse 30 (1998) 56-61
103. West R., Murphy K.J., Armilio M.L., Craik F.I.M., and Stuss D.T. Lapses of intention and performance variability reveal age-related increases in fluctuations of executive control. Brain Cognit. 49 (2002) 402-419
104. Winterer G., Coppola R., Goldberg T.E., Egan M.F., Jones D.W., Sanchez C.E., and Weinberger D.R. Prefrontal broadband noise, working memory, and genetic risk for schizophrenia. Am. J. Psychiatry 161 (2004) 490-500