Surface engineering of inorganic nanoparticles for imaging and therapy

Advanced Drug Delivery Reviews

Volumn 65, Issue 5, 2013, Pages 622-648

  Nam, Jutaek ^a   Won, Nayoun ^a   Bang, Jiwon ^a   Jin, Ho ^a   Park, Joonhyuck ^a   Jung, Sungwook ^a   Jung, Sanghwa ^a   Park, Youngrong ^a   Kim, Sungjee ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Charge; Conjugation; Hydrodynamic size; Imaging; Nanomedicine; Nanoparticle; Quantum dot; Surface; Targeting; Therapy

Indexed keywords

CHARGE; CONJUGATION; HYDRODYNAMIC SIZE; TARGETING; THERAPY;

BIOMOLECULES; CARDIOVASCULAR SYSTEM; CELL MEMBRANES; CYTOLOGY; DESIGN; ELECTRONIC PROPERTIES; HYDRODYNAMICS; IMAGING TECHNIQUES; LIGANDS; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; POLYMERS; RESIDENCE TIME DISTRIBUTION; SEMICONDUCTOR QUANTUM DOTS; SURFACE CHARGE; SURFACE PROPERTIES; SURFACES; TISSUE; TOXICITY;

COATINGS;

INORGANIC COMPOUND; INORGANIC NANOPARTICLE; LANTHANIDE DOPED NANOPARTICLE; LIGAND; LIPID; METAL NANOPARTICLE; METAL OXIDE; MONOCLONAL ANTIBODY; NANOPARTICLE; POLYMER; SEMICONDUCTOR NANOPARTICLE; SURFACTANT; UNCLASSIFIED DRUG;

ADSORPTION; BIOCOMPATIBILITY; CELL INTERACTION; CELL LABELING; CELL MEMBRANE; CHEMICAL ENGINEERING; CHEMICAL REACTION; CIRCULATION; CONJUGATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG TARGETING; DRUG UPTAKE; ENCAPSULATION; HUMAN; HYDRODYNAMICS; HYDROPHOBICITY; IN VIVO STUDY; MATERIAL COATING; MICELLE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; REVIEW; SURFACE ENGINEERING; SURFACE PROPERTY;

ANIMALS; CHEMICAL ENGINEERING; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INORGANIC CHEMICALS; METALS; MOLECULAR IMAGING; NANOPARTICLES; POLYMERS; SURFACE PROPERTIES; TISSUE DISTRIBUTION;

EID: 84878345681     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.08.015     Document Type: Review

References (308)

1. Michalet X., Pinaud F.F., Bentolila L.A., Tsay J.M., Doose S., Li J.J., Sundaresan G., Wu A.M., Gambhir S.S., Weiss S. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 2005, 307:538-544.
2. Jain P.K., Huang X., El-Sayed I.H., El-Sayed M.A. Noble metals on the nanoscale: optical and photothermal properties and some applications in imaging, sensing, biology, and medicine. Acc. Chem. Res. 2008, 41:1578-1586.
3. Biju V., Itoh T., Anas A., Sujith A., Ishikawa M. Semiconductor quantum dots and metal nanoparticles: syntheses, optical properties, and biological applications. Anal. Bioanal. Chem. 2008, 391:2469-2495.
4. Sharma P., Brown S., Walter G., Santra S., Moudgil B. Nanoparticles for bioimaging. Adv. Colloid Interface Sci. 2006, 123-126:471-485.
5. Cho E.C., Glaus C., Chen J., Welch M.J., Xia Y. Inorganic nanoparticle-based contrast agents for molecular imaging. Trends Mol. Med. 2010, 16:561-573.
6. Jana N.R. Design and development of quantum dots and other nanoparticles based cellular imaging probe. Phys. Chem. Chem. Phys. 2011, 13:385-396.
7. Huang X., Jain P., El-Sayed I., El-Sayed M. Plasmonic photothermal therapy (PPTT) using gold nanoparticles. Lasers Med. Sci. 2008, 23:217-228.
8. Lal S., Clare S.E., Halas N.J. Nanoshell-enabled photothermal cancer therapy: impending clinical impact. Acc. Chem. Res. 2008, 41:1842-1851.
9. Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 1986, 46:6387-6392.
10. Peer D., Karp J.M., Hong S., Farokhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2007, 2:751-760.
11. Medintz I.L., Uyeda H.T., Goldman E.R., Mattoussi H. Quantum dot bioconjugates for imaging, labelling and sensing. Nat. Mater. 2005, 4:435-446.
12. Chou L.Y.T., Ming K., Chan W.C.W. Strategies for the intracellular delivery of nanoparticles. Chem. Soc. Rev. 2011, 40:233-245.
13. Smith A.M., Duan H., Mohs A.M., Nie S. Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv. Drug Deliv. Rev. 2008, 60:1226-1240.
14. Murray C.B., Norris D.J., Bawendi M.G. Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites. J. Am. Chem. Soc. 1993, 115:8706-8715.
15. Hussain S., Won N., Nam J., Bang J., Chung H., Kim S. One-pot fabrication of high-quality InP/ZnS (core/shell) quantum dots and their application to cellular imaging. ChemPhysChem 2009, 10:1466-1470.
16. Bang J., Park J., Lee J.H., Won N., Nam J., Lim J., Chang B.Y., Lee H.J., Chon B., Shin J., Park J.B., Choi J.H., Cho K., Park S.M., Joo T., Kim S. ZnTe/ZnSe (core/shell) type-II quantum dots: their optical and photovoltaic properties. Chem. Mater. 2009, 22:233-240.
17. Zhang D., Neumann O., Wang H., Yuwono V.M., Barhoumi A., Perham M., Hartgerink J.D., Wittung-Stafshede P., Halas N.J. Gold nanoparticles can induce the formation of protein-based aggregates at physiological pH. Nano Lett. 2009, 9:666-671.
18. Nel A.E., Madler L., Velegol D., Xia T., Hoek E.M.V., Somasundaran P., Klaessig F., Castranova V., Thompson M. Understanding biophysicochemical interactions at the nano-bio interface. Nat. Mater. 2009, 8:543-557.
19. Bawendi M.G., Steigerwald M.L., Brus L.E. The quantum mechanics of larger semiconductor clusters ("quantum dots"). Annu. Rev. Phys. Chem. 1990, 41:477-496.
20. Alivisatos A.P. Semiconductor clusters, nanocrystals, and quantum dots. Science 1996, 271:933-937.
21. Bang J., Chon B., Won N., Nam J., Joo T., Kim S. Spectral switching of type-II quantum dots by charging. J. Phys. Chem. C 2009, 113:6320-6323.
22. Bruchez M., Moronne M., Gin P., Weiss S., Alivisatos A.P. Semiconductor nanocrystals as fluorescent biological labels. Science 1998, 281:2013-2016.
23. Chan W.C.W., Nie S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 1998, 281:2016-2018.
24. Jaiswal J.K., Mattoussi H., Mauro J.M., Simon S.M. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat. Biotechnol. 2003, 21:47-51.
25. Dahan M., Lévi S., Luccardini C., Rostaing P., Riveau B., Triller A. Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 2003, 302:442-445.
26. Courty S., Luccardini C., Bellaiche Y., Cappello G., Dahan M. Tracking individual kinesin motors in living cells using single quantum-dot imaging. Nano Lett. 2006, 6:1491-1495.
27. Zhang R., Rothenberg E., Fruhwirth G., Simonson P.D., Ye F., Golding I., Ng T., Lopes W., Selvin P.R. Two-photon 3D FIONA of individual quantum dots in an aqueous environment. Nano Lett. 2011, 11:4074-4078.
28. Cai W., Shin D.-W., Chen K., Gheysens O., Cao Q., Wang S.X., Gambhir S.S., Chen X. Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett. 2006, 6:669-676.
29. Kim S., Lim Y.T., Soltesz E.G., De Grand A.M., Lee J., Nakayama A., Parker J.A., Mihaljevic T., Laurence R.G., Dor D.M., Cohn L.H., Bawendi M.G., Frangioni J.V. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat. Biotechnol. 2004, 22:93-97.
30. Gao X., Cui Y., Levenson R.M., Chung L.W.K., Nie S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 2004, 22:969-976.
31. Kobayashi H., Hama Y., Koyama Y., Barrett T., Regino C.A.S., Urano Y., Choyke P.L. Simultaneous multicolor imaging of five different lymphatic basins using quantum dots. Nano Lett. 2007, 7:1711-1716.
32. Henglein A. Small-particle research: physicochemical properties of extremely small colloidal metal and semiconductor particles. Chem. Rev. 1989, 89:1861-1873.
