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Volumn 38, Issue 7, 2013, Pages 993-1008

Dendrimer space concept for innovative nanomedicine: A futuristic vision for medicinal chemistry

Author keywords

Chemical space; Dendrimer space concept; Drug delivery; Druggable compounds; Nanomedicine

Indexed keywords

AIR NAVIGATION; BIOACTIVITY; DENDRIMERS; DRUG DELIVERY; DRUG PRODUCTS; FUNCTIONAL POLYMERS; MEDICAL APPLICATIONS; MEDICAL NANOTECHNOLOGY; METAL NANOPARTICLES; NANOMAGNETICS; RECOMBINANT PROTEINS; SPACE PLATFORMS; TARGETED DRUG DELIVERY;

EID: 84878895972     PISSN: 00796700     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.progpolymsci.2013.03.003     Document Type: Review
Times cited : (103)

References (203)
  • 4
    • 43949137133 scopus 로고    scopus 로고
    • Nanotechnology improving. Targeted delivery
    • M.M. Amiji Nanotechnology improving. Targeted delivery Drug Delivery 17 2007 53 56
    • (2007) Drug Delivery , vol.17 , pp. 53-56
    • Amiji, M.M.1
  • 6
    • 81855170441 scopus 로고    scopus 로고
    • Nanomedicine(s) under the microscope
    • R. Duncan, and R. Gaspar Nanomedicine(s) under the microscope Molecular Pharmaceutics 8 2011 2101 2141
    • (2011) Molecular Pharmaceutics , vol.8 , pp. 2101-2141
    • Duncan, R.1    Gaspar, R.2
  • 7
    • 77953374462 scopus 로고    scopus 로고
    • Recent advances in the field of nanometric drug carriers
    • J. Ogier, T. Arnauld, and E. Doris Recent advances in the field of nanometric drug carriers Future Medicinal Chemistry 1 2009 693 711
    • (2009) Future Medicinal Chemistry , vol.1 , pp. 693-711
    • Ogier, J.1    Arnauld, T.2    Doris, E.3
  • 9
    • 14644439267 scopus 로고    scopus 로고
    • Cancer nanotechnology: Opportunities and challenges
    • M. Ferrari Cancer nanotechnology: opportunities and challenges Nature Reviews Cancer 5 2005 161 171
    • (2005) Nature Reviews Cancer , vol.5 , pp. 161-171
    • Ferrari, M.1
  • 10
    • 80053929670 scopus 로고    scopus 로고
    • Personalizing nanomedicine
    • L.K. Wolf Personalizing nanomedicine Chemical and Engineering News 89 39 2011 29 32
    • (2011) Chemical and Engineering News , vol.89 , Issue.39 , pp. 29-32
    • Wolf, L.K.1
  • 11
    • 84865513273 scopus 로고    scopus 로고
    • Theranostic applications of nanoparticles in cancer
    • N. Ahmed, H. Fessi, and A. Elaissari Theranostic applications of nanoparticles in cancer Drug Discovery Today 17 2012 928 934
    • (2012) Drug Discovery Today , vol.17 , pp. 928-934
    • Ahmed, N.1    Fessi, H.2    Elaissari, A.3
  • 17
    • 84878946032 scopus 로고    scopus 로고
    • Dendrimers: Polymers of 21st century
    • Online only: (accessed February 2013).
    • H.V. Chavda Dendrimers: polymers of 21st century Pharmacological Reviews 5 2007 E.65 Online only: http://www.pharmainfo.net/reviews/dendrimers-polymers- 21-st-century (accessed February 2013).
    • (2007) Pharmacological Reviews , vol.5 , pp. 65
    • Chavda, H.V.1
  • 18
    • 84989581991 scopus 로고
    • "cascade"-and "nonskid-Chain-like" syntheses of molecular cavity topologies
    • E. Buhleier, W. Wehner, and F. Vögtle "Cascade"-and "Nonskid-Chain-like" syntheses of molecular cavity topologies Synthesis 2 1978 155 158
    • (1978) Synthesis , vol.2 , pp. 155-158
    • Buhleier, E.1    Wehner, W.2    Vögtle, F.3
  • 20
    • 78650316044 scopus 로고    scopus 로고
    • Biomedical applications of dendrimers: A tutorial
    • M.A. Mintzer, and M.W. Grinstaff Biomedical applications of dendrimers: a tutorial Chemical Society Reviews 40 2010 173 190
    • (2010) Chemical Society Reviews , vol.40 , pp. 173-190
    • Mintzer, M.A.1    Grinstaff, M.W.2
  • 21
    • 77951234285 scopus 로고    scopus 로고
    • Dendrimers designed for functions: From physical photophysical and supramolecular properties to applications in sensing catalysis molecular electronics photonics and nanomedicine
    • D. Astruc, E. Boisselier, and C. Omelas Dendrimers designed for functions: from physical photophysical and supramolecular properties to applications in sensing catalysis molecular electronics photonics and nanomedicine Chemical Reviews 110 2010 1857 1959
    • (2010) Chemical Reviews , vol.110 , pp. 1857-1959
    • Astruc, D.1    Boisselier, E.2    Omelas, C.3
  • 22
    • 77949275122 scopus 로고    scopus 로고
    • Dendrimer-based drug and imaging conjugates: Design considerations for nanomedical applications
    • A.R. Menjoge, R.M. Kannan, and D.A. Tomalia Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications Drug Discovery Today 15 2010 171 185
    • (2010) Drug Discovery Today , vol.15 , pp. 171-185
    • Menjoge, A.R.1    Kannan, R.M.2    Tomalia, D.A.3
  • 25
    • 12844258906 scopus 로고    scopus 로고
    • Dendrimers and dendritic polymers in drug delivery
    • E.R. Gillies, and J.M. Fréchet Dendrimers and dendritic polymers in drug delivery Drug Discovery Today 10 2005 35 42
    • (2005) Drug Discovery Today , vol.10 , pp. 35-42
    • Gillies, E.R.1    Fréchet, J.M.2
  • 27
    • 43449117468 scopus 로고    scopus 로고
    • Therapeutic and diagnostic applications of dendrimers for cancer treatment
    • J.B. Wolinsky, W. Mark, and M. Grinstaff Therapeutic and diagnostic applications of dendrimers for cancer treatment Advanced Drug Delivery Reviews 60 2008 1037 1055
    • (2008) Advanced Drug Delivery Reviews , vol.60 , pp. 1037-1055
    • Wolinsky, J.B.1    Mark, W.2    Grinstaff, M.3
  • 29
    • 84858679264 scopus 로고    scopus 로고
    • Multifunctional dendritic polymers in nanomedicine: Opportunities and challenges
    • J. Khandare, M. Calderon, N.M. Dagia, and R. Haag Multifunctional dendritic polymers in nanomedicine: opportunities and challenges Chemical Society Reviews 41 2012 2824 2848
    • (2012) Chemical Society Reviews , vol.41 , pp. 2824-2848
    • Khandare, J.1    Calderon, M.2    Dagia, N.M.3    Haag, R.4
  • 30
    • 84862755672 scopus 로고    scopus 로고
    • Polyether based amphiphiles for delivery of active compounds
    • S. Gupta, R. Tyagi, V.S. Parmar, S.K. Sharma, and R. Haag Polyether based amphiphiles for delivery of active compounds Polymer 53 2012 3053 3078
    • (2012) Polymer , vol.53 , pp. 3053-3078
    • Gupta, S.1    Tyagi, R.2    Parmar, V.S.3    Sharma, S.K.4    Haag, R.5
  • 31
    • 77952937434 scopus 로고    scopus 로고
    • Host-guest of dendrimer-drug complexes. An in-depth look into the binding/encapsulation of guanosine monophosphate by dendrimers
    • J. Hu, M. Fang, Y. Cheng, J. Zhang, Q. Wu, and T. Xu Host-guest of dendrimer-drug complexes. An in-depth look into the binding/encapsulation of guanosine monophosphate by dendrimers Journal of Physical Chemistry 114 2010 7148 7157
