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Volumn 6, Issue 6, 2002, Pages 742-748

Biological applications of dendrimers

Author keywords

[No Author keywords available]

Indexed keywords

BETA CYCLODEXTRIN; CARBOHYDRATE DERIVATIVE; CONCANAVALIN A; DENDRIMER; PEPTIDE; CARBOHYDRATE; POLYMER;

EID: 0036899037     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(02)00400-3     Document Type: Review
Times cited : (525)

References (61)
  • 2
    • 0034851810 scopus 로고    scopus 로고
    • Dendrimers: A review of their appeal and applications
    • This review provides basic background information for readers who desire an introduction to dendrimer chemistry
    • Dykes G.M. Dendrimers: a review of their appeal and applications. J Chem Technol Biotechnol. 76:2001;903-918. This review provides basic background information for readers who desire an introduction to dendrimer chemistry.
    • (2001) J Chem Technol Biotechnol , vol.76 , pp. 903-918
    • Dykes, G.M.1
  • 3
    • 0037091001 scopus 로고    scopus 로고
    • Dendritic polymers in biomedical applications: From potential to clinical use in diagnostics and therapy
    • Stiriba S-E., Frey H., Haag R. Dendritic polymers in biomedical applications: from potential to clinical use in diagnostics and therapy. Angew Chem Int Ed Engl. 41:2002;1329-1334.
    • (2002) Angew Chem Int Ed Engl , vol.41 , pp. 1329-1334
    • Stiriba, S-E.1    Frey, H.2    Haag, R.3
  • 4
    • 0036181219 scopus 로고    scopus 로고
    • Design and synthesis of glycodendrimers
    • Turnbull W.B., Stoddart J.F. Design and synthesis of glycodendrimers. Rev Mol Biotechnol. 90:2002;231-255.
    • (2002) Rev Mol Biotechnol , vol.90 , pp. 231-255
    • Turnbull, W.B.1    Stoddart, J.F.2
  • 5
    • 0036462602 scopus 로고    scopus 로고
    • The cluster glycoside effect
    • Many systems that have been reported for the study of glycocluster-, polymer- and glycodendrimer-protein interactions are compared. The hemagglutination assay, the enzyme-linked lectin assay, isothermal titration microcalorimetry and surface plasmon resonance are evaluated
    • Lundquist J.J., Toone E.J. The cluster glycoside effect. Chem Rev. 102:2002;555-578. Many systems that have been reported for the study of glycocluster-, polymer- and glycodendrimer-protein interactions are compared. The hemagglutination assay, the enzyme-linked lectin assay, isothermal titration microcalorimetry and surface plasmon resonance are evaluated.
    • (2002) Chem Rev , vol.102 , pp. 555-578
    • Lundquist, J.J.1    Toone, E.J.2
  • 7
    • 0032476812 scopus 로고    scopus 로고
    • Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
    • Mammen M., Choi S-K., Whitesides G.M. Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors. Angew Chem Int Ed Engl. 37:1998;2754-2794.
    • (1998) Angew Chem Int Ed Engl , vol.37 , pp. 2754-2794
    • Mammen, M.1    Choi, S-K.2    Whitesides, G.M.3
  • 8
    • 0037050414 scopus 로고    scopus 로고
    • The lectin-binding properties of six generations of mannose-functionalized dendrimers
    • Binding enhancements for mannose-functionalized dendrimers relative to methyl mannose were consistent with monovalent interaction (generations 1 and 2), glycoside clustering (generation 3), and multivalent binding generations 4-6). The wide range of activities that were observed indicates that dendrimer systems can be fine-tuned to obtain any desired level of activity in protein-carbohydrate interactions
    • Woller E.K., Cloninger M.C. The lectin-binding properties of six generations of mannose-functionalized dendrimers. Org Lett. 4:2002;7-10. Binding enhancements for mannose-functionalized dendrimers relative to methyl mannose were consistent with monovalent interaction (generations 1 and 2), glycoside clustering (generation 3), and multivalent binding generations 4-6). The wide range of activities that were observed indicates that dendrimer systems can be fine-tuned to obtain any desired level of activity in protein-carbohydrate interactions.
    • (2002) Org Lett , vol.4 , pp. 7-10
    • Woller, E.K.1    Cloninger, M.C.2
  • 9
    • 0034834503 scopus 로고    scopus 로고
    • Mannose functionalization of a sixth generation dendrimer
    • Woller E.K., Cloninger M.C. Mannose functionalization of a sixth generation dendrimer. Biomacromolecules. 2:2001;1052-1054.
