Polymorphisms in the endothelial nitric oxide synthase gene may be protective against preeclampsia in a Chinese population

Reproductive Sciences

Volumn 14, Issue 2, 2007, Pages 175-181

  Chen, Li Kuei ^a   Huang, Chi Hsiang ^a   Yeh, Heui Ming ^a   Lee, Chien Nan ^a   Shyu, Ming Kwang ^a   Hsieh, Fon Jou ^a   Lai, Ling Ping ^a,b   Sun, Wei Zen ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Chinese population; Endothelial nitric oxide synthase; Polymorphism; Preeclampsia

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ADULT; ALLELE; ARTICLE; CHINESE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HELLP SYNDROME; HUMAN; INTRON; MAJOR CLINICAL STUDY; PREECLAMPSIA; PREGNANT WOMAN; PRIORITY JOURNAL; AGAR GEL ELECTROPHORESIS; CASE CONTROL STUDY; CHROMOSOME 7; COMPARATIVE STUDY; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; MALE; NEWBORN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREGNANCY; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TAIWAN;

ADULT; BASE SEQUENCE; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 7; ELECTROPHORESIS, AGAR GEL; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFANT, NEWBORN; MALE; NITRIC OXIDE SYNTHASE TYPE III; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PRE-ECLAMPSIA; PREGNANCY; RISK FACTORS; TAIWAN;

EID: 34648828777     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719107299570     Document Type: Article

References (36)

