Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation

Molecular and Cellular Endocrinology

Volumn 332, Issue 1-2, 2011, Pages 180-188

  Varlakhanova, Natalia ^a   Hahm, Johnnie B ^a   Privalsky, Martin L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Corepressor complex; Dimer; Erk; MAP kinases; SMRT

Indexed keywords

ALANINE; ASPARTIC ACID; DIMER; HISTONE DEACETYLASE 3; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN TBL 1; PROTEIN TBLR 1; SERINE; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR ALPHA; THREONINE; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; SELF DIMERIZATION; TRANSCRIPTION REGULATION;

ANIMALS; DIMERIZATION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIPROTEIN COMPLEXES; NUCLEAR RECEPTOR CO-REPRESSOR 2; PHOSPHORYLATION; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 78650521041     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.10.010     Document Type: Article

References (52)

1. Alenghat T., Meyers K., Mullican S.E., Leitner K., Adeniji-Adele A., Avila J., Bucan M., Ahima R.S., Kaestner K.H., Lazar M.A. Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature 2008, 456:997-1000.
2. Chen G., Nguyen P.H., Courey A.J. A role for Groucho tetramerization in transcriptional repression. Mol. Cell. Biol. 1998, 18:7259-7268.
3. Chen J.D., Evans R.M. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 1995, 377:454-457.
4. Codina A., Love J.D., Li Y., Lazar M.A., Neuhaus D., Schwabe J.W. Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:6009-6014.
5. Downes M., Ordentlich P., Kao H.Y., Alvarez J.G., Evans R.M. Identification of a nuclear domain with deacetylase activity. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:10330-10335.
6. Dubin M.J., Stokes P.H., Sum E.Y., Williams R.S., Valova V.A., Robinson P.J., Lindeman G.J., Glover J.N., Visvader J.E., Matthews J.M. Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif. J. Biol. Chem. 2004, 279:26932-26938.
7. Eisold M., Asim M., Eskelinen H., Linke T., Baniahmad A. Inhibition of MAPK-signaling pathway promotes the interaction of the corepressor SMRT with the human androgen receptor and mediates repression of prostate cancer cell growth in the presence of antiandrogens. J. Mol. Endocrinol. 2009, 42:429-435.
8. Emrick M.A., Hoofnagle A.N., Miller A.S., Ten Eyck L.F., Ahn N.G. Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations. J. Biol. Chem. 2001, 276:46469-46479.
9. Fischle W., Dequiedt F., Hendzel M.J., Guenther M.G., Lazar M.A., Voelter W., Verdin E. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol. Cell 2002, 9:45-57.
10. Glass C.K., Rosenfeld M.G. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 2000, 14:121-141.
11. Guan K.L., Dixon J.E. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem. 1991, 192:262-267.
12. Guenther M.G., Barak O., Lazar M.A. The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol. Cell. Biol. 2001, 21:6091-6101.
13. Guenther M.G., Lane W.S., Fischle W., Verdin E., Lazar M.A., Shiekhattar R. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes Dev. 2000, 14:1048-1057.
14. Guenther M.G., Lazar M.A. Biochemical isolation and analysis of a nuclear receptor corepressor complex. Methods Enzymol. 2003, 364:246-257.
15. Heinzel T., Lavinsky R.M., Mullen T.M., Söderstrom M., Laherty C.D., Torchia J., Yang W.M., Brard G., Ngo S.D., Davie J.R., Seto E., Eisenman R.N., Rose D.W., Glass C.K., Rosenfeld M.G. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 1997, 387:43-48.
16. Hong S.H., Privalsky M.L. The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export. Mol. Cell. Biol. 2000, 20:6612-6625.
17. Hong S.H., Wong C.W., Privalsky M.L. Signaling by tyrosine kinases negatively regulates the interaction between transcription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor. Mol. Endocrinol. 1998, 12:1161-1171.
18. Hong S.-H., Privalsky M.L. Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with its transcription factor partners, including the PML-RARα oncoprotein found in human acute promyelocytic leukemia. Mol. Cell. Biol. 2001, 21:7172-7182.
19. Hörlein A.J., Näär A.M., Heinzel T., Torchia J., Gloss B., Kurokawa R., Ryan A., Kamei Y., Söderström M., Glass C.K., Al E. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 1995, 377:397-404.
20. Huang E.Y., Zhang J.S., Miska E.A., Guenther M.G., Kouzarides T., Lazar M.A. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. Genes Dev. 2000, 14:45-54.
21. Ishizuka T., Lazar M.A. The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor. Mol. Cell. Biol. 2003, 23:5122-5131.