    • (2010) Journal of Physical Chemistry , vol.114 , pp. 7148-7157
    • Hu, J.1    Fang, M.2    Cheng, Y.3    Zhang, J.4    Wu, Q.5    Xu, T.6
  • 32
    • 44749084015 scopus 로고    scopus 로고
    • Potential oral delivery of 7-ethyl-10-hydroxy-camptothecin (SN-38) using poly(amidoamine) dendrimers
    • R.B. Kolhatkar, P. Swaan, and H. Ghandehari Potential oral delivery of 7-ethyl-10-hydroxy-camptothecin (SN-38) using poly(amidoamine) dendrimers Pharmaceutical Research 25 2008 1723 1729
    • (2008) Pharmaceutical Research , vol.25 , pp. 1723-1729
    • Kolhatkar, R.B.1    Swaan, P.2    Ghandehari, H.3
  • 33
    • 67650690627 scopus 로고    scopus 로고
    • Dendrimers as carriers for delivery of chemotherapeutic agents
    • S.H. Medina, and M.E.H. El-Sayed Dendrimers as carriers for delivery of chemotherapeutic agents Chemical Reviews 109 2009 3141 3157
    • (2009) Chemical Reviews , vol.109 , pp. 3141-3157
    • Medina, S.H.1    El-Sayed, M.E.H.2
  • 36
    • 61849153021 scopus 로고    scopus 로고
    • Impact of nanotechnology on drug delivery
    • O.C. Farokhzad, and R. Langer Impact of nanotechnology on drug delivery ACS Nano 3 2009 16 20
    • (2009) ACS Nano , vol.3 , pp. 16-20
    • Farokhzad, O.C.1    Langer, R.2
  • 38
    • 51049083983 scopus 로고    scopus 로고
    • Application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability
    • N.K. Jain, and U. Gupta Application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability Expert Opinion on Drug Metabolism and Toxicology 4 2008 1035 1051
    • (2008) Expert Opinion on Drug Metabolism and Toxicology , vol.4 , pp. 1035-1051
    • Jain, N.K.1    Gupta, U.2
  • 39
    • 77949484232 scopus 로고    scopus 로고
    • Dendrimer-based nanoparticles for cancer therapy
    • J.R. Baker Dendrimer-based nanoparticles for cancer therapy Nanotechnology for Hematology 1 2009 708 719
    • (2009) Nanotechnology for Hematology , vol.1 , pp. 708-719
    • Baker, J.R.1
  • 40
    • 84858064291 scopus 로고    scopus 로고
    • Association of chemotherapeutic drugs with dendrimer nanocarriers: An assessment of the merits of covalent conjugation compared to noncovalent encapsulation
    • L.M. Kaminskas, V.M. McLeod, C.J.H. Porter, and B.J. Boyd Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation Molecular Pharmaceutics 9 2012 355 373
    • (2012) Molecular Pharmaceutics , vol.9 , pp. 355-373
    • Kaminskas, L.M.1    McLeod, V.M.2    Porter, C.J.H.3    Boyd, B.J.4
  • 41
    • 77956517698 scopus 로고    scopus 로고
    • Self immolative dendrimers: A distinctive approach to molecular amplification
    • M. Avital-Shmilovici, and D. Shabat Self immolative dendrimers: a distinctive approach to molecular amplification Soft Matter 6 2010 1073 1080
    • (2010) Soft Matter , vol.6 , pp. 1073-1080
    • Avital-Shmilovici, M.1    Shabat, D.2
  • 42
    • 84861233382 scopus 로고    scopus 로고
    • Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications
    • E. Fleige, M.A. Quadir, and R. Haag Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications Advanced Drug Delivery Reviews 64 2012 866 884
    • (2012) Advanced Drug Delivery Reviews , vol.64 , pp. 866-884
    • Fleige, E.1    Quadir, M.A.2    Haag, R.3
  • 44
    • 59649089796 scopus 로고    scopus 로고
    • Surface-engineered dendrimers: A solution for toxicity issues
    • V. Mishra, U. Gupta, and N.K. Jain Surface-engineered dendrimers: a solution for toxicity issues Journal of Biomaterials Science 20 2009 141 166
    • (2009) Journal of Biomaterials Science , vol.20 , pp. 141-166
    • Mishra, V.1    Gupta, U.2    Jain, N.K.3
  • 45
    • 28744445460 scopus 로고    scopus 로고
    • Dendrimer biocompatibility and toxicity
    • R. Duncan, and L. Izzo Dendrimer biocompatibility and toxicity Advanced Drug Delivery Reviews 57 2005 2215 2237
    • (2005) Advanced Drug Delivery Reviews , vol.57 , pp. 2215-2237
    • Duncan, R.1    Izzo, L.2
  • 46
    • 77953680751 scopus 로고    scopus 로고
    • Understanding specific and nonspecific toxicities: A requirement for the development of dendrimer-based pharmaceuticals
    • D.Q. McNermy, P.R. Leroueil, and J.R. Baker Understanding specific and nonspecific toxicities: a requirement for the development of dendrimer-based pharmaceuticals Nanomedicine and Nanobiotechnology 2 2010 249 259
    • (2010) Nanomedicine and Nanobiotechnology , vol.2 , pp. 249-259
    • McNermy, D.Q.1    Leroueil, P.R.2    Baker, J.R.3
  • 47
    • 79959874185 scopus 로고    scopus 로고
    • Designing dendrimers for drug delivery and imaging: Pharmacokinetic considerations
    • W. Wijagkanalan, S. Kawakami, and M. Hashida Designing dendrimers for drug delivery and imaging: pharmacokinetic considerations Pharmaceutical Research 28 2011 1500 1519
    • (2011) Pharmaceutical Research , vol.28 , pp. 1500-1519
    • Wijagkanalan, W.1    Kawakami, S.2    Hashida, M.3
  • 49
    • 0037345827 scopus 로고    scopus 로고
    • Macromolecular MRI contrast agents with small dendrimers: Pharmacokinetic differences between sizes and cores
    • H. Kobayashi, S. Kawamoto, S.K. Jo, H.L. Bryant, and M.W. Brechbiel Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores Bioconjugate Chemistry 14 2003 388 394
    • (2003) Bioconjugate Chemistry , vol.14 , pp. 388-394
    • Kobayashi, H.1    Kawamoto, S.2    Jo, S.K.3    Bryant, H.L.4    Brechbiel, M.W.5
  • 50
    • 4043103282 scopus 로고    scopus 로고
    • Cytotoxicity hemolysis and acute in vivo toxicity of dendrimers based on melamine candidate vehicles for drug delivery
    • H.T. Chen, M.F. Neerman, A.R. Parrish, and E.E. Simanek Cytotoxicity hemolysis and acute in vivo toxicity of dendrimers based on melamine candidate vehicles for drug delivery Journal of the American Chemical Society 126 2004 10044 10048
    • (2004) Journal of the American Chemical Society , vol.126 , pp. 10044-10048
    • Chen, H.T.1    Neerman, M.F.2    Parrish, A.R.3    Simanek, E.E.4
  • 53
    • 77952066543 scopus 로고    scopus 로고
    • Pre-clinical and behavioural toxicity profile of PAMAM dendrimers in mice
    • A.S. Chauhan, N.K. Jain, and P.V. Diwan Pre-clinical and behavioural toxicity profile of PAMAM dendrimers in mice Proceedings of the Royal Society A 466 2010 1535 1550
    • (2010) Proceedings of the Royal Society A , vol.466 , pp. 1535-1550
    • Chauhan, A.S.1    Jain, N.K.2    Diwan, P.V.3
  • 54
    • 85083125818 scopus 로고    scopus 로고
    • [accessed February 2013, 2012]
    • Anonymous VivaGelÒ. http://www.starpharma.com/vivagel [accessed February 2013, 2012].