    • (2001) Biomacromolecules , vol.2 , pp. 1052-1054
    • Woller, E.K.1    Cloninger, M.C.2
  • 10
    • 0036132021 scopus 로고    scopus 로고
    • Synthesis and protein binding properties of T-antigen containing glycoPAMAM dendrimers
    • Baek M-G., Roy R. Synthesis and protein binding properties of T-antigen containing glycoPAMAM dendrimers. Bioorg Med Chem. 10:2002;11-17.
    • (2002) Bioorg Med Chem , vol.10 , pp. 11-17
    • Baek, M-G.1    Roy, R.2
  • 11
    • 0035667728 scopus 로고    scopus 로고
    • Synthesis of lactose dendrimers and multivalency effects in binding to the cholera toxin B subunit
    • Vrasidas I, de Mol NJ, Liskamp RMJ, Pieters RJ. Synthesis of lactose dendrimers and multivalency effects in binding to the cholera toxin B subunit. Eur J Org Chem. 2001:4685-4692.
    • (2001) Eur J Org Chem , pp. 4685-4692
    • Vrasidas, I.1    De Mol, N.J.2    Liskamp, R.M.J.3    Pieters, R.J.4
  • 12
    • 0035814138 scopus 로고    scopus 로고
    • Wedgelike glycodendrimers as inhibitors of binding of mammalian galectins to glycoproteins, lactose maxiclusters, and cell surface glycoconjugates
    • Lactosefunctionalized dendrimer wedges were evaluated for binding to galectins using a solid-phase assay and a hemagglutination assay. Activity was highest for galectin-1 in the solid phase assay and highest for galectin-3 in the hemagglutination assay, indicating that factors such as time scale, ligand presentation and static or dynamic setup can strongly influence the protein-carbohydrate interaction
    • Andre S., Pieters R.J., Vrsaidas I., Kaltner H., Kusabara I., Liu F-T., Liskamp R.M.J., Gabius H-J. Wedgelike glycodendrimers as inhibitors of binding of mammalian galectins to glycoproteins, lactose maxiclusters, and cell surface glycoconjugates. ChemBioChem. 2:2001;822-830. Lactosefunctionalized dendrimer wedges were evaluated for binding to galectins using a solid-phase assay and a hemagglutination assay. Activity was highest for galectin-1 in the solid phase assay and highest for galectin-3 in the hemagglutination assay, indicating that factors such as time scale, ligand presentation and static or dynamic setup can strongly influence the protein-carbohydrate interaction.
    • (2001) ChemBioChem , vol.2 , pp. 822-830
    • Andre, S.1    Pieters, R.J.2    Vrsaidas, I.3    Kaltner, H.4    Kusabara, I.5    Liu, F-T.6    Liskamp, R.M.J.7    Gabius, H-J.8
  • 13
    • 0034746466 scopus 로고    scopus 로고
    • Dilute solution properties of lactosylated polyamidoamine dendrimers and their structural characteristics
    • Pavlov G.M., Errington N., Harding S.E., Korneeva E.V., Roy R. Dilute solution properties of lactosylated polyamidoamine dendrimers and their structural characteristics. Polymer. 42:2001;3671-3678.
    • (2001) Polymer , vol.42 , pp. 3671-3678
    • Pavlov, G.M.1    Errington, N.2    Harding, S.E.3    Korneeva, E.V.4    Roy, R.5
  • 15
    • 0035856932 scopus 로고    scopus 로고
    • Trehalose-based octopus glycosides for the synthesis of carbohydrate-centered PAMAM dendrimers and thiourea-bridged glycoclusters
    • Dubber M., Lindhorst T.K. Trehalose-based octopus glycosides for the synthesis of carbohydrate-centered PAMAM dendrimers and thiourea-bridged glycoclusters. Org Lett. 3:2001;4019-4022.
