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New York: Wiley-VCH
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Newkome G.R., Moorefield C.N., Vogtle F. Dendrimers and Dendrons: Concepts, Syntheses, Applications. 2001;Wiley-VCH, New York.
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Dendrimers and Dendrons: Concepts, Syntheses, Applications
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Newkome, G.R.1
Moorefield, C.N.2
Vogtle, F.3
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0034851810
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Dendrimers: A review of their appeal and applications
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This review provides basic background information for readers who desire an introduction to dendrimer chemistry
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Dykes G.M. Dendrimers: a review of their appeal and applications. J Chem Technol Biotechnol. 76:2001;903-918. This review provides basic background information for readers who desire an introduction to dendrimer chemistry.
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Dykes, G.M.1
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Dendritic polymers in biomedical applications: From potential to clinical use in diagnostics and therapy
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Stiriba S-E., Frey H., Haag R. Dendritic polymers in biomedical applications: from potential to clinical use in diagnostics and therapy. Angew Chem Int Ed Engl. 41:2002;1329-1334.
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Angew Chem Int Ed Engl
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Stiriba, S-E.1
Frey, H.2
Haag, R.3
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5
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0036462602
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The cluster glycoside effect
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Many systems that have been reported for the study of glycocluster-, polymer- and glycodendrimer-protein interactions are compared. The hemagglutination assay, the enzyme-linked lectin assay, isothermal titration microcalorimetry and surface plasmon resonance are evaluated
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Lundquist J.J., Toone E.J. The cluster glycoside effect. Chem Rev. 102:2002;555-578. Many systems that have been reported for the study of glycocluster-, polymer- and glycodendrimer-protein interactions are compared. The hemagglutination assay, the enzyme-linked lectin assay, isothermal titration microcalorimetry and surface plasmon resonance are evaluated.
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Chem Rev
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Lundquist, J.J.1
Toone, E.J.2
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0032476812
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Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
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Mammen M., Choi S-K., Whitesides G.M. Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors. Angew Chem Int Ed Engl. 37:1998;2754-2794.
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Mammen, M.1
Choi, S-K.2
Whitesides, G.M.3
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8
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0037050414
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The lectin-binding properties of six generations of mannose-functionalized dendrimers
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Binding enhancements for mannose-functionalized dendrimers relative to methyl mannose were consistent with monovalent interaction (generations 1 and 2), glycoside clustering (generation 3), and multivalent binding generations 4-6). The wide range of activities that were observed indicates that dendrimer systems can be fine-tuned to obtain any desired level of activity in protein-carbohydrate interactions
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Woller E.K., Cloninger M.C. The lectin-binding properties of six generations of mannose-functionalized dendrimers. Org Lett. 4:2002;7-10. Binding enhancements for mannose-functionalized dendrimers relative to methyl mannose were consistent with monovalent interaction (generations 1 and 2), glycoside clustering (generation 3), and multivalent binding generations 4-6). The wide range of activities that were observed indicates that dendrimer systems can be fine-tuned to obtain any desired level of activity in protein-carbohydrate interactions.
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Org Lett
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Woller, E.K.1
Cloninger, M.C.2
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9
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0034834503
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Mannose functionalization of a sixth generation dendrimer
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Woller E.K., Cloninger M.C. Mannose functionalization of a sixth generation dendrimer. Biomacromolecules. 2:2001;1052-1054.
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Biomacromolecules
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Woller, E.K.1
Cloninger, M.C.2
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0036132021
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Synthesis and protein binding properties of T-antigen containing glycoPAMAM dendrimers
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Baek M-G., Roy R. Synthesis and protein binding properties of T-antigen containing glycoPAMAM dendrimers. Bioorg Med Chem. 10:2002;11-17.
