Genetic variants in pre-eclampsia: A meta-analysis

Human Reproduction Update

Volumn 19, Issue 3, 2013, Pages 289-303

  Buurma, A J ^a   Turner, R J ^a   Driessen, J H M ^a,b   Mooyaart, A L ^a   Schoones, J W ^a   Bruijn, J A ^a   Bloemenkamp, K W M ^a   Dekkers, O M ^a   Baelde, H J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Cardiovascular disease; Genetic variants; Pre eclampsia; Risk factors

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME GENE; ANGIOTENSIN II RECEPTOR TYPE I GENE; ANGIOTENSINOGEN GENE; APOLIPOPROTEIN E GENE; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING FACTOR 5 GENE; BLOOD CLOTTING FACTOR 5 LEIDEN GENE; CYTOTOXIC T LYMPHOCYTE ASSOCIATED PROTEIN 4 GENE; DIPEPTIDYL CARBOXYPEPTIDASE GENE; DNA POLYMORPHISM; FIBRINOLYSIS; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; INFLAMMATION; INTERLEUKIN 10 GENE; LIPID METABOLISM; LIPOPROTEIN LIPASE GENE; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; NITRIC OXIDE SYNTHASE 3 GENE; OXIDATIVE STRESS; PLASMINOGEN ACTIVATOR INHIBITOR 1 GENE; PREECLAMPSIA; PRIORITY JOURNAL; PROTHROMBIN GENE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SERINE PEPTIDASE INHIBITOR 1 GENE; TOLL LIKE RECEPTOR GENE; TUMOR NECROSIS FACTOR GENE; VASCULAR ENDOTHELIAL GROWTH FACTOR GENE;

ALLELES; CTLA-4 ANTIGEN; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PRE-ECLAMPSIA; PREGNANCY; RISK FACTORS;

EID: 84876788429     PISSN: 13554786     EISSN: 14602369     Source Type: Journal    
DOI: 10.1093/humupd/dms060     Document Type: Article

References (225)

1. Aggarwal PK, Jain V, Jha V. Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy. Hypertens Res 2010;33:473-477.
2. Aggarwal S, Dimri N, Tandon I, Agarwal S. Preeclampsia in North Indian women: the contribution of genetic polymorphisms. J Obstet Gynaecol Res 2011; 37:1335-1341.
3. Agorastos T, Karavida A, Lambropoulos A, Constantinidis T, Tzitzimikas S, Chrisafi S, Saravelos H, Vavilis D, Kotsis A, Bontis J. Factor V Leiden and prothrombin G20210A mutations in pregnancies with adverse outcome. J Matern Fetal Neonatal Med 2002;12:267-273.
4. Akbar SA, Khawaja NP, Brown PR, Tayyeb R, Bamfo J, Nicolaides KH. Angiotensin II type 1 and 2 receptors gene polymorphisms in pre-eclampsia and normal pregnancy in three different populations. Acta Obstet Gynecol Scand 2009; 88:606-611.
5. Alfirevic Z, Mousa HA, Martlew V, Briscoe L, Perez-Casal M, Toh CH. Postnatal screening for thrombophilia in women with severe pregnancy complications. Obstet Gynecol 2001;97:753-759.
6. Al-Habboubi HH, Sater MS, Almawi AW, Al-Khateeb GM, Almawi WY. Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population. Eur Cytokine Netw 2011;22:154-158.
7. Also-Rallo E, Lopez-Quesada E, Urreizti R, Vilaseca MA, Lailla JM, Balcells S, Grinberg D. Polymorphisms of genes involved in homocysteine metabolism in preeclampsia and in uncomplicated pregnancies. Eur J Obstet Gynecol Reprod Biol 2005;120:45-52.
8. Arngrimsson R, Bjornsson S, Geirsson RT, Bjornsson H, Walker JJ, Snaedal G. Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. Br J Obstet Gynaecol 1990;97:762-769.
9. Balam-Ortiz E, Esquivel-Villarreal A, Alfaro-Ruiz L, Carrillo K, Elizalde A, Gil T, Urushihara M, Kobori H, Jimenez-Sanchez G. Variants and haplotypes in angiotensinogen gene are associated with plasmatic angiotensinogen level in Mexican population. Am J Med Sci 2011;342:205-211.
10. Bashford MT, Hefler LA, Vertrees TW, Roa BB, Gregg AR. Angiotensinogen and endothelial nitric oxide synthase gene polymorphisms among Hispanic patients with preeclampsia. Am J Obstet Gynecol 2001;184:1345-1350.
11. Bellamy L, Casas JP, Hingorani AD, Williams DJ. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. Br Med J 2007;335:974.
12. Belo L, Gaffney D, Caslake M, Santos-Silva A, Pereira-Leite L, Quintanilha A, Rebelo I. Apolipoprotein E and cholesteryl ester transfer protein polymorphisms in normal and preeclamptic pregnancies. Eur J Obstet Gynecol Reprod Biol 2004;112:9-15.
13. Benedetto C, Marozio L, Salton L, Maula V, Chieppa G, Massobrio M. Factor V Leiden and factor II G20210A in preeclampsia and HELLP syndrome. Acta Obstet Gynecol Scand 2002;81:1095-1100.
14. Benedetto C, Marozio L, Ciccone G, Chieppa G, Quaglia M, Matullo G, Bertola L, Guarrera S, Carturan S, Stratta P. Synergistic effect of renin-angiotensin system and nitric oxide synthase genes polymorphisms in pre-eclampsia. Acta Obstet Gynecol Scand 2007;86:678-682.
15. Bernard N, Girouard J, Forest JC, Giguere Y. The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension. J Hum Genet 2007; 52:244-254.
16. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de RH, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-67.
17. Best LG, Dorsam ST, Nadeau M, Burd L, Anderson CM. Genetic thrombophilia variants and risk for preeclampsia among American Indians. Hypertens Pregnancy 2009;28:85-94.
18. Best LG, Nadeau M, Bercier S, Dauphinais S, Davis J, Davis K, Poitra S, Anderson CM. Genetic variants, endothelial function, and risk of preeclampsia among American Indians. Hypertens Pregnancy 2010.
19. Best LG, Nadeau M, Davis K, Lamb F, Bercier S, Anderson CM. Genetic variants, immune function, and risk of pre-eclampsia among American Indians. Am J Reprod Immunol 2012;67:152-159.
20. Bombell S, McGuire W. Tumour necrosis factor (-308A) polymorphism in pre-eclampsia: meta-analysis of 16 case-control studies. Aust N Z J Obstet Gynaecol 2008;48:547-551.
21. Bouba I, Makrydimas G, Kalaitzidis R, Lolis DE, Siamopoulos KC, Georgiou I. Interaction between the polymorphisms of the renin-angiotensin system in preeclampsia. Eur J Obstet Gynecol Reprod Biol 2003;110:8-11.
