메뉴 건너뛰기




Volumn 27, Issue 8, 2013, Pages 819-835

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

Author keywords

Cofactor; Development; Epigenetics; Metabolism; Transcription factor

Indexed keywords

CHOLESTEROL; COREPRESSOR PROTEIN; CYCLIN DEPENDENT KINASE 5; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOSE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 5; HISTONE DEACETYLASE 7; I KAPPA B KINASE ALPHA; LIPID; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; NCOR1 PROTEIN; NOTCH RECEPTOR; NUCLEAR RECEPTOR COREPRESSOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RETINOIC ACID RECEPTOR; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; SIRTUIN 1; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84876912279     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.214023.113     Document Type: Review
Times cited : (231)

References (115)
  • 3
    • 0042626227 scopus 로고    scopus 로고
    • A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling
    • Ariyoshi M, Schwabe JW. 2003. A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. Genes Dev 17: 1909-1920.
    • (2003) Genes Dev , vol.17 , pp. 1909-1920
    • Ariyoshi, M.1    Schwabe, J.W.2
  • 6
    • 0037067655 scopus 로고    scopus 로고
    • Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kB and b-amyloid precursor protein
    • Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG. 2002. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kB and b-amyloid precursor protein. Cell 110: 55-67.
    • (2002) Cell , vol.110 , pp. 55-67
    • Baek, S.H.1    Ohgi, K.A.2    Rose, D.W.3    Koo, E.H.4    Glass, C.K.5    Rosenfeld, M.G.6
  • 8
    • 41549156540 scopus 로고    scopus 로고
    • Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control
    • Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW. 2008. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell 30: 61-72.
    • (2008) Mol Cell , vol.30 , pp. 61-72
    • Bhaskara, S.1    Chyla, B.J.2    Amann, J.M.3    Knutson, S.K.4    Cortez, D.5    Sun, Z.W.6    Hiebert, S.W.7
  • 10
    • 70349111436 scopus 로고    scopus 로고
    • Emerging roles of peroxisome proliferator-activated receptor-b/d in inflammation
    • Bishop-Bailey D, Bystrom J. 2009. Emerging roles of peroxisome proliferator-activated receptor-b/d in inflammation. Pharmacol Ther 124: 141-150.
    • (2009) Pharmacol Ther , vol.124 , pp. 141-150
    • Bishop-Bailey, D.1    Bystrom, J.2
  • 11
    • 0029097233 scopus 로고
    • A transcriptional co-repressor that interacts with nuclear hormone receptors
    • Chen JD, Evans RM. 1995. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377: 454-457.
    • (1995) Nature , vol.377 , pp. 454-457
    • Chen, J.D.1    Evans, R.M.2
  • 13
    • 0034975063 scopus 로고    scopus 로고
    • The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains
    • Cohen RN, Brzostek S, Kim B, Chorev M, Wondisford FE, Hollenberg AN. 2001. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol Endocrinol 15: 1049-1061.
    • (2001) Mol Endocrinol , vol.15 , pp. 1049-1061
    • Cohen, R.N.1    Brzostek, S.2    Kim, B.3    Chorev, M.4    Wondisford, F.E.5    Hollenberg, A.N.6
  • 14
    • 0029859318 scopus 로고    scopus 로고
    • Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbAa and RVR: Physical association is dependent on the
    • Downes M, Burke LJ, Bailey PJ, Muscat GE. 1996. Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbAa and RVR: Physical association is dependent on the E region of the orphan receptors. Nucleic Acids Res 24: 4379-4386.
    • (1996) E Region of the Orphan Receptors. Nucleic Acids Res , vol.24 , pp. 4379-4386
    • Downes, M.1    Burke, L.J.2    Bailey, P.J.3    Muscat, G.E.4
  • 16
    • 79952775519 scopus 로고    scopus 로고
    • Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance
    • Fang S, Suh JM, Atkins AR, Hong SH, Leblanc M, Nofsinger RR, Yu RT, Downes M, Evans RM. 2011. Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance. Proc Natl Acad Sci 108: 3412-3417.