33. Steigerwald M.L., Alivisatos A.P., Gibson J.M., Harris T.D., Kortan R., Muller A.J., Thayer A.M., Duncan T.M., Douglass D.C., Brus L.E. Surface derivatization and isolation of semiconductor cluster molecules. J. Am. Chem. Soc. 1988, 110:3046-3050.
34. Spanhel L., Haase M., Weller H., Henglein A. Photochemistry of colloidal semiconductors. 20. Surface modification and stability of strong luminescing CdS particles. J. Am. Chem. Soc. 1987, 109:5649-5655.
35. Peng Z.A., Peng X. Formation of high-quality CdTe, CdSe, and CdS nanocrystals using CdO as precursor. J. Am. Chem. Soc. 2000, 123:183-184.
36. Hines M.A., Guyot-Sionnest P. Bright UV-blue luminescent colloidal ZnSe nanocrystals. J. Phys. Chem. B 1998, 102:3655-3657.
37. Dabbousi B.O., Rodriguez-Viejo J., Mikulec F.V., Heine J.R., Mattoussi H., Ober R., Jensen K.F., Bawendi M.G. (CdSe)ZnS core-shell quantum dots: synthesis and characterization of a size series of highly luminescent nanocrystallites. J. Phys. Chem. B 1997, 101:9463-9475.
38. Xie R., Battaglia D., Peng X. Colloidal InP nanocrystals as efficient emitters covering blue to near-infrared. J. Am. Chem. Soc. 2007, 129:15432-15433.
39. Xie R., Rutherford M., Peng X. Formation of high-quality I-III-VI semiconductor nanocrystals by tuning relative reactivity of cationic precursors. J. Am. Chem. Soc. 2009, 131:5691-5697.
40. Pietryga J.M., Werder D.J., Williams D.J., Casson J.L., Schaller R.D., Klimov V.I., Hollingsworth J.A. Utilizing the lability of lead selenide to produce heterostructured nanocrystals with bright, stable infrared emission. J. Am. Chem. Soc. 2008, 130:4879-4885.
41. Yu W.W., Peng X. Formation of high-quality CdS and other II-VI semiconductor nanocrystals in noncoordinating solvents: tunable reactivity of monomers. Angew. Chem. Int. Ed. 2002, 41:2368-2371.
42. Allen P.M., Bawendi M.G. Ternary I-III-VI quantum dots luminescent in the red to near-infrared. J. Am. Chem. Soc. 2008, 130:9240-9241.
43. Kim S., Fisher B., Eisler H.-J., Bawendi M. Type-II quantum dots: CdTe/CdSe (core/shell) and CdSe/ZnTe (core/shell) heterostructures. J. Am. Chem. Soc. 2003, 125:11466-11467.
44. Hinds S., Myrskog S., Levina L., Koleilat G., Yang J., Kelley S.O., Sargent E.H. NIR-emitting colloidal quantum dots having 26% luminescence quantum yield in buffer solution. J. Am. Chem. Soc. 2007, 129:7218-7219.
45. Xie R., Peng X. Synthetic scheme for high-quality InAs nanocrystals based on self-focusing and one-pot synthesis of InAs-based core-shell nanocrystals. Angew. Chem. Int. Ed. 2008, 47:7677-7680.
46. 2S quantum dots from a single source precursor. J. Am. Chem. Soc. 2010, 132:1470-1471.
47. Xia Y., Xiong Y., Lim B., Skrabalak S.E. Shape-controlled synthesis of metal nanocrystals: simple chemistry meets complex physics?. Angew. Chem. Int. Ed. 2009, 48:60-103.
48. Park J., Joo J., Kwon S.G., Jang Y., Hyeon T. Synthesis of monodisperse spherical nanocrystals. Angew. Chem. Int. Ed. 2007, 46:4630-4660.
49. Jun Y.-w., Choi J.-s., Cheon J. Shape control of semiconductor and metal oxide nanocrystals through nonhydrolytic colloidal routes. Angew. Chem. Int. Ed. 2006, 45:3414.
50. Jeong U., Teng X., Wang Y., Yang H., Xia Y. Superparamagnetic colloids: controlled synthesis and niche applications. Adv. Mater. 2007, 19:33-60.
51. Sun S.H., Murray C.B. Synthesis of monodisperse cobalt nanocrystals and their assembly into magnetic superlattices (invited). J. Appl. Phys. 1999, 85:4325-4330.
52. Hyeon T., Lee S.S., Park J., Chung Y., Bin Na H. Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process. J. Am. Chem. Soc. 2001, 123:12798-12801.
53. Dumestre F., Chaudret B., Amiens C., Renaud P., Fejes P. Superlattices of iron nanocubes synthesized from Fe[N(SiMe3)(2)](2). Science 2004, 303:821-823.
54. Sun S.H., Murray C.B., Weller D., Folks L., Moser A. Monodisperse FePt nanoparticles and ferromagnetic FePt nanocrystal superlattices. Science 2000, 287:1989-1992.
55. Chen M., Liu J.P., Sun S. One-step synthesis of FePt nanoparticles with tunable size. J. Am. Chem. Soc. 2004, 126:8394-8395.
56. Liu C., Wu X., Klemmer T., Shukla N., Yang X., Weller D., Roy A.G., Tanase M., Laughlin D. Polyol process synthesis of monodispersed FePt nanoparticles. J. Phys. Chem. B 2004, 108:6121-6123.
57. Shevchenko E.V., Talapin D.V., Rogach A.L., Kornowski A., Haase M., Weller H. Colloidal synthesis and self-assembly of CoPt(3) nanocrystals. J. Am. Chem. Soc. 2002, 124:11480-11485.
58. Chen M., Nikles D.E. Synthesis of spherical FePd and CoPt nanoparticles. J. Appl. Phys. 2002, 91:8477-8479.
59. 3 nanocrystals. J. Am. Chem. Soc. 2003, 125:9090-9101.
60. 100-x-y nanoparticles. Nano Lett. 2002, 2:211-214.
61. Shankar S.S., Deka S. Metal nanocrystals and their applications in biomedical systems. Sci. Adv. Mater. 2011, 3:169-195.
62. Jain P.K., Lee K.S., El-Sayed I.H., El-Sayed M.A. Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J. Phys. Chem. B 2006, 110:7238-7248.
63. Schultz S., Smith D.R., Mock J.J., Schultz D.A. Single-target molecule detection with nonbleaching multicolor optical immunolabels. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:996-1001.
64. El-Sayed I.H., Huang X., El-Sayed M.A. Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer. Nano Lett. 2005, 5:829-834.
65. Qian W., Huang X., Kang B., El-Sayed M.A. Dark-field light scattering imaging of living cancer cell component from birth through division using bioconjugated gold nanoprobes. J. Biomed. Opt. 2010, 15:46025-46029.
66. Chen J., Saeki F., Wiley B.J., Cang H., Cobb M.J., Li Z.-Y., Au L., Zhang H., Kimmey M.B., Li, Xia Y. Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents. Nano Lett. 2005, 5:473-477.
67. Gobin A.M., Lee M.H., Halas N.J., James W.D., Drezek R.A., West J.L. Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy. Nano Lett. 2007, 7:1929-1934.
68. Jung Y., Reif R., Zeng Y., Wang R.K. Three-dimensional high-resolution imaging of gold nanorods uptake in sentinel lymph nodes. Nano Lett. 2011, 11:2938-2943.
69. Yang X.M., Skrabalak S.E., Li Z.Y., Xia Y.N., Wang L.H.V. Photoacoustic tomography of a rat cerebral cortex in vivo with Au nanocages as an optical contrast agent. Nano Lett. 2007, 7:3798-3802.
70. Mallidi S., Larson T., Aaron J., Sokolov K., Emelianov S. Molecular specific optoacoustic imaging with plasmonic nanoparticles. Opt. Express 2007, 15:6583-6588.
71. Li P.-C., Wang C.-R.C., Shieh D.-B., Wei C.-W., Liao C.-K., Poe C., Jhan S., Ding A.-A., Wu Y.-N. In vivo photoacoustic molecular imaging withsimultaneous multiple selective targeting using antibody-conjugated gold nanorods. Opt. Express 2008, 16:18605-18615.
72. Li M.-L., Wang J.C., Schwartz J.A., Gill-Sharp K.L., Stoica G., Wang L.V. In-vivo photoacoustic microscopy of nanoshell extravasation from solid tumor vasculature. J. Biomed. Opt. 2009, 14:10503-10507.
73. Kim C., Cho E.C., Chen J., Song K.H., Au L., Favazza C., Zhang Q., Cobley C.M., Gao F., Xia Y., Wang L.V. In vivo molecular photoacoustic tomography of melanomas targeted by bioconjugated gold nanocages. ACS Nano 2010, 4:4559-4564.
74. Hirsch L.R., Stafford R.J., Bankson J.A., Sershen S.R., Rivera B., Price R.E., Hazle J.D., Halas N.J., West J.L. Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:13549-13554.
