The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs)

Molecular Endocrinology

Volumn 14, Issue 12, 2000, Pages 1976-1985

  Webb, Paul ^a   Anderson, Carol M ^a   Valentine, Cathleen ^a   Nguyen, Phuong ^a   Marimuthu, Adhirai ^a   West, Brian L ^a   Baxter, John D ^a   Kushner, Peter J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; HYBRID PROTEIN; ISOLEUCINE; NUCLEAR RECEPTOR COREPRESSOR; REPRESSOR PROTEIN; THYROID HORMONE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL CULTURE; CHICKEN; CONTROLLED STUDY; GENETIC TRANSFECTION; HYDROPHOBICITY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ANIMALIA; GALLUS GALLUS;

EID: 0034536085     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.14.12.0566     Document Type: Article

References (56)

1. The steroid and thyroid hormone receptor superfamily
2. Transcriptional control by nuclear receptors
3. Steroid and related receptors
4. The nuclear hormone receptor gene superfamily
5. Thyroid hormone receptors: Multiple forms, multiple possibilities
6. The molecular biology of thyroid hormone action
7. Molecular and structural biology of thyroid hormone receptors
8. Nuclear receptor coactivators and corepressors
9. Nuclear receptor coactivators
10. Something new to hang your HAT on
11. The coregulator exchange in transcriptional functions of nuclear receptors
12. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
13. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex
14. Identity between TRAP and SMCC complexes indicatesnovel pathways for the function of nuclear receptors and diverse mammalian activators
15. A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
16. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
17. Composite co-activator ARC mediates chromatin-directed transcriptional activation
18. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
19. A transcriptional co-repressor that interacts with nuclear hormone receptors
20. Polarity-specific activities of retinoic acid receptors determined by a co-repressor
21. Isolation of proteins that interact specifically with the retinoid x receptor: Two novel orphan receptors
22. Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR
23. 3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors
24. Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements
25. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
26. SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors
27. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
28. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
29. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
30. Transcriptional repression by the SMRT-mSin3 corepressor: Multiple interactions, multiple mechanisms, and a potential role for TFIIB
31. Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity
32. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors
33. A structural role for hormone in the thyroid hormone receptor
34. Ligand-dependent interaction of nuclear receptors with potential transcriptional intermediary factors (mediators)
35. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
36. The transcriptional coactivator p/CIP binds CBP and mediates nuclear-receptor function
37. Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): Multiple motifs with different binding specificities
38. Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins
39. Structure and specificity of nuclear receptor-coactivator interactions
40. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
41. Ligand binding and coactivator assembly of the peroxisome proliferator-activated receptor-γ
42. Co-activators and co-repressors in the integration of transcriptional responses
43. At least three subdomains of v-erbA are involved in its silencing function
44. Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA α
45. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
46. Mechanism of corepressor binding and release from nuclear hormone receptors
47. Molecular determinants of nuclear receptor-corepressor interaction
48. Stoichiometric and steric principles governing repression by nuclear hormone receptors
49. Silencing subdomains of v-ErbA interact cooperatively with corepressors: Involvement of helices 5/6
50. Activation and repression by nuclear hormone receptors: Hormone modulates an equilibrium between active and repressive states
51. A novel role for helix 12 of retinoid X receptor in regulating repression
52. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
53. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
54. Molecular basis of agonism and antagonism in the oestrogen receptor
55. Positive and negative modulation of Jun action by thyroid hormone receptor at a unique AP1 site
56. The limits of the cellular capacity to mediate an estrogen response