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 3412-3417
    • Fang, S.1    Suh, J.M.2    Atkins, A.R.3    Hong, S.H.4    Leblanc, M.5    Nofsinger, R.R.6    Yu, R.T.7    Downes, M.8    Evans, R.M.9
  • 17
    • 0035805501 scopus 로고    scopus 로고
    • Transgenic targeting of a dominant negative corepressor to liver blocks basal repression by thyroid hormone receptor and increases cell proliferation
    • Feng X, Jiang Y, Meltzer P, Yen PM. 2001. Transgenic targeting of a dominant negative corepressor to liver blocks basal repression by thyroid hormone receptor and increases cell proliferation. J Biol Chem 276: 15066-15072.
    • (2001) J Biol Chem , vol.276 , pp. 15066-15072
    • Feng, X.1    Jiang, Y.2    Meltzer, P.3    Yen, P.M.4
  • 18
    • 79952529158 scopus 로고    scopus 로고
    • A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
    • Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA. 2011. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 331: 1315-1319.
    • (2011) Science , vol.331 , pp. 1315-1319
    • Feng, D.1    Liu, T.2    Sun, Z.3    Bugge, A.4    Mullican, S.E.5    Alenghat, T.6    Liu, X.S.7    Lazar, M.A.8
  • 21
    • 0036161439 scopus 로고    scopus 로고
    • Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
    • Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E. 2002. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell 9: 45-57.
    • (2002) Mol Cell , vol.9 , pp. 45-57
    • Fischle, W.1    Dequiedt, F.2    Hendzel, M.J.3    Guenther, M.G.4    Lazar, M.A.5    Voelter, W.6    Verdin, E.7
  • 23
    • 79955473684 scopus 로고    scopus 로고
    • Operating on chromatin, a colorful language where context matters
    • Gardner KE, Allis CD, Strahl BD. 2011. Operating on chromatin, a colorful language where context matters. J Mol Biol 409: 36-46.
    • (2011) J Mol Biol , vol.409 , pp. 36-46
    • Gardner, K.E.1    Allis, C.D.2    Strahl, B.D.3
  • 25
    • 63049122784 scopus 로고    scopus 로고
    • Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways
    • Ghisletti S, Huang W, Jepsen K, Benner C, Hardiman G, Rosenfeld MG, Glass CK. 2009. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev 23: 681-693.
    • (2009) Genes Dev , vol.23 , pp. 681-693
    • Ghisletti, S.1    Huang, W.2    Jepsen, K.3    Benner, C.4    Hardiman, G.5    Rosenfeld, M.G.6    Glass, C.K.7
  • 26
    • 0034650893 scopus 로고    scopus 로고
    • The coregulator exchange in transcriptional functions of nuclear receptors
    • Glass CK, Rosenfeld MG. 2000. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 14: 121-141.
    • (2000) Genes Dev , vol.14 , pp. 121-141
    • Glass, C.K.1    Rosenfeld, M.G.2
  • 28
    • 14844294741 scopus 로고    scopus 로고
    • Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors
    • Goodson ML, Jonas BA, Privalsky ML. 2005. Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. J Biol Chem 280: 7493-7503.
    • (2005) J Biol Chem , vol.280 , pp. 7493-7503
    • Goodson, M.L.1    Jonas, B.A.2    Privalsky, M.L.3
  • 29
    • 84455161762 scopus 로고    scopus 로고
    • Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation
    • Goodson ML, Mengeling BJ, Jonas BA, Privalsky ML. 2011. Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation. J Biol Chem 286: 44988-44999.
    • (2011) J Biol Chem , vol.286 , pp. 44988-44999
    • Goodson, M.L.1    Mengeling, B.J.2    Jonas, B.A.3    Privalsky, M.L.4
  • 30
    • 0035724413 scopus 로고    scopus 로고
    • The SMRTand N-CoR corepressors are activating cofactors for histone deacetylase 3
    • Guenther MG, Barak O, Lazar MA. 2001. The SMRTand N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol 21: 6091-6101.