75. Loo C., Lowery A., Halas N., West J., Drezek R. Immunotargeted nanoshells for integrated cancer imaging and therapy. Nano Lett. 2005, 5:709-711.
76. Huang X., El-Sayed I.H., Qian W., El-Sayed M.A. Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J. Am. Chem. Soc. 2006, 128:2115-2120.
77. Chen J., Wang D., Xi J., Au L., Siekkinen A., Warsen A., Li Z.Y., Zhang H., Xia Y., Li X. Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. Nano Lett. 2007, 7:1318-1322.
78. von Maltzahn G., Park J.-H., Agrawal A., Bandaru N.K., Das S.K., Sailor M.J., Bhatia S.N. Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Res. 2009, 69:3892-3900.
79. Nam J., Won N., Jin H., Chung H., Kim S. pH-induced aggregation of gold nanoparticles for photothermal cancer therapy. J. Am. Chem. Soc. 2009, 131:13639-13645.
80. Wu X., Ming T., Wang X., Wang P., Wang J., Chen J. High-photoluminescence-yield gold nanocubes: for cell imaging and photothermal therapy. ACS Nano 2009, 4:113-120.
81. Kim D., Park S., Lee J.H., Jeong Y.Y., Jon S. Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. J. Am. Chem. Soc. 2007, 129:7661-7665.
82. Alric C., Taleb J., Duc G.L., Mandon C., Billotey C., Meur-Herland A.L., Brochard T., Vocanson F., Janier M., Perriat P., Roux S., Tillement O. Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging. J. Am. Chem. Soc. 2008, 130:5908-5915.
83. Qian X., Peng X.-H., Ansari D.O., Yin-Goen Q., Chen G.Z., Shin D.M., Yang L., Young A.N., Wang M.D., Nie S. In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. Nat. Biotechnol. 2008, 26:83-90.
84. Maiti K.K., Samanta A., Vendrell M., Soh K.-S., Olivo M., Chang Y.-T. Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters. Chem. Commun. 2011, 47:3514-3516.
85. Samanta A., Maiti K.K., Soh K.-S., Liao X., Vendrell M., Dinish U.S., Yun S.-W., Bhuvaneswari R., Kim H., Rautela S., Chung J., Olivo M., Chang Y.-T. Ultrasensitive near-infrared Raman reporters for SERS-based in vivo cancer detection. Angew. Chem. Int. Ed. 2011, 50:6089-6092.
86. Kelly K.L., Coronado E., Zhao L.L., Schatz G.C. The optical properties of metal nanoparticles: the influence of size, shape, and dielectric environment. J. Phys. Chem. B 2002, 107:668-677.
87. Oldenburg S.J., Averitt R.D., Westcott S.L., Halas N.J. Nanoengineering of optical resonances. Chem. Phys. Lett. 1998, 288:243-247.
88. Han M.S., Lytton-Jean A.K.R., Mirkin C.A. A gold nanoparticle based approach for screening triplex DNA binders. J. Am. Chem. Soc. 2006, 128:4954-4955.
89. Jung E., Kim S., Kim Y., Seo S.H., Lee S.S., Han M.S., Lee S. A colorimetric high-throughput screening method for palladium-catalyzed coupling reactions of aryl iodides using a gold nanoparticle-based iodide-selective probe. Angew. Chem. Int. Ed. 2011, 50:4386-4389.
90. Xie J., Zheng Y., Ying J.Y. Protein-directed synthesis of highly fluorescent gold nanoclusters. J. Am. Chem. Soc. 2009, 131:888-889.
91. Lin C.A.J., Yang T.Y., Lee C.H., Huang S.H., Sperling R.A., Zanella M., Li J.K., Shen J.L., Wang H.H., Yeh H.I., Parak W.J., Chang W.H. Synthesis, characterization, and bioconjugation of fluorescent gold nanoclusters toward biological labeling applications. ACS Nano 2009, 3:395-401.
92. Richards C.I., Choi S., Hsiang J.C., Antoku Y., Vosch T., Bongiorno A., Tzeng Y.L., Dickson R.M. Oligonucleotide-stabilized Ag nanocluster fluorophores. J. Am. Chem. Soc. 2008, 130:5038-5039.
93. Wang H., Huff T.B., Zweifel D.A., He W., Low P.S., Wei A., Cheng J.-X. In vitro and in vivo two-photon luminescence imaging of single gold nanorods. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:15752-15756.
94. Durr N.J., Larson T., Smith D.K., Korgel B.A., Sokolov K., Ben-Yakar A. Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods. Nano Lett. 2007, 7:941-945.
95. Park J., An K., Hwang Y., Park J.-G., Noh H.-J., Kim J.-Y., Park J.-H., Hwang N.-M., Hyeon T. Ultra-large-scale syntheses of monodisperse nanocrystals. Nat. Mater. 2004, 3:891-895.
96. Lee Y., Lee J., Bae C.J., Park J.G., Noh H.J., Park J.H., Hyeon T. Large-scale synthesis of uniform and crystalline magnetite nanoparticles using reverse micelles as nanoreactors under reflux conditions. Adv. Funct. Mater. 2005, 15:503-509.
97. Lu A.H., Salabas E.L., Schuth F. Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew. Chem. Int. Ed. 2007, 46:1222-1244.
98. 4, and mixed Co/CoO nanoparticles. Chem. Mater. 1999, 11:2702-2708.
99. Carnes C.L., Stipp J., Klabunde K.J. Synthesis, characterization, and adsorption studies of nanocrystalline copper oxide and nickel oxide. Langmuir 2002, 18:1352-1359.
100. Lee G.H., Huh S.H., Jeong J.W., Choi B.J., Kim S.H., Ri H.C. Anomalous magnetic properties of MnO nanoclusters. J. Am. Chem. Soc. 2002, 124:12094-12095.
101. Hyeon T., Chung Y., Park J., Lee S.S., Kim Y.W., Park B.H. Synthesis of highly crystalline and monodisperse cobalt ferrite nanocrystals. J. Phys. Chem. B 2002, 106:6831-6833.
102. Lee J.H., Huh Y.M., Jun Y., Seo J., Jang J., Song H.T., Kim S., Cho E.J., Yoon H.G., Suh J.S., Cheon J. Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat. Med. 2007, 13:95-99.
103. 4 nanoparticles by coprecipitation. J. Magn. Magn. Mater. 1999, 194:1-7.
104. 4 (M=Co, Ni, Cu) spinels from single-source heterobimetallic alkoxide precursors. J. Mater. Chem. 1999, 9:1755-1763.
105. Weissleder R., Moore A., Mahmood U., Bhorade R., Benveniste H., Chiocca E.A., Basilion J.P. In vivo magnetic resonance imaging of transgene expression. Nat. Med. 2000, 6:351-355.
106. Zhao M., Beauregard D.A., Loizou L., Davletov B., Brindle K.M. Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nat. Med. 2001, 7:1241-1244.
107. Jun Y.-w., Huh Y.-M., Choi J.-s., Lee J.-H., Song H.-T., KimKim S.Yoon, Kim K.-S., Shin J.-S., Suh J.-S., Cheon J. Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. J. Am. Chem. Soc. 2005, 127:5732-5733.
108. Hu F.Q., Wei L., Zhou Z., Ran Y.L., Li Z., Gao M.Y. Preparation of biocompatible magnetite nanocrystals for in vivo magnetic resonance detection of cancer. Adv. Mater. 2006, 18:2553-2556.
109. Harisinghani M.G., Barentsz J., Hahn P.F., Deserno W.M., Tabatabaei S., van de Kaa C.H., de la Rosette J., Weissleder R. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N. Engl. J. Med. 2003, 348:2491-2499.
110. Gupta A.K., Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 2005, 26:3995-4021.
111. Berry C.C., Curtis A.S.G. Functionalisation of magnetic nanoparticles for applications in biomedicine. J. Phys. D Appl. Phys. 2003, 36:R198-R206.
112. Mornet S., Vasseur S., Grasset F., Duguet E. Magnetic nanoparticle design for medical diagnosis and therapy. J. Mater. Chem. 2004, 14:2161-2175.
113. Lee J.-H., Jang J.-t., Choi J.-s., Moon S.H., Noh S.-h., Kim J.-w., Kim J.-G., Kim I.-S., Park K.I., Cheon J. Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat. Nanotechnol. 2011, 6:418-422.
114. Chatterjee D.K., Gnanasammandhan M.K., Zhang Y. Small upconverting fluorescent nanoparticles for biomedical applications. Small 2010, 6:2781-2795.
115. 3+ nanoparticles. Chem. Commun. 2011, 47:8022-8024.