22. Jensen F.C., Girardi A.J., Gilden R.V., Koprowski H. Infection of human and simian tissue cultures with Rous Sarcoma Virus. Proc. Natl. Acad. Sci. U.S.A. 1964, 52:53-59.
23. Jepsen K., Hermanson O., Onami T.M., Gleiberman A.S., Lunyak V., Mcevilly R.J., Kurokawa R., Kumar V., Liu F., Seto E., Hedrick S.M., Mandel G., Glass C.K., Rose D.W., Rosenfeld M.G. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell 2000, 102:753-763.
24. Jepsen K., Rosenfeld M.G. Biological roles and mechanistic actions of co-repressor complexes. J. Cell Sci. 2002, 115:689-698.
25. Jepsen K., Solum D., Zhou T., Mcevilly R.J., Kim H.J., Glass C.K., Hermanson O., Rosenfeld M.G. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 2007, 450:415-419.
26. Jonas B.A., Privalsky M.L. SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J. Biol. Chem. 2004, 279:54676-54686.
27. Jonas B.A., Varlakhanova N., Hayakawa F., Goodson M., Privalsky M.L. Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing. Mol. Endocrinol. 2007, 21:1924-1939.
28. Jones P.L., Sachs L.M., Rouse N., Wade P.A., Shi Y.B. Multiple N-CoR complexes contain distinct histone deacetylases. J. Biol. Chem. 2001, 276:8807-8811.
29. Kao H.Y., Downes M., Ordentlich P., Evans R.M. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000, 14:55-66.
30. Lazar M.A. Nuclear receptor corepressors. Nucl. Recept. Signal 2003, 1:e001.
31. Lee J.W., Lee Y.C., Na S.Y., Jung D.J., Lee S.K. Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors. Cell. Mol. Life Sci. 2001, 58:289-297.
32. Li J., Lin Q., Wang W., Wade P., Wong J. Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression. Genes Dev. 2002, 16:687-692.
33. Li J.W., Wang J., Wang J.X., Nawaz Z., Liu J.M., Qin J., Wong J.M. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J. 2000, 19:4342-4350.
34. Moehren U., Eckey M., Baniahmad A. Gene repression by nuclear hormone receptors. Essays Biochem. 2004, 40:89-104.
35. Nagy L., Kao H.Y., Chakravarti D., Lin R.J., Hassig C.A., Ayer D.E., Schreiber S.L., Evans R.M. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 1997, 89:373-380.
36. Nofsinger R.R., Li P., Hong S.H., Jonker J.W., Barish G.D., Ying H., Cheng S.Y., Leblanc M., Xu W., Pei L., Kang Y.J., Nelson M., Downes M., Yu R.T., Olefsky J.M., Lee C.H., Evans R.M. SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:20021-20026.
37. Obenauer J.C., Cantley L.C., Yaffe M.B. Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res. 2003, 31:3635-3641.
38. Ordentlich P., Downes M., Evans R.M. Corepressors and nuclear hormone receptor function. Curr. Top. Microbiol. Immunol. 2001, 254:101-116.
39. Perissi V., Aggarwal A., Glass C.K., Rose D.W., Rosenfeld M.G. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 2004, 116:511-526.
40. Perissi V., Jepsen K., Glass C.K., Rosenfeld M.G. Deconstructing repression: evolving models of co-repressor action. Nat. Rev. Genet. 2010, 11:109-123.
41. Privalsky M.L. Regulation of SMRT and N-CoR corepressor function. Curr. Top. Microbiol. Immunol. 2001, 254:117-136.
42. Privalsky M.L. The role of corepressors in transcriptional regulation by nuclear hormone receptors. Annu. Rev. Physiol. 2004, 66:315-360.
43. Sande S., Privalsky M.L. Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol. Endocrinol. 1996, 10:813-825.
44. Seol W., Mahon M.J., Lee Y.K., Moore D.D. Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR. Mol. Endocrinol. 1996, 10:1646-1655.
45. Song H., Hasson P., Paroush Z., Courey A.J. Groucho oligomerization is required for repression in vivo. Mol. Cell. Biol. 2004, 24:4341-4350.
46. Stanya K.J., Kao H.Y. New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR. Cell Div. 2009, 4:7.
47. Wen Y.D., Perissi V., Staszewski L.M., Yang W.M., Krones A., Glass C.K., Rosenfeld M.G., Seto E. The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:7202-7207.
48. Wong C.W., Privalsky M.L. Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB. Mol. Cell. Biol. 1998, 18:5500-5510.
49. Yang W.M., Tsai S.C., Wen Y.D., Fejer G., Seto E. Functional domains of histone deacetylase-3. J. Biol. Chem. 2002, 277:9447-9454.
50. Yoon H.G., Chan D.W., Huang Z.Q., Li J., Fondell J.D., Qin J., Wong J. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J. 2003, 22:1336-1346.
51. Zamir I., Harding H.P., Atkins G.B., Hörlein A., Glass C.K., Rosenfeld M.G., Lazar M.A. A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains. Mol. Cell. Biol. 1996, 16:5458-5465.
52. Zhang J., Kalkum M., Chait B.T., Roeder R.G. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol. Cell 2002, 9:611-623.