-
1
-
-
57749195091
-
Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology
-
Alenghat T, Meyers K, Mullican SE, Leitner K, Adeniji-Adele A, Avila J, Bucan M, Ahima RS, Kaestner KH, Lazar MA. 2008. Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature 456: 997-1000.
-
(2008)
Nature
, vol.456
, pp. 997-1000
-
-
Alenghat, T.1
Meyers, K.2
Mullican, S.E.3
Leitner, K.4
Adeniji-Adele, A.5
Avila, J.6
Bucan, M.7
Ahima, R.S.8
Kaestner, K.H.9
Lazar, M.A.10
-
2
-
-
39749140405
-
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1a
-
Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, et al. 2008. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1a. Nature 451: 1008-1012.
-
(2008)
Nature
, vol.451
, pp. 1008-1012
-
-
Arany, Z.1
Foo, S.Y.2
Ma, Y.3
Ruas, J.L.4
Bommi-Reddy, A.5
Girnun, G.6
Cooper, M.7
Laznik, D.8
Chinsomboon, J.9
Rangwala, S.M.10
-
3
-
-
0042626227
-
A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling
-
Ariyoshi M, Schwabe JW. 2003. A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. Genes Dev 17: 1909-1920.
-
(2003)
Genes Dev
, vol.17
, pp. 1909-1920
-
-
Ariyoshi, M.1
Schwabe, J.W.2
-
4
-
-
58049196754
-
The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo
-
Astapova I, Lee LJ, Morales C, Tauber S, Bilban M, Hollenberg AN. 2008. The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci 105: 19544-19549.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 19544-19549
-
-
Astapova, I.1
Lee, L.J.2
Morales, C.3
Tauber, S.4
Bilban, M.5
Hollenberg, A.N.6
-
5
-
-
79951715829
-
The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis
-
Astapova I, Vella KR, Ramadoss P, Holtz KA, Rodwin BA, Liao XH, Weiss RE, Rosenberg MA, Rosenzweig A, Hollenberg AN. 2011. The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis. Mol Endocrinol 25: 212-224.
-
(2011)
Mol Endocrinol
, vol.25
, pp. 212-224
-
-
Astapova, I.1
Vella, K.R.2
Ramadoss, P.3
Holtz, K.A.4
Rodwin, B.A.5
Liao, X.H.6
Weiss, R.E.7
Rosenberg, M.A.8
Rosenzweig, A.9
Hollenberg, A.N.10
-
6
-
-
0037067655
-
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kB and b-amyloid precursor protein
-
Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG. 2002. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kB and b-amyloid precursor protein. Cell 110: 55-67.
-
(2002)
Cell
, vol.110
, pp. 55-67
-
-
Baek, S.H.1
Ohgi, K.A.2
Rose, D.W.3
Koo, E.H.4
Glass, C.K.5
Rosenfeld, M.G.6
-
7
-
-
84859450495
-
The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis
-
Barish GD, Yu RT, Karunasiri MS, Becerra D, Kim J, Tseng TW, Tai LJ, Leblanc M, Diehl C, Cerchietti L, et al. 2012. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab 15: 554-562.
-
(2012)
Cell Metab
, vol.15
, pp. 554-562
-
-
Barish, G.D.1
Yu, R.T.2
Karunasiri, M.S.3
Becerra, D.4
Kim, J.5
Tseng, T.W.6
Tai, L.J.7
Leblanc, M.8
Diehl, C.9
Cerchietti, L.10
-
8
-
-
41549156540
-
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control
-
Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW. 2008. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell 30: 61-72.
-
(2008)
Mol Cell
, vol.30
, pp. 61-72
-
-
Bhaskara, S.1
Chyla, B.J.2
Amann, J.M.3
Knutson, S.K.4
Cortez, D.5
Sun, Z.W.6
Hiebert, S.W.7
-
9
-
-
78249276172
-
Hdac3 is essential for the maintenance of chromatin structure and genome stability
-
Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine- Summers AR, et al. 2010. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell 18: 436-447.
-
(2010)
Cancer Cell
, vol.18
, pp. 436-447
-
-
Bhaskara, S.1
Knutson, S.K.2
Jiang, G.3
Chandrasekharan, M.B.4
Wilson, A.J.5
Zheng, S.6
Yenamandra, A.7
Locke, K.8
Yuan, J.L.9
Bonine-Summers, A.R.10
-
10
-
-
70349111436
-
Emerging roles of peroxisome proliferator-activated receptor-b/d in inflammation
-
Bishop-Bailey D, Bystrom J. 2009. Emerging roles of peroxisome proliferator-activated receptor-b/d in inflammation. Pharmacol Ther 124: 141-150.
-
(2009)
Pharmacol Ther
, vol.124
, pp. 141-150
-
-
Bishop-Bailey, D.1
Bystrom, J.2
-
11
-
-
0029097233
-
A transcriptional co-repressor that interacts with nuclear hormone receptors
-
Chen JD, Evans RM. 1995. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377: 454-457.
-
(1995)
Nature
, vol.377
, pp. 454-457
-
-
Chen, J.D.1
Evans, R.M.2
-
12
-
-
84860264490
-
Regulation of circadian behaviour and metabolism by REV-ERB-a and REV-ERB-b
-
Cho H, Zhao X, Hatori M, Yu RT, Barish GD, Lam MT, Chong LW, DiTacchio L, Atkins AR, Glass CK, et al. 2012. Regulation of circadian behaviour and metabolism by REV-ERB-a and REV-ERB-b. Nature 485: 123-127.
-
(2012)
Nature
, vol.485
, pp. 123-127
-
-
Cho, H.1
Zhao, X.2
Hatori, M.3
Yu, R.T.4
Barish, G.D.5
Lam, M.T.6
Chong, L.W.7
Ditacchio, L.8
Atkins, A.R.9
Glass, C.K.10
-
13
-
-
0034975063
-
The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains
-
Cohen RN, Brzostek S, Kim B, Chorev M, Wondisford FE, Hollenberg AN. 2001. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol Endocrinol 15: 1049-1061.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 1049-1061
-
-
Cohen, R.N.1
Brzostek, S.2
Kim, B.3
Chorev, M.4
Wondisford, F.E.5
Hollenberg, A.N.6
-
14
-
-
0029859318
-
Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbAa and RVR: Physical association is dependent on the
-
Downes M, Burke LJ, Bailey PJ, Muscat GE. 1996. Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbAa and RVR: Physical association is dependent on the E region of the orphan receptors. Nucleic Acids Res 24: 4379-4386.