    • (2001) Mol Cell Biol , vol.21 , pp. 6091-6101
    • Guenther, M.G.1    Barak, O.2    Lazar, M.A.3
  • 34
    • 0037206890 scopus 로고    scopus 로고
    • N-CoR controls differentiation of neural stem cells into astrocytes
    • Hermanson O, Jepsen K, Rosenfeld MG. 2002. N-CoR controls differentiation of neural stem cells into astrocytes. Nature 419: 934-939.
    • (2002) Nature , vol.419 , pp. 934-939
    • Hermanson, O.1    Jepsen, K.2    Rosenfeld, M.G.3
  • 35
    • 6344241039 scopus 로고    scopus 로고
    • SMRT derepression by the IkB kinase a: A prerequisite to NF-kB transcription and survival
    • Hoberg JE, Yeung F, Mayo MW. 2004. SMRT derepression by the IkB kinase a: A prerequisite to NF-kB transcription and survival. Mol Cell 16: 245-255.
    • (2004) Mol Cell , vol.16 , pp. 245-255
    • Hoberg, J.E.1    Yeung, F.2    Mayo, M.W.3
  • 36
    • 0033838465 scopus 로고    scopus 로고
    • The SMRT corepressor is regulated by a MEK-1 kinase pathway: Inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export
    • Hong SH, Privalsky ML. 2000. The SMRT corepressor is regulated by a MEK-1 kinase pathway: Inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export. Mol Cell Biol 20: 6612-6625.
    • (2000) Mol Cell Biol , vol.20 , pp. 6612-6625
    • Hong, S.H.1    Privalsky, M.L.2
  • 37
    • 0032230335 scopus 로고    scopus 로고
    • Signaling by tyrosine kinases negatively regulates the interaction between tran- scription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor
    • Hong SH, Wong CW, Privalsky ML. 1998. Signaling by tyrosine kinases negatively regulates the interaction between tran- scription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor. Mol Endocrinol 12: 1161-1171.
    • (1998) Mol Endocrinol , vol.12 , pp. 1161-1171
    • Hong, S.H.1    Wong, C.W.2    Privalsky, M.L.3
  • 39
    • 0034045480 scopus 로고    scopus 로고
    • Transcriptional repression by nuclear hormone receptors
    • Hu X, Lazar MA. 2000. Transcriptional repression by nuclear hormone receptors. Trends Endocrinol Metab 11: 6-10.
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 6-10
    • Hu, X.1    Lazar, M.A.2
  • 40
    • 67649668789 scopus 로고    scopus 로고
    • Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint
    • Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK. 2009. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell 35: 48-57.
    • (2009) Mol Cell , vol.35 , pp. 48-57
    • Huang, W.1    Ghisletti, S.2    Perissi, V.3    Rosenfeld, M.G.4    Glass, C.K.5
  • 41
    • 0042592941 scopus 로고    scopus 로고
    • The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor
    • Ishizuka T, Lazar MA. 2003. The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor. Mol Cell Biol 23: 5122-5131.
    • (2003) Mol Cell Biol , vol.23 , pp. 5122-5131
    • Ishizuka, T.1    Lazar, M.A.2
  • 42
    • 22344453589 scopus 로고    scopus 로고
    • The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor
    • Ishizuka T, Lazar MA. 2005. The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor. Mol Endocrinol 19: 1443-1451.
    • (2005) Mol Endocrinol , vol.19 , pp. 1443-1451
    • Ishizuka, T.1    Lazar, M.A.2
  • 43
    • 0037084392 scopus 로고    scopus 로고
    • Biological roles and mechanistic actions of co-repressor complexes
    • Jepsen K, Rosenfeld MG. 2002. Biological roles and mechanistic actions of co-repressor complexes. J Cell Sci 115: 689-698.
    • (2002) J Cell Sci , vol.115 , pp. 689-698
    • Jepsen, K.1    Rosenfeld, M.G.2
  • 47
    • 11144230050 scopus 로고    scopus 로고
    • SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways
    • Jonas BA, Privalsky ML. 2004. SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J Biol Chem 279: 54676-54686.