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Bioorg Med Chem
, vol.10
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Baek, M-G.1
Roy, R.2
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11
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0035667728
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Synthesis of lactose dendrimers and multivalency effects in binding to the cholera toxin B subunit
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Vrasidas I, de Mol NJ, Liskamp RMJ, Pieters RJ. Synthesis of lactose dendrimers and multivalency effects in binding to the cholera toxin B subunit. Eur J Org Chem. 2001:4685-4692.
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Eur J Org Chem
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Vrasidas, I.1
De Mol, N.J.2
Liskamp, R.M.J.3
Pieters, R.J.4
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12
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0035814138
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Wedgelike glycodendrimers as inhibitors of binding of mammalian galectins to glycoproteins, lactose maxiclusters, and cell surface glycoconjugates
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Lactosefunctionalized dendrimer wedges were evaluated for binding to galectins using a solid-phase assay and a hemagglutination assay. Activity was highest for galectin-1 in the solid phase assay and highest for galectin-3 in the hemagglutination assay, indicating that factors such as time scale, ligand presentation and static or dynamic setup can strongly influence the protein-carbohydrate interaction
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Andre S., Pieters R.J., Vrsaidas I., Kaltner H., Kusabara I., Liu F-T., Liskamp R.M.J., Gabius H-J. Wedgelike glycodendrimers as inhibitors of binding of mammalian galectins to glycoproteins, lactose maxiclusters, and cell surface glycoconjugates. ChemBioChem. 2:2001;822-830. Lactosefunctionalized dendrimer wedges were evaluated for binding to galectins using a solid-phase assay and a hemagglutination assay. Activity was highest for galectin-1 in the solid phase assay and highest for galectin-3 in the hemagglutination assay, indicating that factors such as time scale, ligand presentation and static or dynamic setup can strongly influence the protein-carbohydrate interaction.
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(2001)
ChemBioChem
, vol.2
, pp. 822-830
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Andre, S.1
Pieters, R.J.2
Vrsaidas, I.3
Kaltner, H.4
Kusabara, I.5
Liu, F-T.6
Liskamp, R.M.J.7
Gabius, H-J.8
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13
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0034746466
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Dilute solution properties of lactosylated polyamidoamine dendrimers and their structural characteristics
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Pavlov G.M., Errington N., Harding S.E., Korneeva E.V., Roy R. Dilute solution properties of lactosylated polyamidoamine dendrimers and their structural characteristics. Polymer. 42:2001;3671-3678.
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Polymer
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Pavlov, G.M.1
Errington, N.2
Harding, S.E.3
Korneeva, E.V.4
Roy, R.5
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14
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0037084343
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Dendritic galactosides based on a β-cyclodextrin core for the construction of site-specific molecular delivery systems: Synthesis and molecular recognition studies
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Vergas-Berenguel A., Ortega-Caballero F., Santoyo-Gonzalez F., Garcia-Lopez J.J., Gimenez-Martinez J.J., Garcia-Fuentes L., Ortiz-Salmeron E. Dendritic galactosides based on a β-cyclodextrin core for the construction of site-specific molecular delivery systems: synthesis and molecular recognition studies. Chem Eur J. 8:2002;812-827.
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Chem Eur J
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Vergas-Berenguel, A.1
Ortega-Caballero, F.2
Santoyo-Gonzalez, F.3
Garcia-Lopez, J.J.4
Gimenez-Martinez, J.J.5
Garcia-Fuentes, L.6
Ortiz-Salmeron, E.7
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15
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0035856932
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Trehalose-based octopus glycosides for the synthesis of carbohydrate-centered PAMAM dendrimers and thiourea-bridged glycoclusters
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Dubber M., Lindhorst T.K. Trehalose-based octopus glycosides for the synthesis of carbohydrate-centered PAMAM dendrimers and thiourea-bridged glycoclusters. Org Lett. 3:2001;4019-4022.