    • Anonymous VivaGelÒ
  • 57
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Advanced Drug Delivery Reviews 23 1997 3 25
    • (1997) Advanced Drug Delivery Reviews , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 58
    • 11144320699 scopus 로고    scopus 로고
    • Navigating chemical space for biology and medicine
    • C.A. Lipinski, and A. Hopkins Navigating chemical space for biology and medicine Nature 432 2004 855 861
    • (2004) Nature , vol.432 , pp. 855-861
    • Lipinski, C.A.1    Hopkins, A.2
  • 59
    • 0030039619 scopus 로고    scopus 로고
    • The art and practice of structure-based drug design: A molecular modeling perspective
    • R.S. Bohacek, C. McMartin, and W.C. Guida The art and practice of structure-based drug design: a molecular modeling perspective Medicinal Research Reviews 16 1996 3 50
    • (1996) Medicinal Research Reviews , vol.16 , pp. 3-50
    • Bohacek, R.S.1    McMartin, C.2    Guida, W.C.3
  • 61
    • 82455186157 scopus 로고    scopus 로고
    • Exploring the chemical space of known and unknown organic small molecules at www.gdb.unibe.ch
    • J.L. Reymond, L.C. Bluma, and R. van Deursen Exploring the chemical space of known and unknown organic small molecules at www.gdb.unibe.ch Chimia 65 2011 863 867
    • (2011) Chimia , vol.65 , pp. 863-867
    • Reymond, J.L.1    Bluma, L.C.2    Van Deursen, R.3
  • 64
    • 20444378945 scopus 로고    scopus 로고
    • The principle of complementarity: Chemical versus biological space
    • S.J. Haggarty The principle of complementarity: chemical versus biological space Current Opinion in Chemical Biology 9 2005 296 303
    • (2005) Current Opinion in Chemical Biology , vol.9 , pp. 296-303
    • Haggarty, S.J.1
  • 66
    • 33645412367 scopus 로고    scopus 로고
    • Kinase patent space visualization using chemical replacements
    • N.T. Southall Kinase patent space visualization using chemical replacements Journal of Medicinal Chemistry 49 2006 2103 2109
    • (2006) Journal of Medicinal Chemistry , vol.49 , pp. 2103-2109
    • Southall, N.T.1
  • 67
  • 68
    • 0035959985 scopus 로고    scopus 로고
    • Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition
    • M. Sodeoka Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition Journal of Medicinal Chemistry 44 2001 3216 3222
    • (2001) Journal of Medicinal Chemistry , vol.44 , pp. 3216-3222
    • Sodeoka, M.1
  • 70
    • 1642389967 scopus 로고    scopus 로고
    • Countering cooperative effects in protease inhibitors using constrained beta-strand mimicking templates in focused combinatorial libraries
    • R.C. Reid Countering cooperative effects in protease inhibitors using constrained beta-strand mimicking templates in focused combinatorial libraries Journal of Medicinal Chemistry 47 2004 1641 1651
    • (2004) Journal of Medicinal Chemistry , vol.47 , pp. 1641-1651
    • Reid, R.C.1
  • 72
    • 9744232909 scopus 로고    scopus 로고
    • Time-related differences in the physical property profiles of oral drugs
    • P.D. Leeson, and A.M. Davis Time-related differences in the physical property profiles of oral drugs Journal of Medicinal Chemistry 47 2004 6338 6348
    • (2004) Journal of Medicinal Chemistry , vol.47 , pp. 6338-6348
    • Leeson, P.D.1    Davis, A.M.2
  • 75
    • 0036589285 scopus 로고    scopus 로고
    • Current trends in lead discovery: Are we looking for the appropriate properties
    • T.I. Opera Current trends in lead discovery: are we looking for the appropriate properties Journal of Computer-Aided Molecular Design 16 2002 325 334
    • (2002) Journal of Computer-Aided Molecular Design , vol.16 , pp. 325-334
    • Opera, T.I.1
  • 79
    • 85083139307 scopus 로고    scopus 로고
    • Charting navigating and populating natural product chemical space for drug discovery
    • H. Lachance, S. Wetzel, K. Kumar, and H. Waldmann Charting navigating and populating natural product chemical space for drug discovery Journal of Medicinal Chemistry 9 2009 1953 1962
    • (2009) Journal of Medicinal Chemistry , vol.9 , pp. 1953-1962
    • Lachance, H.1    Wetzel, S.2    Kumar, K.3    Waldmann, H.4
  • 80
    • 85040103085 scopus 로고    scopus 로고
    • Virtual screening of Chemical Space: From Generic Compound Collections to Tailored Screening Libraries
    • C. Sotriffer, Wiley-VCH Weinbaden
    • M. Boehm Virtual screening of Chemical Space: From Generic Compound Collections to Tailored Screening Libraries C. Sotriffer, Virtual Screening: Principles Challenges and Practical Guidelines 2011 Wiley-VCH Weinbaden 3 34
    • (2011) Virtual Screening: Principles Challenges and Practical Guidelines , pp. 3-34
    • Boehm, M.1
  • 81
    • 61649109015 scopus 로고    scopus 로고
    • The influence of lead discovery strategies on the properties of drug candidates
    • G.M. Keserü, and G.M. Makara The influence of lead discovery strategies on the properties of drug candidates Nature Reviews Drug Discovery 8 2009 203 212
    • (2009) Nature Reviews Drug Discovery , vol.8 , pp. 203-212
    • Keserü, G.M.1    Makara, G.M.2
  • 82
    • 84860359784 scopus 로고    scopus 로고
    • Finding the sweet spot: The role of nature and nurture in medicinal chemistry
    • M.M. Hann, and G.M. Keserü Finding the sweet spot: the role of nature and nurture in medicinal chemistry Nature Reviews Drug Discovery 11 2012 355 365
    • (2012) Nature Reviews Drug Discovery , vol.11 , pp. 355-365
    • Hann, M.M.1    Keserü, G.M.2
  • 83
    • 79960990847 scopus 로고    scopus 로고
    • Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I)
    • X. Morelli, R. Bourgeas, and P. Roche Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I) Current Opinion in Chemical Biology 15 2011 1 7
    • (2011) Current Opinion in Chemical Biology , vol.15 , pp. 1-7
    • Morelli, X.1    Bourgeas, R.2    Roche, P.3
  • 86
    • 79955575780 scopus 로고    scopus 로고
    • The rule of five for non-oral routes of drug delivery: Ophthalmic inhalation and transdermal
    • Y.B. Choy, and M.R. Prausnitz The rule of five for non-oral routes of drug delivery: ophthalmic inhalation and transdermal Pharmaceutical Research 28 2011 943 948
    • (2011) Pharmaceutical Research , vol.28 , pp. 943-948