    • (2004) J Biol Chem , vol.279 , pp. 54676-54686
    • Jonas, B.A.1    Privalsky, M.L.2
  • 48
    • 34547483059 scopus 로고    scopus 로고
    • Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing
    • Jonas BA, Varlakhanova N, Hayakawa F, Goodson M, Privalsky ML. 2007. Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing. Mol Endocrinol 21: 1924-1939.
    • (2007) Mol Endocrinol , vol.21 , pp. 1924-1939
    • Jonas, B.A.1    Varlakhanova, N.2    Hayakawa, F.3    Goodson, M.4    Privalsky, M.L.5
  • 50
    • 0033964223 scopus 로고    scopus 로고
    • Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
    • Kao HY, Downes M, Ordentlich P, Evans RM. 2000. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev 14: 55-66.
    • (2000) Genes Dev , vol.14 , pp. 55-66
    • Kao, H.Y.1    Downes, M.2    Ordentlich, P.3    Evans, R.M.4
  • 51
    • 34547909260 scopus 로고    scopus 로고
    • HDAC3: Taking the SMRT-NCoRrect road to repression
    • Karagianni P, Wong J. 2007. HDAC3: Taking the SMRT-NCoRrect road to repression. Oncogene 26: 5439-5449.
    • (2007) Oncogene , vol.26 , pp. 5439-5449
    • Karagianni, P.1    Wong, J.2
  • 52
    • 64949168643 scopus 로고    scopus 로고
    • Up-regulation of nuclear receptor corepressor (NCoR) in progestin-induced growth suppression of endometrial hyperplasia and carcinoma
    • Kashima H, Horiuchi A, Uchikawa J, Miyamoto T, Suzuki A, Ashida T, Konishi I, Shiozawa T. 2009. Up-regulation of nuclear receptor corepressor (NCoR) in progestin-induced growth suppression of endometrial hyperplasia and carcinoma. Anticancer Res 29: 1023-1029.
    • (2009) Anticancer Res , vol.29 , pp. 1023-1029
    • Kashima, H.1    Horiuchi, A.2    Uchikawa, J.3    Miyamoto, T.4    Suzuki, A.5    Ashida, T.6    Konishi, I.7    Shiozawa, T.8
  • 53
    • 84862829663 scopus 로고    scopus 로고
    • S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator- activated receptor a activity in the liver
    • Kim K, Pyo S, Um SH. 2012. S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator- activated receptor a activity in the liver. Hepatology 55: 1727-1737.
    • (2012) Hepatology , vol.55 , pp. 1727-1737
    • Kim, K.1    Pyo, S.2    Um, S.H.3
  • 54
    • 41949120723 scopus 로고    scopus 로고
    • Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
    • Knutson SK, Chyla BJ, Amann JM, Bhaskara S, Huppert SS, Hiebert SW. 2008. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J 27: 1017-1028.
    • (2008) EMBO J , vol.27 , pp. 1017-1028
    • Knutson, S.K.1    Chyla, B.J.2    Amann, J.M.3    Bhaskara, S.4    Huppert, S.S.5    Hiebert, S.W.6
  • 56
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M, Sabatini DM. 2012. mTOR signaling in growth control and disease. Cell 149: 274-293.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 58
    • 0030784510 scopus 로고    scopus 로고
    • Characterization of receptor interaction and transcriptional repression by the corepressor SMRT
    • Li H, Leo C, Schroen DJ, Chen JD. 1997. Characterization of receptor interaction and transcriptional repression by the corepressor SMRT. Mol Endocrinol 11: 2025-2037.
    • (1997) Mol Endocrinol , vol.11 , pp. 2025-2037
    • Li, H.1    Leo, C.2    Schroen, D.J.3    Chen, J.D.4
  • 59
    • 81055144760 scopus 로고    scopus 로고
    • Adipocyte NCoR knockout decreases PPARg phosphorylation and enhances PPARg activity and insulin sensitivity
    • Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, et al. 2011. Adipocyte NCoR knockout decreases PPARg phosphorylation and enhances PPARg activity and insulin sensitivity. Cell 147: 815-826.
