Targeting protein-protein interactions by rational design: Mimicry of protein surfaces

Journal of the Royal Society Interface

Volumn 3, Issue 7, 2006, Pages 215-233

  Fletcher, Steven ^a   Hamilton, Andrew D ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Inhibitor; Protein protein interaction; Proteomimetics; Recognition; Surface

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIVIRUS AGENT; CARBONATE DEHYDRATASE; CD4 ANTIGEN; CD81 ANTIGEN; CHYMOTRYPSIN INHIBITOR; CHYMOTRYPSINOGEN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYTOCHROME C; ENFUVIRTIDE; ESTROGEN RECEPTOR; GLYCOPROTEIN E2; GLYCOPROTEIN GP 120; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PDZ PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTRANSFERASE INHIBITOR; PORPHYRIN DERIVATIVE; POSTSYNAPTIC DENSITY PROTEIN 95; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN BCL 2; PROTEIN BID; PROTEIN INHIBITOR; PROTEINASE INHIBITOR; RECOMBINANT PROTEIN; TETRA(METHYLPYRIDINIUM)PORPHYRIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN INHIBITOR;

ALPHA HELIX; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; CIRCULAR DICHROISM; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; HUMAN; LUNG CARCINOMA; MOLECULAR MIMICRY; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEOMICS; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 33645827371     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2006.0115     Document Type: Review

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