In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags

Nature Biotechnology

Volumn 26, Issue 1, 2008, Pages 83-90

  Qian, Ximei ^a   Peng, Xiang Hong ^b   Ansari, Dominic O ^a   Yin Goen, Qiqin ^b   Chen, Georgia Z ^b   Shin, Dong M ^b   Yang, Lily ^b   Young, Andrew N ^b   Wang, May D ^c   Nie, Shuming ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; RAMAN SCATTERING; SPECTROSCOPIC ANALYSIS; TUMORS;

GOLD NANOPARTICLES; RHEUMATOID ARTHRITIS; TUMOR DETECTION;

NANOPARTICLES;

COLLOIDAL GOLD; EPIDERMAL GROWTH FACTOR RECEPTOR; MACROGOL; NANOPARTICLE; QUANTUM DOT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NANOTECHNOLOGY; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SEMICONDUCTOR; SURFACE ENHANCED RAMAN SCATTERING; TUMOR DIAGNOSIS; TUMOR XENOGRAFT;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; HUMANS; MICE; NANOPARTICLES; PARTICLE SIZE; SPECTRUM ANALYSIS, RAMAN;

ANIMALIA;

EID: 38049047244     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1377     Document Type: Article

References (57)

1. Alivisatos, P. The use of nanocrystals in biological detection. Nat. Biotechnol. 22, 47-52 (2004).
2. Ferrari, M. Cancer nanotechnology: Opportunities and challenges. Nat. Rev. Cancer 5, 161-171 (2005).
3. Niemeyer, C.M. Nanoparticles, proteins, and nucleic acids: Biotechnology meets materials science. Angew. Chem. Int. Ed. 40, 4128-4158 (2001).
4. Michalet, X. et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307, 538-544 (2005).
5. Rosi, N.L. & Mirkin, C.A. Nanostructures in biodiagnostics. Chem. Rev. 105, 1547-1562 (2005).
6. Cao, Y.C., Jin, R.C. & Mirkin, C.A. Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. Science 297, 1536-1540 (2002).
7. Gao, X. et al. In-vivo molecular and cellular imaging with quantum dots. Curr. Opin. Biotechnol. 16, 63-72 (2005).
8. Nie, S.M., Xing, Y., Kim, G.J. & Simons, J.W. Nanotechnology applications in cancer. Annu. Rev. Biomed. Eng. 9, 257-288 (2007).
9. Yezhelyev, M.V. et al. Emerging use of nanoparticles in diagnosis and treatment of breast cancer. Lancet Oncol. 7, 657-667 (2006).
10. Gao, X., Cui, Y.Y., Levenson, R.M., Chung, L.W.K. & Nie, S.M. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 22, 969-976 (2004).
11. Liu, Z. et al. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat. Nanotechnol. 2, 47-52 (2007).
12. Weissleder, R., Kelly, K., Sun, E.Y., Shtatland, T. & Josephson, L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat. Biotechnol. 23, 1418-1423 (2005).
13. Lee, E.S., Na, K. & Bae, Y.H. Polymeric micelle for tumor pH and folate-mediated targeting. J. Control. Release 91, 103-113 (2003).
14. Torchilin, V.P. Micellar nanocarriers: Pharmaceutical perspectives. Pharm. Res. 24, 1-16 (2007).
15. Moghimi, S.M., Hunter, A.C. & Murray, J.C. Long-circulating and target-specific nanoparticles: Theory to practice. Pharmacol. Rev. 53, 283-318 (2001).
16. Couvreur, P. & Vauthier, C. Nanotechnology: Intelligent design to treat complex diseases. Pharm. Res. 23, 1417-1450 (2006).
17. Duncan, R. Polymer conjugate as anticancer nanomedicines. Nat. Rev. Cancer 6, 688-701 (2006).
18. Hood, J.D. et al. Tumor regression by targeted gene delivery to the neovasculature. Science 296, 2404-2407 (2002).
19. Harisinghani, M.G. et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N. Engl. J. Med. 348, 2491-2499 (2003).
20. McCarthy, J.R., Kelly, K.A., Sun, E.Y. & Weissleder, R. Targeted delivery of multifunctional magnetic nanoparticles. Nanomedicine 2, 153-167 (2007).
21. Wu, X. et al. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor QDs. Nat. Biotechnol. 21, 41-46 (2003).
22. Kim, S. et al. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat. Biotechnol. 22, 93-97 (2004).
23. Rhyner, M.N. et al. Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging. Nanomedicine 1, 209-217 (2006).
24. Xing, Y. et al. Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry. Nat. Protoc. 2, 1152-1165 (2007).
25. Woodle, M.C. & Lu, P.Y. Nanoparticles deliver RNAi therapy. NanoToday, 34-41 (8/2005).
26. Medarova, Z., Pham, W., Farrar, C., Petkova, V. & Moore, A. In-vivo imaging of siRNA delivery and silencing in tumors. Nat. Med. 13, 372-377 (2007).
27. Merchant, B. Gold, the noble metal and the paradoxes of its toxicology. Biologicals 26, 49-59 (1998).
