Combining glycomimetic and multivalent strategies toward designing potent bacterial lectin inhibitors

Chemistry - A European Journal

Volumn 17, Issue 23, 2011, Pages 6545-6562

  Chabre, Yoann M ^a   Giguère, Denis ^a   Blanchard, Bertrand ^b   Rodrigue, Jacques ^a   Rocheleau, Sylvain ^a   Neault, Mathieu ^a   Rauthu, Subhash ^a   Papadopoulos, Alex ^a   Arnold, Alexandre A ^a   Imberty, Anne ^b   Roy, René ^a  

^a UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^b CENTRE DE RECHERCHES SUR LES MACROMOLÉCULES VÉGÉTALES CERMAV CNRS   (France)

Author keywords

glycosides; inhibitors; molecular modeling; multivalency; NMR spectroscopy

Indexed keywords

ANTI-ADHESIVE; AZIDE-ALKYNE CYCLOADDITION; BINDING MODES; COMPREHENSIVE STUDIES; DISSOCIATION CONSTANT; DOCKING CALCULATIONS; EXPERIMENTAL DETERMINATION; GLYCOCONJUGATES; GLYCOMIMETIC; GLYCOMIMETICS; ISOTHERMAL TITRATION CALORIMETRY; LEC; MICROMOLAR RANGE; MIMETICS; MOLECULAR MODELING STUDIES; MULTIVALENCY; MULTIVALENT BINDING; NMR DIFFUSION; PROTEIN-CARBOHYDRATE INTERACTIONS; PSEUDOMONAS AERUGINOSA; RECOGNITION PROCESS; SELECTIVE LIGANDS; SYSTEMATIC INVESTIGATIONS;

ACETYLENE; BACTERIA; BINDING ENERGY; BIOSYNTHESIS; CHELATION; COMPLEXATION; DISSOCIATION; MOLECULAR MODELING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPTIMIZATION; SUGARS;

BACTERIOLOGY;

BACTERIAL PROTEIN; COPPER; GLYCOCONJUGATE; GLYCOSIDE; LECTIN; LIGAND;

ARTICLE; CALORIMETRY; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA;

BACTERIAL PROTEINS; CALORIMETRY; CATALYSIS; COPPER; GLYCOCONJUGATES; GLYCOSIDES; LECTINS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA;

EID: 79958208425     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201003402     Document Type: Article

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