-
(1996)
E Region of the Orphan Receptors. Nucleic Acids Res
, vol.24
, pp. 4379-4386
-
-
Downes, M.1
Burke, L.J.2
Bailey, P.J.3
Muscat, G.E.4
-
15
-
-
0036900873
-
The retinoblastoma-histone deacetylase 3 complex inhibits PPARg and adipocyte differentiation
-
Fajas L, Egler V, Reiter R, Hansen J, Kristiansen K, Debril MB, Miard S, Auwerx J. 2002. The retinoblastoma-histone deacetylase 3 complex inhibits PPARg and adipocyte differentiation. Dev Cell 3: 903-910.
-
(2002)
Dev Cell
, vol.3
, pp. 903-910
-
-
Fajas, L.1
Egler, V.2
Reiter, R.3
Hansen, J.4
Kristiansen, K.5
Debril, M.B.6
Miard, S.7
Auwerx, J.8
-
16
-
-
79952775519
-
Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance
-
Fang S, Suh JM, Atkins AR, Hong SH, Leblanc M, Nofsinger RR, Yu RT, Downes M, Evans RM. 2011. Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance. Proc Natl Acad Sci 108: 3412-3417.
-
(2011)
Proc Natl Acad Sci
, vol.108
, pp. 3412-3417
-
-
Fang, S.1
Suh, J.M.2
Atkins, A.R.3
Hong, S.H.4
Leblanc, M.5
Nofsinger, R.R.6
Yu, R.T.7
Downes, M.8
Evans, R.M.9
-
17
-
-
0035805501
-
Transgenic targeting of a dominant negative corepressor to liver blocks basal repression by thyroid hormone receptor and increases cell proliferation
-
Feng X, Jiang Y, Meltzer P, Yen PM. 2001. Transgenic targeting of a dominant negative corepressor to liver blocks basal repression by thyroid hormone receptor and increases cell proliferation. J Biol Chem 276: 15066-15072.
-
(2001)
J Biol Chem
, vol.276
, pp. 15066-15072
-
-
Feng, X.1
Jiang, Y.2
Meltzer, P.3
Yen, P.M.4
-
18
-
-
79952529158
-
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
-
Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA. 2011. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 331: 1315-1319.
-
(2011)
Science
, vol.331
, pp. 1315-1319
-
-
Feng, D.1
Liu, T.2
Sun, Z.3
Bugge, A.4
Mullican, S.E.5
Alenghat, T.6
Liu, X.S.7
Lazar, M.A.8
-
19
-
-
33846091089
-
Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer
-
Fernandez-Majada V, Aguilera C, Villanueva A, Vilardell F, Robert-Moreno A, Aytes A, Real FX, Capella G, Mayo MW, Espinosa L, et al. 2007a. Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer. Proc Natl Acad Sci 104: 276-281.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 276-281
-
-
Fernandez-Majada, V.1
Aguilera, C.2
Villanueva, A.3
Vilardell, F.4
Robert-Moreno, A.5
Aytes, A.6
Real, F.X.7
Capella, G.8
Mayo, M.W.9
Espinosa, L.10
-
20
-
-
34548265264
-
Aberrant cytoplasmic localization of N-CoR in colorectal tumors
-
Fernandez-Majada V, Pujadas J, Vilardell F, Capella G, Mayo MW, Bigas A, Espinosa L. 2007b. Aberrant cytoplasmic localization of N-CoR in colorectal tumors. Cell Cycle 6: 1748-1752.
-
(2007)
Cell Cycle
, vol.6
, pp. 1748-1752
-
-
Fernandez-Majada, V.1
Pujadas, J.2
Vilardell, F.3
Capella, G.4
Mayo, M.W.5
Bigas, A.6
Espinosa, L.7
-
21
-
-
0036161439
-
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
-
Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E. 2002. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell 9: 45-57.
-
(2002)
Mol Cell
, vol.9
, pp. 45-57
-
-
Fischle, W.1
Dequiedt, F.2
Hendzel, M.J.3
Guenther, M.G.4
Lazar, M.A.5
Voelter, W.6
Verdin, E.7
-
22
-
-
80054826264
-
Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1)
-
Fozzatti L, Lu C, Kim DW, Park JW, Astapova I, Gavrilova O, Willingham MC, Hollenberg AN, Cheng SY. 2011. Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1). Proc Natl Acad Sci 108: 17462-17467.
-
(2011)
Proc Natl Acad Sci
, vol.108
, pp. 17462-17467
-
-
Fozzatti, L.1
Lu, C.2
Kim, D.W.3
Park, J.W.4
Astapova, I.5
Gavrilova, O.6
Willingham, M.C.7
Hollenberg, A.N.8
Cheng, S.Y.9
-
23
-
-
79955473684
-
Operating on chromatin, a colorful language where context matters
-
Gardner KE, Allis CD, Strahl BD. 2011. Operating on chromatin, a colorful language where context matters. J Mol Biol 409: 36-46.
-
(2011)
J Mol Biol
, vol.409
, pp. 36-46
-
-
Gardner, K.E.1
Allis, C.D.2
Strahl, B.D.3
-
24
-
-
33845970925
-
Parallel SUMOylationdependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARg
-
Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK. 2007. Parallel SUMOylationdependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARg. Mol Cell 25: 57-70.
-
(2007)
Mol Cell
, vol.25
, pp. 57-70
-
-
Ghisletti, S.1
Huang, W.2
Ogawa, S.3
Pascual, G.4
Lin, M.E.5
Willson, T.M.6
Rosenfeld, M.G.7
Glass, C.K.8
-
25
-
-
63049122784
-
Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways
-
Ghisletti S, Huang W, Jepsen K, Benner C, Hardiman G, Rosenfeld MG, Glass CK. 2009. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev 23: 681-693.
-
(2009)
Genes Dev
, vol.23
, pp. 681-693
-
-
Ghisletti, S.1
Huang, W.2
Jepsen, K.3
Benner, C.4
Hardiman, G.5
Rosenfeld, M.G.6
Glass, C.K.7
-
26
-
-
0034650893
-
The coregulator exchange in transcriptional functions of nuclear receptors
-
Glass CK, Rosenfeld MG. 2000. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 14: 121-141.
-
(2000)
Genes Dev
, vol.14
, pp. 121-141
-
-
Glass, C.K.1
Rosenfeld, M.G.2
-
27
-
-
84863308567
-
Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression
-
Godoy AS, Sotomayor PC, Villagran M, Yacoub R, Montecinos VP, McNerney EM, Moser M, Foster BA, Onate SA. 2012. Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression. Biochem Biophys Res Commun 423: 564-570.
-
(2012)
Biochem Biophys Res Commun
, vol.423
, pp. 564-570
-
-
Godoy, A.S.1
Sotomayor, P.C.2
Villagran, M.3
Yacoub, R.4
Montecinos, V.P.5
McNerney, E.M.6
Moser, M.7
Foster, B.A.8
Onate, S.A.9
-
28
-
-
14844294741
-
Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors
-
Goodson ML, Jonas BA, Privalsky ML. 2005. Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. J Biol Chem 280: 7493-7503.