    • Choy, Y.B.1    Prausnitz, M.R.2
  • 87
    • 0033025637 scopus 로고    scopus 로고
    • Chance favors the prepared mind - From serendipity to rational drug design
    • H. Kubinyi Chance favors the prepared mind - from serendipity to rational drug design Journal of Receptors and Signal Transduction Research 19 1999 15 39
    • (1999) Journal of Receptors and Signal Transduction Research , vol.19 , pp. 15-39
    • Kubinyi, H.1
  • 89
    • 71249135977 scopus 로고    scopus 로고
    • Exploring novel chemical space through the use of computational and structural biology
    • A.C. Rigby Exploring novel chemical space through the use of computational and structural biology Combinatorial Chemistry and High Throughput Screening 12 2009 927 928
    • (2009) Combinatorial Chemistry and High Throughput Screening , vol.12 , pp. 927-928
    • Rigby, A.C.1
  • 92
    • 0036603905 scopus 로고    scopus 로고
    • Chemical space navigation in lead discovery
    • T.I. Oprea Chemical space navigation in lead discovery Current Opinion in Chemical Biology 6 2002 384 389
    • (2002) Current Opinion in Chemical Biology , vol.6 , pp. 384-389
    • Oprea, T.I.1
  • 93
    • 11144311139 scopus 로고    scopus 로고
    • Lessons from natural molecules
    • J. Clardy, and C. Walsh Lessons from natural molecules Nature 432 2004 829 837
    • (2004) Nature , vol.432 , pp. 829-837
    • Clardy, J.1    Walsh, C.2
  • 94
    • 20444420189 scopus 로고    scopus 로고
    • Natural product-like chemical space: Search for chemical dissectors of macromolecular interactions
    • A. Reayi, and P. Arya Natural product-like chemical space: search for chemical dissectors of macromolecular interactions Current Opinion in Chemical Biology 9 2005 240 247
    • (2005) Current Opinion in Chemical Biology , vol.9 , pp. 240-247
    • Reayi, A.1    Arya, P.2
  • 96
    • 11144323163 scopus 로고    scopus 로고
    • Virtual screening of chemical libraries
    • B.K. Shoichet Virtual screening of chemical libraries Nature 432 2004 862 865
    • (2004) Nature , vol.432 , pp. 862-865
    • Shoichet, B.K.1
  • 98
    • 34247194965 scopus 로고    scopus 로고
    • Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: Assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug discovery
    • T. Fink, and J.L. Reymond Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug discovery Journal of Chemical Information and Modeling 47 2007 342 353
    • (2007) Journal of Chemical Information and Modeling , vol.47 , pp. 342-353
    • Fink, T.1    Reymond, J.L.2
  • 99
    • 80955180074 scopus 로고    scopus 로고
    • Visualisation and subsets of the chemical universe database GDB-13 for virtual screening
    • L.C. Blum, R. van Deursen, and J.L. Reymond Visualisation and subsets of the chemical universe database GDB-13 for virtual screening Journal of Computer-Aided Molecular Design 25 2011 637 647
    • (2011) Journal of Computer-Aided Molecular Design , vol.25 , pp. 637-647
    • Blum, L.C.1    Van Deursen, R.2    Reymond, J.L.3
  • 100
    • 67649619336 scopus 로고    scopus 로고
    • 970 Million drug like small molecules for virtual screening in the chemical universe database GDB-13
    • L.C. Blum, and J.L. Reymond 970 Million drug like small molecules for virtual screening in the chemical universe database GDB-13 Journal of the American Chemical Society 131 2009 8732 8733
    • (2009) Journal of the American Chemical Society , vol.131 , pp. 8732-8733
    • Blum, L.C.1    Reymond, J.L.2
  • 101
    • 34447548576 scopus 로고    scopus 로고
    • Ligand efficiency indices for effective drug discovery
    • C. Abad-Zapatero Ligand efficiency indices for effective drug discovery Expert Opinion on Drug Discovery 2 2007 469 488
    • (2007) Expert Opinion on Drug Discovery , vol.2 , pp. 469-488
    • Abad-Zapatero, C.1
  • 102
    • 77953693716 scopus 로고    scopus 로고
    • Drug efficiency: A new concept to guide lead optimization programs towards the selection of better clinical candidates
    • S. Braggio, D. Montanari, T. Rossi, and E. Ratti Drug efficiency: a new concept to guide lead optimization programs towards the selection of better clinical candidates Expert Opinion on Drug Discovery 5 2010 609 618
    • (2010) Expert Opinion on Drug Discovery , vol.5 , pp. 609-618
    • Braggio, S.1    Montanari, D.2    Rossi, T.3    Ratti, E.4
  • 103
    • 77957682613 scopus 로고    scopus 로고
    • Ligand efficiency indices for an effective mapping of chemico-biological space: The concept of an atlas-like representation
    • C. AbadZapatero, O. Perisic, J. Wass, A.P. Bento, J. Overington, B. Al-Lazikani, and M.E. Johnson Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation Drug Discovery Today 15 2010 804 811
    • (2010) Drug Discovery Today , vol.15 , pp. 804-811
    • Abadzapatero, C.1    Perisic, O.2    Wass, J.3    Bento, A.P.4    Overington, J.5    Al-Lazikani, B.6    Johnson, M.E.7
  • 111
    • 67650698519 scopus 로고    scopus 로고
    • Versatile conjugation of octreotide to dendrimers by cycloaddition ("click") chemistry to yield high-affinity multivalent cyclic Peptide dendrimers
    • C.B. Yim, O.C. Boerman, M. de Visser, M. de Jong, A.C. Dechesne, D.T. Rijkers, and R.M. Liskamp Versatile conjugation of octreotide to dendrimers by cycloaddition ("click") chemistry to yield high-affinity multivalent cyclic Peptide dendrimers Bioconjugate Chemistry 20 2009 1323 1331
    • (2009) Bioconjugate Chemistry , vol.20 , pp. 1323-1331
    • Yim, C.B.1    Boerman, O.C.2    De Visser, M.3    De Jong, M.4    Dechesne, A.C.5    Rijkers, D.T.6    Liskamp, R.M.7
  • 112
    • 0030292260 scopus 로고    scopus 로고
    • Self-assembly of cyclic peptides on a dendrimer: Multiple cyclic antigen peptides
    • J.C. Spetzler, and J.P. Tam Self-assembly of cyclic peptides on a dendrimer: multiple cyclic antigen peptides Peptide Research 9 1996 290 296
    • (1996) Peptide Research , vol.9 , pp. 290-296
    • Spetzler, J.C.1    Tam, J.P.2
  • 114
    • 59549093153 scopus 로고    scopus 로고
    • Polycationic phosphorus dendrimers: Synthesis characterization study of cytotoxicity complexation of DNA and transfection experiments
