In vivo toxicity of poly(propyleneimine) dendrimers

Journal of Biomedical Materials Research - Part A

Volumn 99 A, Issue 2, 2011, Pages 261-268

  Ziemba, Barbara ^a   Janaszewska, Anna ^a   Ciepluch, Karol ^a   Krotewicz, Maria ^a   Fogel, Wiesława A ^b   Appelhans, Dietmar ^c   Voit, Brigitte ^c   Bryszewska, Maria ^a   Klajnert, Barbara ^a  

^a UNIVERSITY OF LODZ   (Poland)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

^c LEIBNIZ INSTITUTE OF POLYMER RESEARCH DRESDEN   (Germany)

Author keywords

dendrimer; glycodendrimer; in vivo toxicity; poly(propyleneimine); PPI; rat

Indexed keywords

AMINO GROUP; BIOMEDICAL APPLICATIONS; BODY WEIGHT; BRANCHED MACROMOLECULES; CATIONIC GROUPS; GLYCODENDRIMERS; HEMATOLOGICAL PARAMETERS; IN VIVO TOXICITY; IN-VIVO; LOWER BODY; MALTOTRIOSE; POLY(PROPYLENE IMINE); POSITIVELY CHARGED SURFACES; PPI; TOXIC EFFECT; URINE EXCRETION; WATER CONSUMPTION; WISTAR RAT;

ANIMALS; ANTHROPOMETRY; BEHAVIORAL RESEARCH; BODY FLUIDS; DENDRIMERS; MEDICAL APPLICATIONS; RATS; SUGARS; TOXICITY; WATER SUPPLY;

FUNCTIONAL POLYMERS;

DENDRIMER; MALTOTRIOSE; POLYPROPYLENEIMINE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; BODY WEIGHT; FLUID INTAKE; FOOD INTAKE; HEMATOLOGICAL PARAMETERS; IN VIVO STUDY; MALE; NONHUMAN; RAT; URINARY EXCRETION; URINE VOLUME; WEIGHT GAIN;

ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; DENDRIMERS; DRINKING; EATING; MALE; MATERIALS TESTING; MOLECULAR STRUCTURE; POLYPROPYLENES; RATS; RATS, WISTAR;

EID: 80053213011     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.33196     Document Type: Article

References (43)