    • (2001) Org Lett , vol.3 , pp. 4019-4022
    • Dubber, M.1    Lindhorst, T.K.2
  • 17
    • 0036680874 scopus 로고    scopus 로고
    • Chemical modification of chitosan 11: Chitosan-dendrimer hybrid as a tree like molecule
    • Dendrimers functionalized with sialic acid residues were attached to chitosan, a non-toxic and biodegradable sugar-based polymer to provide a new graft glycodendrimer-polymer motif
    • Sashiwa H., Shigemasa Y., Roy R. Chemical modification of chitosan 11: chitosan-dendrimer hybrid as a tree like molecule. Carbohydr Polym. 49:2002;195-205. Dendrimers functionalized with sialic acid residues were attached to chitosan, a non-toxic and biodegradable sugar-based polymer to provide a new graft glycodendrimer-polymer motif.
    • (2002) Carbohydr Polym , vol.49 , pp. 195-205
    • Sashiwa, H.1    Shigemasa, Y.2    Roy, R.3
  • 19
    • 0034958233 scopus 로고    scopus 로고
    • Parallel combinatorial synthesis of glycodendrimers and their hydrogelation properties
    • McWatt M, Boons G-J. Parallel combinatorial synthesis of glycodendrimers and their hydrogelation properties. Eur J Org Chem. 2001:2535-2545.
    • (2001) Eur J Org Chem , pp. 2535-2545
    • McWatt, M.1    Boons, G.-J.2
  • 20
    • 0036177932 scopus 로고    scopus 로고
    • Peptide dendrimers: Applications and synthesis
    • Sadler K., Tam J.P. Peptide dendrimers: applications and synthesis. Rev Mol Biotechnol. 90:2002;195-229.
    • (2002) Rev Mol Biotechnol , vol.90 , pp. 195-229
    • Sadler, K.1    Tam, J.P.2
  • 21
    • 0036183822 scopus 로고    scopus 로고
    • Antimicrobial dendrimeric peptides
    • Lysine core dendrimers with tetrapeptides and octapeptides were more soluble in water, more stable to proteolysis and less toxic to human cells than their linear polymeric analogs; comparable antimicrobial potency was demonstrated
    • Tam J.P., Lu Y-A., Yang J-L. Antimicrobial dendrimeric peptides. Eur J Biochem. 269:2002;923-932. Lysine core dendrimers with tetrapeptides and octapeptides were more soluble in water, more stable to proteolysis and less toxic to human cells than their linear polymeric analogs; comparable antimicrobial potency was demonstrated.
    • (2002) Eur J Biochem , vol.269 , pp. 923-932
    • Tam, J.P.1    Lu, Y-A.2    Yang, J-L.3
  • 22
    • 0037170807 scopus 로고    scopus 로고
    • Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin
    • Kasai S., Nagasawa H., Shimamura M., Uto Y., Hori H. Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin. Bioorg Med Chem Lett. 12:2002;951-954.
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 951-954
    • Kasai, S.1    Nagasawa, H.2    Shimamura, M.3    Uto, Y.4    Hori, H.5
  • 24
    • 0037042201 scopus 로고    scopus 로고
    • Increased intracellular calcium is required for neurite outgrowth induced by a synthetic peptide ligand of NCAM
    • Lysine core dendrimers with an 11-mer peptide surface residue that is a ligand of NCAM induced an increase in intracellular calcium. Studies with this dendrimer suggest that NCAM-dependent neurite outgrowth requires calcium mobilization
    • Ronn L.C.B., Dissing S., Holm A., Berezin V., Bock E. Increased intracellular calcium is required for neurite outgrowth induced by a synthetic peptide ligand of NCAM. FEBS Lett. 518:2002;60-66. Lysine core dendrimers with an 11-mer peptide surface residue that is a ligand of NCAM induced an increase in intracellular calcium. Studies with this dendrimer suggest that NCAM-dependent neurite outgrowth requires calcium mobilization.
    • (2002) FEBS Lett , vol.518 , pp. 60-66
    • Ronn, L.C.B.1    Dissing, S.2    Holm, A.3    Berezin, V.4    Bock, E.5
  • 25
    • 0034781645 scopus 로고    scopus 로고
    • Synthesis, isolation and characterization of Plasmodium falciparum antigenic tetrabranched peptide dendrimers obtained by thiazolidine linkages
    • Chaves F., Calvo J.C., Carvajal C., Rivera Z., Ramirez L., Pinto M., Trujillo M., Guzman F., Patarroyo M.E. Synthesis, isolation and characterization of Plasmodium falciparum antigenic tetrabranched peptide dendrimers obtained by thiazolidine linkages. J Pept Res. 58:2001;307-316.