116. Wang F., Liu X.G. Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals. Chem. Soc. Rev. 2009, 38:976-989.
117. Chatterjee D.K., Rufaihah A.J., Zhang Y. Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals. Biomaterials 2008, 29:937-943.
118. Wu S., Han G., Milliron D.J., Aloni S., Altoe V., Talapin D.V., Cohen B.E., Schuck P.J. Non-blinking and photostable upconverted luminescence from single lanthanide-doped nanocrystals. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:10917-10921.
119. Bouzigues C., Gacoin T., Alexandrou A. Biological applications of rare-earth based nanoparticles. ACS Nano 2011, 5:8488-8505.
120. 3+ doped fluoride nanophosphors. Nano Lett. 2008, 8:3834-3838.
121. Kobayashi H., Kosaka N., Ogawa M., Morgan N.Y., Smith P.D., Murray C.B., Ye X., Collins J., Kumar G.A., Bell H., Choyke P.L. In vivo multiple color lymphatic imaging using upconverting nanocrystals. J. Mater. Chem. 2009, 19:6481-6484.
122. 4:Yb/Er nanocrystals by folic acid-chitosan conjugates for targeted lung cancer cell imaging. J. Mater. Chem. 2011, 21:7661-7667.
123. 4:Yb, Er upconversion nanoparticles. ACS Nano 2009, 3:1580-1586.
124. 3+ monodisperse nanocrystals. Nano Lett. 2007, 7:847-852.
125. 3 nanoparticles. Nano Lett. 2002, 2:733-737.
126. 4 nanocrystals: multiple luminescence spanning the UV to NIR regions via low-energy excitation. Adv. Mater. 2009, 21:4025-4028.
127. 4:Er/Tm/Ho upconversion fluorescent nanoparticles with tunable emission colors and their applications in immunolabeling and fluorescent imaging of cancer cells. J. Phys. Chem. C 2009, 113:19021-19027.
128. Babu S., Cho J.-H., Dowding J.M., Heckert E., Komanski C., Das S., Colon J., Baker C.H., Bass M., Self W.T., Seal S. Multicolored redox active upconverter cerium oxide nanoparticle for bio-imaging and therapeutics. Chem. Commun. 2010, 46:6915-6917.
129. 4:Eu nanoparticles as versatile optical bioprobes. Adv. Funct. Mater. 2010, 20:3708-3714.
130. Hifumi H., Yamaoka S., Tanimoto A., Citterio D., Suzuki K. Gadolinium-based hybrid nanoparticles as a positive MR contrast agent. J. Am. Chem. Soc. 2006, 128:15090-15091.
131. Park J.Y., Baek M.J., Choi E.S., Woo S., Kim J.H., Kim T.J., Jung J.C., Chae K.S., Chang Y., Lee G.H. Paramagnetic ultrasmall gadolinium oxide nanoparticles as advanced T1 MRI contrast agent: account for large longitudinal relaxivity, optimal particle diameter, and in vivo T1 MR images. ACS Nano 2009, 3:3663-3669.
132. 4 nanoparticles: insights into their T1 MRI contrast enhancement. Chem. Mater. 2011, 23:3714-3722.
133. Bridot J.-L., Faure A.-C., Laurent S., Rivière C., Billotey C., Hiba B., Janier M., Josserand V., Coll J.-L., Vander Elst L., Muller R., Roux S., Perriat P., Tillement O. Hybrid gadolinium oxide nanoparticles: multimodal contrast agents for in vivo imaging. J. Am. Chem. Soc. 2007, 129:5076-5084.
134. Zhou J., Sun Y., Du X., Xiong L., Hu H., Li F. Dual-modality in vivo imaging using rare-earth nanocrystals with near-infrared to near-infrared (NIR-to-NIR) upconversion luminescence and magnetic resonance properties. Biomaterials 2010, 31:3287-3295.
135. 4 nanocrystals. Adv. Funct. Mater. 2009, 19:853-859.
136. Park Y.I., Kim J.H., Lee K.T., Jeon K.-S., Na H.B., Yu J.H., Kim H.M., Lee N., Choi S.H., Baik S.-I., Kim H., Park S.P., Park B.-J., Kim Y.W., Lee S.H., Yoon S.-Y., Song I.C., Moon W.K., Suh Y.D., Hyeon T. Nonblinking and nonbleaching upconverting nanoparticles as an optical imaging nanoprobe and T1 magnetic resonance imaging contrast agent. Adv. Mater. 2009, 21:4467-4471.
137. 4 core/shell nanocrystals with near-infrared to near-infrared upconversion photoluminescence and magnetic resonance properties. Nanoscale 2011, 3:2003-2008.
138. 4 upconversion nanophosphors. J. Appl. Phys. 2008, 104:094308.
139. 4 upconversion fluorescent nanocrystals. Biomaterials 2008, 29:4122-4128.
140. Bhattacharyya S., Kudgus R., Bhattacharya R., Mukherjee P. Inorganic nanoparticles in cancer therapy. Pharm. Res. 2011, 28:237-259.
141. White M.A., Johnson J.A., Koberstein J.T., Turro N.J. Toward the syntheses of universal ligands for metal oxide surfaces: controlling surface functionality through click chemistry. J. Am. Chem. Soc. 2006, 128:11356-11357.
142. Ma J., Chen J.-Y., Zhang Y., Wang P.-N., Guo J., Yang W.-L., Wang C.-C. Photochemical instability of thiol-capped CdTe quantum dots in aqueous solution and living cells: process and mechanism. J. Phys. Chem. B 2007, 111:12012-12016.
143. Mattoussi H., Mauro J.M., Goldman E.R., Anderson G.P., Sundar V.C., Mikulec F.V., Bawendi M.G. Self-assembly of CdSe-ZnS quantum dot bioconjugates using an engineered recombinant protein. J. Am. Chem. Soc. 2000, 122:12142-12150.
144. Liu W., Howarth M., Greytak A.B., Zheng Y., Nocera D.G., Ting A.Y., Bawendi M.G. Compact biocompatible quantum dots functionalized for cellular imaging. J. Am. Chem. Soc. 2008, 130:1274-1284.
145. Stewart M.H., Susumu K., Mei B.C., Medintz I.L., Delehanty J.B., Blanco-Canosa J.B., Dawson P.E., Mattoussi H. Multidentate poly(ethylene glycol) ligands provide colloidal stability to semiconductor and metallic nanocrystals in extreme conditions. J. Am. Chem. Soc. 2010, 132:9804-9813.
146. Zhang Y., Schnoes A.M., Clapp A.R. Dithiocarbamates as capping ligands for water-soluble quantum dots. ACS Appl. Mater. Interfaces 2010, 2:3384-3395.
147. Dubois F., Mahler B., Dubertret B., Doris E., Mioskowski C. A versatile strategy for quantum dot ligand exchange. J. Am. Chem. Soc. 2006, 129:482-483.
148. Boeneman K., Prasuhn D.E., Blanco-Canosa J.B., Dawson P.E., Melinger J.S., Ancona M., Stewart M.H., Susumu K., Huston A., Medintz I.L. Self-assembled quantum dot-sensitized multivalent DNA photonic wires. J. Am. Chem. Soc. 2010, 132:18177-18190.
149. Clapp A.R., Medintz I.L., Mauro J.M., Fisher B.R., Bawendi M.G., Mattoussi H. Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors. J. Am. Chem. Soc. 2003, 126:301-310.
150. Medintz I.L., Clapp A.R., Brunel F.M., Tiefenbrunn T., Tetsuo Uyeda H., Chang E.L., Deschamps J.R., Dawson P.E., Mattoussi H. Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates. Nat. Mater. 2006, 5:581-589.
151. Medintz I.L., Pons T., Delehanty J.B., Susumu K., Brunel F.M., Dawson P.E., Mattoussi H. Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides. Bioconjugate Chem. 2008, 19:1785-1795.
152. Liu W., Greytak A.B., Lee J., Wong C.R., Park J., Marshall L.F., Jiang W., Curtin P.N., Ting A.Y., Nocera D.G., Fukumura D., Jain R.K., Bawendi M.G. Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand. J. Am. Chem. Soc. 2009, 132:472-483.
153. Jin H., Nam J., Park J., Jung S., Im K., Hur J., Park J.-J., Kim J.-M., Kim S. Strong polyelectrolyte quantum dot surface for stable bioconjugation and layer-by-layer assembly applications. Chem. Commun. 2011, 47:1758-1760.
154. Susumu K., Uyeda H.T., Medintz I.L., Pons T., Delehanty J.B., Mattoussi H. Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands. J. Am. Chem. Soc. 2007, 129:13987-13996.
155. Earhart C., Jana N.R., Erathodiyil N., Ying J.Y. Synthesis of carbohydrate-conjugated nanoparticles and quantum dots. Langmuir 2008, 24:6215-6219.