    • (2011) Cell , vol.147 , pp. 815-826
    • Li, P.1    Fan, W.2    Xu, J.3    Lu, M.4    Yamamoto, H.5    Auwerx, J.6    Sears, D.D.7    Talukdar, S.8    Oh, D.9    Chen, A.10
  • 62
    • 84860413257 scopus 로고    scopus 로고
    • Identification and characterization of a functional zebrafish smrt corepressor (ncor2)
    • Linney E, Perz-Edwards A, Kelley B. 2011. Identification and characterization of a functional zebrafish smrt corepressor (ncor2). Gene 486: 31-36.
    • (2011) Gene , vol.486 , pp. 31-36
    • Linney, E.1    Perz-Edwards, A.2    Kelley, B.3
  • 64
    • 84883488905 scopus 로고    scopus 로고
    • NMR assignments of SPOC domain of the human transcriptional corepressor SHARP in complex with a C-terminal SMRT peptide
    • doi: 10.1007/s12104-012-9424-8
    • Mikami S, Kanaba T, Ito Y, Mishima M. 2012. NMR assignments of SPOC domain of the human transcriptional corepressor SHARP in complex with a C-terminal SMRT peptide. Biomol NMR Assign doi: 10.1007/s12104-012-9424-8.
    • (2012) Biomol NMR Assign
    • Mikami, S.1    Kanaba, T.2    Ito, Y.3    Mishima, M.4
  • 65
    • 84874605154 scopus 로고    scopus 로고
    • GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/ SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans
    • Mikolas P, Kollarova J, Sebkova K, Saudek V, Yilma P, Kostrouchova M, Krause MW, Kostrouch Z. 2013. GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/ SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans. PLoS ONE 8: e58462.
    • (2013) PLoS ONE , vol.8
    • Mikolas, P.1    Kollarova, J.2    Sebkova, K.3    Saudek, V.4    Yilma, P.5    Kostrouchova, M.6    Krause, M.W.7    Kostrouch, Z.8
  • 67
    • 0032526615 scopus 로고    scopus 로고
    • The corepressor N-CoR and its variants RIP13a and RIP13D1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70
    • Muscat GE, Burke LJ, Downes M. 1998. The corepressor N-CoR and its variants RIP13a and RIP13D1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70. Nucleic Acids Res 26: 2899-2907.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2899-2907
    • Muscat, G.E.1    Burke, L.J.2    Downes, M.3
  • 72
    • 0033616676 scopus 로고    scopus 로고
    • SMRTe, a silencing mediator for retinoid and thyroid hormone re- ceptors-extended isoform that is more related to the nuclear receptor corepressor
    • Park EJ, Schroen DJ, Yang M, Li H, Li L, Chen JD. 1999. SMRTe, a silencing mediator for retinoid and thyroid hormone re- ceptors-extended isoform that is more related to the nuclear receptor corepressor. Proc Natl Acad Sci 96: 3519-3524.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 3519-3524
    • Park, E.J.1    Schroen, D.J.2    Yang, M.3    Li, H.4    Li, L.5    Chen, J.D.6
  • 77
    • 1342264315 scopus 로고    scopus 로고
    • A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
    • Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG. 2004. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 116: 511-526.
    • (2004) Cell , vol.116 , pp. 511-526
    • Perissi, V.1    Aggarwal, A.2    Glass, C.K.3    Rose, D.W.4    Rosenfeld, M.G.5
  • 78
    • 40849086600 scopus 로고    scopus 로고
    • TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/ SMRT transcriptional repression checkpoints
    • Perissi V, Scafoglio C, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG. 2008. TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/ SMRT transcriptional repression checkpoints. Mol Cell 29: 755-766.
    • (2008) Mol Cell , vol.29 , pp. 755-766
    • Perissi, V.1    Scafoglio, C.2    Zhang, J.3    Ohgi, K.A.4    Rose, D.W.5    Glass, C.K.6    Rosenfeld, M.G.7
  • 79
    • 75649135910 scopus 로고    scopus 로고
    • Deconstructing repression: Evolving models of co-repressor action
    • Perissi V, Jepsen K, Glass CK, Rosenfeld MG. 2010. Deconstructing repression: Evolving models of co-repressor action. Nat Rev Genet 11: 109-123.