22. Brown MA, Lindheimer MD, de SM, Van AA, Moutquin JM. The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP).Hypertens Pregnancy 2001;20:IX-XIV.
23. Canto P, Canto-Cetina T, Juarez-Velazquez R, Rosas-Vargas H, Rangel-Villalobos H, Canizales-Quinteros S, Velazquez-Wong AC, Villarreal-Molina MT, Fernandez G, Coral-Vazquez R. Methylenetetrahydrofolate reductase C677T and glutathione S-transferase P1 A313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women. Hypertens Res 2008;31:1015-1019.
24. Canto-Cetina T, Canizales-Quinteros S, de la Chesnaye E, Coral-Vazquez R, Mendez JP, Canto P. Analysis of C-850T and G-308A polymorphisms of the tumor necrosis factor-alpha gene in Maya-Mestizo women with preeclampsia. Hypertens Pregnancy 2007;26:283-291.
25. Ceelie H, Spaargaren-van Riel CC, Bertina RM, Vos HL. G20210A is a functional mutation in the prothrombin gene; effect on protein levels and 3′-end formation. J Thromb Haemost 2004;2:119-127.
26. Chappell S, Morgan L. Searching for genetic clues to the causes of pre-eclampsia. Clin Sci (Lond) 2006;110:443-458.
27. Chen G, Wilson R, Wang SH, Zheng HZ, Walker JJ, McKillop JH. Tumour necrosis factor-alpha (TNF-alpha) gene polymorphism and expression in pre-eclampsia. Clin Exp Immunol 1996;104:154-159.
28. Chen LK, Huang CH, Yeh HM, Lee CN, Shyu MK, Hsieh FJ, Lai LP, Sun WZ. Polymorphisms in the endothelial nitric oxide synthase gene may be protective against preeclampsia in a Chinese population. Reprod Sci 2007;14:175-181.
29. Chesley LC, Cooper DW. Genetics of hypertension in pregnancy: possible single gene control of pre-eclampsia and eclampsia in the descendants of eclamptic women. Br J Obstet Gynaecol 1986;93:898-908.
30. Chikosi AB, Moodley J, Pegoraro RJ, Lanning PA, Rom L. 5,10-Methylenetetrahydrofolate reductase polymorphism in black South African women with pre-eclampsia. Br J Obstet Gynaecol 1999;106:1219-1220.
31. Chikosi AB, Moodley J, Pegoraro RJ, Lanning PA, Rom L. Apolipoprotein E polymorphism in South African Zulu women with preeclampsia. Hypertens Pregnancy 2000;19:309-314.
32. Choi H, Kang JY, Yoon HS, Han SS, Whang CS, Moon IG, Shin HH, Park JB. Association of angiotensin-converting enzyme and angiotensinogen gene polymorphisms with preeclampsia. J Korean Med Sci 2004;19:253-257.
33. Cincotta RB, Brennecke SP. Family history of pre-eclampsia as a predictor for pre-eclampsia in primigravidas. Int J Gynaecol Obstet 1998;60:23-27.
34. Currie L, Peek M, McNiven M, Prosser I, Mansour J, Ridgway J. Is there an increased maternal-infant prevalence of Factor V Leiden in association with severe pre-eclampsia? BJOG 2002;109:191-196.
35. Daher S, Sass N, Oliveira LG, Mattar R. Cytokine genotyping in preeclampsia. Am J Reprod Immunol 2006;55:130-135.
36. Dalmaz CA, Santos KG, Botton MR, Tedoldi CL, Roisenberg I. Relationship between polymorphisms in thrombophilic genes and preeclampsia in a Brazilian population. Blood Cells Mol Dis 2006;37:107-110.
37. Davalos IP, Moran MC, Martinez-Abundis E, Gonzalez-Ortiz M, Flores-Martinez SE, Machorro V, Sandoval L, Figuera LE, Mena JP, Oliva JM et al. Methylenetetrahydrofolate reductase C677T polymorphism and Factor V Leiden variant in Mexican women with preeclampsia/eclampsia. Blood Cells Mol Dis 2005;35:66-69.
38. de Groot CJ, Bloemenkamp KW, Duvekot EJ, Helmerhorst FM, Bertina RM, Van Der Meer F, De RH, Oei SG, Kanhai HH, Rosendaal FR. Preeclampsia and genetic risk factors for thrombosis: a case-control study. Am J Obstet Gynecol 1999;181:975-980.
39. de Groot CJ, Jansen MW, Bertina RM, Schonkeren JJ, Helmerhorst FM, Huizinga TW. Interleukin 10-2849AA genotype protects against pre-eclampsia. Genes Immun 2004;5:313-314.
40. de Lima TH, Sass N, Mattar R, Moron AF, Torloni MR, Franchim CS, Daher S. Cytokine gene polymorphisms in preeclampsia and eclampsia. Hypertens Res 2009;32:565-569.
41. De Maat MP, Jansen MW, Hille ET, Vos HL, Bloemenkamp KW, Buitendijk S, Helmerhorst FM, Wladimiroff JW, Bertina RM, de Groot CJ. Preeclampsia and its interaction with common variants in thrombophilia genes. J Thromb Haemost 2004;2:1588-1593.
42. Demir SC, Evruke C, Ozgunen T, Kadayifci O, Altintas U, Kokangul S. The relationship between pregnancy induced hypertension and congenital thrombophilia. Saudi Med J 2006;27:1161-1166.
43. Diaz-Olguin L, Coral-Vazquez RM, Canto-Cetina T, Canizales-Quinteros S, Ramirez RB, Fernandez G, Canto P. Endothelial nitric oxide synthase haplotypes are associated with preeclampsia in Maya mestizo women. Dis Markers 2011;31:83-89.
44. Dissanayake VH, Giles V, Jayasekara RW, Seneviratne HR, Kalsheker N, Broughton PF, Morgan L. A study of three candidate genes for pre-eclampsia in a Sinhalese population from Sri Lanka. J Obstet Gynaecol Res 2009;35:234-242.
45. Dizon-Townson DS, Nelson LM, Easton K, Ward K. The factor V Leiden mutation may predispose women to severe preeclampsia. Am J Obstet Gynecol 1996; 175:902-905.
46. Dizon-Townson DS, Major H, Ward K. A promoter mutation in the tumor necrosis factor alpha gene is not associated with preeclampsia. J Reprod Immunol 1998; 38:55-61.
47. Dogan OO, Simsek Y, Celen S, Danisman N. Frequency of hereditary thrombophilia, anticoagulant activity, and homocysteine levels in patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome. J Obstet Gynaecol Res 2011;37:527-533.
48. Dudding T, Heron J, Thakkinstian A, Nurk E, Golding J, Pembrey M, Ring SM, Attia J, Scott RJ. Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis. J Thromb Haemost 2008;6:1869-1875.