-
(2005)
J Biol Chem
, vol.280
, pp. 7493-7503
-
-
Goodson, M.L.1
Jonas, B.A.2
Privalsky, M.L.3
-
29
-
-
84455161762
-
Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation
-
Goodson ML, Mengeling BJ, Jonas BA, Privalsky ML. 2011. Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation. J Biol Chem 286: 44988-44999.
-
(2011)
J Biol Chem
, vol.286
, pp. 44988-44999
-
-
Goodson, M.L.1
Mengeling, B.J.2
Jonas, B.A.3
Privalsky, M.L.4
-
30
-
-
0035724413
-
The SMRTand N-CoR corepressors are activating cofactors for histone deacetylase 3
-
Guenther MG, Barak O, Lazar MA. 2001. The SMRTand N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol 21: 6091-6101.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 6091-6101
-
-
Guenther, M.G.1
Barak, O.2
Lazar, M.A.3
-
31
-
-
15444347751
-
Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat
-
Hallakou S, Doare L, Foufelle F, Kergoat M, Guerre-Millo M, Berthault MF, Dugail I, Morin J, Auwerx J, Ferre P. 1997. Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat. Diabetes 46: 1393-1399.
-
(1997)
Diabetes
, vol.46
, pp. 1393-1399
-
-
Hallakou, S.1
Doare, L.2
Foufelle, F.3
Kergoat, M.4
Guerre-Millo, M.5
Berthault, M.F.6
Dugail, I.7
Morin, J.8
Auwerx, J.9
Ferre, P.10
-
33
-
-
17744413444
-
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
-
Heinzel T, Lavinsky RM, Mullen TM, Soderstrom M, Laherty CD, Torchia J, Yang WM, Brard G, Ngo SD, Davie JR, et al. 1997. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387: 43-48.
-
(1997)
Nature
, vol.387
, pp. 43-48
-
-
Heinzel, T.1
Lavinsky, R.M.2
Mullen, T.M.3
Soderstrom, M.4
Laherty, C.D.5
Torchia, J.6
Yang, W.M.7
Brard, G.8
Ngo, S.D.9
Davie, J.R.10
-
34
-
-
0037206890
-
N-CoR controls differentiation of neural stem cells into astrocytes
-
Hermanson O, Jepsen K, Rosenfeld MG. 2002. N-CoR controls differentiation of neural stem cells into astrocytes. Nature 419: 934-939.
-
(2002)
Nature
, vol.419
, pp. 934-939
-
-
Hermanson, O.1
Jepsen, K.2
Rosenfeld, M.G.3
-
35
-
-
6344241039
-
SMRT derepression by the IkB kinase a: A prerequisite to NF-kB transcription and survival
-
Hoberg JE, Yeung F, Mayo MW. 2004. SMRT derepression by the IkB kinase a: A prerequisite to NF-kB transcription and survival. Mol Cell 16: 245-255.
-
(2004)
Mol Cell
, vol.16
, pp. 245-255
-
-
Hoberg, J.E.1
Yeung, F.2
Mayo, M.W.3
-
36
-
-
0033838465
-
The SMRT corepressor is regulated by a MEK-1 kinase pathway: Inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export
-
Hong SH, Privalsky ML. 2000. The SMRT corepressor is regulated by a MEK-1 kinase pathway: Inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export. Mol Cell Biol 20: 6612-6625.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6612-6625
-
-
Hong, S.H.1
Privalsky, M.L.2
-
37
-
-
0032230335
-
Signaling by tyrosine kinases negatively regulates the interaction between tran- scription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor
-
Hong SH, Wong CW, Privalsky ML. 1998. Signaling by tyrosine kinases negatively regulates the interaction between tran- scription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor. Mol Endocrinol 12: 1161-1171.
-
(1998)
Mol Endocrinol
, vol.12
, pp. 1161-1171
-
-
Hong, S.H.1
Wong, C.W.2
Privalsky, M.L.3
-
38
-
-
0029132202
-
Ligandindependent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
-
Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, et al. 1995. Ligandindependent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377: 397-404.
-
(1995)
Nature
, vol.377
, pp. 397-404
-
-
Horlein, A.J.1
Naar, A.M.2
Heinzel, T.3
Torchia, J.4
Gloss, B.5
Kurokawa, R.6
Ryan, A.7
Kamei, Y.8
Soderstrom, M.9
Glass, C.K.10
-
39
-
-
0034045480
-
Transcriptional repression by nuclear hormone receptors
-
Hu X, Lazar MA. 2000. Transcriptional repression by nuclear hormone receptors. Trends Endocrinol Metab 11: 6-10.
-
(2000)
Trends Endocrinol Metab
, vol.11
, pp. 6-10
-
-
Hu, X.1
Lazar, M.A.2
-
40
-
-
67649668789
-
Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint
-
Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK. 2009. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell 35: 48-57.
-
(2009)
Mol Cell
, vol.35
, pp. 48-57
-
-
Huang, W.1
Ghisletti, S.2
Perissi, V.3
Rosenfeld, M.G.4
Glass, C.K.5
-
41
-
-
0042592941
-
The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor
-
Ishizuka T, Lazar MA. 2003. The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor. Mol Cell Biol 23: 5122-5131.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 5122-5131
-
-
Ishizuka, T.1
Lazar, M.A.2
-
42
-
-
22344453589
-
The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor
-
Ishizuka T, Lazar MA. 2005. The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor. Mol Endocrinol 19: 1443-1451.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 1443-1451
-
-
Ishizuka, T.1
Lazar, M.A.2
-
43
-
-
0037084392
-
Biological roles and mechanistic actions of co-repressor complexes
-
Jepsen K, Rosenfeld MG. 2002. Biological roles and mechanistic actions of co-repressor complexes. J Cell Sci 115: 689-698.
-
(2002)
J Cell Sci
, vol.115
, pp. 689-698
-
-
Jepsen, K.1
Rosenfeld, M.G.2
-
44
-
-
0034664769
-
Combinatorial roles of the nuclear receptor corepressor in transcription and development
-
Jepsen K, Hermanson O, Onami TM, Gleiberman AS, Lunyak V, McEvilly RJ, Kurokawa R, Kumar V, Liu F, Seto E, et al. 2000. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell 102: 753-763.
-
(2000)
Cell
, vol.102
, pp. 753-763
-
-
Jepsen, K.1
Hermanson, O.2
Onami, T.M.3
Gleiberman, A.S.4
Lunyak, V.5
McEvilly, R.J.6
Kurokawa, R.7
Kumar, V.8
Liu, F.9
Seto, E.10
-
45
-
-
36248990248
-
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
-
Jepsen K, Solum D, Zhou T, McEvilly RJ, Kim HJ, Glass CK, Hermanson O, Rosenfeld MG. 2007. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 450: 415-419.