    • (2010) Nat Rev Genet , vol.11 , pp. 109-123
    • Perissi, V.1    Jepsen, K.2    Glass, C.K.3    Rosenfeld, M.G.4
  • 81
    • 0035890135 scopus 로고    scopus 로고
    • The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program
    • Pijnappel WW, Schaft D, Roguev A, Shevchenko A, Tekotte H, Wilm M, Rigaut G, Seraphin B, Aasland R, Stewart AF. 2001. The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15: 2991-3004.
    • (2001) Genes Dev , vol.15 , pp. 2991-3004
    • Pijnappel, W.W.1    Schaft, D.2    Roguev, A.3    Shevchenko, A.4    Tekotte, H.5    Wilm, M.6    Rigaut, G.7    Seraphin, B.8    Aasland, R.9    Stewart, A.F.10
  • 83
    • 84860783115 scopus 로고    scopus 로고
    • Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBPb and KAISO
    • Raghav SK, Waszak SM, Krier I, Gubelmann C, Isakova A, Mikkelsen TS, Deplancke B. 2012. Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBPb and KAISO. Mol Cell 46: 335-350.
    • (2012) Mol Cell , vol.46 , pp. 335-350
    • Raghav, S.K.1    Waszak, S.M.2    Krier, I.3    Gubelmann, C.4    Isakova, A.5    Mikkelsen, T.S.6    Deplancke, B.7
  • 85
    • 63549117300 scopus 로고    scopus 로고
    • Pinning down HER2-ER crosstalk in SMRT regulation
    • Ryo A, Wulf G, Lee TH, Lu KP. 2009. Pinning down HER2-ER crosstalk in SMRT regulation. Trends Biochem Sci 34: 162-165.
    • (2009) Trends Biochem Sci , vol.34 , pp. 162-165
    • Ryo, A.1    Wulf, G.2    Lee, T.H.3    Lu, K.P.4
  • 86
    • 81055144779 scopus 로고    scopus 로고
    • Derepressing nuclear receptors for metabolic adaptation
    • Saltiel AR. 2011. Derepressing nuclear receptors for metabolic adaptation. Cell 147: 717-718.
    • (2011) Cell , vol.147 , pp. 717-718
    • Saltiel, A.R.1
  • 87
    • 78650848337 scopus 로고    scopus 로고
    • Mtorc1 controls fasting-induced ketogenesis and its modulation by ageing
    • Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. 2010. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468: 1100-1104.
    • (2010) Nature , vol.468 , pp. 1100-1104
    • Sengupta, S.1    Peterson, T.R.2    Laplante, M.3    Oh, S.4    Sabatini, D.M.5
  • 88
    • 0029856508 scopus 로고    scopus 로고
    • Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR
    • Seol W, Mahon MJ, Lee YK, Moore DD. 1996. Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR. Mol Endocrinol 10: 1646-1655.
    • (1996) Mol Endocrinol , vol.10 , pp. 1646-1655
    • Seol, W.1    Mahon, M.J.2    Lee, Y.K.3    Moore, D.D.4
  • 92
    • 80053070714 scopus 로고    scopus 로고
    • Thyroid hormone action in metabolic regulation
    • Song Y, Yao X, Ying H 2011. Thyroid hormone action in metabolic regulation. Protein Cell 2: 358-368.
    • (2011) Protein Cell , vol.2 , pp. 358-368
    • Song, Y.1    Yao, X.2    Ying, H.3
  • 93
    • 53749085961 scopus 로고    scopus 로고
    • Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT
    • Stanya KJ, Liu Y, Means AR, Kao HY. 2008. Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT. J Cell Biol 183: 49-61.