    • (2001) J Pept Res , vol.58 , pp. 307-316
    • Chaves, F.1    Calvo, J.C.2    Carvajal, C.3    Rivera, Z.4    Ramirez, L.5    Pinto, M.6    Trujillo, M.7    Guzman, F.8    Patarroyo, M.E.9
  • 26
    • 0035833065 scopus 로고    scopus 로고
    • Synthesis and nuclease stability of trilysyl dendrimer-oligodeoxyribonucleotide hybrids
    • Sarracino D.A., Richert C. Synthesis and nuclease stability of trilysyl dendrimer-oligodeoxyribonucleotide hybrids. Bioorg Med Chem Lett. 11:2001;1733-1736.
    • (2001) Bioorg Med Chem Lett , vol.11 , pp. 1733-1736
    • Sarracino, D.A.1    Richert, C.2
  • 27
    • 0003366405 scopus 로고    scopus 로고
    • Nanofabrication of helical peptide-shelled dendrimers
    • Higashi N., Koga T., Niwa M. Nanofabrication of helical peptide-shelled dendrimers. J Nanosci Nanotechnol. 3:2001;309-315.
    • (2001) J Nanosci Nanotechnol , vol.3 , pp. 309-315
    • Higashi, N.1    Koga, T.2    Niwa, M.3
  • 28
    • 0036905735 scopus 로고    scopus 로고
    • Enantioselective binding and stable encapsulation of α-amino acids in a helical Poly(L-glutamic acid)-shelled dendrimer in aqueous solutions
    • (Polyglutamic acid) residues on the surface of a PAMAM dendrimer adopted an α-helical conformation and bound the D-α-amino acids Trp, Phe and Tyr with higher affinity than their enantiomers
    • Higashi N., Koga T., Niwa M. Enantioselective binding and stable encapsulation of α-amino acids in a helical Poly(L-glutamic acid)-shelled dendrimer in aqueous solutions. ChemBioChem. 3:2002;448-454. (Polyglutamic acid) residues on the surface of a PAMAM dendrimer adopted an α-helical conformation and bound the D-α-amino acids Trp, Phe and Tyr with higher affinity than their enantiomers.
    • (2002) ChemBioChem , vol.3 , pp. 448-454
    • Higashi, N.1    Koga, T.2    Niwa, M.3
  • 29
    • 0011984899 scopus 로고    scopus 로고
    • Solid-phase synthesis of peptide-dendrimer conjugates for an investigation of integrin binding
    • Monaghan S., Griffith-Johnson D., Matthews I., Bradley M. Solid-phase synthesis of peptide-dendrimer conjugates for an investigation of integrin binding. ARKIVOC. 2:2001;U42-U49.
    • (2001) ARKIVOC , vol.2
    • Monaghan, S.1    Griffith-Johnson, D.2    Matthews, I.3    Bradley, M.4
  • 30
    • 0036905907 scopus 로고    scopus 로고
    • New dendrimer-peptide host-guest complexes: Towards dendrimers as peptide carriers
    • Boas U., Sontjens S.H.M., Jensen K.J., Christensen J.B., Meijer E.W. New dendrimer-peptide host-guest complexes: towards dendrimers as peptide carriers. ChemBioChem. 3:2002;433-439.
    • (2002) ChemBioChem , vol.3 , pp. 433-439
    • Boas, U.1    Sontjens, S.H.M.2    Jensen, K.J.3    Christensen, J.B.4    Meijer, E.W.5
  • 31
    • 0036148318 scopus 로고    scopus 로고
    • Fluorescence studies of PAMAM dendrimers interactions with bovine serum albumin
    • Klajnert B., Bryszewska M. Fluorescence studies of PAMAM dendrimers interactions with bovine serum albumin. Bioelectrochemistry. 55:2002;33-35.
    • (2002) Bioelectrochemistry , vol.55 , pp. 33-35
    • Klajnert, B.1    Bryszewska, M.2
  • 32
    • 0035888228 scopus 로고    scopus 로고
    • Preparation of tris-based dendrimer-grafted core-shell type resin for solid-phase peptide synthesis
    • Cho J.K., Kim D-W., Namgung J., Lee Y-S. Preparation of tris-based dendrimer-grafted core-shell type resin for solid-phase peptide synthesis. Tetrahedron Lett. 42:2001;7443-7445.