1. Tomalia DA, Baker H, Dewald JR, Hall M, Kallos G, Martin S, Roeck S, Ryder J, Smith P,. A new class of polymers: Starburst-dendric macromolecules. Polym J 1985; 17: 117-132.
2. Newkome GR, Yao ZQ, Baker GR, Gupta VK,. Cascade molecules: A new approach to micelles. A[27]-arborol. J Org Chem 1985; 50: 2003-2006.
3. Boas U, Heegaard PM,. Dendrimers in drug research. Chem Soc Rev 2004; 33: 43-63. (Pubitemid 38376610)
4. Dutta T, Jain NK, McMillan NA, Parekh HS,. Dendrimer nanocarriers as versatile vectors in gene delivery. Nanomedicine 2010; 6: 25-34.
5. Bumb A, Brechbiel MW, Choyke P,. Macromolecular and dendrimer-based magnetic resonance contrast agents. Acta Radiol 2010; 51: 751-767.
6. Crooks RM, Lemon BI, Sun L, Yeung LK, Zhao M,. Dendrimer-encapsulated metal nanoparticles: Synthesis, characterization, and applications to catalysis. Acc Chem Res 2001; 34: 181-190. (Pubitemid 32816381)
7. Pittelkow M, Nielsen CB, Broeren MAC, van Dongen JL, van Genderen MH, Meijer EW, Christensen JB,. Molecular recognition: Comparative study of a tunable guest-host system using a fluorescent model system and CID-mass spectrometry on dendrimers. Chem Eur J 2005; 11: 5126-5135. (Pubitemid 41251682)
8. Zhou X, Turchi C, Wang D,. Carbohydrate cluster microarrays fabricated on three-dimensional dendrimeric platforms for functional glycomics exploration. J Proteome Res 2009; 8: 5031-5040.
9. Cai CZ, Chen ZY,. Intrinsic viscosity of starburst dendrimers. Macromolecules 1998; 31: 6393-6396. (Pubitemid 128563420)
10. Duncan R, Izzo L,. Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev 2005; 57: 2215-2237. (Pubitemid 41759394)
11. Boas U, Heegaard PMH,. Dendrimer based anti-infective and anti-inflammatory drugs. Recent Pat Antiinfect Drug Discov 2006; 1: 331-351.
12. Roberts JC, Bhalgat MK, Zera RT,. Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst™ dendrimers. J Biomed Mater Res 1996; 30: 53-65.
13. Okuda T, Kawakami S, Maeie T, Niidome T, Yamashita F, Hashida M,. Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration. J Controlled Release 2006; 114: 69-77. (Pubitemid 44128625)
14. Neerman MF, Zhang W, Parrish AR, Simanek EE,. In vitro and in vivo evaluation of a melamine dendrimer as a vehicle for drug delivery. Int J Pharm 2004; 281: 129-132. (Pubitemid 39024270)
15. Jain K, Kesharwani P, Gupta U, Jain NK,. Dendrimer toxicity: Let's meet the challenge. Int J Pharm 2010; 394: 122-142.
16. Bharda D, Yadav AK, Bhadra S, Jain NK,. Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting. Int J Pharm 2005; 295: 221-233. (Pubitemid 40558805)
17. Agashe HB, Dutta T, Garg M, Jain NK,. Investigations on the toxicological profile of functionalized fifth-generation poly (propylene imine) dendrimer. J Pharm Pharmacol 2006; 58: 1491-1498. (Pubitemid 44785538)
18. Klajnert B, Appelhans D, Komber H, Morgner N, Schwarz S, Richter S, Brutschy B, Ionov M, Tonkikh AK, Bryszewska M, Voit B,. The influence of densely organized maltose shells on biological properties of poly(propylene imine) dendrimers: New effect dependet on hydrogen bonding. Chem Eur J 2008; 14: 7030-7041.
19. Fischer M, Appelhans D, Klajnert B, Bryszewska M, Voit B, Rogers M,. The influence of surface functionality of poly(propylene imine) dendrimers on aggregation and propagation of the scrapie prion protein. Biomacromolecules 2010; 11: 1314-1325.
20. Zahedi P, De Souza R, Piquette-Miller M, Allen C,. Docetaxel distribution following intraperitoneal administration in mice. J Pharm Pharm Sci 2011; 14: 90-99.
21. Shalby AB, Assaf N, Ahmed HH,. Possible mechanisms for N-acetyl cysteine and taurine in ameliorating acute renal failure induced by cisplatin in rats. Toxicol Mech Methods Doi:10.3109/15376516.2011.568985
22. Echarri Gonzalez MJ, Green R, Muggia FM,. Intraperitoneal drug delivery for ovarian cancer: why, how, who, what, and when? Oncology (Williston Park) 2011; 25: 156-165, 170.