    • C. Padié, M. Maszewska, K. Majchrzak, B. Nawrot, A.M. Caminade, and J.P. Majoral Polycationic phosphorus dendrimers: synthesis characterization study of cytotoxicity complexation of DNA and transfection experiments New Journal of Chemistry 33 2009 318 326
    • (2009) New Journal of Chemistry , vol.33 , pp. 318-326
    • Padié, C.1    Maszewska, M.2    Majchrzak, K.3    Nawrot, B.4    Caminade, A.M.5    Majoral, J.P.6
  • 115
    • 79959267067 scopus 로고    scopus 로고
    • Synthesis of PAMAM dendrimer derivatives with enhanced buffering capacity and remarkable gene transfection efficiency
    • G.S. Yu, Y.M. Bae, H. Choi, B. Kong, I.S. Choi, and J.S. Choi Synthesis of PAMAM dendrimer derivatives with enhanced buffering capacity and remarkable gene transfection efficiency Bioconjugate Chemistry 22 2011 1046 1055
    • (2011) Bioconjugate Chemistry , vol.22 , pp. 1046-1055
    • Yu, G.S.1    Bae, Y.M.2    Choi, H.3    Kong, B.4    Choi, I.S.5    Choi, J.S.6
  • 116
    • 0027655718 scopus 로고
    • Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
    • J. Haensler, C. Francis, and F.C. Szoka Polyamidoamine cascade polymers mediate efficient transfection of cells in culture Bioconjugate Chemistry 4 1993 372 379
    • (1993) Bioconjugate Chemistry , vol.4 , pp. 372-379
    • Haensler, J.1    Francis, C.2    Szoka, F.C.3
  • 117
    • 0029945799 scopus 로고    scopus 로고
    • Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers
    • A. Bielinska, J.F. Kukowska-Latallo, J. Johnson, D.A. Tomalia, and J.R. Baker Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers Nucleic Acids Research 24 1996 2176 2182
    • (1996) Nucleic Acids Research , vol.24 , pp. 2176-2182
    • Bielinska, A.1    Kukowska-Latallo, J.F.2    Johnson, J.3    Tomalia, D.A.4    Baker, J.R.5
  • 118
    • 0033404268 scopus 로고    scopus 로고
    • PAMAM dendrimers as delivery agents for antisense oligonucleotides
    • H. Yoo, P. Sazani, and R.L. Juliano PAMAM dendrimers as delivery agents for antisense oligonucleotides Pharmaceutical Research 16 1999 1799 1804
    • (1999) Pharmaceutical Research , vol.16 , pp. 1799-1804
    • Yoo, H.1    Sazani, P.2    Juliano, R.L.3
  • 120
    • 79957582182 scopus 로고    scopus 로고
    • Dendrimers-delivered short hairpin RNA targeting hTERT inhibits oral cancer cell growth in vitro and in vivo
    • X. Liu, H. Huang, J. Wang, C. Wang, M. Wang, B. Zhang, and C. Pan Dendrimers-delivered short hairpin RNA targeting hTERT inhibits oral cancer cell growth in vitro and in vivo Biochemical Pharmacology 82 2011 17 23
    • (2011) Biochemical Pharmacology , vol.82 , pp. 17-23
    • Liu, X.1    Huang, H.2    Wang, J.3    Wang, C.4    Wang, M.5    Zhang, B.6    Pan, C.7
  • 121
    • 79952972079 scopus 로고    scopus 로고
    • Multifunctional triblock nanocarrier (PAMAM-PEG-PLL) for the efficient intracellular siRNA delivery and gene silencing
    • M.L. Patil, M. Zhang, and T. Minko Multifunctional triblock nanocarrier (PAMAM-PEG-PLL) for the efficient intracellular siRNA delivery and gene silencing ACS Nano 5 2011 1877 1887
    • (2011) ACS Nano , vol.5 , pp. 1877-1887
    • Patil, M.L.1    Zhang, M.2    Minko, T.3
  • 123
    • 84863116554 scopus 로고    scopus 로고
    • SiRNA delivery systems based on neutral cross-linked dendrimers
    • J. Liu, J. Zhou, and Y. Luo SiRNA delivery systems based on neutral cross-linked dendrimers Bioconjugate Chemistry 23 2012 174 183
    • (2012) Bioconjugate Chemistry , vol.23 , pp. 174-183
    • Liu, J.1    Zhou, J.2    Luo, Y.3
  • 124
    • 42949087378 scopus 로고    scopus 로고
    • Antibody-dendrimer conjugates: The number not the size of the dendrimers determines the immunoreactivity
    • C. Wängler, G. Moldenhauer, M. Eisenhut, U. Haberkorn, and W. Mier Antibody-dendrimer conjugates: the number not the size of the dendrimers determines the immunoreactivity Bioconjugate Chemistry 19 2008 813 820
    • (2008) Bioconjugate Chemistry , vol.19 , pp. 813-820
    • Wängler, C.1    Moldenhauer, G.2    Eisenhut, M.3    Haberkorn, U.4    Mier, W.5
  • 125
    • 84863230506 scopus 로고    scopus 로고
    • Preparation of cystamine core dendrimer and anti-body-dendrimer conjugates for RMI angiography
    • K. New, D.E. Milenic, G.L. Ray, Y.S. Kim, and M.W. Brechbiel Preparation of cystamine core dendrimer and anti-body-dendrimer conjugates for RMI angiography Molecular Pharmaceutics 9 2012 374 381
    • (2012) Molecular Pharmaceutics , vol.9 , pp. 374-381
    • New, K.1    Milenic, D.E.2    Ray, G.L.3    Kim, Y.S.4    Brechbiel, M.W.5
  • 127
  • 129
    • 33746415181 scopus 로고    scopus 로고
    • Enhanced transfection of primary cortical cultures using arginine-grafted PAMAM dendrimer PAMAM-Arg
    • J.B. Kim, J.S. Choi, K. Nam, M. Lee, J.S. Park, and J.K. Lee Enhanced transfection of primary cortical cultures using arginine-grafted PAMAM dendrimer PAMAM-Arg Journal of Controlled Release 114 2006 110 117
    • (2006) Journal of Controlled Release , vol.114 , pp. 110-117
    • Kim, J.B.1    Choi, J.S.2    Nam, K.3    Lee, M.4    Park, J.S.5    Lee, J.K.6
  • 131
    • 84884790598 scopus 로고    scopus 로고
    • Dendrimer-coated carbohydrates as drug delivery Trojan horses in glycosciences
    • Y.Y. Cheng, Wiley-VCH Weinheim
    • Y.M. Chabre, and R. Roy Dendrimer-coated carbohydrates as drug delivery Trojan horses in glycosciences Y.Y. Cheng, Dendrimer-based Drug delivery Systems: From Theory to Practice 2012 Wiley-VCH Weinheim 405 436
    • (2012) Dendrimer-based Drug Delivery Systems: From Theory to Practice , pp. 405-436
    • Chabre, Y.M.1    Roy, R.2
  • 132
    • 84856735496 scopus 로고    scopus 로고
    • Glycodendrimers as functional antigens and antitumorales vaccines
    • R. Roy, and T.C. Shiao Glycodendrimers as functional antigens and antitumorales vaccines New Journal of Chemistry 36 2012 324 339
    • (2012) New Journal of Chemistry , vol.36 , pp. 324-339
    • Roy, R.1    Shiao, T.C.2
  • 133
    • 52949100596 scopus 로고    scopus 로고
    • Recent trends in glycodendrimer syntheses and applications
    • Y.M. Chabre, and R.R. Roy Recent trends in glycodendrimer syntheses and applications Current Topics in Medicinal Chemistry 14 2008 1237 1285