    • (2008) J Cell Biol , vol.183 , pp. 49-61
    • Stanya, K.J.1    Liu, Y.2    Means, A.R.3    Kao, H.Y.4
  • 97
    • 77953297721 scopus 로고    scopus 로고
    • The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo
    • Sutanto MM, Ferguson KK, Sakuma H, Ye H, Brady MJ, Cohen RN. 2010. The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo. J Biol Chem 285: 18485-18495.
    • (2010) J Biol Chem , vol.285 , pp. 18485-18495
    • Sutanto, M.M.1    Ferguson, K.K.2    Sakuma, H.3    Ye, H.4    Brady, M.J.5    Cohen, R.N.6
  • 99
    • 33745393452 scopus 로고    scopus 로고
    • SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription
    • Tiefenbach J, Novac N, Ducasse M, Eck M, Melchior F, Heinzel T. 2006. SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription. Mol Biol Cell 17: 1643-1651.
    • (2006) Mol Biol Cell , vol.17 , pp. 1643-1651
    • Tiefenbach, J.1    Novac, N.2    Ducasse, M.3    Eck, M.4    Melchior, F.5    Heinzel, T.6
  • 100
    • 0033180592 scopus 로고    scopus 로고
    • SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development
    • Tsai CC, Kao HY, Yao TP, McKeown M, Evans RM. 1999. SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. Mol Cell 4: 175-186.
    • (1999) Mol Cell , vol.4 , pp. 175-186
    • Tsai, C.C.1    Kao, H.Y.2    Yao, T.P.3    McKeown, M.4    Evans, R.M.5
  • 101
    • 33746306689 scopus 로고    scopus 로고
    • An NRSF/REST-like repressor downstream of Ebi/SMRTER/ Su(H) regulates eye development in Drosophila
    • Tsuda L, Kaido M, Lim YM, Kato K, Aigaki T, Hayashi S. 2006. An NRSF/REST-like repressor downstream of Ebi/SMRTER/ Su(H) regulates eye development in Drosophila. EMBO J 25: 3191-3202.
    • (2006) EMBO J , vol.25 , pp. 3191-3202
    • Tsuda, L.1    Kaido, M.2    Lim, Y.M.3    Kato, K.4    Aigaki, T.5    Hayashi, S.6
  • 102
    • 78650521041 scopus 로고    scopus 로고
    • Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation
    • Varlakhanova N, Hahm JB, Privalsky ML. 2011. Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation. Mol Cell Endocrinol 332: 180-188.
    • (2011) Mol Cell Endocrinol , vol.332 , pp. 180-188
    • Varlakhanova, N.1    Hahm, J.B.2    Privalsky, M.L.3
  • 103
    • 53549125545 scopus 로고    scopus 로고
    • A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
    • Vokes SA, Ji H, Wong WH, McMahon AP. 2008. A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev 22: 2651-2663.
    • (2008) Genes Dev , vol.22 , pp. 2651-2663
    • Vokes, S.A.1    Ji, H.2    Wong, W.H.3    McMahon, A.P.4
  • 104
    • 84855984763 scopus 로고    scopus 로고
    • Structure of HDAC3 bound to co-repressor and inositol tetraphosphate
    • Watson PJ, Fairall L, Santos GM, Schwabe JW. 2012a. Structure of HDAC3 bound to co-repressor and inositol tetraphosphate. Nature 481: 335-340.
    • (2012) Nature , vol.481 , pp. 335-340
    • Watson, P.J.1    Fairall, L.2    Santos, G.M.3    Schwabe, J.W.4
  • 105
    • 82655181792 scopus 로고    scopus 로고
    • Nuclear hormone receptor co-repressors: Structure and function
    • Watson PJ, Fairall L, Schwabe JW. 2012b. Nuclear hormone receptor co-repressors: Structure and function. Mol Cell Endocrinol 348: 440-449.
    • (2012) Mol Cell Endocrinol , vol.348 , pp. 440-449
    • Watson, P.J.1    Fairall, L.2    Schwabe, J.W.3
  • 106
    • 0034536085 scopus 로고    scopus 로고
    • The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/ LXXII) that serve as receptor interaction domains (IDs)
    • Webb P, Anderson CM, Valentine C, Nguyen P, Marimuthu A, West BL, Baxter JD, Kushner PJ. 2000. The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/ LXXII) that serve as receptor interaction domains (IDs). Mol Endocrinol 14: 1976-1985.
