A mutation in the 5,10-methylenetetrahydrofolate reductase gene is not associated with preeclampsia in women of southeast mexico

Archives of Medical Research

Volumn 35, Issue 3, 2004, Pages 231-234

  Pérez Mutul, José ^a,c   González Herrera, Lízbeth ^a   Sosa Cabrera, Tayde ^b   Martínez Olivares, Ramón ^b  

^a UNIVERSIDAD AUTÓNOMA DE YUCATÁN   (Mexico)

^b SECRETARÍA DE SALUD   (Mexico)

^c Ctro Invest Regionales Dr H   (Mexico)

Author keywords

C677T mutation; MTHFR gene; Preeclampsia

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ADOLESCENT; ADULT; ARTICLE; CALCULATION; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; FEMALE; FISHER EXACT TEST; GENE AMPLIFICATION; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; MEXICO; POLYMERASE CHAIN REACTION; PREECLAMPSIA; PREGNANCY; RISK; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VOLUNTEER;

ADOLESCENT; ADULT; ALLELES; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MUTATION; ODDS RATIO; POLYMORPHISM, GENETIC; PRE-ECLAMPSIA; PREGNANCY; RISK; RISK FACTORS;

EID: 2442490581     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2004.02.004     Document Type: Article

References (24)

1. Kenny L., Baker P.N. Maternal pathophysiology in preeclampsia. Baillieres Best Pract Res Clin Obstet Gynaecol. 13:1999;59-75
2. Lain K.Y., Roberts J.M. Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA. 287:2002;3183-3186
3. Powers R.W. Plasma homocysteine concentration increased in preeclampsia and is associated with evidence of endothelial activation. Am J Obstet Gynecol. 179:1998;1605-1611
4. Dizon-Townson D.S., Nelson L.M., Easton K., Ward K. The factor V-Leiden mutation may predispose women to severe preeclampsia. Am J Obstet Gynecol. 173:1995;1042-1048
5. Raijmakers M.T., Zusterzeel P.L., Steegers E.A., Peters W.H. Hyperhomocysteinaemia: a risk factor for preeclampsia? Eur J Obstet Gynecol Reprod Biol. 95:2001;226-228
6. Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Mathews R.G., Boers G.J.H., den Heijer M., Kluijtmans L.A.J., van der Heuvel L.P., Rozen R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genet. 10:1995;111-113
7. Kim Y.J., Williamson R.A., Murray J.C., Andrews J., Pietscher J., Peraud P., Merril D. Genetic susceptibility to preeclampsia: roles of cytosine-to-thymine substitution at nucleotide 677 of the gene for methylenetetrahydrofolate reductase, 68-base pair insertion at nucleotide 844 of the gene for cystathionine β-synthase, and factor V Leiden mutation. Am J Obstet Gynecol. 184:2001;1211-1217
8. Grandone E., Margaglione M., Colaizzo D., Cappucci G., Paladini D., Martinelli P., Montanaro S., Pavone G., Di Minno G. Factor V Leiden, C>T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thromb Haemost. 77:1997;1052-1054
9. Sohda S., Arinami T., Hamada H., Yamada N., Hamaguchi H., Kubo T. Methylenetetrahydrofolate reductase polymorphism and preeclampsia. J Med Genet. 34:1997;525-526
10. Kobashi K., Yamada H., Asano T., Nagano S., Hata A., Kishi R., Fujimoto S., Kondo K. Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women. Am J Med Genet. 93:2000;122-125
11. Rajkovic A., Mahomed K., Rozen R., Malinow M.R., King I.B., Williams M.A. Methylenetetrahydrofolate reductase 677 C-T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe. Mol Genet Metab. 69:2000;33-39
12. Kaiser T., Brennecke S.P., Moses E.K. Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for preeclampsia/eclampsia among Australian women. Gynecol Obstet Invest. 50:2000;100-102
13. Kaiser T., Brennecke S.P., Moses E.K. C677T methylenetetrahydrofolate reductase polymorphism is not a risk factor for preeclampsia/eclampsia among Australian women. Hum Hered. 51:2001;20-22
14. Prasmusinto D., Skrablin S., Hofstaetter C., Fimmers R., van der Ven K. The methylenetetrahydrofolate reductase 677 C-T polymorphism and preeclampsia in two populations. Obstet Gynecol. 99:2002;1085-1092
15. Martínez de Villarreal L., Delgado-Enciso I., Valdéz-Leal R., Ortiz-López R., Rojas-Martínez A., Limón-Benavides C., Sánchez-Peña M., Ancer-Rodríguez J., Barrera-Saldaña H., Villarreal-Pérez J. Folate levels and N5, N10- methylenetetrahydrofolate reductase genotype (MTHFR) in mothers of offspring with neural tube defects: a case-control study. Arch Med Res. 32:2001;277-282
16. Dávalos I.P., Olivares N., Castillo M.T., Cantú J.M., Ibarra B., Sandoval L., Morán M.C., Gallegos M.P., Chakraborty R., Rivas F. The C677T polymorphism of the methylenetetrahydrofolate reductase gene in Mexican mestizo neural-tube defect parents, control mestizo and native populations. Ann Genet. 43:2000;89-92
17. Mutchinik O.M., López M.A., Luna L., Waxman J., Babinsky V.E., the RYVEMCE Collaborative Group. High prevalence of the thermolabile methylenetetrahydrofolate reductase variant in Mexico: a country with a very high prevalence of neural tube defects. Mol Genet Metab. 68:1999;461-467
18. nd ed:1998;INEGI, México
19. Lenfant C., Gifford R.W. Jr., Zuspan F. National High Blood Pressure on Education Program Working Group report on high blood pressure in pregnancy. Am J Obstet Gynecol. 163:1990;1689-1712
20. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning: a laboratory manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, USA
21. Födinger M., Hörl W.H., Sunder-Plassmann G. Molecular biology of 5, 10-methylenetetrahydrofolate reductase. J Nephrol. 13:2000;20-23
22. Papapetrou C., Lynch S.A., Burn J., Edwards Y.H. Methylenetetrahydrofolate reductase and neural tube defects. Lancet. 348:1996;58
23. Botto L.D., Yang Q. 5, 10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HUGE review. Am J Epidemiol. 151:2000;862-877
24. Perales-Dávila J., Martínez de Villarreal L., Triana-Saldaña H., Saldívar-Rodríguez D., Barrera-Saldaña H., Rojas-Martínez A., López-Valdéz R., Garza-Elizondo M., García-Cavazos R., Valdéz-Leal R., Villarreal-Pérez J. Niveles de ácido fólico, homocisteína y polimorfismo de la enzima metilentetrahidrofolato reductasa (MTHFR) en pacientes con preeclampsia severa y eclampsia. Ginecol Obstet Mex. 69:2001;6-11