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Org Lett
, vol.3
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Dubber, M.1
Lindhorst, T.K.2
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16
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0037006232
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Ferrocene-containing carbohydrate dendrimers
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Ashton P.R., Balzani V., Clemente-Leon M., Colonna B., Credi A., Jayaraman J., Raymo F.M., Stoddart J.F., Venturi M. Ferrocene-containing carbohydrate dendrimers. Chem Eur J. 8:2002;673-684.
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Chem Eur J
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Ashton, P.R.1
Balzani, V.2
Clemente-Leon, M.3
Colonna, B.4
Credi, A.5
Jayaraman, J.6
Raymo, F.M.7
Stoddart, J.F.8
Venturi, M.9
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17
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0036680874
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Chemical modification of chitosan 11: Chitosan-dendrimer hybrid as a tree like molecule
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Dendrimers functionalized with sialic acid residues were attached to chitosan, a non-toxic and biodegradable sugar-based polymer to provide a new graft glycodendrimer-polymer motif
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Sashiwa H., Shigemasa Y., Roy R. Chemical modification of chitosan 11: chitosan-dendrimer hybrid as a tree like molecule. Carbohydr Polym. 49:2002;195-205. Dendrimers functionalized with sialic acid residues were attached to chitosan, a non-toxic and biodegradable sugar-based polymer to provide a new graft glycodendrimer-polymer motif.
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Carbohydr Polym
, vol.49
, pp. 195-205
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Sashiwa, H.1
Shigemasa, Y.2
Roy, R.3
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0034958233
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Parallel combinatorial synthesis of glycodendrimers and their hydrogelation properties
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McWatt M, Boons G-J. Parallel combinatorial synthesis of glycodendrimers and their hydrogelation properties. Eur J Org Chem. 2001:2535-2545.
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Eur J Org Chem
, pp. 2535-2545
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McWatt, M.1
Boons, G.-J.2
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0036177932
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Peptide dendrimers: Applications and synthesis
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Sadler K., Tam J.P. Peptide dendrimers: applications and synthesis. Rev Mol Biotechnol. 90:2002;195-229.
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Rev Mol Biotechnol
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Sadler, K.1
Tam, J.P.2
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21
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0036183822
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Antimicrobial dendrimeric peptides
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Lysine core dendrimers with tetrapeptides and octapeptides were more soluble in water, more stable to proteolysis and less toxic to human cells than their linear polymeric analogs; comparable antimicrobial potency was demonstrated
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Tam J.P., Lu Y-A., Yang J-L. Antimicrobial dendrimeric peptides. Eur J Biochem. 269:2002;923-932. Lysine core dendrimers with tetrapeptides and octapeptides were more soluble in water, more stable to proteolysis and less toxic to human cells than their linear polymeric analogs; comparable antimicrobial potency was demonstrated.
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Eur J Biochem
, vol.269
, pp. 923-932
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Tam, J.P.1
Lu, Y-A.2
Yang, J-L.3
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22
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0037170807
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Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin
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Kasai S., Nagasawa H., Shimamura M., Uto Y., Hori H. Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin. Bioorg Med Chem Lett. 12:2002;951-954.
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Bioorg Med Chem Lett
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Kasai, S.1
Nagasawa, H.2
Shimamura, M.3
Uto, Y.4
Hori, H.5
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24
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0037042201
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Increased intracellular calcium is required for neurite outgrowth induced by a synthetic peptide ligand of NCAM
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Lysine core dendrimers with an 11-mer peptide surface residue that is a ligand of NCAM induced an increase in intracellular calcium. Studies with this dendrimer suggest that NCAM-dependent neurite outgrowth requires calcium mobilization
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Ronn L.C.B., Dissing S., Holm A., Berezin V., Bock E. Increased intracellular calcium is required for neurite outgrowth induced by a synthetic peptide ligand of NCAM. FEBS Lett. 518:2002;60-66. Lysine core dendrimers with an 11-mer peptide surface residue that is a ligand of NCAM induced an increase in intracellular calcium. Studies with this dendrimer suggest that NCAM-dependent neurite outgrowth requires calcium mobilization.