49. Dusse LM, Carvalho MG, Braganca WF, Paiva SG, Godoi LC, Guimaraes DA, Fernandes AP. Inherited thrombophilias and pre-eclampsia in Brazilian women. Eur J Obstet Gynecol Reprod Biol 2007;134:20-23.
50. Esplin MS, Fausett MB, Fraser A, Kerber R, Mineau G, Carrillo J, Varner MW. Paternal and maternal components of the predisposition to preeclampsia. N Engl J Med 2001;344:867-872.
51. Fabbro D, D'Elia AV, Spizzo R, Driul L, Barillari G, di LC, Marchesoni D, Damante G. Association between plasminogen activator inhibitor 1 gene polymorphisms and preeclampsia. Gynecol Obstet Invest 2003;56:17-22.
52. Faisel F, Romppanen EL, Hiltunen M, Helisalmi S, Laasanen J, Punnonen K, Salonen JT, Heinonen S. Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. Eur J Hum Genet 2004;12:187-191.
53. Fatini C, Sticchi E, Gensini F, Genuardi M, Tondi F, Gensini GF, Riviello C, Parretti E, Mello G, Abbate R. Endothelial nitric oxide synthase gene influences the risk of pre-eclampsia, the recurrence of negative pregnancy events, and the maternal-fetal flow. J Hypertens 2006;24:1823-1829.
54. Fisher RM, Humphries SE, Talmud PJ. Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis. Atherosclerosis 1997; 135:145-159.
55. Franchim CS, Sass N, Mattar R, Pendeloski KP, Lin LH, Torloni MR, Daher S. Inflammatory mediators gene polymorphisms in preeclampsia. Hypertens Pregnancy 2011;30:338-346.
56. Francoual J, Audibert F, Trioche P, Chalas J, Capel L, Lindenbaum A, Labrune P, Frydman R. Is a polymorphism of the apolipoprotein E gene associated with preeclampsia? Hypertens Pregnancy 2002;21:127-133.
57. Freeman DJ, McManus F, Brown EA, Cherry L, Norrie J, Ramsay JE, Clark P, Walker ID, Sattar N, Greer IA. Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension 2004; 44:708-714.
58. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den HM, Kluijtmans LA, van den Heuvel LP. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-113.
59. Galao AO, de Souza LH, da Costa BE, Scheibe RM, Poli de Figueiredo CE. Angiotensin-converting enzyme gene polymorphism in preeclampsia and normal pregnancy. Am J Obstet Gynecol 2004;191:821-824.
60. Gerhardt A, Goecke TW, Beckmann MW, Wagner KJ, Tutschek B, Willers R, Bender HG, Scharf RE, Zotz RB. The G20210A prothrombin-gene mutation and the plasminogen activator inhibitor (PAI-1) 5G/5G genotype are associated with early onset of severe preeclampsia. J Thromb Haemost 2005; 3:686-691.
61. Grandone E, Margaglione M, Colaizzo D, Cappucci G, Scianname N, Montanaro S, Paladini D, Martinelli P, Di MG. Prothrombotic genetic risk factors and the occurrence of gestational hypertension with or without proteinuria. Thromb Haemost 1999;81:349-352.
62. Grandone E, Colaizzo D, Martinelli P, Pavone G, Errico M, Vecchione G, Margaglione M. Does endothelial nitric oxide synthase gene variation play a role in the occurrence of hypertension in pregnancy? Hypertens Pregnancy 2003; 22:149-155.
63. Guo G, Wilton AN, Fu Y, Qiu H, Brennecke SP, Cooper DW. Angiotensinogen gene variation in a population case-control study of preeclampsia/eclampsia in Australians and Chinese. Electrophoresis 1997;18:1646-1649.
64. Gurdol F, Isbilen E, Yilmaz H, Isbir T, Dirican A. The association between preeclampsia and angiotensin-converting enzyme insertion/deletion polymorphism. Clin Chim Acta 2004;341:127-131.
65. Haggerty CL, Ferrell RE, Hubel CA, Markovic N, Harger G, Ness RB. Association between allelic variants in cytokine genes and preeclampsia. Am J Obstet Gynecol 2005;193:209-215.
66. Hakli T, Romppanen EL, Hiltunen M, Helisalmi S, Punnonen K, Heinonen S. Endothelial nitric oxide synthase polymorphism in preeclampsia. J Soc Gynecol Investig 2003;10:154-157.
67. Hannaford P, Ferry S, Hirsch S. Cardiovascular sequelae of toxaemia of pregnancy. Heart 1997;77:154-158.
68. Healy DG, Abou-Sleiman PM, Casas JP, Ahmadi KR, Lynch T, Gandhi S, Muqit MM, Foltynie T, Barker R, Bhatia KP et al. UCHL-1 is not a Parkinson's disease susceptibility gene. Ann Neurol 2006;59:627-633.
69. Heiskanen JT, Pirskanen MM, Hiltunen MJ, Mannermaa AJ, Punnonen KR, Heinonen ST. Insertion-deletion polymorphism in the gene for angiotensin-converting enzyme is associated with obstetric cholestasis but not with preeclampsia. Am J Obstet Gynecol 2001;185:600-603.
70. Heiskanen J, Romppanen EL, Hiltunen M, Iivonen S, Mannermaa A, Punnonen K, Heinonen S. Polymorphism in the tumor necrosis factor-alpha gene in women with preeclampsia. J Assist Reprod Genet 2002;19:220-223.
71. Higgins JR, Kaiser T, Moses EK, North R, Brennecke SP. Prothrombin G20210A mutation: is it associated with pre-eclampsia? Gynecol Obstet Invest 2000; 50:254-257.
72. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Br Med J 2003;327:557-560.
73. Hill LD, York TP, Kusanovic JP, Gomez R, Eaves LJ, Romero R, Strauss JF III. Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia. PLoS One 2011;6:e16681.
74. Hiltunen LM, Laivuori H, Rautanen A, Kaaja R, Kere J, Krusius T, Paunio M, Rasi V. Blood group AB and factor V Leiden as risk factors for pre-eclampsia: a population-based nested case-control study. Thromb Res 2009;124:167-173.
75. Hubel CA, Roberts JM, Ferrell RE. Association of pre-eclampsia with common coding sequence variations in the lipoprotein lipase gene. Clin Genet 1999; 56:289-296.
76. Ioannidis JP, Trikalinos TA. Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials. J Clin Epidemiol 2005;58:543-549.
77. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic association studies. Nat Genet 2001;29:306-309.
78. Irgens HU, Reisaeter L, Irgens LM, Lie RT. Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study. Br Med J 2001; 323:1213-1217.
79. Isermann B, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, Mackman N, Weiler H. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med 2003;9:331-337.
80. Jaaskelainen E, Keski-Nisula L, Toivonen S, Romppanen EL, Helisalmi S, Punnonen K, Heinonen S. MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women. Hypertens Pregnancy 2006; 25:73-80.