156. Park J., Nam J., Won N., Jin H., Jung S., Jung S., Cho S.-H., Kim S. Compact and stable quantum dots with positive, negative, or zwitterionic surface: specific cell interactions and non-specific adsorptions by the surface charges. Adv. Funct. Mater. 2011, 21:1558-1566.
157. Muro E., Pons T., Lequeux N., Fragola A., Sanson N., Lenkei Z., Dubertret B. Small and stable sulfobetaine zwitterionic quantum dots for functional live-cell imaging. J. Am. Chem. Soc. 2010, 132:4556-4557.
158. Susumu K., Oh E., Delehanty J.B., Blanco-Canosa J.B., Johnson B.J., Jain V., Hervey W.J., Algar W.R., Boeneman K., Dawson P.E., Medintz I.L. Multifunctional compact zwitterionic ligands for preparing robust biocompatible semiconductor quantum dots and gold nanoparticles. J. Am. Chem. Soc. 2011, 133:9480-9496.
159. Hezinger A.F.E., Teßmar J., Göpferich A. Polymer coating of quantum dots - a powerful tool toward diagnostics and sensorics. Eur. J. Pharm. Biopharm. 2008, 68:138-152.
160. Kalyuzhny G., Murray R.W. Ligand effects on optical properties of CdSe nanocrystals. J. Phys. Chem. B 2005, 109:7012-7021.
161. Aldana J., Wang Y.A., Peng X. Photochemical instability of CdSe nanocrystals coated by hydrophilic thiols. J. Am. Chem. Soc. 2001, 123:8844-8850.
162. Wang Y.A., Li J.J., Chen H., Peng X. Stabilization of inorganic nanocrystals by organic dendrons. J. Am. Chem. Soc. 2002, 124:2293-2298.
163. Guo W., Li J.J., Wang Y.A., Peng X. Luminescent CdSe/CdS core/shell nanocrystals in dendron boxes: superior chemical, photochemical and thermal stability. J. Am. Chem. Soc. 2003, 125:3901-3909.
164. Duan H., Nie S. Cell-penetrating quantum dots based on multivalent and endosome-disrupting surface coatings. J. Am. Chem. Soc. 2007, 129:3333-3338.
165. Nikolic M.S., Krack M., Aleksandrovic V., Kornowski A., Förster S., Weller H. Tailor-made ligands for biocompatible nanoparticles. Angew. Chem. Int. Ed. 2006, 45:6577-6580.
166. Wang M., Oh J.K., Dykstra T.E., Lou X., Scholes G.D., Winnik M.A. Surface modification of CdSe and CdSe/ZnS semiconductor nanocrystals with poly(N,N-dimethylaminoethyl methacrylate). Macromolecules 2006, 39:3664-3672.
167. Smith A.M., Nie S. Minimizing the hydrodynamic size of quantum dots with multifunctional multidentate polymer ligands. J. Am. Chem. Soc. 2008, 130:11278-11279.
168. Kim S., Bawendi M.G. Oligomeric ligands for luminescent and stable nanocrystal quantum dots. J. Am. Chem. Soc. 2003, 125:14652-14653.
169. Kim S.-W., Kim S., Tracy J.B., Jasanoff A., Bawendi M.G. Phosphine oxide polymer for water-soluble nanoparticles. J. Am. Chem. Soc. 2005, 127:4556-4557.
170. Anderson R.E., Chan W.C.W. Systematic investigation of preparing biocompatible, single, and small ZnS-capped CdSe quantum dots with amphiphilic polymers. ACS Nano 2008, 2:1341-1352.
171. Wu X., Liu H., Liu J., Haley K.N., Treadway J.A., Larson J.P., Ge N., Peale F., Bruchez M.P. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat. Biotechnol. 2003, 21:41-46.
172. Yu W.W., Chang E., Falkner J.C., Zhang J., Al-Somali A.M., Sayes C.M., Johns J., Drezek R., Colvin V.L. Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymers. J. Am. Chem. Soc. 2007, 129:2871-2879.
173. Qi L., Gao X. Quantum dot-amphipol nanocomplex for intracellular delivery and real-time imaging of siRNA. ACS Nano 2008, 2:1403-1410.
174. Pellegrino T., Manna L., Kudera S., Liedl T., Koktysh D., Rogach A.L., Keller S., Rädler J., Natile G., Parak W.J. Hydrophobic nanocrystals coated with an amphiphilic polymer shell: a general route to water soluble nanocrystals. Nano Lett. 2004, 4:703-707.
175. Lees E.E., Nguyen T.-L., Clayton A.H.A., Mulvaney P. The preparation of colloidally stable, water-soluble, biocompatible, semiconductor nanocrystals with a small hydrodynamic diameter. ACS Nano 2009, 3:1121-1128.
176. Zhang L., Sun X., Song Y., Jiang X., Dong S., Wang E. Didodecyldimethylammonium bromide lipid bilayer-protected gold nanoparticles: synthesis, characterization, and self-assembly. Langmuir 2006, 22:2838-2843.
177. Dubertret B., Skourides P., Norris D.J., Noireaux V., Brivanlou A.H., Libchaber A. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 2002, 298:1759-1762.
178. Carion O., Mahler B., Pons T., Dubertret B. Synthesis, encapsulation, purification and coupling of single quantum dots in phospholipid micelles for their use in cellular and in vivo imaging. Nat. Protoc. 2007, 2:2383-2390.
179. Mulder W.J.M., Koole R., Brandwijk R.J., Storm G., Chin P.T.K., Strijkers G.J., de Mello Donegá C., Nicolay K., Griffioen A.W. Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe. Nano Lett. 2005, 6:1-6.
180. Ducongé F.d.r., Pons T., Pestourie C., Hérin L., Thézé B., Gombert K., Mahler B., Hinnen F.o., Kühnast B., Dollé F.d.r., Dubertret B., Tavitian B. Fluorine-18-labeled phospholipid quantum dot micelles for in vivo multimodal imaging from whole body to cellular scales. Bioconjugate Chem. 2008, 19:1921-1926.
181. Travert-Branger N., Dubois F., Carion O., Carrot G., Mahler B., Dubertret B., Doris E., Mioskowski C. Oligomeric PEG-phospholipids for solubilization and stabilization of fluorescent nanocrystals in water. Langmuir 2008, 24:3016-3019.
182. Fan H., Yang K., Boye D.M., Sigmon T., Malloy K.J., Xu H., López G.P., Brinker C.J. Self-assembly of ordered, robust, three-dimensional gold nanocrystal/silica arrays. Science 2004, 304:567-571.
183. Fan H., Leve E.W., Scullin C., Gabaldon J., Tallant D., Bunge S., Boyle T., Wilson M.C., Brinker C.J. Surfactant-assisted synthesis of water-soluble and biocompatible semiconductor quantum dot micelles. Nano Lett. 2005, 5:645-648.
184. Swami A., Kumar A., Sastry M. Formation of water-dispersible gold nanoparticles using a technique based on surface-bound interdigitated bilayers. Langmuir 2003, 19:1168-1172.
185. Kim J.H., Park J., Won N., Chung H., Kim S. A highly effective and facile way to prepare cellular labelling quantum dots with cetyltrimethylammonium bromide. J. Exp. Nanosci. 2009, 4:105-112.
186. Tada H., Higuchi H., Wanatabe T.M., Ohuchi N. In vivo real-time tracking of single quantum dots conjugated with monoclonal anti-HER2 antibody in tumors of mice. Cancer Res. 2007, 67:1138-1144.
187. Diagaradjane P., Orenstein-Cardona J.M., Colón-Casasnovas N.E., Deorukhkar A., Shentu S., Kuno N., Schwartz D.L., Gelovani J.G., Krishnan S. Imaging epidermal growth factor receptor expression in vivo: pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobe. Clin. Cancer Res. 2008, 14:731-741.
188. Lutz J.F., Zarafshani Z. Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry. Adv. Drug Deliv. Rev. 2008, 60:958-970.
189. Chen C.T., Munot Y.S., Salunke S.B., Wang Y.C., Lin R.K., Lin C.C., Chen C.C., Liu Y.H. A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells. Adv. Funct. Mater. 2008, 18:527-540.
190. Han H.-S., Devaraj N.K., Lee J., Hilderbrand S.A., Weissleder R., Bawendi M.G. Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition. J. Am. Chem. Soc. 2010, 132:7838-7839.
191. Haun J.B., Devaraj N.K., Hilderbrand S.A., Lee H., Weissleder R. Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat. Nanotechnol. 2010, 5:660-665.
192. Haun J.B., Devaraj N.K., Marinelli B.S., Lee H., Weissleder R. Probing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry. ACS Nano 2011, 5:3204-3213.
