Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent

Nature Medicine

Volumn 7, Issue 11, 2001, Pages 1241-1244

  Zhao, Ming ^a   Beauregard, Daniel A ^a   Loizou, Louiza ^a   Davletov, Bazbek ^b   Brindle, Kevin M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CONTRAST MEDIUM; CYCLOPHOSPHAMIDE; ETOPOSIDE; NANOPARTICLE; PHOSPHOLIPID; SUPERPARAMAGNETIC IRON OXIDE; SYNAPTOTAGMIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LABELING; CELL MEMBRANE; CONFOCAL MICROSCOPY; CONJUGATION; CONTRAST ENHANCEMENT; FLOW CYTOMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BINDING; TUMOR;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CALCIUM-BINDING PROTEINS; CELL MEMBRANE; CONTRAST MEDIA; ETOPOSIDE; FERRIC COMPOUNDS; FLOW CYTOMETRY; MAGNETIC RESONANCE IMAGING; MAGNETICS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NEOPLASMS, EXPERIMENTAL; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; SYNAPTOTAGMIN I; SYNAPTOTAGMINS;

ANIMALIA;

EID: 0035173736     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1101-1241     Document Type: Article

References (29)

1. Apoptosis in the pathogenesis and treatment of disease
2. Apoptotic and antiapoptotic mechanisms in stroke
3. Histological assessment of apoptotic cell death in cardiomyopathies
4. Apoptosis, graft rejection, and transplantation tolerance
5. Heterogeneity in apoptosis development in irradiated murine tumours of different histologies
6. Apoptosis in murine tumours treated with chemotherapy agents
7. 31P MRS
8. Quantitative analysis of apoptotic cell death using proton nuclear magnetic resonance spectroscopy
9. Characterisation of secondary metabolites associated with neutrophil apoptosis
10. 1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: Implications for the in vivo detection of apoptosis
11. Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging
12. Exposure of phosphatidylethanolamine on the surface of apoptotic cells
13. Early redistribution of plasma-membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
14. In vivo detection and imaging of phosphatidylserine expression during programmed cell death
15. Ultra-high-resolution imaging of small animals: Implications for preclinical and research studies
16. 2+/phospholipid binding
17. Ultrasmall superparamagnetic iron oxide (USPIO): Characterization of a new class of contrast agents for MR imaging
18. - efflux in the activation of apoptosis
19. 31P magnetic resonance spectroscopy
20. Safety and preliminary findings with the intravascular contrast agent NC100150 injection for MR coronary angiography
21. In vivo magnetic resonance imaging of transgene expression
22. In vivo visualization of gene expression using magnetic resonance imaging
23. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
24. 2+/phospholipidbinding fold
25. Iron-dextran antibody conjugates: General method for simultaneous staining of two components in high-resolution immunoelectron microscopy
26. Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties
27. Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells
28. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry