The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program

Genes and Development

Volumn 15, Issue 22, 2001, Pages 2991-3004

  Pim Pijnappel, W W M ^a,b   Schaft, Daniel ^a,b   Roguev, Assen ^a,b   Shevchenko, Anna ^a   Tekotte, Hille ^d   Wilm, Matthias ^a   Rigaut, Guillaume ^a   Séraphin, Bertrand ^e   Aasland, Rein ^c   Francis Stewart, A ^a,b  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF BERGEN   (Norway)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e CENTRE DE GÉNÉTIQUE MOLÉCULAIRE   (France)

Author keywords

Deacetylase; Hos2; Hst1; Repression; SET domain; Sporulation

Indexed keywords

FUNGAL PROTEIN; HISTONE DEACETYLASE; HOS2 PROTEIN; HST1 PROTEIN; SET3 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; GENE; GENE REPRESSION; MEIOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SPOROGENESIS;

AMINO ACID SEQUENCE; FUNGAL PROTEINS; HAPLOIDY; HISTONE DEACETYLASES; MASS SPECTROMETRY; MEIOSIS; MOLECULAR SEQUENCE DATA; PHENOTYPE; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES POMBE PROTEINS; SIRTUINS; TIME FACTORS;

EID: 0035890135     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.207401     Document Type: Article

References (64)

1. The PHD finger: Implications for chromatin-mediated transcriptional regulation
2. The SANT domain: A putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB
3. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
4. NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines
5. Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase
6. Genomic disruption of six budding yeast genes gives one drastic example of phenotype strain-dependence
7. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
8. Solution structure of the PHD domain from the KAP-1 corepressor: Structural determinants for PHD, RING and LIM zinc-binding domains
9. Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80
10. The transcriptional program of sporulation in budding yeast
11. Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast
12. Association of SET domain and myotubularin-related proteins modulates growth control
13. Peptidyl-prolyl isomerases (PPIases)
14. Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4
15. Mutations in the fission yeast silencing factors clr4+ and rikl+ disrupt the localisation of the chromo domain protein Swi6p and impair centromere function
16. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
17. Flow cytometric analysis of DNA content in budding yeast
18. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression
19. NDT80 and the meiotic recombination checkpoint regulate expression of middle sporulation-specific genes in Saccharomyces cerevisiae
20. Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators
21. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
22. Trithorax and the regulation of homeotic gene expression in Drosophila: A historical perspective
23. A comprehensive two-hybrid analysis to explore the yeast protein interactome
24. The chromo and SET domains of the C1r4 protein are essential for silencing in fission yeast
25. The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax
26. Functional dissection of the B′ component of RNA polymerase III transcription factor IIIB: A scaffolding protein with multiple roles in assembly and initiation of transcription
27. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
28. Protein folding: Versatility of the cytosolic chaperonin TRiC/CCT
29. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3
30. The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor
31. Purification and biochemical properties of yeast SWI/SNF complex
32. Positive control of sporulation genes by the Ime1 and Ime2 products in Saccharomyces cerevisiae
33. SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes
34. The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3
35. Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor
36. Polycombing the genome: PcG, trxG, and chromatin silencing
37. The core meiotic transcriptome in budding yeasts
38. New constructs and strategies for efficient PCR-based gene manipulations in yeast
39. Regulation of chromatin structure by site-specific histone H3 methyltransferases
40. A generic protein purification method for protein complex characterization and proteome exploration
41. The S. cerevisiae Set1 complex includes an Ash2 homolog and methylates histone 3 lysine 4
42. The C-terminal SET domains of ALL-1 and trithorax interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex
43. Self-association of the SET domains of human ALL-1 and of Drosophila Trithorax and ASH1 proteins
44. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
45. Conversion of a gene-specific repressor to a regional silencer
46. The ankyrin repeat: A diversity of interactions on a common structural framework
47. Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly
48. A strategy for the characterization of protein interaction networks by mass spectrometry
49. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels
50. Linking genome and proteome by mass spectrometry: Large-scale identification of yeast proteins from two dimensional gels
51. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
52. Parameters affecting lithium acetate-mediated transformation of Saccharomyces cerevisiae and development of a rapid and simplified procedure
53. The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins
54. WHSC1, a 90 kb SET domain-containing gene maps in the Wolf-Hirschorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma
55. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
56. The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools
57. The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger
58. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes
59. A comprehensive analysis of protein-protein interactions in Saccharomyees cerevisiae
60. A biological atlas of functional maps
61. Beyond the nucleosome: Epigenetic aspects of position-effect variegation in Drosophila
62. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids
63. Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae
64. Altered Hox expression and segmental identity in Mll-mutant mice