    • (2001) Tetrahedron Lett , vol.42 , pp. 7443-7445
    • Cho, J.K.1    Kim, D-W.2    Namgung, J.3    Lee, Y-S.4
  • 33
    • 0035850212 scopus 로고    scopus 로고
    • Evaluation of polyplexes as gene transfer agents
    • Many polycationic transport systems were tested with a variety of cell lines for ability to transfect DNA and for toxicity. Some of the polycation-DNA complexes were less toxic than lipid-DNA systems. A degraded PAMAM dendrimer carrier was one of the more efficient polycations for DNA delivery, but its cytotoxicity was also significant
    • Gebhart C.L., Kabanov A.V. Evaluation of polyplexes as gene transfer agents. J Controlled Release. 73:2001;401-416. Many polycationic transport systems were tested with a variety of cell lines for ability to transfect DNA and for toxicity. Some of the polycation-DNA complexes were less toxic than lipid-DNA systems. A degraded PAMAM dendrimer carrier was one of the more efficient polycations for DNA delivery, but its cytotoxicity was also significant.
    • (2001) J Controlled Release , vol.73 , pp. 401-416
    • Gebhart, C.L.1    Kabanov, A.V.2
  • 34
    • 0034841690 scopus 로고    scopus 로고
    • Efficient in-vitro transfer of a 60-Mb mammalian artificial chromosome into murine and hamster cells using cationic lipids and dendrimers
    • De Jong G., Telenius A., Vanderbyl S., Meitz A., Drayer J. Efficient in-vitro transfer of a 60-Mb mammalian artificial chromosome into murine and hamster cells using cationic lipids and dendrimers. Chromosome Res. 9:2001;475-485.
    • (2001) Chromosome Res , vol.9 , pp. 475-485
    • De Jong, G.1    Telenius, A.2    Vanderbyl, S.3    Meitz, A.4    Drayer, J.5
  • 36
    • 0037134799 scopus 로고    scopus 로고
    • Molecular structure of single DNA complexes with positively charged dendronized polymers
    • Scanning force microscopy data indicates that DNA wraps around the dendronized polymers. How dendrimer carrier systems increase the efficiency of transfection is currently not well understood; this paper represents the first molecular level analysis of DNA-dendrimer interactions that might clarify this issue
    • Gossl I., Shu L., Schluter A.D., Rabe J.P. Molecular structure of single DNA complexes with positively charged dendronized polymers. J Am Chem Soc. 124:2002;6860-6865. Scanning force microscopy data indicates that DNA wraps around the dendronized polymers. How dendrimer carrier systems increase the efficiency of transfection is currently not well understood; this paper represents the first molecular level analysis of DNA-dendrimer interactions that might clarify this issue.
    • (2002) J Am Chem Soc , vol.124 , pp. 6860-6865
    • Gossl, I.1    Shu, L.2    Schluter, A.D.3    Rabe, J.P.4
  • 38
    • 0034794980 scopus 로고    scopus 로고
    • Substituted β-cyclodextrins interact with PAMAM dendrimer-DNA complexes and modify transfection efficiency
    • Roessler B.J., Bielinska A.U., Janczak K., Lee I., Baker J.R. Substituted β-cyclodextrins interact with PAMAM dendrimer-DNA complexes and modify transfection efficiency. Biochem Biophys Res Commun. 283:2001;124-129.
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 124-129
    • Roessler, B.J.1    Bielinska, A.U.2    Janczak, K.3    Lee, I.4    Baker, J.R.5
  • 39
    • 0034915353 scopus 로고    scopus 로고
    • Enhancement of gene expression by polyamidoamine dendrimer conjugates with α-, β-, and γ-cyclodextrins
    • Arima H., Kihara F., Hirayama F., Uekama K. Enhancement of gene expression by polyamidoamine dendrimer conjugates with α-, β-, and γ-cyclodextrins. Bioconjugate Chem. 12:2001;476-484.
    • (2001) Bioconjugate Chem , vol.12 , pp. 476-484
    • Arima, H.1    Kihara, F.2    Hirayama, F.3    Uekama, K.4
  • 40
    • 0037161405 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible high-efficiency DNA delivery
    • Luo D., Haverstick K., Belcheva N., Han E., Saltzman W.M. Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible high-efficiency DNA delivery. Macromolecules. 35:2002;3456-3462.
