Synthesis and bactericidal efficacy of novel dendrimers

Synlett

Volumn , Issue 7, 2005, Pages 1121-1124

  Rajakumar, Perumal ^a   Ganesan, Kilivelu ^a   Jayavelu, S ^a   Murugesan, K ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antibacterial; Dendrimers; Enone; m terphenyl; Salmonella typhi

Indexed keywords

DENDRIMER; TERPHENYL DERIVATIVE;

BACTERICIDAL ACTIVITY; CONFERENCE PAPER; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; SALMONELLA PARATYPHI; SALMONELLA TYPHI; STAPHYLOCOCCUS AUREUS;

EID: 18744371942     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-865201     Document Type: Conference Paper

References (30)

1. Grayson, S. M.; Fréchet, J. M. J. Chem. Rev. 2001, 101, 3819; and references therein.
2. Nithyanandhan, J.; Jayaraman, N. J. Org. Chem. 2002, 67, 6282.
3. Abramov, M. A.; Shukla, R.; Amabilin, D. B.; Dehaen, J. W. J. Org. Chem. 2002, 67, 1004.
4. Carnahan, M. A.; Grinstaff, M. W. J. Am. Chem. Soc. 2001, 123, 2905.
5. Gilat, S. L.; Adronov, A.; Fréchet, J. M. J. J. Org. Chem. 1999, 64, 7474.
6. Tomalia, D. A.; Baker, H.; Dewald, J.; Hall, M.; Kallos, G.; Martin, S.; Roeck, J.; Ryder, J.; Smith, P. Polym. J. 1985, 17, 117.
7. Hawker, C. J.; Fréchet, J. M. J. J. Am. Chem. Soc. 1990, 112, 7638.
8. Liao, L. X.; Junge, D. M.; McGrath, D. V. Macromolecules 2002, 35, 319; and references therein.
9. Diez-Barra, E.; Garcia-Martinez, J. C.; Ray, R. D.; Rodriguez-Lopez, J.; Giacalone, F.; Segura, J. L.; Martin, N. J. Org. Chem. 2003, 68, 3178.
10. Ghosh, S.; Banthia, A. K. Tetrahedron Lett. 2003, 43, 6457.
11. Hyakawa, J.; Mamotabe, A.; Arai, T. Chem. Commun. 2003, 94.
12. Rajakumar, P.; Ganesan, K. Synth. Commun. 2004, 34, 2009.
13. Rajakumar, P.; Ganesan, K. Synth. Lett. 2004, 2236.
14. Boas, U.; Heegaard, P. M. H. Chem. Soc. Rev. 2004, 33, 43.
15. Sciraufstattel, E.; Bernt, H. Nature 1947, 164, 456.
16. Tam, J. P.; Ya, Y. A.; Yang, J. L. Eur. J. Biochem. 2002, 269, 923.
17. (a) Chen, C. Z.; Cooper, S. L. Adv. Mater. 2000, 12, 843.
18. (b) Chen, C. Z.; Cooper, S. L. Biomater. 2002, 23, 3359.
19. Bourne, N.; Stanberry, L. R.; Kern, E. R.; Holan, G.; Matthews, B.; Bernstein, D. I. Antimicrob. Agents Chemother. 2000, 44, 2471.
20. Du, C. J. F.; Hart, H.; Ng, K. K. D. J. Org. Chem. 1987, 52, 4311.
21. Rajakumar, P.; Kannan, A. Tetrahedron Lett. 1993, 4407.
22. Arun, A.; Reddy, B. S. R. J. Polym. Sci., Part A: Polym. Chem. 2003, 41, 1632.
23. 3 as eluent to give the corresponding dendrimer.
24. 3: C, 88.00; H, 5.60. Found: C, 87.98; H, 5.56.
25. Chudgar, N. K.; Kansara, S. S.; Negai, R.; Sharma, H. C. Macromol. Rep. 1995, A32, 323.
26. 4: C, 87.11; H, 5.38. Found: C, 87.05; H, 5.32.
27. Freeman, A. W.; Christoffels, L. A. J.; Fréchet, J. M. J. J. Org. Chem. 2000, 65, 7612.
28. 8: C, 86.47; H, 5.43. Found: C, 86.40; H, 5.36.
29. 16: C, 86.10; H, 5.46. Found: C, 86.06; H, 5.40.
30. Antibacterial activity: All the test bacteria were subcultured in nutrient broth from which 1 mL of cell suspension was taken and was adjusted to 0.5 OD. This was spread as a thin film over the nutrient agar plates. Concentrations of 60, 40 and 20 μg/mL of the compound were loaded into a disc, which was placed over the inoculated plates. All the plates were incubated for 48 h at 37 °C and growth was measured. A streptomycin disc from Hi-media (10 μg/disc) was used as the standard.