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(2002)
FEBS Lett
, vol.518
, pp. 60-66
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Ronn, L.C.B.1
Dissing, S.2
Holm, A.3
Berezin, V.4
Bock, E.5
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25
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0034781645
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Synthesis, isolation and characterization of Plasmodium falciparum antigenic tetrabranched peptide dendrimers obtained by thiazolidine linkages
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Chaves F., Calvo J.C., Carvajal C., Rivera Z., Ramirez L., Pinto M., Trujillo M., Guzman F., Patarroyo M.E. Synthesis, isolation and characterization of Plasmodium falciparum antigenic tetrabranched peptide dendrimers obtained by thiazolidine linkages. J Pept Res. 58:2001;307-316.
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J Pept Res
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Chaves, F.1
Calvo, J.C.2
Carvajal, C.3
Rivera, Z.4
Ramirez, L.5
Pinto, M.6
Trujillo, M.7
Guzman, F.8
Patarroyo, M.E.9
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26
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0035833065
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Synthesis and nuclease stability of trilysyl dendrimer-oligodeoxyribonucleotide hybrids
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Sarracino D.A., Richert C. Synthesis and nuclease stability of trilysyl dendrimer-oligodeoxyribonucleotide hybrids. Bioorg Med Chem Lett. 11:2001;1733-1736.
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Bioorg Med Chem Lett
, vol.11
, pp. 1733-1736
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Sarracino, D.A.1
Richert, C.2
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27
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0003366405
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Nanofabrication of helical peptide-shelled dendrimers
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Higashi N., Koga T., Niwa M. Nanofabrication of helical peptide-shelled dendrimers. J Nanosci Nanotechnol. 3:2001;309-315.
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J Nanosci Nanotechnol
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, pp. 309-315
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Higashi, N.1
Koga, T.2
Niwa, M.3
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28
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0036905735
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Enantioselective binding and stable encapsulation of α-amino acids in a helical Poly(L-glutamic acid)-shelled dendrimer in aqueous solutions
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(Polyglutamic acid) residues on the surface of a PAMAM dendrimer adopted an α-helical conformation and bound the D-α-amino acids Trp, Phe and Tyr with higher affinity than their enantiomers
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Higashi N., Koga T., Niwa M. Enantioselective binding and stable encapsulation of α-amino acids in a helical Poly(L-glutamic acid)-shelled dendrimer in aqueous solutions. ChemBioChem. 3:2002;448-454. (Polyglutamic acid) residues on the surface of a PAMAM dendrimer adopted an α-helical conformation and bound the D-α-amino acids Trp, Phe and Tyr with higher affinity than their enantiomers.
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(2002)
ChemBioChem
, vol.3
, pp. 448-454
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Higashi, N.1
Koga, T.2
Niwa, M.3
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29
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0011984899
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Solid-phase synthesis of peptide-dendrimer conjugates for an investigation of integrin binding
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Monaghan S., Griffith-Johnson D., Matthews I., Bradley M. Solid-phase synthesis of peptide-dendrimer conjugates for an investigation of integrin binding. ARKIVOC. 2:2001;U42-U49.
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ARKIVOC
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Monaghan, S.1
Griffith-Johnson, D.2
Matthews, I.3
Bradley, M.4
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30
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0036905907
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New dendrimer-peptide host-guest complexes: Towards dendrimers as peptide carriers
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Boas U., Sontjens S.H.M., Jensen K.J., Christensen J.B., Meijer E.W. New dendrimer-peptide host-guest complexes: towards dendrimers as peptide carriers. ChemBioChem. 3:2002;433-439.
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ChemBioChem
, vol.3
, pp. 433-439
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Boas, U.1
Sontjens, S.H.M.2
Jensen, K.J.3
Christensen, J.B.4
Meijer, E.W.5
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31
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0036148318
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Fluorescence studies of PAMAM dendrimers interactions with bovine serum albumin
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Klajnert B., Bryszewska M. Fluorescence studies of PAMAM dendrimers interactions with bovine serum albumin. Bioelectrochemistry. 55:2002;33-35.