81. Jaaskelainen E, Toivonen S, Keski-Nisula L, Paattiniemi EL, Helisalmi S, Punnonen K, Heinonen S. CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women. Clin Chem Lab Med 2008;46:169-173.
82. Jarvenpaa J, Pakkila M, Savolainen ER, Perheentupa A, Jarvela I, Ryynanen M. Evaluation of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase gene mutations in patients with severe pregnancy complications in northern Finland. Gynecol Obstet Invest 2006;62:28-32.
83. Jenkins LD, Powers RW, Cooper M, Gallaher MJ, Markovic N, Ferrell R, Ness RB, Roberts JM. Preeclampsia risk and angiotensinogen polymorphisms M235T and AGT -217 in African American and Caucasian women. Reprod Sci 2008; 15:696-701.
84. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992;71:169-180.
85. Jonsdottir LS, Arngrimsson R, Geirsson RT, Sigvaldason H, Sigfusson N. Death rates from ischemic heart disease in women with a history of hypertension in pregnancy. Acta Obstet Gynecol Scand 1995;74:772-776.
86. Kaiser T, Brennecke SP, Moses EK. C677T methylenetetrahydrofolate reductase polymorphism is not a risk factor for pre-eclampsia/eclampsia among Australian women. Hum Hered 2001;51:20-22.
87. Kaiser T, Grehan M, Brennecke SP, Moses EK. Association of the TNF2 allele with eclampsia. Gynecol Obstet Invest 2004;57:204-209.
88. Kamali-Sarvestani E, Kiany S, Gharesi-Fard B, Robati M. Association study of IL-10 and IFN-gamma gene polymorphisms in Iranian women with preeclampsia. J Reprod Immunol 2006;72:118-126.
89. Kankova K, Benes P, Unzeitig V, Izakovicova-Holla L, Znojil V, Vacha J. Lack of association between pregnancy-induced hypertension and familial thrombophilia in a Czech population. Prenat Neonatal Med 2000;5:223-229.
90. Karakantza M, Androutsopoulos G, Mougiou A, Sakellaropoulos G, Kourounis G, Decavalas G. Inheritance and perinatal consequences of inherited thrombophilia in Greece. Int J Gynecol Obstet 2008;100:124-129.
91. Karimi S, Yavarian M, Azinfar A, Rajaei M, Kootenaee MA. Evaluation the frequency of factor V Leiden mutation in pregnant women with preeclampsia syndrome in an Iranian population. Iran J Reprod Med 2012;10:59-66.
92. Kaur R, Jain V, Khuller M, Gupta I, Sherawat BS. Association of angiotensinconverting enzyme gene polymorphism with pregnancy-induced hypertension. Acta Obstet Gynecol Scand 2005;84:929-933.
93. Keavney B, McKenzie C, Parish S, Palmer A, Clark S, Youngman L, Delepine M, Lathrop M, Peto R, Collins R. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators. Lancet 2000; 355:434-442.
94. Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J, Schwartz DA. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 2002;347:185-192.
95. Kim YJ, Williamson RA, Chen K, Smith JL, Murray JC, Merrill DC. Lipoprotein lipase gene mutations and the genetic susceptibility of preeclampsia. Hypertension 2001a; 38:992-996.
96. Kim YJ, Williamson RA, Murray JC, Andrews J, Pietscher JJ, Peraud PJ, Merrill DC. Genetic susceptibility to preeclampsia: roles of cytosineto-thymine substitution at nucleotide 677 of the gene for methylenetetrahydrofolate reductase, 68-base pair insertion at nucleotide 844 of the gene for cystathionine beta-synthase, and factor V Leiden mutation. Am J Obstet Gynecol 2001b; 184:1211-1217.
97. Kim YJ, Park HS, Lee HY, Ha EH, Suh SH, Oh SK, Yoo HS. Reduced L-arginine level and decreased placental eNOS activity in preeclampsia. Placenta 2006; 27:438-444.
98. Kim YJ, Park BH, Park H, Jung SC, Pang MG, Ryu HM, Lee KS, Eom SM, Park HY. No association of the genetic polymorphisms of endothelial nitric oxide synthase, dimethylarginine dimethylaminohydrolase, and vascular endothelial growth factor with preeclampsia in Korean populations. Twin Res Hum Genet 2008; 11:77-83.
99. Klai S, Fekih-Mrissa N, El HS, Kaabechi N, Nsiri B, Rachdi R, Gritli N. Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies. Blood Coagul Fibrinolysis 2011; 22:374-378.
100. Knyrim E, Muetze S, Eggermann T, Rudnik-Schoeneborn S, Lindt R, Ortlepp JR, Rath W, Zerres K. Genetic analysis of the angiotensinogen gene in pre-eclampsia: study of german women and review of the literature. Gynecol Obstet Invest 2008;66:203-208.
101. Kobashi G, Hata A, Shido K, Kato EH, Yamada H, Fujimoto S, Kishi R, Kondo K. Association of a variant of the angiotensinogen gene with pure type of hypertension in pregnancy in the Japanese: implication of a racial difference and significance of an age factor. Am J Med Genet 1999;86:232-236.
102. Kobashi G, Yamada H, Asano T, Nagano S, Hata A, Kishi R, Fujimoto S, Kondo K. Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women. Am J Med Genet 2000;93:122-125.
103. Kobashi G, Yamada H, Ohta K, Kato E, Ebina Y, Fujimoto S. Endothelial nitric oxide synthase gene (NOS3) variant and hypertension in pregnancy. Am J Med Genet 2001;103:241-244.
104. Kobashi G, Hata A, Shido K, Ohta K, Yamada H, Kato EH, Minakami H, Tamashiro H, Fujimoto S, Kondo K. Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and preeclampsia in Japanese patients. Semin Thromb Hemost 2005;31:346-350.
105. Kroeger KM, Carville KS, Abraham LJ. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol 1997;34:391-399.
106. Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, Fait G, Lessing JB. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999;340:9-13.
107. Kupferminc MJ, Fait G, Many A, Gordon D, Eldor A, Lessing JB. Severe preeclampsia and high frequency of genetic thrombophilic mutations. Obstet Gynecol 2000a; 96:45-49.
108. Kupferminc MJ, Peri H, Zwang E, Yaron Y, Wolman I, Eldor A. High prevalence of the prothrombin gene mutation in women with intrauterine growth retardation, abruptio placentae and second trimester loss. Acta Obstet Gynecol Scand 2000b; 79:963-967.
109. Kyrle PA, Mannhalter C, Beguin S, Stumpflen A, Hirschl M, Weltermann A, Stain M, Brenner B, Speiser W, Pabinger I et al. Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene. Arterioscler Thromb Vasc Biol 1998;18:1287-1291.
110. Laivuori H, Kaaja R, Ylikorkala O, Hiltunen T, Kontula K. 677 C-.T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia. Obstet Gynecol 2000;96:277-280.