-
(2007)
Nature
, vol.450
, pp. 415-419
-
-
Jepsen, K.1
Solum, D.2
Zhou, T.3
McEvilly, R.J.4
Kim, H.J.5
Glass, C.K.6
Hermanson, O.7
Rosenfeld, M.G.8
-
46
-
-
41149118120
-
Cooperative regulation in development by SMRT and FOXP1
-
Jepsen K, Gleiberman AS, Shi C, Simon DI, Rosenfeld MG. 2008. Cooperative regulation in development by SMRT and FOXP1. Genes Dev 22: 740-745.
-
(2008)
Genes Dev
, vol.22
, pp. 740-745
-
-
Jepsen, K.1
Gleiberman, A.S.2
Shi, C.3
Simon, D.I.4
Rosenfeld, M.G.5
-
47
-
-
11144230050
-
SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways
-
Jonas BA, Privalsky ML. 2004. SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J Biol Chem 279: 54676-54686.
-
(2004)
J Biol Chem
, vol.279
, pp. 54676-54686
-
-
Jonas, B.A.1
Privalsky, M.L.2
-
48
-
-
34547483059
-
Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing
-
Jonas BA, Varlakhanova N, Hayakawa F, Goodson M, Privalsky ML. 2007. Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing. Mol Endocrinol 21: 1924-1939.
-
(2007)
Mol Endocrinol
, vol.21
, pp. 1924-1939
-
-
Jonas, B.A.1
Varlakhanova, N.2
Hayakawa, F.3
Goodson, M.4
Privalsky, M.L.5
-
49
-
-
0032145527
-
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
-
Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T. 1998. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev 12: 2269-2277.
-
(1998)
Genes Dev
, vol.12
, pp. 2269-2277
-
-
Kao, H.Y.1
Ordentlich, P.2
Koyano-Nakagawa, N.3
Tang, Z.4
Downes, M.5
Kintner, C.R.6
Evans, R.M.7
Kadesch, T.8
-
50
-
-
0033964223
-
Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
-
Kao HY, Downes M, Ordentlich P, Evans RM. 2000. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev 14: 55-66.
-
(2000)
Genes Dev
, vol.14
, pp. 55-66
-
-
Kao, H.Y.1
Downes, M.2
Ordentlich, P.3
Evans, R.M.4
-
51
-
-
34547909260
-
HDAC3: Taking the SMRT-NCoRrect road to repression
-
Karagianni P, Wong J. 2007. HDAC3: Taking the SMRT-NCoRrect road to repression. Oncogene 26: 5439-5449.
-
(2007)
Oncogene
, vol.26
, pp. 5439-5449
-
-
Karagianni, P.1
Wong, J.2
-
52
-
-
64949168643
-
Up-regulation of nuclear receptor corepressor (NCoR) in progestin-induced growth suppression of endometrial hyperplasia and carcinoma
-
Kashima H, Horiuchi A, Uchikawa J, Miyamoto T, Suzuki A, Ashida T, Konishi I, Shiozawa T. 2009. Up-regulation of nuclear receptor corepressor (NCoR) in progestin-induced growth suppression of endometrial hyperplasia and carcinoma. Anticancer Res 29: 1023-1029.
-
(2009)
Anticancer Res
, vol.29
, pp. 1023-1029
-
-
Kashima, H.1
Horiuchi, A.2
Uchikawa, J.3
Miyamoto, T.4
Suzuki, A.5
Ashida, T.6
Konishi, I.7
Shiozawa, T.8
-
53
-
-
84862829663
-
S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator- activated receptor a activity in the liver
-
Kim K, Pyo S, Um SH. 2012. S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator- activated receptor a activity in the liver. Hepatology 55: 1727-1737.
-
(2012)
Hepatology
, vol.55
, pp. 1727-1737
-
-
Kim, K.1
Pyo, S.2
Um, S.H.3
-
54
-
-
41949120723
-
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
-
Knutson SK, Chyla BJ, Amann JM, Bhaskara S, Huppert SS, Hiebert SW. 2008. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J 27: 1017-1028.
-
(2008)
EMBO J
, vol.27
, pp. 1017-1028
-
-
Knutson, S.K.1
Chyla, B.J.2
Amann, J.M.3
Bhaskara, S.4
Huppert, S.S.5
Hiebert, S.W.6
-
55
-
-
0035881448
-
Active repression of RAR signaling is required for head formation
-
Koide T, Downes M, Chandraratna RA, Blumberg B, Umesono K. 2001. Active repression of RAR signaling is required for head formation. Genes Dev 15: 2111-2121.
-
(2001)
Genes Dev
, vol.15
, pp. 2111-2121
-
-
Koide, T.1
Downes, M.2
Chandraratna, R.A.3
Blumberg, B.4
Umesono, K.5
-
56
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante M, Sabatini DM. 2012. mTOR signaling in growth control and disease. Cell 149: 274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
57
-
-
0142116239
-
Transcriptional repression of atherogenic inflammation: Modulation by PPARd
-
Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Evans RM, Curtiss LK. 2003. Transcriptional repression of atherogenic inflammation: Modulation by PPARd. Science 302: 453-457.
-
(2003)
Science
, vol.302
, pp. 453-457
-
-
Lee, C.H.1
Chawla, A.2
Urbiztondo, N.3
Liao, D.4
Boisvert, W.A.5
Evans, R.M.6
Curtiss, L.K.7
-
58
-
-
0030784510
-
Characterization of receptor interaction and transcriptional repression by the corepressor SMRT
-
Li H, Leo C, Schroen DJ, Chen JD. 1997. Characterization of receptor interaction and transcriptional repression by the corepressor SMRT. Mol Endocrinol 11: 2025-2037.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 2025-2037
-
-
Li, H.1
Leo, C.2
Schroen, D.J.3
Chen, J.D.4
-
59
-
-
81055144760
-
Adipocyte NCoR knockout decreases PPARg phosphorylation and enhances PPARg activity and insulin sensitivity
-
Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, et al. 2011. Adipocyte NCoR knockout decreases PPARg phosphorylation and enhances PPARg activity and insulin sensitivity. Cell 147: 815-826.
-
(2011)
Cell
, vol.147
, pp. 815-826
-
-
Li, P.1
Fan, W.2
Xu, J.3
Lu, M.4
Yamamoto, H.5
Auwerx, J.6
Sears, D.D.7
Talukdar, S.8
Oh, D.9
Chen, A.10
-
60
-
-
0038475953
-
Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT
-
Liao G, Chen LY, Zhang A, Godavarthy A, Xia F, Ghosh JC, Li H, Chen JD. 2003. Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT. J Biol Chem 278: 5052-5061.
