Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and Cdc25B inhibition

Journal of Medicinal Chemistry

Volumn 44, Issue 20, 2001, Pages 3216-3222

  Sodeoka, M ^a,b   Sampe, R ^b   Kojima, S ^b   Baba, Y ^a,b   Usui, T ^c   Ueda, K ^c   Osada, H ^c  

^a TOHOKU UNIVERSITY   (Japan)

^b SAGAMI CHEMICAL RESEARCH CENTER   (Japan)

^c RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; TETRONIC ACID DERIVATIVE;

ARTICLE; CELL CYCLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME SPECIFICITY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; ESCHERICHIA COLI; FURANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035959985     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0100741     Document Type: Article

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