111. Landau R, Xie HG, Dishy V, Wood AJ, Stein CM, Smiley RM. No association of the Asp298 variant of the endothelial nitric oxide synthase gene with preeclampsia. Am J Hypertens 2004;17:391-394.
112. Larciprete G, Gioia S, Angelucci PA, Brosio F, Barbati G, Angelucci GP, Frigo MG, Baiocco F, Romanini ME, Arduini D et al. Single inherited thrombophilias and adverse pregnancy outcomes. J Obstet Gynaecol Res 2007;33:423-430.
113. Le W, Yu JD, Lu L, Tao R, You B, Cai X, Cao WJ, Huang W, He RM, Zhu DL et al. Association of the R485K polymorphism of the factor V gene with poor response to activated protein C and increased risk of coronary artery disease in the Chinese population. Clin Genet 2000;57:296-303.
114. Levesque S, Moutquin JM, Lindsay C, Roy MC, Rousseau F. Implication of an AGT haplotype in a multigene association study with pregnancy hypertension. Hypertension 2004;43:71-78.
115. Li H, Ma Y, Fu Q, Wang L. Angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensin II type 1 receptor (AT1R) gene polymorphism and its association with preeclampsia in Chinese women. Hypertens Pregnancy 2007; 26:293-301.
116. Lin J, August P. Genetic thrombophilias and preeclampsia: a meta-analysis. Obstet Gynecol 2005;105:182-192.
117. Lin S, Huiya Z, Bo L, Wei W, Yongmei G. The plasminogen activator inhibitor-1 (PAI-1) gene -844 A/G and -675 4G/5G promoter polymorphism significantly influences plasma PAI-1 levels in women with polycystic ovary syndrome. Endocrine 2009;36:503-509.
118. Lindoff C, Ingemarsson I, Martinsson G, Segelmark M, Thysell H, Astedt B. Preeclampsia is associated with a reduced response to activated protein C. Am J Obstet Gynecol 1997;176:457-460.
119. Livingston JC, Barton JR, Park V, Haddad B, Phillips O, Sibai BM. Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia. Am J Obstet Gynecol 2001;185:153-157.
120. Malek-Khosravi S, Rahimi Z, Jalilvand F, Parsian A. Thrombophilic mutations and susceptibility to preeclapmsia in Western Iran. J Thromb Thrombolysis 2011.
121. Mando C, Antonazzo P, Tabano S, Zanutto S, Pileri P, Somigliana E, Colleoni F, Martinelli A, Zolin A, Benedetto C et al. Angiotensin-converting enzyme and adducin-1 polymorphisms in women with preeclampsia and gestational hypertension. Reprod Sci 2009;16:819-826.
122. Mayret-Mesquiti M, Perez-Mendez O, Rodriguez ME, Fortoul TI, Gorocica P, Bernal-Alcantara D, Montano LF, Alvarado-Vasquez N. Hypertriglyceridemia is linked to reduced nitric oxide synthesis in women with hypertensive disorders of pregnancy. Hypertens Pregnancy 2007;26:423-431.
123. McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008;9:356-369.
124. Medica I, Kastrin A, Peterlin B. Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis. Eur J Obstet Gynecol Reprod Biol 2007; 131:115-126.
125. Mello G, Parretti E, Martini E, Mecacci F, La TP, Cioni R, Lucchetti R, Fedi S, Gori AM, Pepe G et al. Usefulness of screening for congenital or acquired hemostatic abnormalities in women with previous complicated pregnancies. Haemostasis 1999;29:197-203.
126. Mello G, Parretti E, Marozio L, Pizzi C, Lojacono A, Frusca T, Facchinetti F, Benedetto C. Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study. Hypertension 2005; 46:1270-1274.
127. Mendilcioglu I, Bilgen T, Arikan Y, Keser I, Simsek M, Timuragaoglu A. The association between inherited thrombophilias and pregnancy-related hypertension recurrence. Arch Gynecol Obstet 2011;284:837-841.
128. Mirahmadian M, Kalantar F, Heidari G, Safdarian L, Mansouri R, Amirzargar AA. Association of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in Iranian patients with pre-eclampsia. Am J Reprod Immunol 2008;60:179-185.
129. Miskovic B, Sertic J, Stavljenic-Rukavina A, Stipoljev F. Association of angiotensin-converting enzyme insertion-deletion polymorphism with preeclampsia. Coll Antropol 2008;32:339-343.
130. Molvarec A, Jermendy A, Kovacs M, Prohaszka Z, Rigo J Jr. Toll-like receptor 4 gene polymorphisms and preeclampsia: lack of association in a Caucasian population. Hypertens Res 2008a;31:859-864.
131. Molvarec A, Jermendy A, Nagy B, Kovacs M, Varkonyi T, Hupuczi P, Prohaszka Z, Rigo J Jr. Association between tumor necrosis factor (TNF)-alpha G-308A gene polymorphism and preeclampsia complicated by severe fetal growth restriction. Clin Chim Acta 2008b;392:52-57.
132. Molvarec A, Jermendy A, Nagy B, Kovacs M, Varkonyi T, Hupuczi P, Prohaszka Z, Rigo J Jr. Association between tumor necrosis factor (TNF)-alpha G-308A gene polymorphism and preeclampsia complicated by severe fetal growth restriction. Clin Chim Acta 2008c;392:52-57.
133. Mooyaart AL, Valk EJ, van Es LA, Bruijn JA, de Heer E, Freedman BI, Dekkers OM, Baelde HJ. Genetic associations in diabetic nephropathy: a meta-analysis. Diabetologia 2011;54:544-553.
134. Morgan L, Crawshaw S, Baker PN, Brookfield JF, Broughton PF, Kalsheker N. Distortion of maternal-fetal angiotensin II type 1 receptor allele transmission in pre-eclampsia. J Med Genet 1998;35:632-636.
135. Morgan L, Crawshaw S, Baker PN, Broughton PF, Kalsheker N. Maternal and fetal angiotensinogen gene allele sharing in pre-eclampsia. Br J Obstet Gynaecol 1999a;106:244-251.
136. Morgan L, Foster F, Hayman R, Crawshaw S, Baker PN, Broughton PF, Kalsheker N. Angiotensin-converting enzyme insertion-deletion polymorphism in normotensive and pre-eclamptic pregnancies. J Hypertens 1999b;17:765-768.
137. Morrison ER, Miedzybrodzka ZH, Campbell DM, Haites NE, Wilson BJ, Watson MS, Greaves M, Vickers MA. Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large populationbased study and systematic review. Thromb Haemost 2002;87:779-785.
138. Murphy RP, Donoghue C, Nallen RJ, D'Mello M, Regan C, Whitehead AS, Fitzgerald DJ. Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy. Arterioscler Thromb Vasc Biol 2000;20:266-270.
139. Nagy B, Rigo J Jr, Fintor L, Karadi I, Toth T. Apolipoprotein E alleles in women with severe pre-eclampsia. J Clin Pathol 1998;51:324-325.