193. Dirksen A., Dawson P.E. Rapid oxime and hydrazone ligations with aromatic aldehydes for biomolecular labeling. Bioconjugate Chem. 2008, 19:2543-2548.
194. Blanco-Canosa J.B., Medintz I.L., Farrell D., Mattoussi H., Dawson P.E. Rapid covalent ligation of fluorescent peptides to water solubilized quantum dots. J. Am. Chem. Soc. 2010, 132:10027-10033.
195. Bhang S.H., Won N., Lee T.-J., Jin H., Nam J., Park J., Chung H., Park H.-S., Sung Y.-E., Hahn S.K., Kim B.-S., Kim S. Hyaluronic acid-quantum dot conjugates for in vivo lymphatic vessel imaging. ACS Nano 2009, 3:1389-1398.
196. Boeneman K., Delehanty J.B., Susumu K., Stewart M.H., Medintz I.L. Intracellular bioconjugation of targeted proteins with semiconductor quantum dots. J. Am. Chem. Soc. 2010, 132:5975-5977.
197. Goldman E.R., Balighian E.D., Mattoussi H., Kuno M.K., Mauro J.M., Tran P.T., Anderson G.P. Avidin: a natural bridge for quantum dot-antibody conjugates. J. Am. Chem. Soc. 2002, 124:6378-6382.
198. Xing Y., Chaudry Q., Shen C., Kong K.Y., Zhau H.E., Chung L.W., Petros J.A., O'Regan R.M., Yezhelyev M.V., Simons J.W., Wang M.D., Nie S. Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry. Nat. Protoc. 2007, 2:1152-1165.
199. Tiwari D., Tanaka S.-I., Inouye Y., Yoshizawa K., Watanabe T., Jin T. Synthesis and characterization of anti-HER2 antibody conjugated CdSe/CdZnS quantum dots for fluorescence imaging of breast cancer cells. Sensors 2009, 9:9332-9354.
200. Conner S.D., Schmid S.L. Regulated portals of entry into the cell. Nature 2003, 422:37-44.
201. Krpetić Ž., Nativo P., Prior I.A., Brust M. Acrylate-facilitated cellular uptake of gold nanoparticles. Small 2011, 7:1982-1986.
202. Chithrani B.D., Ghazani A.A., Chan W.C.W. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 2006, 6:662-668.
203. Chithrani B.D., Chan W.C.W. Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett. 2007, 7:1542-1550.
204. Osaki F., Kanamori T., Sando S., Sera T., Aoyama Y. A quantum dot conjugated sugar ball and its cellular uptake. on the size effects of endocytosis in the subviral region. J. Am. Chem. Soc. 2004, 126:6520-6521.
205. Wang S.-H., Lee C.-W., Chiou A., Wei P.-K. Size-dependent endocytosis of gold nanoparticles studied by three-dimensional mapping of plasmonic scattering images. J. Nanobiotechnol. 2010, 8:33.
206. Gao H., Shi W., Freund L.B. Mechanics of receptor-mediated endocytosis. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:9469-9474.
207. Zhang S., Li J., Lykotrafitis G., Bao G., Suresh S. Size-dependent endocytosis of nanoparticles. Adv. Mater. 2009, 21:419-424.
208. Li X. A simple method to evaluate the optimal size of nanoparticles for endocytosis based on kinetic diffusion of receptors. Appl. Phys. Lett. 2010, 97:153704.
209. Yuan H., Li J., Bao G., Zhang S. Variable nanoparticle-cell adhesion strength regulates cellular uptake. Phys. Rev. Lett. 2010, 105:138101.
210. De Jong W.H., Hagens W.I., Krystek P., Burger M.C., Sips A.J.A.M., Geertsma R.E. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 2008, 29:1912-1919.
211. Sonavane G., Tomoda K., Makino K. Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size. Colloids Surf. B 2008, 66:274-280.
212. Semmler-Behnke M., Kreyling W.G., Lipka J., Fertsch S., Wenk A., Takenaka S., Schmid G., Brandau W. Biodistribution of 1.4- and 18-nm gold particles in rats. Small 2008, 4:2108-2111.
213. Soo Choi H., Liu W., Misra P., Tanaka E., Zimmer J.P., Itty Ipe B., Bawendi M.G., Frangioni J.V. Renal clearance of quantum dots. Nat. Biotechnol. 2007, 25:1165-1170.
214. Choi H.S., Ashitate Y., Lee J.H., Kim S.H., Matsui A., Insin N., Bawendi M.G., Semmler-Behnke M., Frangioni J.V., Tsuda A. Rapid translocation of nanoparticles from the lung airspaces to the body. Nat. Biotechnol. 2010, 28:1300-1303.
215. Perrault S.D., Walkey C., Jennings T., Fischer H.C., Chan W.C.W. Mediating tumor targeting efficiency of nanoparticles through design. Nano Lett. 2009, 9:1909-1915.
216. Hobbs S.K., Monsky W.L., Yuan F., Roberts W.G., Griffith L., Torchilin V.P., Jain R.K. Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:4607-4612.
217. Yuan F., Dellian M., Fukumura D., Leunig M., Berk D.A., Torchilin V.P., Jain R.K. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res. 1995, 55:3752-3756.
218. Popović Z., Liu W., Chauhan V.P., Lee J., Wong C., Greytak A.B., Insin N., Nocera D.G., Fukumura D., Jain R.K., Bawendi M.G. A nanoparticle size series for in vivo fluorescence imaging. Angew. Chem. Int. Ed. 2010, 49:8649-8652.
219. Tam J.M., Tam J.O., Murthy A., Ingram D.R., Ma L.L., Travis K., Johnston K.P., Sokolov K.V. Controlled assembly of biodegradable plasmonic nanoclusters for near-infrared imaging and therapeutic applications. ACS Nano 2010, 4:2178-2184.
220. Albrecht R.M., Hillyer J.F. Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J. Pharm. Sci. 2001, 90:1927-1936.
221. Lai S.K., Wang Y.Y., Hanes J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv. Drug Deliv. Rev. 2009, 61:158-171.
222. Hillyer J.F., Albrecht R.M. Correlative instrumental neutron activation analysis, light microscopy, transmission electron microscopy, and X-ray microanalysis for qualitative and quantitative detection of colloidal gold spheres in biological specimens. Microsc. Microanal. 1998, 4:481-490.
223. Sonavane G., Tomoda K., Sano A., Ohshima H., Terada H., Makino K. In vitro permeation of gold nanoparticles through rat skin and rat intestine: effect of particle size. Colloid Surface B 2008, 65:1-10.
224. Sadauskas E., Jacobsen N.R., Danscher G., Stoltenberg M., Vogel U., Larsen A., Kreyling W., Wallin H. Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation. Chem. Cent. J. 2009, 3:16.
225. Pujals S., Fernández-Carneado J., López-Iglesias C., Kogan M.J., Giralt E. Mechanistic aspects of CPP-mediated intracellular drug delivery: relevance of CPP self-assembly. Biochim. Biophys. Acta, Biomembr. 2006, 1758:264-279.
226. Cho E.C., Xie J., Wurm P.A., Xia Y. Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant. Nano Lett. 2009, 9:1080-1084.
227. Banerji S.K., Hayes M.A. Examination of nonendocytotic bulk transport of nanoparticles across phospholipid membranes. Langmuir 2007, 23:3305-3313.
228. Wang B., Zhang L., Bae S.C., Granick S. Nanoparticle-induced surface reconstruction of phospholipid membranes. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:18171-18175.
229. Leroueil P.R., Berry S.A., Duthie K., Han G., Rotello V.M., McNerny D.Q., Baker J.R., Orr B.G., Banaszak Holl M.M. Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers. Nano Lett. 2008, 8:420-424.
230. Uyeda H.T., Medintz I.L., Jaiswal J.K., Simon S.M., Mattoussi H. Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores. J. Am. Chem. Soc. 2005, 127:3870-3878.
231. Kairdolf B.A., Mancini M.C., Smith A.M., Nie S. Minimizing nonspecific cellular binding of quantum dots with hydroxyl-derivatized surface coatings. Anal. Chem. 2008, 80:3029-3034.
232. Daou T.J., Li L., Reiss P., Josserand V., Texier I. Effect of poly(ethylene glycol) length on the in vivo behavior of coated quantum dots. Langmuir 2009, 25:3040-3044.
233. Ballou B., Lagerholm B.C., Ernst L.A., Bruchez M.P., Waggoner A.S. Noninvasive imaging of quantum dots in mice. Bioconjugate Chem. 2004, 15:79-86.
234. Uchida K., Otsuka H., Kaneko M., Kataoka K., Nagasaki Y. A reactive poly(ethylene glycol) layer to achieve specific surface plasmon resonance sensing with a high S/N ratio: the substantial role of a short underbrushed PEG layer in minimizing nonspecific adsorption. Anal. Chem. 2005, 77:1075-1080.