    • (2008) Current Topics in Medicinal Chemistry , vol.14 , pp. 1237-1285
    • Chabre, Y.M.1    Roy, R.R.2
  • 135
    • 1542509564 scopus 로고    scopus 로고
    • The use of a dendrimer propranolol prodrug to bypass efflux transporters and enhance oral bioavailability
    • A. D'Emanuel, R. Jevprasesphant, J. Penny, and D. Attwood The use of a dendrimer propranolol prodrug to bypass efflux transporters and enhance oral bioavailability Journal of Controlled Release 95 2004 447 453
    • (2004) Journal of Controlled Release , vol.95 , pp. 447-453
    • D'Emanuel, A.1    Jevprasesphant, R.2    Penny, J.3    Attwood, D.4
  • 136
    • 39749200864 scopus 로고    scopus 로고
    • Methotrexate loaded polyether- copolyester dendrimers for the treatment of gliomas: Enhanced efficacy and intratumoral transport capability
    • R.S. Dhanikula, A. Argaw, J.F. Bouchard, and P. Hildgen Methotrexate loaded polyether- copolyester dendrimers for the treatment of gliomas: enhanced efficacy and intratumoral transport capability Molecular Pharmaceutics 5 2008 105 116
    • (2008) Molecular Pharmaceutics , vol.5 , pp. 105-116
    • Dhanikula, R.S.1    Argaw, A.2    Bouchard, J.F.3    Hildgen, P.4
  • 138
    • 38349134916 scopus 로고    scopus 로고
    • Dendrimers as drug carriers: Applications in different routes of drug administration
    • Y. Cheng, Z. Xu, M. MA, and T. Xu Dendrimers as drug carriers: applications in different routes of drug administration Journal of Pharmaceutical Sciences 97 2008 123 143
    • (2008) Journal of Pharmaceutical Sciences , vol.97 , pp. 123-143
    • Cheng, Y.1    Xu, Z.2    Ma, M.3    Xu, T.4
  • 140
    • 84859338068 scopus 로고    scopus 로고
    • Dendrimer-mediated drug delivery to the skin
    • M. Sun, A. Fan, Z. Wang, and Y. Zhao Dendrimer-mediated drug delivery to the skin Soft Matter 8 2012 4301 4305
    • (2012) Soft Matter , vol.8 , pp. 4301-4305
    • Sun, M.1    Fan, A.2    Wang, Z.3    Zhao, Y.4
  • 142
    • 67349190954 scopus 로고    scopus 로고
    • The chemist as astronaut: Searching for biologically useful space in the chemical universe
    • D.J. Triggle The chemist as astronaut: searching for biologically useful space in the chemical universe Biochemical Pharmacology 78 2009 217 223
    • (2009) Biochemical Pharmacology , vol.78 , pp. 217-223
    • Triggle, D.J.1
  • 143
    • 77955517509 scopus 로고    scopus 로고
    • Druggable pockets and binding site centric chemical space: A paradigm shift in drug discovery
    • S. Pérot, O. Sperandio, M.A. Miteva, A.C. Camproux, and B.O. Villoutreix Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery Drug Discovery Today 15 2010 656 667
    • (2010) Drug Discovery Today , vol.15 , pp. 656-667
    • Pérot, S.1    Sperandio, O.2    Miteva, M.A.3    Camproux, A.C.4    Villoutreix, B.O.5
  • 144
    • 78649254350 scopus 로고    scopus 로고
    • Accessing new chemical space for 'undruggable' targets
    • S. Dandapani, and L.A. Marcaurelle Accessing new chemical space for 'undruggable' targets Nature Chemical Biology 6 2010 861 863
    • (2010) Nature Chemical Biology , vol.6 , pp. 861-863
    • Dandapani, S.1    Marcaurelle, L.A.2
  • 145
    • 77749283338 scopus 로고    scopus 로고
    • Design of stimuli-responsive dendrimers
    • C. Kojima Design of stimuli-responsive dendrimers Expert Opinion on Drug Discovery 7 2010 307 319
    • (2010) Expert Opinion on Drug Discovery , vol.7 , pp. 307-319
    • Kojima, C.1
  • 148
    • 76149109071 scopus 로고    scopus 로고
    • Targeting protein-protein interactions for therapeutic intervention: A challenge for the future
    • G. Zinzalla, and D.E. Thurstoon Targeting protein-protein interactions for therapeutic intervention: a challenge for the future Future Medicinal Chemistry 1 2009 65 93
    • (2009) Future Medicinal Chemistry , vol.1 , pp. 65-93
    • Zinzalla, G.1    Thurstoon, D.E.2
  • 149
    • 33645469420 scopus 로고    scopus 로고
    • Peptide peptidomimetic and small-molecule antagonists of the p53-HDM2 protein-protein interaction
    • P.M. Fischer Peptide peptidomimetic and small-molecule antagonists of the p53-HDM2 protein-protein interaction International Journal of Peptide Research and Therapeutics 12 2006 3 19
    • (2006) International Journal of Peptide Research and Therapeutics , vol.12 , pp. 3-19
    • Fischer, P.M.1
  • 150
    • 33645827371 scopus 로고    scopus 로고
    • Targeting protein-protein interactions by rational design: Mimicry of protein surfaces
    • S. Fletcher, and A.D. Hamilton Targeting protein-protein interactions by rational design: mimicry of protein surfaces Journal of the Royal Society Interface 3 2006 215 233
    • (2006) Journal of the Royal Society Interface , vol.3 , pp. 215-233
    • Fletcher, S.1    Hamilton, A.D.2
  • 151
    • 0034278978 scopus 로고    scopus 로고
    • Quaternary ammonium functionalized poly(propylene imine) dendrimers as effective antimicrobials: Srtructure-activity studies
    • C.Z. Chen, N.C. Beck-Tan, P. Dhurjati, T.K. van Dyk, R.A. LaRossa, and S.L. Cooper Quaternary ammonium functionalized poly(propylene imine) dendrimers as effective antimicrobials: srtructure-activity studies Biomacromolecules 1 2000 473 480
    • (2000) Biomacromolecules , vol.1 , pp. 473-480
    • Chen, C.Z.1    Beck-Tan, N.C.2    Dhurjati, P.3    Van Dyk, T.K.4    Larossa, R.A.5    Cooper, S.L.6
  • 152
    • 0009882170 scopus 로고    scopus 로고
    • Incorporation of dimethyldodecylammonium chloride functionalities onto poly(propylene imine) dendrimers significantly enhances their antibacterial properties
    • C.Z. Chen, S.L. Cooper, and N.C.B. Tan Incorporation of dimethyldodecylammonium chloride functionalities onto poly(propylene imine) dendrimers significantly enhances their antibacterial properties Chemical Communications 1999 1585 1586
    • (1999) Chemical Communications , pp. 1585-1586
    • Chen, C.Z.1    Cooper, S.L.2    Tan, N.C.B.3
  • 153
    • 70349339347 scopus 로고    scopus 로고
    • Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimers
    • A.I. Lopez, R.Y. Reins, A.M. McDermott, B.W. Trautner, and C. Cai Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimers Molecular BioSystems 5 2009 1148 1156