-
(2003)
J Biol Chem
, vol.278
, pp. 5052-5061
-
-
Liao, G.1
Chen, L.Y.2
Zhang, A.3
Godavarthy, A.4
Xia, F.5
Ghosh, J.C.6
Li, H.7
Chen, J.D.8
-
61
-
-
0037102256
-
Transcriptional co-activator PGC-1a drives the formation of slow-twitch muscle fibres
-
Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, et al. 2002. Transcriptional co-activator PGC-1a drives the formation of slow-twitch muscle fibres. Nature 418: 797-801.
-
(2002)
Nature
, vol.418
, pp. 797-801
-
-
Lin, J.1
Wu, H.2
Tarr, P.T.3
Zhang, C.Y.4
Wu, Z.5
Boss, O.6
Michael, L.F.7
Puigserver, P.8
Isotani, E.9
Olson, E.N.10
-
62
-
-
84860413257
-
Identification and characterization of a functional zebrafish smrt corepressor (ncor2)
-
Linney E, Perz-Edwards A, Kelley B. 2011. Identification and characterization of a functional zebrafish smrt corepressor (ncor2). Gene 486: 31-36.
-
(2011)
Gene
, vol.486
, pp. 31-36
-
-
Linney, E.1
Perz-Edwards, A.2
Kelley, B.3
-
63
-
-
79955815135
-
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
-
Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, Shaw RJ. 2011. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 145: 607-621.
-
(2011)
Cell
, vol.145
, pp. 607-621
-
-
Mihaylova, M.M.1
Vasquez, D.S.2
Ravnskjaer, K.3
Denechaud, P.D.4
Yu, R.T.5
Alvarez, J.G.6
Downes, M.7
Evans, R.M.8
Montminy, M.9
Shaw, R.J.10
-
64
-
-
84883488905
-
NMR assignments of SPOC domain of the human transcriptional corepressor SHARP in complex with a C-terminal SMRT peptide
-
doi: 10.1007/s12104-012-9424-8
-
Mikami S, Kanaba T, Ito Y, Mishima M. 2012. NMR assignments of SPOC domain of the human transcriptional corepressor SHARP in complex with a C-terminal SMRT peptide. Biomol NMR Assign doi: 10.1007/s12104-012-9424-8.
-
(2012)
Biomol NMR Assign
-
-
Mikami, S.1
Kanaba, T.2
Ito, Y.3
Mishima, M.4
-
65
-
-
84874605154
-
GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/ SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans
-
Mikolas P, Kollarova J, Sebkova K, Saudek V, Yilma P, Kostrouchova M, Krause MW, Kostrouch Z. 2013. GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/ SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans. PLoS ONE 8: e58462.
-
(2013)
PLoS ONE
, vol.8
-
-
Mikolas, P.1
Kollarova, J.2
Sebkova, K.3
Saudek, V.4
Yilma, P.5
Kostrouchova, M.6
Krause, M.W.7
Kostrouch, Z.8
-
66
-
-
55849084700
-
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice
-
Montgomery RL, Potthoff MJ, Haberland M, Qi X, Matsuzaki S, Humphries KM, Richardson JA, Bassel-Duby R, Olson EN. 2008. Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest 118: 3588-3597.
-
(2008)
J Clin Invest
, vol.118
, pp. 3588-3597
-
-
Montgomery, R.L.1
Potthoff, M.J.2
Haberland, M.3
Qi, X.4
Matsuzaki, S.5
Humphries, K.M.6
Richardson, J.A.7
Bassel-Duby, R.8
Olson, E.N.9
-
67
-
-
0032526615
-
The corepressor N-CoR and its variants RIP13a and RIP13D1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70
-
Muscat GE, Burke LJ, Downes M. 1998. The corepressor N-CoR and its variants RIP13a and RIP13D1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70. Nucleic Acids Res 26: 2899-2907.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 2899-2907
-
-
Muscat, G.E.1
Burke, L.J.2
Downes, M.3
-
68
-
-
0030953186
-
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
-
Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM. 1997. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 89: 373-380.
-
(1997)
Cell
, vol.89
, pp. 373-380
-
-
Nagy, L.1
Kao, H.Y.2
Chakravarti, D.3
Lin, R.J.4
Hassig, C.A.5
Ayer, D.E.6
Schreiber, S.L.7
Evans, R.M.8
-
69
-
-
58149380715
-
SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis
-
Nofsinger RR, Li P, Hong SH, Jonker JW, Barish GD, Ying H, Cheng SY, Leblanc M, Xu W, Pei L, et al. 2008. SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci 105: 20021-20026.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 20021-20026
-
-
Nofsinger, R.R.1
Li, P.2
Hong, S.H.3
Jonker, J.W.4
Barish, G.D.5
Ying, H.6
Cheng, S.Y.7
Leblanc, M.8
Xu, W.9
Pei, L.10
-
70
-
-
79551626803
-
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery
-
Oberoi J, Fairall L, Watson PJ, Yang JC, Czimmerer Z, Kampmann T, Goult BT, Greenwood JA, Gooch JT, Kallenberger BC, et al. 2011. Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. Nat Struct Mol Biol 18: 177-184.
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 177-184
-
-
Oberoi, J.1
Fairall, L.2
Watson, P.J.3
Yang, J.C.4
Czimmerer, Z.5
Kampmann, T.6
Goult, B.T.7
Greenwood, J.A.8
Gooch, J.T.9
Kallenberger, B.C.10
-
71
-
-
0033020203
-
Unique forms of human and mouse nuclear receptor corepressor SMRT
-
Ordentlich P, Downes M, Xie W, Genin A, Spinner NB, Evans RM. 1999. Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci 96: 2639-2644.
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 2639-2644
-
-
Ordentlich, P.1
Downes, M.2
Xie, W.3
Genin, A.4
Spinner, N.B.5
Evans, R.M.6
-
72
-
-
0033616676
-
SMRTe, a silencing mediator for retinoid and thyroid hormone re- ceptors-extended isoform that is more related to the nuclear receptor corepressor
-
Park EJ, Schroen DJ, Yang M, Li H, Li L, Chen JD. 1999. SMRTe, a silencing mediator for retinoid and thyroid hormone re- ceptors-extended isoform that is more related to the nuclear receptor corepressor. Proc Natl Acad Sci 96: 3519-3524.
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 3519-3524
-
-
Park, E.J.1
Schroen, D.J.2
Yang, M.3
Li, H.4
Li, L.5
Chen, J.D.6
-
73
-
-
33847776362
-
N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation
-
Park DM, Li J, Okamoto H, Akeju O, Kim SH, Lubensky I, Vortmeyer A, Dambrosia J, Weil RJ, Oldfield EH, et al. 2007. N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation. Cell Cycle 6: 467-470.