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Bioelectrochemistry
, vol.55
, pp. 33-35
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Klajnert, B.1
Bryszewska, M.2
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32
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0035888228
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Preparation of tris-based dendrimer-grafted core-shell type resin for solid-phase peptide synthesis
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Cho J.K., Kim D-W., Namgung J., Lee Y-S. Preparation of tris-based dendrimer-grafted core-shell type resin for solid-phase peptide synthesis. Tetrahedron Lett. 42:2001;7443-7445.
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Tetrahedron Lett
, vol.42
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Cho, J.K.1
Kim, D-W.2
Namgung, J.3
Lee, Y-S.4
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33
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0035850212
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Evaluation of polyplexes as gene transfer agents
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Many polycationic transport systems were tested with a variety of cell lines for ability to transfect DNA and for toxicity. Some of the polycation-DNA complexes were less toxic than lipid-DNA systems. A degraded PAMAM dendrimer carrier was one of the more efficient polycations for DNA delivery, but its cytotoxicity was also significant
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Gebhart C.L., Kabanov A.V. Evaluation of polyplexes as gene transfer agents. J Controlled Release. 73:2001;401-416. Many polycationic transport systems were tested with a variety of cell lines for ability to transfect DNA and for toxicity. Some of the polycation-DNA complexes were less toxic than lipid-DNA systems. A degraded PAMAM dendrimer carrier was one of the more efficient polycations for DNA delivery, but its cytotoxicity was also significant.
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(2001)
J Controlled Release
, vol.73
, pp. 401-416
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Gebhart, C.L.1
Kabanov, A.V.2
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0034841690
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Efficient in-vitro transfer of a 60-Mb mammalian artificial chromosome into murine and hamster cells using cationic lipids and dendrimers
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De Jong G., Telenius A., Vanderbyl S., Meitz A., Drayer J. Efficient in-vitro transfer of a 60-Mb mammalian artificial chromosome into murine and hamster cells using cationic lipids and dendrimers. Chromosome Res. 9:2001;475-485.
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Chromosome Res
, vol.9
, pp. 475-485
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De Jong, G.1
Telenius, A.2
Vanderbyl, S.3
Meitz, A.4
Drayer, J.5
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35
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0035181482
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Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice
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Sato N., Kobayashi H., Saga T., Nakamoto Y., Ishimori T., Togashi K., Fujibayashi Y., Konishi J., Brechbiel M.W. Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice. Clin Cancer Res. 7:2001;3606-3612.
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Clin Cancer Res
, vol.7
, pp. 3606-3612
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Sato, N.1
Kobayashi, H.2
Saga, T.3
Nakamoto, Y.4
Ishimori, T.5
Togashi, K.6
Fujibayashi, Y.7
Konishi, J.8
Brechbiel, M.W.9
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36
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0037134799
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Molecular structure of single DNA complexes with positively charged dendronized polymers
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Scanning force microscopy data indicates that DNA wraps around the dendronized polymers. How dendrimer carrier systems increase the efficiency of transfection is currently not well understood; this paper represents the first molecular level analysis of DNA-dendrimer interactions that might clarify this issue
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Gossl I., Shu L., Schluter A.D., Rabe J.P. Molecular structure of single DNA complexes with positively charged dendronized polymers. J Am Chem Soc. 124:2002;6860-6865. Scanning force microscopy data indicates that DNA wraps around the dendronized polymers. How dendrimer carrier systems increase the efficiency of transfection is currently not well understood; this paper represents the first molecular level analysis of DNA-dendrimer interactions that might clarify this issue.