140. Nagy B, Hupuczi P, Papp Z. High frequency of methylenetetrahydrofolate reductase 677TT genotype in Hungarian HELLP syndrome patients determined by quantitative real-time PCR. J Hum Hypertens 2007;21:154-158.
141. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, Ogawa H, Motoyama T, Saito Y, Ogawa Y, Miyamoto Y et al. T-786-.C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 1999;99:2864-2870.
142. Nilsson E, Salonen RH, Cnattingius S, Lichtenstein P. The importance of genetic and environmental effects for pre-eclampsia and gestational hypertension: a family study. BJOG 2004;111:200-206.
143. Nishizawa H, Pryor-Koishi K, Suzuki M, Kato T, Sekiya T, Tada S, Kurahashi H, Udagawa Y. Analysis of nitric oxide metabolism as a placental or maternal factor underlying the etiology of pre-eclampsia. Gynecol Obstet Invest 2009; 68:239-247.
144. Omar SZ, Qvist R, Khaing SL, Muniandy S, Bhalla S. Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension. J Obstet Gynaecol Res 2008; 34:174-178.
145. O'Shaughnessy KM, Fu B, Ferraro F, Lewis I, Downing S, Morris NH. Factor V Leiden and thermolabile methylenetetrahydrofolate reductase gene variants in an East Anglian preeclampsia cohort. Hypertension 1999;33:1338-1341.
146. O'Shaughnessy KM, Fu B, Downing S, Morris NH. Thrombophilic polymorphisms in pre-eclampsia: altered frequency of the functional 98C.T polymorphism of glycoprotein IIIa. J Med Genet 2001;38:775-777.
147. Ozturk E, Balat O, Pehlivan S, Ugur MG, Ozcan C, Sever T, Kul S. Endothelial nitric oxide synthase gene polymorphisms in preeclampsia with or without eclampsia in a Turkish population. J Obstet Gynaecol Res 2011.
148. Papazoglou D, Galazios G, Koukourakis MI, Panagopoulos I, Kontomanolis EN, Papatheodorou K, Maltezos E. Vascular endothelial growth factor gene polymorphisms and pre-eclampsia. Mol Hum Reprod 2004;10:321-324.
149. Pappa KI, Roubelakis M, Vlachos G, Marinopoulos S, Zissou A, Anagnou NP, Antsaklis A. Variable effects of maternal and paternal-fetal contribution to the risk for preeclampsia combining GSTP1, eNOS, and LPL gene polymorphisms. J Matern Fetal Neonatal Med 2011;24:628-635.
150. Pazarbasi A, Kasap M, Guzel AI, Kasap H, Onbasioglu M, Ozbakir B, Demirkazik A, Ozgunen FT, Gurtunc E. Polymorphisms in the tumor necrosis factor-alpha gene in Turkish women with pre-eclampsia and eclampsia. Acta Med Okayama 2007; 61:153-160.
151. Pegoraro RJ, Hira B, Rom L, Moodley J. Plasminogen activator inhibitor type 1 (PAI1) and platelet glycoprotein IIIa (PGIIIa) polymorphisms in Black South Africans with pre-eclampsia. Acta Obstet Gynecol Scand 2003;82:313-317.
152. Pegoraro RJ, Chikosi A, Rom L, Roberts C, Moodley J. Methylenetetrahydrofolate reductase gene polymorphisms in black South Africans and the association with preeclampsia. Acta Obstet Gynecol Scand 2004;83:449-454.
153. Pendeloski KP, Sass N, Torloni MR, Mattar R, Moron AF, Franchim CS, Daher S. Immunoregulatory gene polymorphisms in women with preeclampsia. Hypertens Res 2011;34:384-388.
154. Perez-Mutul J, Gonzalez-Herrera L, Sosa-Cabrera T, Martinez-Olivares R. A mutation in the 5,10-methylenetetrahydrofolate reductase gene is not associated with preeclampsia in women of southeast Mexico. Arch Med Res 2004; 35:231-234.
155. Plummer S, Tower C, Alonso P, Morgan L, Baker P, Broughton-Pipkin F, Kalsheker N. Haplotypes of the angiotensin II receptor genes AGTR1 and AGTR2 in women with normotensive pregnancy and women with preeclampsia. Hum Mutat 2004;24:14-20.
156. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88:3698-3703.
157. Powers RW, Minich LA, Lykins DL, Ness RB, Crombleholme WR, Roberts JM. Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia. J Soc Gynecol Investig 1999;6:74-79.
158. Prasmusinto D, Skrablin S, Hofstaetter C, Fimmers R, van DV. The methylenetetrahydrofolate reductase 677 C-.T polymorphism and preeclampsia in two populations. Obstet Gynecol 2002;99:1085-1092.
159. Prasmusinto D, Skrablin S, Fimmers R, van DV. Ethnic differences in the association of factor V Leiden mutation and the C677T methylenetetrahydrofolate reductase gene polymorphism with preeclampsia. Eur J Obstet Gynecol Reprod Biol 2004; 112:162-169.
160. Procopciuc L, Caracostea G, Iordache G, Olteanu I, Stamatian F. Influence of RAS polymorphisms on the development and perinatal outcome of preeclampsia. Genetic RAS evaluation. Gineco Ro 2009;5:88-93.
161. Procopciuc LM, Caracostea G, Zaharie G, Puscas M, Iordache G, Olteanu I, Stamatian F. Mutant maternal and fetal thrombophilic genotypes as a risk factor for preeclampsia. Gineco Ro 2010;6:74-81.
162. Procopciuc LM, Hazi GM, Caracostea G, Nemeti G, Olteanu I, Stamatian F. Apolipoprotein E polymorphism-a risk factor in Romanian pregnant women with preeclampsia. Gineco Ro 2011;7:134-140.
163. Puthothu B, Bierbaum S, Kopp MV, Forster J, Heinze J, Weckmann M, Krueger M, Heinzmann A. Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma. Pediatr Allergy Immunol 2009;20:157-163.
164. Rajkovic A, Mahomed K, Rozen R, Malinow MR, King IB, Williams MA. Methylenetetrahydrofolate reductase 677C-.T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe. Mol Genet Metab 2000;69:33-39
165. Rallidis LS, Gialeraki A, Merkouri E, Liakos G, Dagres N, Sionis D, Travlou A, Lekakis J, Kremastinos DT. Reduced carriership of 4G allele of plasminogen activator inhibitor-1 4G/5G polymorphism in very young survivors of myocardial infarction. J Thromb Thrombolysis 2010;29:497-502.
166. Rigo J Jr, Nagy B, Fintor L, Tanyi J, Beke A, Karadi I, Papp Z. Maternal and neonatal outcome of preeclamptic pregnancies: the potential roles of factor V Leiden mutation and 5,10 methylenetetrahydrofolate reductase. Hypertens Pregnancy 2000;19:163-172.