-
(2007)
Cell Cycle
, vol.6
, pp. 467-470
-
-
Park, D.M.1
Li, J.2
Okamoto, H.3
Akeju, O.4
Kim, S.H.5
Lubensky, I.6
Vortmeyer, A.7
Dambrosia, J.8
Weil, R.J.9
Oldfield, E.H.10
-
74
-
-
26444471700
-
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-g
-
Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, Perissi V, Rose DW, Willson TM, Rosenfeld MG, Glass CK. 2005. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-g. Nature 437: 759-763.
-
(2005)
Nature
, vol.437
, pp. 759-763
-
-
Pascual, G.1
Fong, A.L.2
Ogawa, S.3
Gamliel, A.4
Li, A.C.5
Perissi, V.6
Rose, D.W.7
Willson, T.M.8
Rosenfeld, M.G.9
Glass, C.K.10
-
75
-
-
81255127671
-
Thyroid hormone receptor repression is linked to type I pneumocyteassociated respiratory distress syndrome
-
Pei L, Leblanc M, Barish G, Atkins A, Nofsinger R, Whyte J, Gold D, He M, Kawamura K, Li HR, et al. 2011. Thyroid hormone receptor repression is linked to type I pneumocyteassociated respiratory distress syndrome. Nat Med 17: 1466-1472.
-
(2011)
Nat Med
, vol.17
, pp. 1466-1472
-
-
Pei, L.1
Leblanc, M.2
Barish, G.3
Atkins, A.4
Nofsinger, R.5
Whyte, J.6
Gold, D.7
He, M.8
Kawamura, K.9
Li, H.R.10
-
76
-
-
84871902783
-
The corepressor NCoR1 antagonizes PGC-1a and estrogen-related receptor a in the regulation of skeletal muscle function and oxidative metabolism
-
Perez-Schindler J, Summermatter S, Salatino S, Zorzato F, Beer M, Balwierz PJ, van Nimwegen E, Feige JN, Auwerx J, Handschin C. 2012. The corepressor NCoR1 antagonizes PGC-1a and estrogen-related receptor a in the regulation of skeletal muscle function and oxidative metabolism. Mol Cell Biol 32: 4913-4924.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 4913-4924
-
-
Perez-Schindler, J.1
Summermatter, S.2
Salatino, S.3
Zorzato, F.4
Beer, M.5
Balwierz, P.J.6
van Nimwegen, E.7
Feige, J.N.8
Auwerx, J.9
Handschin, C.10
-
77
-
-
1342264315
-
A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
-
Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG. 2004. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 116: 511-526.
-
(2004)
Cell
, vol.116
, pp. 511-526
-
-
Perissi, V.1
Aggarwal, A.2
Glass, C.K.3
Rose, D.W.4
Rosenfeld, M.G.5
-
78
-
-
40849086600
-
TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/ SMRT transcriptional repression checkpoints
-
Perissi V, Scafoglio C, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG. 2008. TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/ SMRT transcriptional repression checkpoints. Mol Cell 29: 755-766.
-
(2008)
Mol Cell
, vol.29
, pp. 755-766
-
-
Perissi, V.1
Scafoglio, C.2
Zhang, J.3
Ohgi, K.A.4
Rose, D.W.5
Glass, C.K.6
Rosenfeld, M.G.7
-
79
-
-
75649135910
-
Deconstructing repression: Evolving models of co-repressor action
-
Perissi V, Jepsen K, Glass CK, Rosenfeld MG. 2010. Deconstructing repression: Evolving models of co-repressor action. Nat Rev Genet 11: 109-123.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 109-123
-
-
Perissi, V.1
Jepsen, K.2
Glass, C.K.3
Rosenfeld, M.G.4
-
80
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-g
-
Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L. 2004. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-g. Nature 429: 771-776.
-
(2004)
Nature
, vol.429
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
De Machado, O.R.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
81
-
-
0035890135
-
The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program
-
Pijnappel WW, Schaft D, Roguev A, Shevchenko A, Tekotte H, Wilm M, Rigaut G, Seraphin B, Aasland R, Stewart AF. 2001. The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15: 2991-3004.
-
(2001)
Genes Dev
, vol.15
, pp. 2991-3004
-
-
Pijnappel, W.W.1
Schaft, D.2
Roguev, A.3
Shevchenko, A.4
Tekotte, H.5
Wilm, M.6
Rigaut, G.7
Seraphin, B.8
Aasland, R.9
Stewart, A.F.10
-
82
-
-
73349130440
-
Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate
-
Pospisilik JA, Schramek D, Schnidar H, Cronin SJ, Nehme NT, Zhang X, Knauf C, Cani PD, Aumayr K, Todoric J, et al. 2010. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell 140: 148-160.
-
(2010)
Cell
, vol.140
, pp. 148-160
-
-
Pospisilik, J.A.1
Schramek, D.2
Schnidar, H.3
Cronin, S.J.4
Nehme, N.T.5
Zhang, X.6
Knauf, C.7
Cani, P.D.8
Aumayr, K.9
Todoric, J.10
-
83
-
-
84860783115
-
Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBPb and KAISO
-
Raghav SK, Waszak SM, Krier I, Gubelmann C, Isakova A, Mikkelsen TS, Deplancke B. 2012. Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBPb and KAISO. Mol Cell 46: 335-350.
-
(2012)
Mol Cell
, vol.46
, pp. 335-350
-
-
Raghav, S.K.1
Waszak, S.M.2
Krier, I.3
Gubelmann, C.4
Isakova, A.5
Mikkelsen, T.S.6
Deplancke, B.7
-
84
-
-
78649513372
-
Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration
-
Reilly SM, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. 2010. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. Cell Metab 12: 643-653.
-
(2010)
Cell Metab
, vol.12
, pp. 643-653
-
-
Reilly, S.M.1
Bhargava, P.2
Liu, S.3
Gangl, M.R.4
Gorgun, C.5
Nofsinger, R.R.6
Evans, R.M.7
Qi, L.8
Hu, F.B.9
Lee, C.H.10
-
86
-
-
81055144779
-
Derepressing nuclear receptors for metabolic adaptation
-
Saltiel AR. 2011. Derepressing nuclear receptors for metabolic adaptation. Cell 147: 717-718.
-
(2011)
Cell
, vol.147
, pp. 717-718
-
-
Saltiel, A.R.1
-
87
-
-
78650848337
-
Mtorc1 controls fasting-induced ketogenesis and its modulation by ageing
-
Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. 2010. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468: 1100-1104.
