Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1)

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 42, 2011, Pages 17462-17467

  Fozzatti, Laura ^a   Lu, Changxue ^a   Kim, Dong Wook ^a   Park, Jeong Won ^a   Astapova, Inna ^b   Gavrilova, Oksana ^c   Willingham, Mark C ^d   Hollenberg, Anthony N ^b   Cheng, Sheue Yann ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Dominant negative activity; Mouse models; Thyroid hormone receptor mutant

Indexed keywords

CHOLESTEROL 7ALPHA MONOOXYGENASE; LIOTHYRONINE; RECEPTOR INTERACTING PROTEIN 140; THYROID HORMONE RECEPTOR BETA; THYROTROPIN; THYROXINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GROWTH RETARDATION; HISTOPATHOLOGY; HORMONE RECEPTOR INTERACTION; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; LIVER WEIGHT; LONG BONE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; THYROID FUNCTION TEST; THYROID HORMONE METABOLISM; THYROID HORMONE RESISTANCE; THYROID HYPERPLASIA; THYROID WEIGHT; THYROTROPIN BLOOD LEVEL; WEIGHT GAIN; WEIGHT REDUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; GENES, ERBA; HUMANS; MALE; MICE; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MUTATION; NUCLEAR RECEPTOR CO-REPRESSOR 1; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION; THYROID HORMONE RECEPTORS BETA; THYROID HORMONE RESISTANCE SYNDROME; THYROID HORMONES;

MUS;

EID: 80054826264     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1107474108     Document Type: Article

References (27)

1. Hollenberg AN, Forrest D (2008) The thyroid and metabolism: The action continues. Cell Metab 8:10-12. (Pubitemid 351859232)
2. Cheng SY (2000) Multiple mechanisms for regulation of the transcriptional activity of thyroid hormone receptors. Rev Endocr Metab Disord 1:9-18.
3. Glass CK, Rosenfeld MG (2000) The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 14:121-141. (Pubitemid 30070977)
4. Alenghat T, et al. (2008) Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature 456:997-1000.
5. Astapova I, et al. (2008) The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci USA 105:19544-19549.
6. Astapova I, et al. (2011) The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis. Mol Endocrinol 25:212-224.
7. Refetoff S, Weiss RE, Usala SJ (1993) The syndromes of resistance to thyroid hormone. Endocr Rev 14:348-399. (Pubitemid 23168055)
8. Kaneshige M, et al. (2000) Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone. Proc Natl Acad Sci USA 97:13209-13214.
9. Hashimoto K, et al. (2001) An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci USA 98:3998-4003. (Pubitemid 32249887)
10. Cheng SY (2004) New development in thyroid hormone resistance. Hot Thyroidology January, No. 1.
11. Yen PM, Sugawara A, Refetoff S, Chin WW (1992) New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone. J Clin Invest 90:1825-1831.
12. Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM (1998) Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors. Endocrinology 139:4197-4204. (Pubitemid 28513706)
13. Safer JD, Cohen RN, Hollenberg AN, Wondisford FE (1998) Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone. J Biol Chem 273:30175-30182. (Pubitemid 28545480)
14. Agostini M, et al. (2006) Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance. Cell Metab 4:303-311. (Pubitemid 44430916)
15. Parrilla R, Mixson AJ, McPherson JA, McClaskey JH, Weintraub BD (1991) Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain. J Clin Invest 88:2123-2130.
16. O'Shea PJ, et al. (2003) A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone. Mol Endocrinol 17:1410-1424. (Pubitemid 36819960)
17. Araki O, Ying H, Zhu XG, Willingham MC, Cheng SY (2009) Distinct dysregulation of lipid metabolism by unliganded thyroid hormone receptor isoforms. Mol Endocrinol 23:308-315.
18. Kamiya Y, et al. (2003) Modulation by steroid receptor coactivator-1 of target-tissue responsiveness in resistance to thyroid hormone. Endocrinology 144:4144-4153. (Pubitemid 37088770)
19. Forrest D, Vennström B (2000) Functions of thyroid hormone receptors in mice. Thyroid 10:41-52. (Pubitemid 30090364)
20. Suzuki H, Willingham MC, Cheng SY (2002) Mice with a mutation in the thyroid hormone receptor beta gene spontaneously develop thyroid carcinoma: A mouse model of thyroid carcinogenesis. Thyroid 12:963-969. (Pubitemid 35404130)
21. Guigon CJ, Cheng SY (2009) Novel oncogenic actions of TRbeta mutants in tumorigenesis. IUBMB Life 61:528-536.
22. Mitchell CS, et al. (2010) Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia. J Clin Invest 120:1345-1354.
23. Gullberg H, Rudling M, Forrest D, Angelin B, Vennström B (2000) Thyroid hormone receptor beta-deficient mice show complete loss of the normal cholesterol 7alphahydroxylase (CYP7A) response to thyroid hormone but display enhanced resistance to dietary cholesterol. Mol Endocrinol 14:1739-1749.
24. O'Shea PJ, Bassett JH, Cheng SY, Williams GR (2006) Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: Implications for tissue thyroid status and T3 target gene expression. Nucl Recept Signal 4 e011.
25. Furumoto H, et al. (2005) An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis. Mol Cell Biol 25:124-135. (Pubitemid 40039805)
26. Ying H, et al. (2003) Alterations in genomic profiles during tumor progression in a mouse model of follicular thyroid carcinoma. Carcinogenesis 24:1467-1479. (Pubitemid 37160837)
27. ZhangXY, et al. (2002) Differential expression of thyroidhormonereceptor isoforms dictates the dominant negative activity of mutant Beta receptor. Mol Endocrinol 16:2077-2092.