Sharp, an inducible cofactor that integrates nuclear receptor repression and activation

Genes and Development

Volumn 15, Issue 9, 2001, Pages 1140-1151

  Shi, Yanhong ^a   Downes, Michael ^a   Xie, Wen ^a   Kao, Hung Ying ^a,c   Ordentlich, Peter ^a,b   Tsai, Chih Cheng ^a   Hon, Michelle ^a   Evans, Ronald M ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b EXELIXIS INC   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Attenuation of hormonal response; HDAC1; SMRT; SRA

Indexed keywords

GENE PRODUCT; PROTEIN SHARP; RNA; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; FEEDBACK SYSTEM; GENE ACTIVATION; GENE REPRESSION; HORMONAL REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; ESTROGENS; HISTONE DEACETYLASES; HUMANS; MICE; MOLECULAR SEQUENCE DATA; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; REPRESSOR PROTEINS; RNA, UNTRANSLATED;

EID: 0035339146     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.871201     Document Type: Article

References (50)

1. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
2. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
3. The CBP co-activator is a histone acetyltransferase
4. The histone acetylase PCAF is a nuclear receptor coactivator
5. Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7
6. Conserved structures and diversity of functions of RNA-binding proteins
7. Estrogens and growth factors induce the mRNA of the 52K-pro-cathepsin-D secreted by breast cancer cells
8. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
9. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
10. A transcriptional co-repressor that interacts with nuclear hormone receptors
11. Identification of a nuclear domain with deacetylase activity
12. Transcriptional regulation of c-myc oncogene expression by estrogen in hormone-responsive human breast cancer cells
13. The coregulator exchange in transcriptional functions of nuclear receptors
14. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
15. Histone deacetylase activity is required for full transcriptional repression by mSin3A
16. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
17. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
18. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor corepressor
19. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
20. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
21. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
22. Sin meets NuRD and other tails of repression
23. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression
24. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex
25. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
26. The RXR heterodimers and orphan receptors
27. The nuclear receptor superfamily: The second decade
28. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
29. Nuclear roceptor coregulators: Cellular and molecular biology
30. Nuclear receptor repression mediatod by a complex containing SMRT, mSin3A, and histone deacetylase
31. Mechanism of corepressor binding and release from nuclear hormone receptors
32. The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter
33. The transcriptional coactivators p300 and CBP are histone acetyltransferases
34. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
35. Unique forms of human and mouse nuclear receptor corepressor SMRT
36. Molecular determinants of nuclear receptor-corepressor interaction
37. Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin
38. Molecular chaperones as HSF1-specific transcriptional repressors
39. RNA-binding proteins as regulators of gene expression
40. Steroid receptor coactivator-1 is a histone acetyltransferase
41. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
42. SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development
43. Nuclear receptor coactivators
44. Humanized xenobiotic response in mice expressing nuclear receptor SXR
45. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene
46. The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development
47. A p300/CBP-associated factor that competes with tho adenoviral oncoprotein E1A
48. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300
49. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex
50. Analysis of the NuRD subunits roveals a histone deacetylase core complex and a connection with DNA methylation