167. Roberts CB, Rom L, Moodley J, Pegoraro RJ. Hypertension-related gene polymorphisms in pre-eclampsia, eclampsia and gestational hypertension in Black South African women. J Hypertens 2004;22:945-948.
168. Rodie VA, Freeman DJ, Sattar N, Greer IA. Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy? Atherosclerosis 2004;175:189-202.
169. Ruggiero D, Dalmasso C, Nutile T, Sorice R, Dionisi L, Aversano M, Broet P, Leutenegger AL, Bourgain C, Ciullo M. Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms. PLoS One 2011;6:e16982.
170. Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M. Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia. Mol Hum Reprod 2005;11:437-440.
171. Sagoo GS, Tatt I, Salanti G, Butterworth AS, Sarwar N, van Maarle M, Jukema JW, Wiman B, Kastelein JJ, Bennet AM et al. Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis. Am J Epidemiol 2008;168:1233-1246.
172. Salimi S, Mokhtari M, Yaghmaei M, Jamshidi M, Naghavi A. Association of angiotensin-converting enzyme intron 16 insertion/deletion and angiotensin II type 1 receptor A1166C gene polymorphisms with preeclampsia in South East of Iran. J Biomed Biotechnol 2011a;2011:941515.
173. Salimi S, Naghavi A, Mokhtari M, Noora M, Yaghmaei M. Lack of relationship between endothelial nitric oxide synthase gene 4b/a and T-786C polymorphisms with preeclampsia in southeast of Iran. Arch Gynecol Obstet 2011b.
174. Samsami DA, Doroudchi M, Kalantari T, Pezeshki AM, Ghaderi A. Heterozygosity in CTLA-4 gene and severe preeclampsia. Int J Gynaecol Obstet 2005;88:19-24.
175. Sandrim VC, Palei AC, Cavalli RC, Araujo FM, Ramos ES, Duarte G, Tanus-Santos JE. eNOS haplotypes associated with gestational hypertension or preeclampsia. Pharmacogenomics 2008;9:1467-1473.
176. Sandrim VC, Palei AC, Sertorio JT, Cavalli RC, Duarte G, Tanus-Santos JE. Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia. Mol Hum Reprod 2010;16:506-510.
177. Sayed-Tabatabaei FA, Oostra BA, Isaacs A, van Duijn CM, Witteman JC. ACE polymorphisms. Circ Res 2006;98:1123-1133.
178. Seremak-Mrozikiewicz A, Dubiel M, Drews K, Breborowicz GH, Mrozikiewicz PM. 1166C mutation of angiotensin II type 1 receptor gene is correlated with umbilical blood flow velocimetry in women with preeclampsia. J Matern Fetal Neonatal Med 2005;17:117-121.
179. Seremak-Mrozikiewicz A, Drews K, Wender-Ozegowska E, Mrozikiewicz PM. The significance of genetic polymorphisms of factor V Leiden and prothrombin in the preeclamptic Polish women. J Thromb Thrombolysis 2010;30:97-104.
180. Seremak-Mrozikiewicz A, Drews K, Barlik M, Sieroszewski P, Grzeskowiak E, Mrozikiewicz P. The significance of -786T. C polymorphism of endothelial NO synthase (eNOS) gene in severe preeclampsia. J Matern Fetal Neonatal Med 2011;24:432-436.
181. Serrano NC, Casas JP, Diaz LA, Paez C, Mesa CM, Cifuentes R, Monterrosa A, Bautista A, Hawe E, Hingorani AD et al. Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study. Hypertension 2004; 44:702-707.
182. Serrano NC, Diaz LA, Paez MC, Mesa CM, Cifuentes R, Monterrosa A, Gonzalez A, Smeeth L, Hingorani AD, Casas JP. Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: evidence of small-study bias. PLoS Med 2006;3:e520.
183. Sharma D, Trivedi SS, Bhattacharjee J. Oxidative stress and eNOS (Glu298Asp) gene polymorphism in preeclampsia in Indian population. Mol Cell Biochem 2011; 353:189-193.
184. Shim JY, Jun JK, Jung BK, Kim SH, Won HS, Lee PR, Kim A. Vascular endothelial growth factor gene +936 C/T polymorphism is associated with preeclampsia in Korean women. Am J Obstet Gynecol 2007;197:271-274.
185. Singh A, Sharma D, Raghunandan C, Bhattacharjee J. Role of inflammatory cytokines and eNOS gene polymorphism in pathophysiology of pre-eclampsia. Am J Reprod Immunol 2010;63:244-251.
186. Smith GC, Pell JP, Walsh D. Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129,290 births. Lancet 2001; 357:2002-2006.
187. Sofowora G, Dishy V, Xie HG, Imamura H, Nishimi Y, Morales CR, Morrow JD, Kim RB, Stein CM, Wood AJ. In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism. Pharmacogenetics 2001;11:809-814.
188. Sohda S, Arinami T, Hamada H, Yamada N, Hamaguchi H, Kubo T. Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. J Med Genet 1997;34:525-526.
189. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. Lancet 2010; 376:631-644.
190. Stiefel P, Miranda ML, Bellido LM, Luna J, Jimenez L, Pamies E, de Frutos PG, Villar J. Genotype of the CYBA promoter -930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: an observational study. Med Clin (Barc) 2009;133:657-661.
191. Stonek F, Hafner E, Metzenbauer M, Katharina S, Stumpflen I, Schneeberger C, Zeisler H, Husslein P, Philipp K. Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia. J Reprod Immunol 2008a;77:85-90.
192. Stonek F, Metzenbauer M, Hafner E, Philipp K, Tempfer C. Interleukin-10-1082 G/A promoter polymorphism and pregnancy complications: results of a prospective cohort study in 1,616 pregnant women. Acta Obstet Gynecol Scand 2008b; 87:430-433.
193. Sun T, Zhou Y, Yang M, Hu Z, Tan W, Han X, Shi Y, Yao J, Guo Y, Yu D et al. Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer. Cancer Res 2008;68:7025-7034.
194. Sutherland A, Cooper DW, Howie PW, Liston WA, Mac illivray I. The indicence of severe pre-eclampsia amongst mothers and mothers-in-law of pre-eclamptics and controls. Br J Obstet Gynaecol 1981;88:785-791.
195. Teft WA, Kirchhof MG, Madrenas J. A molecular perspective of CTLA-4 function. Annu Rev Immunol 2006;24:65-97.
196. Tempfer CB, Dorman K, Deter RL, O'Brien WE, Gregg AR. An endothelial nitric oxide synthase gene polymorphism is associated with preeclampsia. Hypertens Pregnancy 2001;20:107-118.
197. Tempfer CB, Jirecek S, Riener EK, Zeisler H, Denschlag D, Hefler L, Husslein PW. Polymorphisms of thrombophilic and vasoactive genes and severe preeclampsia: a pilot study. J Soc Gynecol Investig 2004;11:227-231.