235. Bentzen E.L., Tomlinson I.D., Mason J., Gresch P., Warnement M.R., Wright D., Sanders-Bush E., Blakely R., Rosenthal S.J. Surface modification to reduce nonspecific binding of quantum dots in live cell assays. Bioconjugate Chem. 2005, 16:1488-1494.
236. Liu W., Choi H.S., Zimmer J.P., Tanaka E., Frangioni J.V., Bawendi M. Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications. J. Am. Chem. Soc. 2007, 129:14530-14531.
237. Rouhana L.L., Jaber J.A., Schlenoff J.B. Aggregation-resistant water-soluble gold nanoparticles. Langmuir 2007, 23:12799-12801.
238. Lai S.K., O'Hanlon D.E., Harrold S., Man S.T., Wang Y.Y., Cone R., Hanes J. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:1482-1487.
239. Wang Y.-Y., Lai S.K., Suk J.S., Pace A., Cone R., Hanes J. Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier. Angew. Chem. Int. Ed. 2008, 47:9726-9729.
240. Lipka J., Semmler-Behnke M., Sperling R.A., Wenk A., Takenaka S., Schleh C., Kissel T., Parak W.J., Kreyling W.G. Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection. Biomaterials 2010, 31:6574-6581.
241. Lee H.A., Imran M., Monteiro-Riviere N.A., Colvin V.L., Yu W.W., Riviere J.E. Biodistribution of quantum dot nanoparticles in perfused skin: evidence of coating dependency and periodicity in arterial extraction. Nano Lett. 2007, 7:2865-2870.
242. Scheinberg D.A., Villa C.H., Escorcia F.E., McDevitt M.R. Conscripts of the infinite armada: systemic cancer therapy using nanomaterials. Nat. Rev. Clin. Oncol. 2010, 7:266-276.
243. Weinberg W., Frazier-Jessen M., Wu W., Weir A., Hartsough M., Keegan P., Fuchs C. Development and regulation of monoclonal antibody products: challenges and opportunities. Cancer Metastasis Rev. 2005, 24:569-584.
244. Bardhan R., Chen W., Bartels M., Perez-Torres C., Botero M.F., McAninch R.W., Contreras A., Schiff R., Pautler R.G., Halas N.J., Joshi A. Tracking of multimodal therapeutic nanocomplexes targeting breast cancer in vivo. Nano Lett. 2010, 10:4920-4928.
245. Jiang W., KimBetty Y.S., Rutka J.T., Chan W.C.W. Nanoparticle-mediated cellular response is size-dependent. Nat. Nanotechnol. 2008, 3:145-150.
246. Melancon M.P., Lu W., Yang Z., Zhang R., Cheng Z., Elliot A.M., Stafford J., Olson T., Zhang J.Z., Li C. In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol. Cancer Ther. 2008, 7:1730-1739.
247. Au L., Zhang Q., Cobley C.M., Gidding M., Schwartz A.G., Chen J., Xia Y. Quantifying the cellular uptake of antibody-conjugated Au nanocages by two-photon microscopy and inductively coupled plasma mass spectrometry. ACS Nano 2009, 4:35-42.
248. Yang P.-H., Sun X., Chiu J.-F., Sun H., He Q.-Y. Transferrin-mediated gold nanoparticle cellular uptake. Bioconjugate Chem. 2005, 16:494-496.
249. Li J.-L., Wang L., Liu X.-Y., Zhang Z.-P., Guo H.-C., Liu W.-M., Tang S.-H. In vitro cancer cell imaging and therapy using transferrin-conjugated gold nanoparticles. Cancer Lett. 2009, 274:319-326.
250. Choi C.H.J., Alabi C.A., Webster P., Davis M.E. Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:1235-1240.
251. Yang L., Mao H., Wang Y.A., Cao Z., Peng X., Wang X., Duan H., Ni C., Yuan Q., Adams G., Smith M.Q., Wood W.C., Gao X., Nie S. Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imaging. Small 2009, 5:235-243.
252. Dickson K.K., Diego A.R., Carl A.B. Gold hybrid nanoparticles for targeted phototherapy and cancer imaging. Nanotechnology 2010, 21:105105.
253. Barat B., Sirk S.J., McCabe K.E., Li J., Lepin E.J., Remenyi R., Koh A.L., Olafsen T., Gambhir S.S., Weiss S., Wu A.M. Cys-diabody quantum dot conjugates (ImmunoQdots) for cancer marker detection. Bioconjugate Chem. 2009, 20:1474-1481.
254. Chen H., Gao J., Lu Y., Kou G., Zhang H., Fan L., Sun Z., Guo Y., Zhong Y. Preparation and characterization of PE38KDEL-loaded anti-HER2 nanoparticles for targeted cancer therapy. J. Control. Release 2008, 128:209-216.
255. Nimjee S.M., Rusconi C.P., Sullenger B.A. Aptamers: an emerging class of therapeutics. Annu. Rev. Med. 2005, 56:555-583.
256. Wang A.Z., Gu F., Zhang L., Chan J.M., Radovic-Moreno A., Shaikh M.R., Farokhzad O.C. Biofunctionalized targeted nanoparticles for therapeutic applications. Expert. Opin. Biol. Ther. 2008, 8:1063-1070.
257. Javier D.J., Nitin N., Levy M., Ellington A., Richards-Kortum R. Aptamer-targeted gold nanoparticles as molecular-specific contrast agents for reflectance imaging. Bioconjugate Chem. 2008, 19:1309-1312.
258. Chu T.C., Shieh F., Lavery L.A., Levy M., Richards-Kortum R., Korgel B.A., Ellington A.D. Labeling tumor cells with fluorescent nanocrystal-aptamer bioconjugates. Biosens. Bioelectron. 2006, 21:1859-1866.
259. Bagalkot V., Zhang L., Levy-Nissenbaum E., Jon S., Kantoff P.W., Langer R., Farokhzad O.C. Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on Bi-fluorescence resonance energy transfer. Nano Lett. 2007, 7:3065-3070.
260. Huang Y.-F., Lin Y.-W., Lin Z.-H., Chang H.-T. Aptamer-modified gold nanoparticles for targeting breast cancer cells through light scattering. J. Nanopart. Res. 2009, 11:775-783.
261. Kim Y.-H., Jeon J., Hong S.H., Rhim W.-K., Lee Y.-S., Youn H., Chung J.-K., Lee M.C., Lee D.S., Kang K.W., Nam J.-M. Tumor targeting and imaging using cyclic RGD-PEGylated gold nanoparticle probes with directly conjugated iodine-125. Small 2011, 7:2052-2060.
262. Oostendorp M., Douma K., Hackeng T.M., Dirksen A., Post M.J., van Zandvoort M.A.M.J., Backes W.H. Quantitative molecular magnetic resonance imaging of tumor angiogenesis using cNGR-labeled paramagnetic quantum dots. Cancer Res. 2008, 68:7676-7683.
263. Yong K.-T., Hu R., Roy I., Ding H., Vathy L.A., Bergey E.J., Mizuma M., Maitra A., Prasad P.N. Tumor targeting and imaging in live animals with functionalized semiconductor quantum rods. ACS Appl. Mater. Interfaces 2009, 1:710-719.
264. Choi H.S., Liu W., Liu F., Nasr K., Misra P., Bawendi M.G., Frangioni J.V. Design considerations for tumour-targeted nanoparticles. Nat. Nanotechnol. 2010, 5:42-47.
265. Bharali D.J., Lucey D.W., Jayakumar H., Pudavar H.E., Prasad P.N. Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy. J. Am. Chem. Soc. 2005, 127:11364-11371.
266. Dixit V., Van den Bossche J., Sherman D.M., Thompson D.H., Andres R.P. Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells. Bioconjugate Chem. 2006, 17:603-609.
267. Aubin-Tam M.-E., Hamad-Schifferli K. Gold nanoparticle-cytochrome c complexes: the effect of nanoparticle ligand charge on protein structure. Langmuir 2005, 21:12080-12084.
268. Howarth M., Chinnapen D.J.F., Gerrow K., Dorrestein P.C., Grandy M.R., Kelleher N.L., El-Husseini A., Ting A.Y. A monovalent streptavidin with a single femtomolar biotin binding site. Nat. Methods 2006, 3:267-273.
269. Groc L., Lafourcade M., Heine M., Renner M., Racine V., Sibarita J.-B., Lounis B., Choquet D., Cognet L. Surface trafficking of neurotransmitter receptor: comparison between single-molecule/quantum dot strategies. J. Neurosci. 2007, 27:12433-12437.
