Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia

Journal of Medical Genetics

Volumn 34, Issue 6, 1997, Pages 525-526

  Sohda, Satoshi ^a   Arinami, Tadao ^a   Hamada, Hiromi ^a   Yamada, Naoki ^a   Hamaguchi, Hideo ^a   Kubo, Takeshi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Homocysteine; Methylenetetrahydrofolate reductase; Polymorphism; Preeclampsia

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE; NUCLEOTIDE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME ACTIVITY; FEMALE; GENE FREQUENCY; GENOTYPE; HOMOZYGOTE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MISSENSE MUTATION; NUCLEIC ACID BASE SUBSTITUTION; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; RISK; VASCULAR DISEASE;

EID: 0030919077     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: 10.1136/jmg.34.6.525     Document Type: Article

References (5)

1. McCully KS. Homocysteine and vascular disease. Nat Med 1996;2:386-9.
2. Dekker GA, de Vries JIP, Doelitzsch PM, et al. Underlying disorders associated with severe early-onset preeclampsia. Am J Obstet Gynecol 1995;173:1042-8.
3. Steegers-Theunissen RPM, Boers GHJ, Blom HJ, et al. Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae. Lancet 1992;339:1122-3.
4. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-13.
5. American College of Obstetricians and Gynecologists. National high blood pressure education program working group report on high blood pressure in pregnancy. Am J Obstet Gynecol 1990;163:1689-712.