198. Turan F, Ilhan N, Kaman D, Ates K, Kafkasli A. Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and plasma concentrations of asymmetric dimethylarginine in Turkish pre-eclamptic women without fetal growth retardation. J Obstet Gynaecol Res 2010;36:495-501.
199. Uma R, Forsyth SJ, Struthers AD, Fraser CG, Godfrey V, Murphy DJ. Polymorphisms of the angiotensin converting enzyme gene in early-onset and late-onset pre-eclampsia. J Matern Fetal Neonatal Med 2010;23:874-879.
200. Utermann G. Apolipoprotein E polymorphism in health and disease. Am Heart J 1987;113:433-440.
201. van Geel PP, Pinto YM, Voors AA, Buikema H, Oosterga M, Crijns HJ, van Gilst WH. Angiotensin II type 1 receptor A1166C gene polymorphism is associated with an increased response to angiotensin II in human arteries. Hypertension 2000;35:717-721.
202. van Rijn BB, Franx A, Steegers EA, de Groot CJ, Bertina RM, Pasterkamp G, Voorbij HA, Bruinse HW, Roest M. Maternal TLR4 and NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset preeclampsia and HELLP syndrome. PLoS One 2008;3:e1865.
203. Veldman BA, Spiering W, Doevendans PA, Vervoort G, Kroon AA, de Leeuw PW, Smits P. The Glu298Asp polymorphism of the NOS 3 gene as a determinant of the baseline production of nitric oxide. J Hypertens 2002;20:2023-2027.
204. von Tempelhoff GF, Heilmann L, Spanuth E, Kunzmann E, Hommel G. Incidence of the factor V Leiden-mutation, coagulation inhibitor deficiency, and elevated antiphospholipid-antibodies in patients with preeclampsia or HELLPsyndrome. Hemolysis, elevated liver-enzymes, low platelets. Thromb Res 2000; 100:363-365.
205. Vural P, Degirmencioglu S, Saral NY, Demirkan A, Akgul C, Yildirim G, Issever H, Eroglu H. Tumor necrosis factor alpha, interleukin-6 and interleukin-10 polymorphisms in preeclampsia. J Obstet Gynaecol Res 2010;36:64-71.
206. Wang XL, Wang J. Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metab 2000;70:241-251.
207. Wang L, Feng Y, Zhang Y, Zhou H, Jiang S, Niu T, Wei LJ, Xu X, Wang X. Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia. Am J Obstet Gynecol 2006;195:162-171.
208. Wang AH, Lam WJ, Han DY, Ding Y, Hu R, Fraser AG, Ferguson LR, Morgan AR. The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population. Hum Immunol 2011;72:431-435.
209. Ward K, Hata A, Jeunemaitre X, Helin C, Nelson L, Namikawa C, Farrington PF, Ogasawara M, Suzumori K, Tomoda S. A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet 1993;4:59-61.
210. Watanabe H, Hamada H, Yamakawa-Kobayashi K, Yoshikawa H, Arinami T. Evidence for an association of the R485K polymorphism in the coagulation factor V gene with severe preeclampsia from screening 35 polymorphisms in 27 candidate genes. Thromb Haemost 2001;86:1594-1595.
211. Williams MA, Sanchez SE, Zhang C, Bazul V. Methylenetetrahydrofolate reductase 677 C-.T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women. J Matern Fetal Neonatal Med 2004;15:337-344.
212. Xie F, Hu Y, Speert DP, Turvey SE, Peng G, Money DM, Magee LA, von DP. Toll-like receptor gene polymorphisms and preeclampsia risk: a case-control study and data synthesis. Hypertens Pregnancy 2010;29:390-398.
213. Xie C, Yao MZ, Liu JB, Xiong LK. A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia. Cytokine 2011;56:550-559.
214. Yaghmaei M, Salimi S, Mokhtari M, Naghavi A, Saravani M, Farajian-Mashhadi F. Endothelial nitric oxide synthase gene Glu298Asp polymorphism and risk of preeclampsia in South East of Iran. Afr J Biotechnol 2011;10:10712-10717.
215. Yalinkaya A, Erdemoglu M, Akdeniz N, Kale A, Kale E. The relationship between thrombophilic mutations and preeclampsia: a prospective case-control study. Ann Saudi Med 2006;26:105-109.
216. Yamada N, Arinami T, Yamakawa-Kobayashi K, Watanabe H, Sohda S, Hamada H, Kubo T, Hamaguchi H. The 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with severe preeclampsia. J Hum Genet 2000; 45:138-141.
217. Ye S, Green FR, Scarabin PY, Nicaud V, Bara L, Dawson SJ, Humphries SE, Evans A, Luc G, Cambou JP. The 4G/5G genetic polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene is associated with differences in plasma PAI-1 activity but not with risk of myocardial infarction in the ECTIM study. Etude CasTemoins de I'nfarctus du Mycocarde. Thromb Haemost 1995; 74:837-841.
218. Ye Z, Liu EH, Higgins JP, Keavney BD, Lowe GD, Collins R, Danesh J. Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. Lancet 2006;367:651-658.
219. Yilmaz H, Unlucerci Y, Gurdol F, Isbilen E, Isbir T. Association of pre-eclampsia with hyperhomocysteinaemia and methylenetetrahydrofolate reductase gene C677T polymorphism in a Turkish population. Aust N Z J Obstet Gynaecol 2004; 44:423-427.
220. Yoshida A, Miura K, Nakayama D, Masuzaki H. Correlation between preeclampsia and prevalence of polymorphism of angiotensinogen, methyleneteterahydrofolate reductase and factor V, prothrombin genes among Japanese women. Acta Med Nagasakiensia 2008;53:37-41.
221. Yoshimura T, Yoshimura M, Tabata A, Shimasaki Y, Nakayama M, Miyamoto Y, Saito Y, Nakao K, Yasue H, Okamura H. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with severe preeclampsia. J Soc Gynecol Investig 2000;7:238-241.
222. Yoshimura T, Chowdhury FA, Yoshimura M, Okamura H. Genetic and environmental contributions to severe preeclampsia: lack of association with the endothelial nitric oxide synthase Glu298Asp variant in a developing country. Gynecol Obstet Invest 2003;56:10-13.
223. Zdoukopoulos N, Doxani C, Messinis IE, Stefanidis I, Zintzaras E. Polymorphisms of the endothelial nitric oxide synthase (NOS3) gene in preeclampsia: a candidate-gene association study. BMC Pregnancy Childbirth 2011;11:89.
224. Zhang XQ, Varner M, Dizon-Townson D, Song F, Ward K. A molecular variant of angiotensinogen is associated with idiopathic intrauterine growth restriction. Obstet Gynecol 2003;101:237-242.
225. Zhang C, Austin MA, Edwards KL, Farin FM, Li N, Hsu L, Srinouanprachanh SL, Williams MA. Functional variants of the lipoprotein lipase gene and the risk of preeclampsia among non-Hispanic Caucasian women. Clin Genet 2006; 69:33-39.