23. Felippotti TT, Ribeiro do Carmo D, Paim LL, Stradiotto NR, Bicalho UD, Parada CA, Grillo R, Fraceto LF, Coimbra NC,. Effect of a nanostructured dendrimer-naloxonazine complex on endogenous opioid peptides μ(1) receptor-mediated post-ictal antinociception. Nanomedicine Doi:10.1016/j.nano. 2011. 02.005.
24. Vannucci L, Fiserová A, Sadalapure K, Lindhorst TK, Kuldová M, Rossmann P, Horváth O, Kren V, Krist P, Bezouska K, Luptovcová M, Mosca F, Pospísil M,. Effects of N-acetyl-glucosamine-coated glycodendrimers as biological modulators in the B16F10 melanoma model in vivo. Int J Oncol 2003; 23: 285-296.
25. Appelhans D, Oertel U, Mazzeo R, Komber H, Hoffmann J, Weidner S, Brutschy B, Voit B, Ottaviani MF,. Dense-shell glycodendrimers: UV/Vis and electron paramagnetic resonance study of metal ion complexation. Proc R Soc A 2010; 466: 1489-1513.
26. Mkandawire M, Pohl A, Gubarevich T, Lapina V, Appelhans D, Rödel G, Pompe W, Schreiber J, Opitz J,. Selective targeting of green fluorescent nanodiamond conjugates to mitochondria in HeLa cells. J Biophoton 2009; 2: 596-606.
27. Stam R, Croiset G, Akkermans LMA, Wiegant VM,. Behavioural and intestinal responses to novelty in rats selected for diverging reactivity in the open field test. Behav Brain Res 1997; 88: 231-238. (Pubitemid 27496319)
28. Chauhan AS, Jain NK, Diwan PV,. Pre-clinical and behavioural toxicity profile of PAMAM dendrimers in mice. Proc R Soc A 2010; 466: 1535-1550.
29. Schubert ML, Peura DA,. Control of gastric acid secretion in health and disease. Gastroenterology 2008; 134: 1842-1860. (Pubitemid 351783299)
30. Stankiewicz W,. Laboratory Tests in Veterinary Diagnostics (in Polish). Warsaw: PWN; 1973. 507 p.
31. Woschnagg H, Exel W,. How to Interpret Test Results (in Polish). Warsaw: Bertelsmann Media Sp.; 2000. 365 p.
32. Amara IB, Troudi A, Garoui E, Hakim A, Boudawara T, Zeghal KM, Zeghal N,. Protective effects of selenium in methimazole nephrotoxicity in adult rats and their offspring. Exp Toxic Pathol. Doi: 10.1016/j.etp. 2010.04.007.
33. Walker GW,. Renal disease and disturbances in renal function. In:, Harvey AM, Johns RJ, McKusick VA, Owens AH, Ross AH, editors. Principles and Practice of Medicine. New York: ACC; 1984, p 93-154.
34. Kokot F, Kokot S,. Interpretation of Blood Serum, Urine and Cerebrospinal Fluid Tests Results (in Polish). Warsaw: Wiedza Medyczna; 1996. 88 p.
35. Papadimitriou JM, van Duijn P,. The ultrastructural localization of the isozymes of aspartate aminotransferase in murine tissues. J Cell Biol 1970; 47: 84-98.
36. Krawiec A, Chrostek L, Cylwik B, Supronowicz Z, Szmitkowski M,. The concentration of sialylated glycoproteins in the sera of alcohol dependent men. Pol Merk Lek 2007; 23: 251-254.
37. Waterbury L,. Haematology (in Polish). Wroclaw: Urban & Partner; 1998. 161 p.
38. Malik N, Wiwattanapatapee R, Klopsch R, Lorenz K, Frey H, Weener JW, Meijer EW, Paulus W, Duncan R,. Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo. J Controlled Release 2000; 65: 133-148. (Pubitemid 30122922)
39. Aillon KL, Xie Y, El-Gendy N, Berkland CJ, Forrest ML,. Effects of nanomaterial physicochemical properties on in vivo toxicity. Adv Drug Deliv Rev 2009; 61: 457-466.
40. Dunn J,. Impact of mobility impairment on the burden of caregiving in individuals with multiple sclerosis. Expert Rev Pharmacoecon Outcomes Res 2010; 10: 433-440.
41. Agashe HB, Babbar AK, Jain S, Sharma RK, Mishra AK, Asthana A, Garg M, Dutta T, Jain NK,. Investigations on biodistribiution of technetium-99m-labeled carbohydrate-coated poly(propylene) dendrimers. Nanomedicine 2007; 3: 120-127. (Pubitemid 46899616)
42. Kunzmann A, Andersson B, Thurnherr T, Krug H, Scheynius A, Fadeel B,. Toxicology of engineered nanomaterials: Focus on biocompatibility, biodistribution and biodegradation. Biochim Biophys Acta 2010. DOI: 10.1016/j.bbagen.2010.04.007.
43. Payal A, Gupta U, Jain NK,. Glycoconjugated peptide dendrimers-based nanoparticulate system for the delivery of chloroquine phosphate. Biomaterials 2007; 28: 3349-3359. (Pubitemid 46693974)