1. Sibai BM, Anderson GD Hypertension. In: Gabbe SG, Niebyl JR, Simpson JL, eds. Obstetrics: Normal and Problem Pregnancies. 2 nd ed. New York, NY: Churchill Livingstone ; 1991: 993-1055.
2. Robert JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol. 1989 ; 161: 1200-1204.
3. Walsh SW Preeclampsia: an imbalance in placental prostacyclin and thrombaxane production. Am J Obstet Gynecol. 1985 ; 152: 335-340.
4. Boura AL, Walters WA, Read MA, Leitch IM Autacoids and control of human placental blood flow. Clin Exp Pharmacol Physiol. 1994 ; 21: 737-748.
5. Förstermann U. Biochemistry and molecular biology of nitric oxide synthases. Drug Res. 1994 ; 44: 402-407.
6. Seligman SP, Buyon JP, Clancy RM, Young BK, Abramson SB The role of nitric oxide in the pathgenesis of preeclampsia. Am J Obstet Gynecol. 1994 ; 171: 944-948.
7. Moncada S., Palmer Rmj, Higgs EA Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 1991 ; 13: 109-142.
8. Noris M., Remuzzi G. Physiology and pathophysiology of nitric oxide in chronic renal disease. Proc Assoc Am Physicians. 1999 ; 111: 602-610.
9. Faxén M., Nisell H., Kublickiene KR Altered mRNA expression of ecNOS and iNOS in myometrium and placenta from women with preeclampsia. Arch Gynecol Obstet. 2001 ; 265: 45-50.
10. Marsden PA, Heng Hhq, Scherer SW, et al. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem. 1993 ; 268: 17478-17488.
11. Nadaud S., Bonnardeaux A., Lathrop M., Soubrier F. Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene. Biochem Biophys Res Commun. 1994 ; 198: 1027-1033.
12. Miyahara K., Kawamoto T., Sase K., et al. Cloning and structural characterization of the human endothelial nitric-oxide-synthase gene. Eur J Biochem. 1994 ; 223: 719-726.
13. Li R., Lyn D., Lapu-Bula R., et al. Relationship of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans. Am J Hypertens. 2004 ; 17: 560-567.
14. Tanus-Santos JE, Dasai M., Flockgart DA Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants. Pharmacogenetics. 2001 ; 11: 719-725.
15. Hoffmann IS, Tavares-Mordwinkin R., Castejon AM, Alfieri AB, Cubeddu LX Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics. J Hum Hypertens. 2005 ; 19: 233-240.
16. Taukada T., Yokoyama K., Arai T., Takemoto F. Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun. 1998 ; 245: 190-193.
17. Yoshimura M., Yasue H., Nakayama M., et al. A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. Hum Genet. 1998 ; 103: 65-69.
18. Wang XL, Sim AS, Badenhop RF, McCredie RM, Wilcken Del. A smoking dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat Med. 1996 ; 2: 41-45.
19. Benjafield AV, Morris BJ Association analyses of endothelial nitric oxide synthase gene polymorphisms in essential hypertension. Am J Hypertens. 2000 ; 13: 994-998.
20. Hibi K., Ishigami T., Tamura K., et al. Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction. Hypertension. 1998 ; 32: 521-526.
21. Elbaz A., Poirier O., Moulin T., Chedru F., Cambien F., Amarenco P. Association between the Glu298Asp polymorphism in the endothelial constitutive nitric oxide synthase gene and brain infarction: the GENIC Investigators. Stroke. 2000 ; 31: 1634-1639.
22. Yoshimura T., Yoshimura M., Tabata A., et al. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with severe preeclampsia. J Soc Gynecol Investig. 2000 ; 7: 238-241.
23. Kobashi G., Yamada H., Ohta K., Kato E., Ebina Y., Fujimoto S. Endothelial nitric oxide synthase gene (NOS3) variant and hypertension in pregnancy. Am J Med Genet. 2001 ; 20: 107-118.
24. Yoshimura T., Chowdhury FA, Yoshimura M., Okamura H. Genetic and environmental contribution to severe preeclampsia: lack of association with the endothelial nitric oxide synthase Glu298Asp variant in a developing country. Gynecol Obstet Invest. 2003 ; 56: 10-13.
25. Hakli T., Romppanen EL, Hiltunen M., Helisalmi S., Punnonen K., Heinonen S. Endothelial nitric oxide synthase polymorphism in preeclampsia. J Soc Gynecol Invest. 2003 ; 10: 154-157.
26. Landau R., Xie HG, Dishy V., Wood Ajj, Stein CM, Smiley RM No association of the Asp298 variant of the endothelial nitric oxide synthase gene with preeclampsia. Am J Hypertens. 2004 ; 17: 391-394.
27. Andolfatto S., Namour F., Garnier AL, Chabot F., Gueant JL, Aimone-Gastin I. Genomic DNA extraction from small amounts of serum to be used for α1-antitrypsin genotype analysis. Eur Respir J. 2003 ; 21: 215-219.
28. Arngrimsson R., Hayward C., Nadaud S., Baldursdottir A., Walker JJ, Liston WA Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region. Am J Hum Genet. 1997 ; 61: 354-362.
29. Ward K., Hata A., Jeunemaitre X. A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet. 1993 ; 4: 59-61.
30. Kupferminc MJ, Eldor A., Steinman N. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med. 1999 ; 340: 9-13.
31. Chen G., Wilson R., Wang SH, Zheng HZ, WalkerJJ,Mckillop JH. Tumor necrosis factor-alpha (TNF-α) gene polymorphism and expression in preeclampsia. Clin Exp Immunol. 1996 ; 104: 154-159.
32. Powers RW, Minich LA, Lykins DL, Ness RB, Crombleholme WR, Roberts JM Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia. J Soc Gynecol Invest. 1999 ; 6: 74-76.
33. Tesauro M., Thompson WC, Rogliani P., Qi L., Chaudhary PP, Moss J. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with asparate vs. glutamate at position 298. Proc Natl Acad Sci U S A. 2000 ; 97: 2832-2835.
34. Savvidou MD, Vallance PJ, Nicolaides KH, Hingorani AD Endothelial nitric oxide synthase gene polymorphism and maternal vascular adaptation to pregnancy. Hypertension. 2001 ; 38: 1289-1293.
35. Xiang W., Chen H., Xu X., Zhang M., Jiang R. Expression of endothelial nitric oxide synthase traffic inducer in the placentas of women with preeclampsia. Int J Gyanecol Obstet. 2005 ; 89: 103-107.
36. Orange SJ, Painter D., Horvath J., Yu B., Trent R., Hennessy A. Placental endothelial nitric oxide synthase localization and expression in normal human pregnancy and preeclampsia. Clin Exp Pharmacol Physiol. 2003 ; 30: 376-381.