MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women

Hypertension in Pregnancy

Volumn 25, Issue 2, 2006, Pages 73-80

  Jääskeläinen, Ester ^a   Keski Nisula, Leea ^a   Toivonen, Sari ^a   Romppanen, Eeva Liisa ^a   Helisalmi, Seppo ^a   Punnonen, Kari ^a   Heinonen, Seppo ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

C677T; Finnish; MTHFR; Placental abruption; Preeclampsia

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CODE; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; PREECLAMPSIA; RISK ASSESSMENT; SAMPLE SIZE; SOLUTIO PLACENTAE;

ABRUPTIO PLACENTAE; ADULT; CASE-CONTROL STUDIES; CYTOSINE; FEMALE; FINLAND; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, SINGLE NUCLEOTIDE; PRE-ECLAMPSIA; PREGNANCY; THYMINE;

EID: 33746806663     PISSN: 10641955     EISSN: 15256065     Source Type: Journal    
DOI: 10.1080/10641950600745137     Document Type: Article

References (25)

1. th ed. New York: McGraw-Hill Book Company, International Edition, 1987; 1615-1616.
2. Kang SS, Zhou J, Wong PW, Kowalisyn J, Strokosch G. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet 1988; 43:414-421.
3. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10:11-13.
4. Castro R, Rivera I, Ravasco P, Jakobs C, Blom HJ, Camilo ME, et al. 5,10-Methylenetetrahydrofolate reductase 677C→T and 1298A→C mutations are genetic determinants of elevated homocysteine. QJM 2003; 96:297-303.
5. Nelen WL, Blom HJ, Steegers EA, den Heijer M, Eskes TK. Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis. Fertil Steril 2000; 74:1196-1199.
6. Abbate R, Sofi F, Gensini F, Fatini C, Sticchi E, Fedi S. Thrombophilias as risk factors for disorders of pregnancy and fetal damage. Pathophysiol Haemost Thromb 2002; 32:318-21.
7. Brenner B. Inherited thrombophilia and fetal loss. Curr Opin Hematol 2000; 7:290-295.
8. Kupferminc MJ. Thrombophilia and pregnancy. Curr Pharm Des 2005;11:735-748.
9. Eskes TK. Clotting disorders and placental abruption: homocysteine - a new risk factor. Eur J Obstet Gynecol Reprod Biol 2001; 95:206-212.
10. Vollset SE, Refsum H, Irgens LM, Emblem BM, Tverdal A, Gjessing HK, et al. Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study. Am J Clin Nutr 2000; 71:962-968.
11. Goddijn-Wessel TA, Wouters MG, van der Molen EF, Spuijbroek MD, Steegers-Theunissen RP, Blom HJ, et al. Hyperhomocysteinemia: A risk factor for placental abruption or infarction. Eur J Obstet Gynecol Reprod Biol 1996; 66:23-29.
12. van der Molen EF, Arends GE, Nelen WL, van der Put NJ, Heil SG, Eskes TK, et al. A common mutation in the 5, 10-methylenetetrahydrofolate reductase gene as a new risk factor for placental vasculopathy. Am J Obstet Gynecol 2000; 182:1258-1263.
13. Lin J, August P. Genetic thrombophilias and preeclampsia: a meta-analysis. Obstet Gynecol 2005; 105:182-192.
14. Nurk E, Tell GS, Refsum H, Ueland PM, Vollset SE. Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine Study. Am J Med 2004; 117:26-31.
15. Hira B, Pegoraro RJ, Rom L, Govender T, Moodley J. Polymorphisms in various coagulation genes in black South African women with placental abruption. BJOG 2002; 109:574-575.
16. D'Elia AV, Driul L, Giacomello R, Colaone R, Fabbro D, Di Leonardo C, et al. Frequency of factor V, prothrombin and methylenetetrahydrofolate reductase gene variants in preeclampsia. Gynecol Obstet Invest 2002; 53:84-87.
17. Morrison ER, Miedzybrodzka ZH, Campbell DM, Haites NE, Wilson BJ, Watson MS, et al. Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review. Thromb Haemost 2002; 87:779-785.
18. Laivuori H, Kaaja R, Ylikorkala O, Hiltunen T, Kontula K. 677 C→T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia. Obstet Gynecol 2000; 96:277-280.
19. Scholl TO, Johnson WG. Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr 2000; 7:1295S-1303S.
20. Jääskeläinen E, Toivonen S, Romppanen EL, Helisalmi S, Keski-Nisula L, Punnonen K, Heinonen S. M385T polymorphism in the factor V gene, but not Leiden mutation, is associated with placental abruption in Finnish women. Placenta 2004; 25:730-734.
21. Saarela T, Jääskeläinen J, Tenhola S, Voutilainen R, Heinonen S. Preeclampsia and androgen receptor gene CAG repeat length: results from both children and women. J Assist Reprod Genet 2005; 22:269-275.
22. Parle-McDermott A, Mills JL, Kirke PN, Cox C, Signore CC, Kirke S, et al. MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae. Am J Med Genet 2005; 132:365-368.
23. Cortese C, Motti C. MTHFR gene polymorphism, homocysteine and cardiovascular disease. Public Health Nutr. 2001; 4:493-497.
24. Alfthan G, Laurinen MS, Valsta LM, Pastinen T, Aro A. Folate intake, plasma folate and homocysteine status in a random Finnish population. Eur J Clin Nutr 2003: 57:81-88.
25. Kaaja R, Kinnunen T, Luoto R. Regional differences in the prevalence of preeclampsia in relation to the risk factors for coronary artery disease in women in Finland. Eur Heart J 2005; 26:44-50.