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Volumn 4, Issue 1, 2013, Pages 125-129

Discovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokinetics

(21) Henderson, Jaclyn L a Sawant Basak, Aarti a Tuttle, Jamison B a Dounay, Amy B a McAllister, Laura A a Pandit, Jayvardhan a Rong, Suobao a Hou, Xinjun a Bechle, Bruce M a Kim, Ji Young a Parikh, Vinod a Ghosh, Somraj a Evrard, Edelweiss a Zawadzke, Laura E a Salafia, Michelle A a Rago, Brian a Obach, Ronald S a Clark, Alan a Fonseca, Kari R a Chang, Cheng a Verhoest, Patrick R a more..

a Neuroscience Medicinal Chemistry (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ENZYME INHIBITOR; HETEROCYCLIC COMPOUND; HYDROXAMATE BIOISOSTERE DERIVATIVE; HYDROXAMIC ACID DERIVATIVE; KYNURENINE AMINOTRANSFERASE; KYNURENINE AMINOTRANSFERASE 2; KYNURENINE AMINOTRANSFERASE 2 INHIBITOR; PF 04859989; TRIAZOLE DERIVATIVE; TRIAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

EID: 84871803863 PISSN: 20402503 EISSN: 20402511 Source Type: Journal
DOI: 10.1039/c2md20166f Document Type: Article

Times cited : (17)

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