28. Root, S.W., Andrews, G.A., Kniseley, R.M. & Tyor, M.P. The distribution and radiation effects of intravenously administered colloidal gold-198 in man. Cancer 7, 856-866 (1954).
29. Paciotti, G.F., Kingston, D.G.I. & Tamarkin, L. Colloidal gold nanoparticles: a novel nanoparticle platform for developing multifunctional tumor-targeted drug delivery vectors. Drug Dev. Res. 67, 47-54 (2006).
30. Paciotti, G.F. et al. Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery. Drug Deliv. 11, 169-183 (2004).
31. James, W.D., Hirsch, L.R., West, J.L., O'Neal, P.D. & Payne, J.D. Application of INAA to the build-up and clearance of gold nanoshells in clinical studies in mice. J. Radioanal. Nucl. Chem. 271, 455-459 (2007).
32. Connor, E.E., Mwamuka, J., Gole, A., Murphy, C.J. & Wyatt, M.D. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 1, 325-327 (2005).
33. Shukla, R. et al. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 21, 10644-10654 (2005).
34. Kneipp, K., Kneipp, H., Itzkan, I., Dasari, R.R. & Feld, M.S. Ultrasensitive chemical analysis by Raman spectroscopy. Chem. Rev. 99, 2957-2976 (1999).
35. Campion, A. & Kambhampati, P. Surface-enhanced Raman scattering. Chem. Soc. Rev. 27, 241-250 (1998).
36. Nie, S.M. & Emory, S.R. Probing single molecules and single nanoparticles by surface-enhanced Raman scattering. Science 275, 1102-1106 (1997).
37. Kneipp, K. et al. Single molecule detection using surface enhanced Raman scattering. Phys. Rev. Lett. 78, 1667-1670 (1997).
38. Michaels, A.M., Nirmal, M. & Brus, L.E. Surface enhanced Raman spectroscopy of individual rhodamine 6G molecules on large Ag nanocrystals. J. Am. Chem. Soc. 121, 9932-9939 (1999).
39. Tian, J.H. et al. Study of molecular junctions with a combined surface-enhanced Raman and mechanically controllable break junction method. J. Am. Chem. Soc. 128, 14748-14749 (2006).
40. Moore, B.D. et al. Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering. Nat. Biotechnol. 22, 1133-1138 (2004).
41. Krug, J.T., Wang, G.D., Emory, S.R. & Nie, S.M. Efficient Raman enhancement and intermittent light emission observed in single gold nanocrystals. J. Am. Chem. Soc. 121, 9208-9214 (1999).
42. Doering, W.E. & Nie, S.M. Spectroscopic tags using dye-embedded nanoparticles and surface-enhanced Raman scattering. Anal. Chem. 75, 6171-6176 (2003).
43. Paez, J.G. et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004).
44. Lynch, T.J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004).
45. Mahmood, U. & Weissleder, R. Near-infrared optical imaging of proteases in cancer. Mol. Cancer Ther. 2, 489-496 (2003).
46. Wuelfing, W.P., Gross, S.M., Miles, D.T. & Murray, R.W. Nanometer gold clusters protected by surface-bound monolayers of thiolated poly(ethylene glycol) polymer electrolyte. J. Am. Chem. Soc. 120, 12696-12697 (1998).
47. Jiang, J.D., Burstein, E. & Kobayashi, H. Resonant raman-scattering by crystal-violet molecules adsorbed on a smooth gold surface - Evidence for a charge-transfer excitation. Phys. Rev. Lett. 57, 1793-1796 (1986).
48. Gobin, A.M. et al. Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy. Nano Lett. 7, 1929-1934 (2007).
49. Herbst, R.S. & Shin, D.M. Monoclonal antibodies to target epidermal growth factor receptor-positive tumors - A new paradigm for cancer therapy. Cancer 94, 1593-1611 (2002).
50. Reuter, C.W.M., Morgan, M.A. & Eckardt, A. Targeting EGF-receptor-signalling in squamous cell carcinomas of the head and neck. Br. J. Cancer 96, 408-416 (2007).
51. Ntziachristos, V., Bremer, C. & Weissleder, R. Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur. Radiol. 13, 195-208 (2003).
52. Jain, R.K. Transport of molecules, particles, and cells in solid tumors. Annu. Rev. Biomed. Eng. 1, 241-263 (1999).
53. Matsumura, Y. & Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46, 6387-6392 (1986).
54. Huang, X., El-Sayed, I.H., Qian, W. & El-Sayed, M.A. Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J. Am. Chem. Soc. 128, 2115-2120 (2006).
55. Zhang, H.F., Maslov, K., Stoica, G. & Wang, L.H.V. Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging. Nat. Biotechnol. 24, 848-851 (2006).
56. Ntziachristos, V., Ripoll, J., Wang, L.H.V. & Weissleder, R. Looking and listening to light: the evolution of whole-body photonic imaging. Nat. Biotechnol. 23, 313-320 (2005).
57. Hirsch, L.R. et al. Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc. Natl. Acad. Sci. USA 100, 13549-13554 (2003).