    • (2009) Molecular BioSystems , vol.5 , pp. 1148-1156
    • Lopez, A.I.1    Reins, R.Y.2    McDermott, A.M.3    Trautner, B.W.4    Cai, C.5
  • 154
    • 34347338838 scopus 로고    scopus 로고
    • Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups
    • M.K. Calabretta, A. Kumar, A.M. McDermott, and C. Cai Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups Biomacromolecules 8 2007 1807 1811
    • (2007) Biomacromolecules , vol.8 , pp. 1807-1811
    • Calabretta, M.K.1    Kumar, A.2    McDermott, A.M.3    Cai, C.4
  • 158
    • 18744371942 scopus 로고    scopus 로고
    • Synthesis and bactericidal efficacy of novel dendrimers
    • P. Rajakumar, K. Ganesan, S. Jayavelu, and K. Murugesan Synthesis and bactericidal efficacy of novel dendrimers Synlett 7 2005 1121 1124
    • (2005) Synlett , vol.7 , pp. 1121-1124
    • Rajakumar, P.1    Ganesan, K.2    Jayavelu, S.3    Murugesan, K.4
  • 162
    • 12244292949 scopus 로고    scopus 로고
    • Inhibition of adhesion of type 1 fimbriated Escherichia coli to highly mannosylated ligands
    • N. Nagahori, R.T. Lee, S.I. Nishimura, D. Pagé, R. Roy, and Y.C. Lee Inhibition of adhesion of type 1 fimbriated Escherichia coli to highly mannosylated ligands ChemBioChem 3 2002 836 844
    • (2002) ChemBioChem , vol.3 , pp. 836-844
    • Nagahori, N.1    Lee, R.T.2    Nishimura, S.I.3    Pagé, D.4    Roy, R.5    Lee, Y.C.6
  • 163
    • 33750162390 scopus 로고    scopus 로고
    • Oligomannoside mimetics by glycosylation of 'octopus glycosides' and their investigation as inhibitors of type 1 fimbriae-mediated adhesion of Escherichia coli
    • M. Dubber, O. Sperling, and T.K. Linhorst Oligomannoside mimetics by glycosylation of 'octopus glycosides' and their investigation as inhibitors of type 1 fimbriae-mediated adhesion of Escherichia coli Organic & Biomolecular Chemistry 4 2006 3901 3912
    • (2006) Organic & Biomolecular Chemistry , vol.4 , pp. 3901-3912
    • Dubber, M.1    Sperling, O.2    Linhorst, T.K.3
  • 165
    • 34447122753 scopus 로고    scopus 로고
    • Synthesis of glycodendrimers containing both fucoside and galactoside residues and their binding properties to PA-IL and PA-IIL lectins from pseudomonas aeruginosa
    • I. Deguise, D. Lagnoux, and R. Roy Synthesis of glycodendrimers containing both fucoside and galactoside residues and their binding properties to PA-IL and PA-IIL lectins from pseudomonas aeruginosa New Journal of Chemistry 31 2007 1321 1331
    • (2007) New Journal of Chemistry , vol.31 , pp. 1321-1331
    • Deguise, I.1    Lagnoux, D.2    Roy, R.3
  • 166
    • 57449104162 scopus 로고    scopus 로고
    • The First Synthesis of "majoral-type" glycodendrimers bearing covalently bound a-d-mannopyranoside residues onto a hexachlorocyclo- triphosphazene core
    • M. Touaibia, and R. Roy The First Synthesis of "Majoral-type" glycodendrimers bearing covalently bound a-d-mannopyranoside residues onto a hexachlorocyclo-triphosphazene core Journal of Organic Chemistry 73 2008 9292 9302
    • (2008) Journal of Organic Chemistry , vol.73 , pp. 9292-9302
    • Touaibia, M.1    Roy, R.2
  • 177
    • 32044442705 scopus 로고    scopus 로고
    • Proteo-dendrimers designed for complementary recognition of cytochromec: Dendrimer architecture toward nanoscale protein complexation
    • D. Paul, H. Miyake, S. Shinoda, and H. Tsukude Proteo-dendrimers designed for complementary recognition of cytochromec: dendrimer architecture toward nanoscale protein complexation Chemistry: A European Journal 12 2006 1328 1338
    • (2006) Chemistry: A European Journal , vol.12 , pp. 1328-1338
    • Paul, D.1    Miyake, H.2    Shinoda, S.3    Tsukude, H.4
  • 178
    • 52649091805 scopus 로고    scopus 로고
    • Dendrimers as size selective inhibitors to protein-protein binding
    • F. Chiba, T.C. Hu, L.J. Twyman, and M. Wagstaff Dendrimers as size selective inhibitors to protein-protein binding Chemical Communications 2008 4351 4353
    • (2008) Chemical Communications , pp. 4351-4353
    • Chiba, F.1    Hu, T.C.2    Twyman, L.J.3    Wagstaff, M.4
  • 180
    • 77953807630 scopus 로고    scopus 로고
    • Bioanalytical method development for a generation 5 polyamidoamine folic acid methotrexate conjugated nanoparticle
    • L. van Haandel, and J.F. Stoaugh Bioanalytical method development for a generation 5 polyamidoamine folic acid methotrexate conjugated nanoparticle Analytical and Bioanalytical Chemistry 397 2010 1841 1852
    • (2010) Analytical and Bioanalytical Chemistry , vol.397 , pp. 1841-1852
    • Van Haandel, L.1    Stoaugh, J.F.2
  • 181
    • 79951851197 scopus 로고    scopus 로고
    • Multifunctional dendrimer/combretastatin A4 inclusion complexes enable in vitro targeted cancer therapy
    • Y. Wang, R. Guo, X. Cao, M. Shen, and X. Shi Multifunctional dendrimer/combretastatin A4 inclusion complexes enable in vitro targeted cancer therapy Biomaterials 32 2011 3322 3329
    • (2011) Biomaterials , vol.32 , pp. 3322-3329
    • Wang, Y.1    Guo, R.2    Cao, X.3    Shen, M.4    Shi, X.5
  • 182
    • 33644593095 scopus 로고    scopus 로고
    • PAMAM dendrimer-based multifunctional conjugate for cancer therapy: Synthesis characterization and functionality
    • I.J. Majoros, A. Myc, and T. Thomas PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis characterization and functionality Biomacromolecules 7 2006 572 579
    • (2006) Biomacromolecules , vol.7 , pp. 572-579
    • Majoros, I.J.1    Myc, A.2    Thomas, T.3
  • 185
    • 0027950222 scopus 로고
    • Boronated starburst dendrimer-monoclonal antibody immunoconjugates: Evaluation as a potential delivery system for neutron capture therapy
    • R.F. Barth, D.M. Adams, A.H. Soloway, F. Alam, and M.V. Darby Boronated starburst dendrimer-monoclonal antibody immunoconjugates: evaluation as a potential delivery system for neutron capture therapy Bioconjugate Chemistry 5 1994 58 66
    • (1994) Bioconjugate Chemistry , vol.5 , pp. 58-66
    • Barth, R.F.1    Adams, D.M.2    Soloway, A.H.3    Alam, F.4    Darby, M.V.5
  • 186
    • 34547177723 scopus 로고    scopus 로고
    • Synthesis and characterization of PAMAM dendrimer-based multifunctional nanodevices for targeting a v b 3 integrins
    • W.G. Lesniak, M.S.T. Kariapper, and B.M. Nair Synthesis and characterization of PAMAM dendrimer-based multifunctional nanodevices for targeting a v b 3 integrins Bioconjugate Chemistry 18 2007 1148 1154
    • (2007) Bioconjugate Chemistry , vol.18 , pp. 1148-1154
    • Lesniak, W.G.1    Kariapper, M.S.T.2    Nair, B.M.3
  • 187
    • 77953295131 scopus 로고    scopus 로고
    • Synthesis and cytotoxic activity of G3 PAMAM-NH2 dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells
    • K. Winnicka, K. Bielawski, and A. Bielawska Synthesis and cytotoxic activity of G3 PAMAM-NH2 dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells Pharmacological Reports 62 2010 414 423
    • (2010) Pharmacological Reports , vol.62 , pp. 414-423
    • Winnicka, K.1    Bielawski, K.2    Bielawska, A.3
  • 191
    • 33750127627 scopus 로고    scopus 로고
    • Intracellular macrophage uptake of rifampicin loaded mannosylated dendrimers
    • P.V. Kumar, A. Asthana, T. Dutta, and N.K. Jain Intracellular macrophage uptake of rifampicin loaded mannosylated dendrimers Journal of Drug Targeting 14 2006 546 556
    • (2006) Journal of Drug Targeting , vol.14 , pp. 546-556
    • Kumar, P.V.1    Asthana, A.2    Dutta, T.3    Jain, N.K.4
  • 194
    • 77951097615 scopus 로고    scopus 로고
    • Synthesis biodistribution and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates
    • Y. Zhang, X. Sun, X. Xu, X. Zhang, H. Zhu, L. Huang, Y. Qi, and Y.M. Shen Synthesis biodistribution and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates Journal of Medicinal Chemistry 53 2010 3262 3272
    • (2010) Journal of Medicinal Chemistry , vol.53 , pp. 3262-3272
    • Zhang, Y.1    Sun, X.2    Xu, X.3    Zhang, X.4    Zhu, H.5    Huang, L.6    Qi, Y.7    Shen, Y.M.8
  • 195
    • 79954473034 scopus 로고    scopus 로고
    • Lactoferrin-conjugated dendritic nanoconstructs for lung targeting of methotrexate
    • B.D. Kurmi, V. Gajbhiye, J. Kayat, and N.K. Jain Lactoferrin-conjugated dendritic nanoconstructs for lung targeting of methotrexate Journal of Pharmaceutical Sciences 100 2011 2311 2320
    • (2011) Journal of Pharmaceutical Sciences , vol.100 , pp. 2311-2320
    • Kurmi, B.D.1    Gajbhiye, V.2    Kayat, J.3    Jain, N.K.4
  • 196
    • 17644395605 scopus 로고    scopus 로고
    • Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting
    • D. Bhadra, A.K. Yadav, S. Bhadra, and N.K. Jain Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting International Journal of Pharmaceutics 295 2005 221 233
    • (2005) International Journal of Pharmaceutics , vol.295 , pp. 221-233
    • Bhadra, D.1    Yadav, A.K.2    Bhadra, S.3    Jain, N.K.4
  • 197
    • 33750160205 scopus 로고    scopus 로고
    • The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats
    • D. Chandrasekar, R. Sistla, F.J. Ahmad, R.K. Khar, and P.V. Diwan The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats Biomaterials 28 2007 504 512
    • (2007) Biomaterials , vol.28 , pp. 504-512
    • Chandrasekar, D.1    Sistla, R.2    Ahmad, F.J.3    Khar, R.K.4    Diwan, P.V.5
  • 198
    • 78449252867 scopus 로고    scopus 로고
    • PEGylated poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors
    • H. He, Y. Li, X.R. Jia, J. Du, X. Ying, W.L. Lu, J.N. Lou, and Y. Wei PEGylated poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors Biomaterials 32 2011 478 487
    • (2011) Biomaterials , vol.32 , pp. 478-487
    • He, H.1    Li, Y.2    Jia, X.R.3    Du, J.4    Ying, X.5    Lu, W.L.6    Lou, J.N.7    Wei, Y.8
  • 199
    • 79959861668 scopus 로고    scopus 로고
    • The treatment of glioblastoma xenografts by surfactant conjugated dendritic nanoconjugates
    • V. Gajbhiye, and N.K. Jain The treatment of glioblastoma xenografts by surfactant conjugated dendritic nanoconjugates Biomaterials 32 2011 6213 6225
    • (2011) Biomaterials , vol.32 , pp. 6213-6225
    • Gajbhiye, V.1    Jain, N.K.2
  • 200
    • 56349134979 scopus 로고    scopus 로고
    • Surface-engineered dendrimers for dual drug delivery: A receptor up-regulation and enhanced cancer targeting strategy
    • R.K. Tekade, T. Dutta, A. Tyagi, A.C. Bharti, B.C. Das, and N.K. Jain Surface-engineered dendrimers for dual drug delivery: a receptor up-regulation and enhanced cancer targeting strategy Journal of Drug Targeting 16 2008 758 772
    • (2008) Journal of Drug Targeting , vol.16 , pp. 758-772
    • Tekade, R.K.1    Dutta, T.2    Tyagi, A.3    Bharti, A.C.4    Das, B.C.5    Jain, N.K.6
  • 201
    • 79961076051 scopus 로고    scopus 로고
    • Dendritic poly(ethylene glycol) bearing paclitaxel and alendronate for targeting bone neoplasms
    • C. Clementi, K. Miller, A. Mero, R. Satchi-Fainaro, and G. Pasut Dendritic poly(ethylene glycol) bearing paclitaxel and alendronate for targeting bone neoplasms Molecular Pharmaceutics 8 2011 1063 1072
    • (2011) Molecular Pharmaceutics , vol.8 , pp. 1063-1072
    • Clementi, C.1    Miller, K.2    Mero, A.3    Satchi-Fainaro, R.4    Pasut, G.5
  • 202
    • 77954579231 scopus 로고    scopus 로고
    • Amino acid- functionalized dendrimers with hetero-bifunctional chemoselective peripheral groups for drug delivery
    • R.S. Navath, A.R. Menjoge, B. Wang, R. Romero, S. Kannan, and R.M. Kannan Amino acid- functionalized dendrimers with hetero-bifunctional chemoselective peripheral groups for drug delivery Biomacromolecules 11 2010 1544 1563
    • (2010) Biomacromolecules , vol.11 , pp. 1544-1563
    • Navath, R.S.1    Menjoge, A.R.2    Wang, B.3    Romero, R.4    Kannan, S.5    Kannan, R.M.6
  • 203
    • 77049109479 scopus 로고    scopus 로고
    • Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide
    • D.K. Tosh, L.S. Yoo, M. Chinn, K. Hong, K.S.M. Kilbey, M.O. Barrett, I.P. Fricks, T.K. Harden, Z.G. Gao, and K.A. Jacobson Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide Bioconjugate Chemistry 21 2010 372 384
    • (2010) Bioconjugate Chemistry , vol.21 , pp. 372-384
    • Tosh, D.K.1    Yoo, L.S.2    Chinn, M.3    Hong, K.4    Kilbey, K.S.M.5    Barrett, M.O.6    Fricks, I.P.7    Harden, T.K.8    Gao, Z.G.9    Jacobson, K.A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.