    • (2002) Macromolecules , vol.35 , pp. 3456-3462
    • Luo, D.1    Haverstick, K.2    Belcheva, N.3    Han, E.4    Saltzman, W.M.5
  • 41
    • 0035478442 scopus 로고    scopus 로고
    • Transcytosis of nanoparticle and dendrimer delivery systems: Evolving vistas
    • Florence A.T., Hussain N. Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas. Adv Drug Deliv Rev. 50:2001;S69-S89.
    • (2001) Adv Drug Deliv Rev , vol.50
    • Florence, A.T.1    Hussain, N.2
  • 42
    • 0035342007 scopus 로고    scopus 로고
    • Poly(amidoamine) (PAMAM) dendrimers: From biomimicry to drug delivery and biomedical applications
    • Esfand R., Tomalia D.A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discov Today. 6:2001;427-436.
    • (2001) Drug Discov Today , vol.6 , pp. 427-436
    • Esfand, R.1    Tomalia, D.A.2
  • 43
    • 0035926274 scopus 로고    scopus 로고
    • Phosphorus dendrimers as new tools to deliver active substances
    • Insecticide (fipronil) residues were attached to the surface of phosphorus-containing dendrimers. The rate of release of fipronil was modulated based on the size of the dendrimer framework and on the nature of the linking functional group
    • Goller R., Vors J-P., Caminade A-M., Majoral J-P. Phosphorus dendrimers as new tools to deliver active substances. Tetrahedron Lett. 42:2001;3587-3590. Insecticide (fipronil) residues were attached to the surface of phosphorus-containing dendrimers. The rate of release of fipronil was modulated based on the size of the dendrimer framework and on the nature of the linking functional group.
    • (2001) Tetrahedron Lett , vol.42 , pp. 3587-3590
    • Goller, R.1    Vors, J-P.2    Caminade, A-M.3    Majoral, J-P.4
  • 44
    • 0037012426 scopus 로고    scopus 로고
    • Detecting the adsorption of dye molecules in homogeneous poly(propylene imine) dendrimer monolayers by surface plasmon resonance sensor
    • Chen S., Yu Q., Li L., Boozer C.L., Homola J., Yee S.S., Jiang S. Detecting the adsorption of dye molecules in homogeneous poly(propylene imine) dendrimer monolayers by surface plasmon resonance sensor. J Am Chem Soc. 124:2002;3395-3401.
    • (2002) J Am Chem Soc , vol.124 , pp. 3395-3401
    • Chen, S.1    Yu, Q.2    Li, L.3    Boozer, C.L.4    Homola, J.5    Yee, S.S.6    Jiang, S.7
  • 45
    • 0036218793 scopus 로고    scopus 로고
    • Dendrimer grafts for delivery of 5-flurouracil
    • Complexation of 5-flurouracil in aqueous solution by a fatty acid functionalized PAMAM dendrimer was observed. After phospholipid coating of the dendrimer-fatty acid macromolecule, oral bioavailability in rats of 5-flurouracil was nearly twice the level of free 5-flurouracil
    • Tripathi P.K., Khopade A.J., Nagaich S., Shrivastava S., Jain S., Jain N.K. Dendrimer grafts for delivery of 5-flurouracil. Pharmazie. 57:2002;261-264. Complexation of 5-flurouracil in aqueous solution by a fatty acid functionalized PAMAM dendrimer was observed. After phospholipid coating of the dendrimer-fatty acid macromolecule, oral bioavailability in rats of 5-flurouracil was nearly twice the level of free 5-flurouracil.
    • (2002) Pharmazie , vol.57 , pp. 261-264
    • Tripathi, P.K.1    Khopade, A.J.2    Nagaich, S.3    Shrivastava, S.4    Jain, S.5    Jain, N.K.6
  • 46
    • 0037203696 scopus 로고    scopus 로고
    • Effect of dendrimer on entrapment and release of bioactive from liposomes
    • Khopade A.J., Caruso F., Tripathi P., Nagaich S., Jain N.K. Effect of dendrimer on entrapment and release of bioactive from liposomes. Int J Pharm. 232:2002;157-162.
    • (2002) Int J Pharm , vol.232 , pp. 157-162
    • Khopade, A.J.1    Caruso, F.2    Tripathi, P.3    Nagaich, S.4    Jain, N.K.5
  • 48
    • 0035206958 scopus 로고    scopus 로고
    • Synthesis and biological studies of 5-aminolevulinic acid-containing dendrimers for photodynamic therapy
    • Battah S.H., Chee C-E., Nakanishi H., Gerscher S., MacRobert A.J., Edwards C. Synthesis and biological studies of 5-aminolevulinic acid-containing dendrimers for photodynamic therapy. Bioconjugate Chem. 12:2001;980-988.
