Pinning down HER2-ER crosstalk in SMRT regulation

Trends in Biochemical Sciences

Volumn 34, Issue 4, 2009, Pages 162-165

  Ryo, Akihide ^a   Wulf, Gerburg ^b   Lee, Tae Ho ^b   Lu, Kun Ping ^b  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; GROWTH FACTOR; NEU DIFFERENTIATION FACTOR; PEPTIDYLPROLYL ISOMERASE PIN1; PROLINE DERIVATIVE; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; TAMOXIFEN; TRASTUZUMAB;

BREAST CANCER; BREAST CARCINOGENESIS; CATALYSIS; CELL PROLIFERATION; DOWNSTREAM PROCESSING; DRUG INHIBITION; DRUG TARGETING; ENZYME REGULATION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; ISOMERIZATION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REGULATORY MECHANISM; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 63549117300     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2008.12.004     Document Type: Short Survey

References (22)

1. Berry D.A., et al. Effect of screening and adjuvant therapy on mortality from breast cancer. N. Engl. J. Med. 353 (2005) 1784-1792
2. Joslyn S.A. Hormone receptors in breast cancer: racial differences in distribution and survival. Breast Cancer Res. Treat. 73 (2002) 45-59
3. Dawood S., and Cristofanilli M. Endocrine resistance in breast cancer: what really matters?. Ann. Oncol. 18 (2007) 1289-1291
4. Stanya K.J., et al. Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT. J. Cell Biol. 183 (2008) 49-61
5. Parker M.G. Steroid and related receptors. Curr. Opin. Cell Biol. 5 (1993) 499-504
6. Xu L., et al. Coactivator and corepressor complexes in nuclear receptor function. Curr. Opin. Genet. Dev. 9 (1999) 140-147
7. Privalsky M.L. The role of corepressors in transcriptional regulation by nuclear hormone receptors. Annu. Rev. Physiol. 66 (2004) 315-360
8. Moasser M.M. The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene 26 (2007) 6469-6487
9. Shou J., et al. Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J. Natl. Cancer Inst. 96 (2004) 926-935
10. Osborne C.K., et al. Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer. Clin. Cancer Res. 11 (2005) 865s-870s
11. Font de Mora J., and Brown M. AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol. Cell. Biol. 20 (2000) 5041-5047
12. Jonas B.A., and Privalsky M.L. SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J. Biol. Chem. 279 (2004) 54676-54686
13. Frasor J., et al. Estrogen down-regulation of the corepressor N-CoR: mechanism and implications for estrogen derepression of N-CoR-regulated genes. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 13153-13157
14. Lu K.P., and Zhou X.Z. The prolyl isomerase Pin1: a pivotal new twist in phosphorylation signalling and human disease. Nat. Rev. Mol. Cell Biol. 8 (2007) 904-916
15. Wulf G.M., et al. Pin1 is overexpressed in breast cancer and potentiates the transcriptional activity of phosphorylated c-Jun towards the cyclin D1 gene. EMBO J. 20 (2001) 3459-3472
16. Ryo A., et al. Pin1 is an E2F target gene essential for the Neu/Ras-induced transformation of mammary epithelial cells. Mol. Cell. Biol. 22 (2002) 5281-5295
17. Wulf G., et al. Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis. EMBO J. 23 (2004) 3397-3407
18. Yi P., et al. Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1). Mol. Cell. Biol. 25 (2005) 9687-9699
19. Ryo A., et al. Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3 (2001) 793-801
20. Neve R.M., et al. Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells. Oncogene 19 (2000) 1647-1656
21. Riggs B.L., and Hartmann L.C. Selective estrogen-receptor modulators - mechanisms of action and application to clinical practice. N. Engl. J. Med. 348 (2003) 618-629
22. Fujita T., et al. Full activation of estrogen receptor α activation function-1 induces proliferation of breast cancer cells. J. Biol. Chem. 278 (2003) 26704-26714