Administration of kynurenine during adolescence, but not during adulthood, impairs social behavior in rats

Schizophrenia Research

Volumn 133, Issue 1-3, 2011, Pages 156-158

  Trecartin, Katelyn V ^a   Bucci, David J ^a  

^a Dartmouth College   (United States)

Author keywords

Acetylcholine; Glia; Glutamate; L kynurenine; Schizophrenia

Indexed keywords

KYNURENIC ACID; KYNURENINE;

ADOLESCENCE; ADOLESCENT; ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE ASSOCIATION; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; SOCIAL BEHAVIOR; SOCIAL DISABILITY; SOCIAL INTERACTION;

AGING; ANIMALS; DISEASE MODELS, ANIMAL; INTERPERSONAL RELATIONS; KYNURENINE; MALE; MOTOR ACTIVITY; RATS; RATS, LONG-EVANS; SOCIAL BEHAVIOR DISORDERS; TIME FACTORS;

EID: 81955162911     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2011.08.014     Document Type: Article

References (26)

1. Akagbosu, C.O., Evans, G.C., Gulick, D., Suckow, R.F., Bucci, D.J., in press. Exposure tokynurenic acid during adolescence produces memory deficits in adulthood. Schizophr. Bull. (Electronic publication ahead of print). doi:10.1093/schbul/sbq151.
2. Bast T., Zhang W.N., Feldon J. Dorsal hippocampus and classical fear conditioning to tone and context in rats: effects of local NMDA-receptor blockade and stimulation. Hippocampus 2003, 13:657-675.
3. Blin O. A comparative review of new antipsychotics. Can. J. Psychiatry 1999, 44(3):235-244.
4. Broide R.S., Leslie F.M. The alpha7 nicotinic acetylcholine receptor in neuronal plasticity. Mol. Neurobiol. 1999, 20(1):1-16.
5. Chess A.C., Bucci D.J. Increased concentration of cerebral kynurenic acid alters stimulus processing and conditioned responding. Behav. Brain Res. 2006, 170:326-332.
6. Chess A.C., Simoni M.K., Alling T.E., Bucci D.J. Elevations of endogenous kynurenic acid produce spatial working memory deficits. Schizophr. Bull. 2007, 33:797-804.
7. Chess A.C., Landers A.M., Bucci D.J. l-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning. Behav. Brain Res. 2009, 201:325-331.
8. Erhardt S., Blennow K., Nordin C., Skogh E., Lindstrom L.H., Engberg G. Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia. Neurosci. Lett. 2001, 313:96-98.
9. Erhardt S., Schwieler L., Emanuelsson C., Geyer M. Endogenous kynurenic acid disrupts prepulse inhibition. Biol. Psychiatry 2004, 56:255-260.
10. File S.E. The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs. J. Neurosci. Methods 1980, 2:219-238.
11. File S.E., Seth P. A review of 25years of the social interaction test. Eur. J. Pharmacol. 2003, 463:35-53.
12. Gould T.J., Higgins J.S. Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7days post-training. Neurobiol. Learn. Mem. 2003, 80:147-157.
13. Harrop C., Trower P. Why does schizophrenia develop at late adolescence?. Clin. Psychol. Rev. 2001, 21:241-265.
14. Hilmas C., Pereira E.F.R., Alkondon M., Rassoulpour A., Schwarcz R., Albuquerque E.X. The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. J. Neurosci. 2001, 21:7463-7473.
15. Hopkins M.E., Sharma M., Evans G.C., Bucci D.J. Voluntary physical exercise alters attentional orienting and social behavior in rat model of attention-deficit/hyperactivity disorder. Behav. Neurosci. 2009, 123:599-606.
16. Komuro H., Rakic P. Modulation of neuronal migration by NMDA receptors. Science 1993, 260(5104):95-97.
17. Miller C.L., Llenos I.C., Dulay J.R., Barillo M.M., Yolken R.H., Weis S. Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia. Neurobiol. Dis. 2004, 15:618-629.
18. Miller C.L., Llenos I.C., Dulay J.R., Weis S. Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res. 2006, 1073-1074:25-37.
19. Miller C.L., Llenos I.C., Cwik M., Walkup J., Weis S. Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder. Neurochem. Int. 2008, 52:1297-1303.
20. Miller C.L., Murakami P., Ruczinski I., Ross R.G., Sinkus M., Sullivan B., Leonard S. Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder. Schizophr. Res. 2009, 113:259-267.
21. Sams-Dodd F. Phencyclidine in the social interaction test: an animal model of schizophrenia with face and predictive validity. Rev. Neurosci. 1999, 10(1):59-90.
22. Schwarcz R., Rassoulpour A., Wu H.-Q., Medoff D., Tamminga C.A., Roberts R.C. Increased cortical kynurenate content in schizophrenia. Biol. Psychiatry 2001, 50:521-530.
23. Shepard P.D., Joy B., Clerkin L., Schwarcz R. Micromolar brain levels of kynurenic acid are associated with a disruption of auditory sensory gating in the rat. Neuropsychopharmacology 2003, 28:1454-1462.
24. Stansfield K.H., Kirstein C.L. Effects of novelty on behavior in the adolescent and adult rat. Dev. Psychobiol. 2006, 48(1):10-15.
25. Stone T.W. Neuropharmacology of quinolinic and kynurenic acids. Pharmacol. Rev. 1993, 45:309-379.
26. Vecsei L., Miller J., MacGarvey U., Beal F.M. Effects of kynurenine and probenecid on plasma and brain tissue concentrations of kynurenic acid. Neurodegeneration 1992, 1:17-26.