Synthesis and biochemical evaluation of N-(4-phenylthiazol-2- yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3- hydroxylase

Journal of Medicinal Chemistry

Volumn 40, Issue 26, 1997, Pages 4378-4385

  Röver, Stephan ^a   Cesura, Andrea M ^a   Huguenin, Philipp ^b   Kettler, Rolf ^a   Szente, Andre ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIMETHOXY N [4 (3 NITROPHENYL) 2 THIAZOLYL]BENZENESULFONAMIDE; 3,4 DIMETHOXY N [4 (3 NITROPHENYL)THIAZOL 2 YL]BENZENESULFONAMIDE; 4 AMINO N [4 [2 FLUORO 5 (TRIFLUOROMETHYL)PHENYL]THIAZOL 2 YL]BENZENESULFONAMIDE; ENZYME INHIBITOR; KYNURENINE 3 HYDROXYLASE INHIBITOR; N (4 PHENYLTHIAZOL 2 YL)BENZENESULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DOSE RESPONSE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; GERBIL; HIPPOCAMPUS; MICRODIALYSIS; NERVE CELL LESION; NONHUMAN; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; ENZYME INHIBITORS; EXTRACELLULAR SPACE; GERBILLINAE; KIDNEY; KINETICS; KYNURENIC ACID; KYNURENINE 3-MONOOXYGENASE; LIVER; MITOCHONDRIA; MIXED FUNCTION OXYGENASES; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIAZOLES;

EID: 0031434549     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970467t     Document Type: Article

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