-
(2010)
Nature
, vol.468
, pp. 1100-1104
-
-
Sengupta, S.1
Peterson, T.R.2
Laplante, M.3
Oh, S.4
Sabatini, D.M.5
-
88
-
-
0029856508
-
Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR
-
Seol W, Mahon MJ, Lee YK, Moore DD. 1996. Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR. Mol Endocrinol 10: 1646-1655.
-
(1996)
Mol Endocrinol
, vol.10
, pp. 1646-1655
-
-
Seol, W.1
Mahon, M.J.2
Lee, Y.K.3
Moore, D.D.4
-
89
-
-
0035339146
-
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation
-
Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM. 2001. Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. Genes Dev 15: 1140-1151.
-
(2001)
Genes Dev
, vol.15
, pp. 1140-1151
-
-
Shi, Y.1
Downes, M.2
Xie, W.3
Kao, H.Y.4
Ordentlich, P.5
Tsai, C.C.6
Hon, M.7
Evans, R.M.8
-
90
-
-
84863544286
-
Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy
-
Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, et al. 2012. Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest 122: 2428-2438.
-
(2012)
J Clin Invest
, vol.122
, pp. 2428-2438
-
-
Sinha, R.A.1
You, S.H.2
Zhou, J.3
Siddique, M.M.4
Bay, B.H.5
Zhu, X.6
Privalsky, M.L.7
Cheng, S.Y.8
Stevens, R.D.9
Summers, S.A.10
-
91
-
-
84860291442
-
Regulation of circadian behaviour and metabolism by synthetic REVERB agonists
-
Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin DJ, Lundasen T, Shin Y, Liu J, Cameron MD, Noel R, et al. 2012. Regulation of circadian behaviour and metabolism by synthetic REVERB agonists. Nature 485: 62-68.
-
(2012)
Nature
, vol.485
, pp. 62-68
-
-
Solt, L.A.1
Wang, Y.2
Banerjee, S.3
Hughes, T.4
Kojetin, D.J.5
Lundasen, T.6
Shin, Y.7
Liu, J.8
Cameron, M.D.9
Noel, R.10
-
92
-
-
80053070714
-
Thyroid hormone action in metabolic regulation
-
Song Y, Yao X, Ying H 2011. Thyroid hormone action in metabolic regulation. Protein Cell 2: 358-368.
-
(2011)
Protein Cell
, vol.2
, pp. 358-368
-
-
Song, Y.1
Yao, X.2
Ying, H.3
-
93
-
-
53749085961
-
Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT
-
Stanya KJ, Liu Y, Means AR, Kao HY. 2008. Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT. J Cell Biol 183: 49-61.
-
(2008)
J Cell Biol
, vol.183
, pp. 49-61
-
-
Stanya, K.J.1
Liu, Y.2
Means, A.R.3
Kao, H.Y.4
-
94
-
-
33749999530
-
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
-
St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jager S, Handschin C, Zheng K, Lin J, Yang W, et al. 2006. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127: 397-408.
-
(2006)
Cell
, vol.127
, pp. 397-408
-
-
St-Pierre, J.1
Drori, S.2
Uldry, M.3
Silvaggi, J.M.4
Rhee, J.5
Jager, S.6
Handschin, C.7
Zheng, K.8
Lin, J.9
Yang, W.10
-
95
-
-
80052992257
-
Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle
-
Sun Z, Singh N, Mullican SE, Everett LJ, Li L, Yuan L, Liu X, Epstein JA, Lazar MA. 2011. Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem 286: 33301-33309.
-
(2011)
J Biol Chem
, vol.286
, pp. 33301-33309
-
-
Sun, Z.1
Singh, N.2
Mullican, S.E.3
Everett, L.J.4
Li, L.5
Yuan, L.6
Liu, X.7
Epstein, J.A.8
Lazar, M.A.9
-
96
-
-
84862025421
-
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
-
Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, et al. 2012. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med 18: 934-942.
-
(2012)
Nat Med
, vol.18
, pp. 934-942
-
-
Sun, Z.1
Miller, R.A.2
Patel, R.T.3
Chen, J.4
Dhir, R.5
Wang, H.6
Zhang, D.7
Graham, M.J.8
Unterman, T.G.9
Shulman, G.I.10
-
97
-
-
77953297721
-
The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo
-
Sutanto MM, Ferguson KK, Sakuma H, Ye H, Brady MJ, Cohen RN. 2010. The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo. J Biol Chem 285: 18485-18495.
-
(2010)
J Biol Chem
, vol.285
, pp. 18485-18495
-
-
Sutanto, M.M.1
Ferguson, K.K.2
Sakuma, H.3
Ye, H.4
Brady, M.J.5
Cohen, R.N.6
-
98
-
-
41949123156
-
PPARdmediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis
-
Takata Y, Liu J, Yin F, Collins AR, Lyon CJ, Lee CH, Atkins AR, Downes M, Barish GD, Evans RM, et al. 2008. PPARdmediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis. Proc Natl Acad Sci 105: 4277-4282.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 4277-4282
-
-
Takata, Y.1
Liu, J.2
Yin, F.3
Collins, A.R.4
Lyon, C.J.5
Lee, C.H.6
Atkins, A.R.7
Downes, M.8
Barish, G.D.9
Evans, R.M.10
-
99
-
-
33745393452
-
SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription
-
Tiefenbach J, Novac N, Ducasse M, Eck M, Melchior F, Heinzel T. 2006. SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription. Mol Biol Cell 17: 1643-1651.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 1643-1651
-
-
Tiefenbach, J.1
Novac, N.2
Ducasse, M.3
Eck, M.4
Melchior, F.5
Heinzel, T.6
-
100
-
-
0033180592
-
SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development
-
Tsai CC, Kao HY, Yao TP, McKeown M, Evans RM. 1999. SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. Mol Cell 4: 175-186.
-
(1999)
Mol Cell
, vol.4
, pp. 175-186
-
-
Tsai, C.C.1
Kao, H.Y.2
Yao, T.P.3
McKeown, M.4
Evans, R.M.5
-
101
-
-
33746306689
-
An NRSF/REST-like repressor downstream of Ebi/SMRTER/ Su(H) regulates eye development in Drosophila
-
Tsuda L, Kaido M, Lim YM, Kato K, Aigaki T, Hayashi S. 2006. An NRSF/REST-like repressor downstream of Ebi/SMRTER/ Su(H) regulates eye development in Drosophila. EMBO J 25: 3191-3202.
-
(2006)
EMBO J
, vol.25
, pp. 3191-3202
-
-
Tsuda, L.1
Kaido, M.2
Lim, Y.M.3
Kato, K.4
Aigaki, T.5
Hayashi, S.6
-
102
-
-
78650521041
-
Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation
-
Varlakhanova N, Hahm JB, Privalsky ML. 2011. Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation. Mol Cell Endocrinol 332: 180-188.