    • (2001) Bioconjugate Chem , vol.12 , pp. 980-988
    • Battah, S.H.1    Chee, C-E.2    Nakanishi, H.3    Gerscher, S.4    MacRobert, A.J.5    Edwards, C.6
  • 49
    • 0037124469 scopus 로고    scopus 로고
    • Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers
    • Lowgeneration PAMAM dendrimers crossed Caco-2-cell monolayers without significant cytotoxicity
    • El-Sayed M., Ginski M., Rhodes C., Ghandehari H. Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers. J Controlled Release. 81:2002;355-365. Lowgeneration PAMAM dendrimers crossed Caco-2-cell monolayers without significant cytotoxicity.
    • (2002) J Controlled Release , vol.81 , pp. 355-365
    • El-Sayed, M.1    Ginski, M.2    Rhodes, C.3    Ghandehari, H.4
  • 50
    • 0036201994 scopus 로고    scopus 로고
    • Biodistribution of a 153Gd-folate dendrimer, generation = 4, in mice with folate-receptor positive and negative ovarian tumor xenografts
    • Konda S.D., Wang S., Brechbiel M., Wiener E.C. Biodistribution of a 153Gd-folate dendrimer, generation = 4, in mice with folate-receptor positive and negative ovarian tumor xenografts. Invest Radiol. 37:2002;199-204.
    • (2002) Invest Radiol , vol.37 , pp. 199-204
    • Konda, S.D.1    Wang, S.2    Brechbiel, M.3    Wiener, E.C.4
  • 51
    • 0037041242 scopus 로고    scopus 로고
    • Reversible affinity interactions of antibody molecules at functionalized dendrimer monolayer: Affinity-sensing surface with reusability
    • Yoon H.C., Lee D., Kim H-S. Reversible affinity interactions of antibody molecules at functionalized dendrimer monolayer: affinity-sensing surface with reusability. Anal Chim Acta. 456:2002;209-218.
    • (2002) Anal Chim Acta , vol.456 , pp. 209-218
    • Yoon, H.C.1    Lee, D.2    Kim, H-S.3
  • 53
  • 57
    • 12244292949 scopus 로고    scopus 로고
    • Inhibition of adhesion of type 1 fimbriated Escherichia coli to highly mannosylated ligands
    • Nagahori N., Lee R.T., Nishimura S-I., Page D., Roy R., Lee Y.C. Inhibition of adhesion of type 1 fimbriated Escherichia coli to highly mannosylated ligands. ChemBioChem. 3:2002;836-844.
    • (2002) ChemBioChem , vol.3 , pp. 836-844
    • Nagahori, N.1    Lee, R.T.2    Nishimura, S-I.3    Page, D.4    Roy, R.5    Lee, Y.C.6
  • 59
    • 0035997509 scopus 로고    scopus 로고
    • The lower-generation polypropylenimine dendrimers are effective gene-transfer agents
    • Zinselmeyer B.H., Mackay S.P., Schatzlein A.G., Uchegbu I.F. The lower-generation polypropylenimine dendrimers are effective gene-transfer agents. Pharm Res. 19:2002;960-967.
    • (2002) Pharm Res , vol.19 , pp. 960-967
    • Zinselmeyer, B.H.1    Mackay, S.P.2    Schatzlein, A.G.3    Uchegbu, I.F.4
  • 60
    • 0036680012 scopus 로고    scopus 로고
    • Dendritic polymer macromolecular carriers for drug delivery
    • Patri A.K., Majoros I.J., Baker J.R. Dendritic polymer macromolecular carriers for drug delivery. Curr Opin Chem Biol. 6:2002;466-471.
    • (2002) Curr Opin Chem Biol , vol.6 , pp. 466-471
    • Patri, A.K.1    Majoros, I.J.2    Baker, J.R.3
  • 61
    • 0037136016 scopus 로고    scopus 로고
    • Synthesis of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates
    • Sun C., Wirsching P., Janda K.D. Synthesis of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates. Bioorg Med Chem Lett. 12:2002;2213-2215.
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 2213-2215
    • Sun, C.1    Wirsching, P.2    Janda, K.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.