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(2002)
J Am Chem Soc
, vol.124
, pp. 6860-6865
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Gossl, I.1
Shu, L.2
Schluter, A.D.3
Rabe, J.P.4
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37
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0035502556
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Combination of electroporation and DNA/dendrimer complexes enhances gene transfer into murine cardiac transplants
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Wang Y., Bai Y., Price C., Boros P., Qin L., Bielinska A.U., Kukowska-Latallo J.F., Baker J.R., Bromberg J.S. Combination of electroporation and DNA/dendrimer complexes enhances gene transfer into murine cardiac transplants. Am J Transplant. 1:2001;334-338.
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Am J Transplant
, vol.1
, pp. 334-338
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Wang, Y.1
Bai, Y.2
Price, C.3
Boros, P.4
Qin, L.5
Bielinska, A.U.6
Kukowska-Latallo, J.F.7
Baker, J.R.8
Bromberg, J.S.9
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38
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0034794980
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Substituted β-cyclodextrins interact with PAMAM dendrimer-DNA complexes and modify transfection efficiency
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Roessler B.J., Bielinska A.U., Janczak K., Lee I., Baker J.R. Substituted β-cyclodextrins interact with PAMAM dendrimer-DNA complexes and modify transfection efficiency. Biochem Biophys Res Commun. 283:2001;124-129.
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Biochem Biophys Res Commun
, vol.283
, pp. 124-129
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Roessler, B.J.1
Bielinska, A.U.2
Janczak, K.3
Lee, I.4
Baker, J.R.5
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39
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0034915353
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Enhancement of gene expression by polyamidoamine dendrimer conjugates with α-, β-, and γ-cyclodextrins
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Arima H., Kihara F., Hirayama F., Uekama K. Enhancement of gene expression by polyamidoamine dendrimer conjugates with α-, β-, and γ-cyclodextrins. Bioconjugate Chem. 12:2001;476-484.
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Bioconjugate Chem
, vol.12
, pp. 476-484
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Arima, H.1
Kihara, F.2
Hirayama, F.3
Uekama, K.4
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40
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0037161405
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Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible high-efficiency DNA delivery
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Luo D., Haverstick K., Belcheva N., Han E., Saltzman W.M. Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible high-efficiency DNA delivery. Macromolecules. 35:2002;3456-3462.
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Macromolecules
, vol.35
, pp. 3456-3462
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Luo, D.1
Haverstick, K.2
Belcheva, N.3
Han, E.4
Saltzman, W.M.5
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41
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0035478442
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Transcytosis of nanoparticle and dendrimer delivery systems: Evolving vistas
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Florence A.T., Hussain N. Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas. Adv Drug Deliv Rev. 50:2001;S69-S89.
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(2001)
Adv Drug Deliv Rev
, vol.50
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Florence, A.T.1
Hussain, N.2
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42
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0035342007
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Poly(amidoamine) (PAMAM) dendrimers: From biomimicry to drug delivery and biomedical applications
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Esfand R., Tomalia D.A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discov Today. 6:2001;427-436.
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Drug Discov Today
, vol.6
, pp. 427-436
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Esfand, R.1
Tomalia, D.A.2
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43
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0035926274
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Phosphorus dendrimers as new tools to deliver active substances
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Insecticide (fipronil) residues were attached to the surface of phosphorus-containing dendrimers. The rate of release of fipronil was modulated based on the size of the dendrimer framework and on the nature of the linking functional group
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Goller R., Vors J-P., Caminade A-M., Majoral J-P. Phosphorus dendrimers as new tools to deliver active substances. Tetrahedron Lett. 42:2001;3587-3590. Insecticide (fipronil) residues were attached to the surface of phosphorus-containing dendrimers. The rate of release of fipronil was modulated based on the size of the dendrimer framework and on the nature of the linking functional group.
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(2001)
Tetrahedron Lett
, vol.42
, pp. 3587-3590
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Goller, R.1
Vors, J-P.2
Caminade, A-M.3
Majoral, J-P.4
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44
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