270. Howarth M., Liu W., Puthenveetil S., Zheng Y., Marshall L.F., Schmidt M.M., Wittrup K.D., Bawendi M.G., Ting A.Y. Monovalent, reduced-size quantum dots for imaging receptors on living cells. Nat. Methods 2008, 5:397-399.
271. Clarke S., Pinaud F., Beutel O., You C., Piehler J., Dahan M. Covalent monofunctionalization of peptide-coated quantum dots for single-molecule assays. Nano Lett. 2010, 10:2147-2154.
272. Dif A.l., Boulmedais F., Pinot M., Roullier V., Baudy-Floc'h M.l., Coquelle F.d.r.M., Clarke S., Neveu P., Vignaux F.o., Borgne R.L., Dahan M., Gueroui Z., Marchi-Artzner V.r. Small and stable peptidic PEGylated quantum dots to target polyhistidine-tagged proteins with controlled stoichiometry. J. Am. Chem. Soc. 2009, 131:14738-14746.
273. Liu H.Y., Gao X. Engineering monovalent quantum dot-antibody bioconjugates with a hybrid gel system. Bioconjugate Chem. 2011, 22:510-517.
274. You C., Wilmes S., Beutel O., Löchte S., Podoplelowa Y., Roder F., Richter C., Seine T., Schaible D., Uzé G., Clarke S., Pinaud F., Dahan M., Piehler J. Self-controlled monofunctionalization of quantum dots for multiplexed protein tracking in live cells. Angew. Chem. Int. Ed. 2010, 49:4108-4112.
275. Yoo J., Kim H., Won N., Bang J., Kim S., Ahn S., Lee B.-C., Soh K.-S. Evidence for an additional metastatic route: in vivo imaging of cancer cells in the primo-vascular system around tumors and organs. Mol. Imaging Biol. 2011, 13:471-480.
276. Yoo J.S. In vivo imaging of cancer cells with electroporation of quantum dots and multispectral imaging. J. Appl. Phys. 2010, 107:124702.
277. Yoo J.S., Won N., Kim H.B., Bang J., Kim S., Ahn S., Soh K.S. In vivo imaging of cancer cells with electroporation of quantum dots and multispectral imaging. J. Appl. Phys. 2010, 107.
278. Zorko M., Langel Ü. Cell-penetrating peptides: mechanism and kinetics of cargo delivery. Adv. Drug Deliv. Rev. 2005, 57:529-545.
279. Lagerholm B.C., Wang M., Ernst L.A., Ly D.H., Liu H., Bruchez M.P., Waggoner A.S. Multicolor coding of cells with cationic peptide coated quantum dots. Nano Lett. 2004, 4:2019-2022.
280. Chen B., Liu Q., Zhang Y., Xu L., Fang X. Transmembrane delivery of the cell-penetrating peptide conjugated semiconductor quantum dots. Langmuir 2008, 24:11866-11871.
281. Delehanty J.B., Medintz I.L., Pons T., Brunel F.M., Dawson P.E., Mattoussi H. Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery. Bioconjugate Chem. 2006, 17:920-927.
282. Lewin M., Carlesso N., Tung C.H., Tang X.W., Cory D., Scadden D.T., Weissleder R. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat. Biotechnol. 2000, 18:410-414.
283. Yukawa H., Mizufune S., Mamori C., Kagami Y., Oishi K., Kaji N., Okamoto Y., Takeshi M., Noguchi H., Baba Y., Hamaguchi M., Hamajima N., Hayashi S. Quantum dots for labeling adipose tissue-derived stem cells. Cell Transplant. 2009, 18:591-599.
284. Derfus A.M., Chan W.C.W., Bhatia S.N. Intracellular delivery of quantum dots for live cell labeling and organelle tracking. Adv. Mater. 2004, 16:961-966.
285. Tan S.J., Jana N.R., Gao S., Patra P.K., Ying J.Y. Surface-ligand-dependent cellular interaction, subcellular localization, and cytotoxicity of polymer-coated quantum dots. Chem. Mater. 2010, 22:2239-2247.
286. Verma A., Uzun O., Hu Y., Hu Y., Han H.-S., Watson N., Chen S., Irvine D.J., Stellacci F. Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. Nat. Mater. 2008, 7:588-595.
287. Chen F., Gerion D. Fluorescent CdSe/ZnS nanocrystal-peptide conjugates for long-term, nontoxic imaging and nuclear targeting in living cells. Nano Lett. 2004, 4:1827-1832.
288. de la Fuente J.M., Berry C.C. Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus. Bioconjugate Chem. 2005, 16:1176-1180.
289. Tkachenko A.G., Xie H., Coleman D., Glomm W., Ryan J., Anderson M.F., Franzen S., Feldheim D.L. Multifunctional gold nanoparticle-peptide complexes for nuclear targeting. J. Am. Chem. Soc. 2003, 125:4700-4701.
290. Kang B., Mackey M.A., El-Sayed M.A. Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosis. J. Am. Chem. Soc. 2010, 132:1517-1519.
291. Tkachenko A.G., Xie H., Liu Y., Coleman D., Ryan J., Glomm W.R., Shipton M.K., Franzen S., Feldheim D.L. Cellular trajectories of peptide-modified gold particle complexes: comparison of nuclear localization signals and peptide transduction domains. Bioconjugate Chem. 2004, 15:482-490.
292. Wang L., Liu Y., Li W., Jiang X., Ji Y., Wu X., Xu L., Qiu Y., Zhao K., Wei T., Li Y., Zhao Y., Chen C. Selective targeting of gold nanorods at the mitochondria of cancer cells: implications for cancer therapy. Nano Lett. 2010, 11:772-780.
293. Hoshino A., Hanada S., Yamamoto K. Toxicity of nanocrystal quantum dots: the relevance of surface modifications. Arch. Toxicol. 2011, 85:707-720.
294. Zhang Y., He J., Wang P.-N., Chen J.-Y., Lu Z.-J., Lu D.-R., Guo J., Wang C.-C., Yang W.-L. Time-dependent photoluminescence blue shift of the quantum dots in living cells: effect of oxidation by singlet oxygen. J. Am. Chem. Soc. 2006, 128:13396-13401.
295. Brzóska M.M., Kamiński M., Supernak-Bobko D., Zwierz K., Moniuszko-Jakoniuk J. Changes in the structure and function of the kidney of rats chronically exposed to cadmium. I. Biochemical and histopathological studies. Arch. Toxicol. 2003, 77:344-352.
296. Hardman R. A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ. Health Perspect. 2006, 114.
297. Shiohara A., Hanada S., Prabakar S., Fujioka K., Lim T.H., Yamamoto K., Northcote P.T., Tilley R.D. Chemical reactions on surface molecules attached to silicon quantum dots. J. Am. Chem. Soc. 2009, 132:248-253.
298. Lewinski N., Colvin V., Drezek R. Cytotoxicity of nanoparticles. Small 2008, 4:26-49.
299. Derfus A.M., Chan W.C.W., Bhatia S.N. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett. 2003, 4:11-18.
300. Kirchner C., Liedl T., Kudera S., Pellegrino T., Muñoz Javier A., Gaub H.E., Stölzle S., Fertig N., Parak W.J. Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett. 2004, 5:331-338.
301. Selvan S.T., Tan T.T., Ying J.Y. Robust, non-cytotoxic, silica-coated CdSe quantum dots with efficient photoluminescence. Adv. Mater. 2005, 17:1620-1625.
302. Murphy C.J., Gole A.M., Stone J.W., Sisco P.N., Alkilany A.M., Goldsmith E.C., Baxter S.C. Gold nanoparticles in biology: beyond toxicity to cellular imaging. Acc. Chem. Res. 2008, 41:1721-1730.
303. Goodman C.M., McCusker C.D., Yilmaz T., Rotello V.M. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjugate Chem. 2004, 15:897-900.
304. Leroueil P.R., Hong S., Mecke A., Baker J.R., Orr B.G., Banaszak Holl M.M. Nanoparticle interaction with biological membranes: does nanotechnology present a Janus face?. Acc. Chem. Res. 2007, 40:335-342.
305. Hauck T.S., Anderson R.E., Fischer H.C., Newbigging S., Chan W.C.W. In vivo quantum-dot toxicity assessment. Small 2010, 6:138-144.
306. Åkerman M.E., Chan W.C.W., Laakkonen P., Bhatia S.N., Ruoslahti E. Nanocrystal targeting in vivo. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:12617-12621.
307. Geys J., Nemmar A., Verbeken E., Smolders E., Ratoi M., Hoylaerts M.F., Nemery B., Hoet P.H.M. Acute toxicity and prothrombotic effects of quantum dots: impact of surface charge. Environ. Health Perspect. 2008, 116:1607-1613.
308. Nann T. Phase-transfer of CdSe@ZnS quantum dots using amphiphilic hyperbranched polyethylenimine. Chem. Commun. 2005, 1735-1736.