Lipoprotein lipase gene mutations and the genetic susceptibility of preeclampsia

Hypertension

Volumn 38, Issue 5, 2001, Pages 992-996

  Kim, Young J ^a   Williamson, Roger A ^a   Chen, K ^a   Smith, Jennifer L ^a   Murray, Jeffrey C ^a   Merrill, David C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Genetic susceptibility; Lipoprotein lipase; Mutations; Preeclampsia

Indexed keywords

LIPOPROTEIN LIPASE;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HELLP SYNDROME; HUMAN; MAJOR CLINICAL STUDY; PREECLAMPSIA; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0035725012     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/hy1101.093105     Document Type: Article

References (16)

1. Etiology and pathogenesis of preeclampsia: Current concepts
2. Increased lipolytic activity and high ratio of free fatty acids to albumin in sera from women with preeclampsia leads to triglyceride accumulation in cultured endothelial cells
3. Fasting serum free fatty acids and triglycerides are increased before 20 weeks of gestation in women who later develop preeclampsia
4. Genetics of hypertension in pregnancy: Possible single gene control of preeclampsia and eclampsia in decedents of eclamptic women
5. Is genetic susceptibility to preeclampsia conferred by homozygosity for the same single recessive gene in mother and fetus?
6. New insights into the genetics of preeclampsia
7. Tabulations and expectations regarding the genetics of human hypertension
8. The Asn9 variant of lipoprotein lipase is associated with the -93 G promotor mutation and an increased risk of coronary artery disease
9. A common mutation in the lipoprotein lipase gene (N291S) alters the lipoprotein phenotype and risk for cardiovascular disease in patients with familial hypercholesterolemia
10. 156→Gly) causing familial lipoprotein lipase deficiency
11. A common variant in the gene for lipoprotein lipase (Asp9→Asn): Functional implications and prevalence in normal and hyperlipidemic subjects
12. Potential pathogenic roles of aberrant lipoprotein and fatty acid metabolism in preeclampsia
13. Fatty acid pattern of esterified and free fatty acids in sera of women with normal and preeclamptic pregnancy
14. Lipoprotein subfraction concentrations in preeclampsia: Pathogenic parallels to atherosclerosis
15. Common mutations in the lipoprotein lipase gene are associated with increased risk of preeclampsia
16. Patients with apoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn291→Ser mutation in the human LPL gene