Crystal structure-based selective targeting of the pyridoxal 5?-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement

Journal of Medicinal Chemistry

Volumn 53, Issue 15, 2010, Pages 5684-5689

  Rossi, Franca ^a   Valentina, Casazza ^a   Garavaglia, Silvia ^a   Sathyasaikumar, Korrapati V ^b   Schwarcz, Robert ^b   Kojima, Shin Ichi ^c   Okuwaki, Keisuke ^c   Ono, Shin Ichiro ^c   Kajii, Yasushi ^c   Rizzi, Menico ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

^c MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

9 (4 AMINOPIPERAZIN 1 YL) 8 FLUORO 3 METHYL 6 OXO 2,3 DIHYDRO 6H 1 OXA 3A AZAPHENALENE 5 CARBOXYLIC ACID; BFF 122; KYNURENIC ACID; KYNURENINE AMINOTRANSFERASE; PIPERAZINE DERIVATIVE; PYRIDOXAL 5 PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN HOMOGENATE; COGNITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME INHIBITOR COMPLEX; ENZYME STRUCTURE; HUMAN; HUMAN TISSUE;

ADULT; BRAIN; CRYSTALLOGRAPHY, X-RAY; FLUOROQUINOLONES; HUMANS; MODELS, MOLECULAR; NOOTROPIC AGENTS; PIPERAZINES; PROTEIN CONFORMATION; PYRIDOXAL PHOSPHATE; STEREOISOMERISM; TRANSAMINASES;

EID: 77955359155     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100464k     Document Type: Article

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