-
(2011)
Mol Cell Endocrinol
, vol.332
, pp. 180-188
-
-
Varlakhanova, N.1
Hahm, J.B.2
Privalsky, M.L.3
-
103
-
-
53549125545
-
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
-
Vokes SA, Ji H, Wong WH, McMahon AP. 2008. A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev 22: 2651-2663.
-
(2008)
Genes Dev
, vol.22
, pp. 2651-2663
-
-
Vokes, S.A.1
Ji, H.2
Wong, W.H.3
McMahon, A.P.4
-
104
-
-
84855984763
-
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate
-
Watson PJ, Fairall L, Santos GM, Schwabe JW. 2012a. Structure of HDAC3 bound to co-repressor and inositol tetraphosphate. Nature 481: 335-340.
-
(2012)
Nature
, vol.481
, pp. 335-340
-
-
Watson, P.J.1
Fairall, L.2
Santos, G.M.3
Schwabe, J.W.4
-
105
-
-
82655181792
-
Nuclear hormone receptor co-repressors: Structure and function
-
Watson PJ, Fairall L, Schwabe JW. 2012b. Nuclear hormone receptor co-repressors: Structure and function. Mol Cell Endocrinol 348: 440-449.
-
(2012)
Mol Cell Endocrinol
, vol.348
, pp. 440-449
-
-
Watson, P.J.1
Fairall, L.2
Schwabe, J.W.3
-
106
-
-
0034536085
-
The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/ LXXII) that serve as receptor interaction domains (IDs)
-
Webb P, Anderson CM, Valentine C, Nguyen P, Marimuthu A, West BL, Baxter JD, Kushner PJ. 2000. The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/ LXXII) that serve as receptor interaction domains (IDs). Mol Endocrinol 14: 1976-1985.
-
(2000)
Mol Endocrinol
, vol.14
, pp. 1976-1985
-
-
Webb, P.1
Anderson, C.M.2
Valentine, C.3
Nguyen, P.4
Marimuthu, A.5
West, B.L.6
Baxter, J.D.7
Kushner, P.J.8
-
107
-
-
0031839177
-
Transcriptional repression by the SMRT-mSin3 corepressor: Multiple interactions, multiple mechanisms, and a potential role for TFIIB
-
Wong CW, Privalsky ML. 1998. Transcriptional repression by the SMRT-mSin3 corepressor: Multiple interactions, multiple mechanisms, and a potential role for TFIIB. Mol Cell Biol 18: 5500-5510.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 5500-5510
-
-
Wong, C.W.1
Privalsky, M.L.2
-
108
-
-
70349481797
-
N-CoR is required for patterning the anterior-posterior axis of zebrafish hindbrain by actively repressing retinoid signaling
-
Xu F, Li K, Tian M, Hu P, Song W, Chen J, Gao X, Zhao Q. 2009. N-CoR is required for patterning the anterior-posterior axis of zebrafish hindbrain by actively repressing retinoid signaling. Mech Dev 126: 771-780.
-
(2009)
Mech Dev
, vol.126
, pp. 771-780
-
-
Xu, F.1
Li, K.2
Tian, M.3
Hu, P.4
Song, W.5
Chen, J.6
Gao, X.7
Zhao, Q.8
-
109
-
-
81055125669
-
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function
-
Yamamoto H, Williams EG, Mouchiroud L, Canto C, Fan W, Downes M, Heligon C, Barish GD, Desvergne B, Evans RM, et al. 2011. NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell 147: 827-839.
-
(2011)
Cell
, vol.147
, pp. 827-839
-
-
Yamamoto, H.1
Williams, E.G.2
Mouchiroud, L.3
Canto, C.4
Fan, W.5
Downes, M.6
Heligon, C.7
Barish, G.D.8
Desvergne, B.9
Evans, R.M.10
-
110
-
-
22344445394
-
The orphan nuclear receptor Rev-erba recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene
-
Yin L, Lazar MA. 2005. The orphan nuclear receptor Rev-erba recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. Mol Endocrinol 19: 1452-1459.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 1452-1459
-
-
Yin, L.1
Lazar, M.A.2
-
111
-
-
37249086610
-
Reverba, a heme sensor that coordinates metabolic and circadian pathways
-
Yin L, Wu N, Curtin JC, Qatanani M, Szwergold NR, Reid RA, Waitt GM, Parks DJ, Pearce KH, Wisely GB, et al. 2007. Reverba, a heme sensor that coordinates metabolic and circadian pathways. Science 318: 1786-1789.
-
(2007)
Science
, vol.318
, pp. 1786-1789
-
-
Yin, L.1
Wu, N.2
Curtin, J.C.3
Qatanani, M.4
Szwergold, N.R.5
Reid, R.A.6
Waitt, G.M.7
Parks, D.J.8
Pearce, K.H.9
Wisely, G.B.10
-
112
-
-
77954835174
-
Nuclear receptor Rev-erba: A heme receptor that coordinates circadian rhythm and metabolism
-
Yin L, Wu N, Lazar MA. 2010. Nuclear receptor Rev-erba: A heme receptor that coordinates circadian rhythm and metabolism. Nucl Recept Signal 8: e001.
-
(2010)
Nucl Recept Signal
, vol.8
-
-
Yin, L.1
Wu, N.2
Lazar, M.A.3
-
113
-
-
33746507785
-
The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor
-
Yoon HG, Wong J. 2006. The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor. Mol Endocrinol 20: 1048-1060.
-
(2006)
Mol Endocrinol
, vol.20
, pp. 1048-1060
-
-
Yoon, H.G.1
Wong, J.2
-
114
-
-
84873571381
-
Nuclear receptor co-repressors are required for the histonedeacetylase activity of HDAC3 in vivo
-
You SH, Lim HW, Sun Z, Broache M, Won KJ, Lazar MA. 2013. Nuclear receptor co-repressors are required for the histonedeacetylase activity of HDAC3 in vivo. Nat Struct Mol Biol 20: 182-187.
-
(2013)
Nat Struct Mol Biol
, vol.20
, pp. 182-187
-
-
You, S.H.1
Lim, H.W.2
Sun, Z.3
Broache, M.4
Won, K.J.5
Lazar, M.A.6
-
115
-
-
0037925529
-
A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation
-
Yu J, Li Y, Ishizuka T, Guenther MG, Lazar MA. 2003. A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation. EMBO J 22: 3403-3410.
-
(2003)
EMBO J
, vol.22
, pp. 3403-3410
-
-
Yu, J.1
Li, Y.2
Ishizuka, T.3
Guenther, M.G.4
Lazar, M.A.5
|