    • (2000) Mol Endocrinol , vol.14 , pp. 1976-1985
    • Webb, P.1    Anderson, C.M.2    Valentine, C.3    Nguyen, P.4    Marimuthu, A.5    West, B.L.6    Baxter, J.D.7    Kushner, P.J.8
  • 107
    • 0031839177 scopus 로고    scopus 로고
    • Transcriptional repression by the SMRT-mSin3 corepressor: Multiple interactions, multiple mechanisms, and a potential role for TFIIB
    • Wong CW, Privalsky ML. 1998. Transcriptional repression by the SMRT-mSin3 corepressor: Multiple interactions, multiple mechanisms, and a potential role for TFIIB. Mol Cell Biol 18: 5500-5510.
    • (1998) Mol Cell Biol , vol.18 , pp. 5500-5510
    • Wong, C.W.1    Privalsky, M.L.2
  • 108
    • 70349481797 scopus 로고    scopus 로고
    • N-CoR is required for patterning the anterior-posterior axis of zebrafish hindbrain by actively repressing retinoid signaling
    • Xu F, Li K, Tian M, Hu P, Song W, Chen J, Gao X, Zhao Q. 2009. N-CoR is required for patterning the anterior-posterior axis of zebrafish hindbrain by actively repressing retinoid signaling. Mech Dev 126: 771-780.
    • (2009) Mech Dev , vol.126 , pp. 771-780
    • Xu, F.1    Li, K.2    Tian, M.3    Hu, P.4    Song, W.5    Chen, J.6    Gao, X.7    Zhao, Q.8
  • 110
    • 22344445394 scopus 로고    scopus 로고
    • The orphan nuclear receptor Rev-erba recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene
    • Yin L, Lazar MA. 2005. The orphan nuclear receptor Rev-erba recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. Mol Endocrinol 19: 1452-1459.
    • (2005) Mol Endocrinol , vol.19 , pp. 1452-1459
    • Yin, L.1    Lazar, M.A.2
  • 112
    • 77954835174 scopus 로고    scopus 로고
    • Nuclear receptor Rev-erba: A heme receptor that coordinates circadian rhythm and metabolism
    • Yin L, Wu N, Lazar MA. 2010. Nuclear receptor Rev-erba: A heme receptor that coordinates circadian rhythm and metabolism. Nucl Recept Signal 8: e001.
    • (2010) Nucl Recept Signal , vol.8
    • Yin, L.1    Wu, N.2    Lazar, M.A.3
  • 113
    • 33746507785 scopus 로고    scopus 로고
    • The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor
    • Yoon HG, Wong J. 2006. The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor. Mol Endocrinol 20: 1048-1060.
    • (2006) Mol Endocrinol , vol.20 , pp. 1048-1060
    • Yoon, H.G.1    Wong, J.2
  • 114
    • 84873571381 scopus 로고    scopus 로고
    • Nuclear receptor co-repressors are required for the histonedeacetylase activity of HDAC3 in vivo
    • You SH, Lim HW, Sun Z, Broache M, Won KJ, Lazar MA. 2013. Nuclear receptor co-repressors are required for the histonedeacetylase activity of HDAC3 in vivo. Nat Struct Mol Biol 20: 182-187.
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 182-187
    • You, S.H.1    Lim, H.W.2    Sun, Z.3    Broache, M.4    Won, K.J.5    Lazar, M.A.6
  • 115
    • 0037925529 scopus 로고    scopus 로고
    • A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation
    • Yu J, Li Y, Ishizuka T, Guenther MG, Lazar MA. 2003. A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation. EMBO J 22: 3403-3410.
    • (2003) EMBO J , vol.22 , pp. 3403-3410
    • Yu, J.1    Li, Y.2    Ishizuka, T.3    Guenther, M.G.4    Lazar, M.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.