Immunoregulatory gene polymorphisms in women with preeclampsia

Hypertension Research

Volumn 34, Issue 3, 2011, Pages 384-388

  Pendeloski, Karen P T ^a   Sass, Nelson ^a   Torloni, Maria R ^a   Mattar, Rosiane ^a   Moron, Antonio F ^a   Franchim, Camila S ^a   Daher, Silvia ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

costimulatory molecules; gene polymorphism; immunotolerance; preeclampsia

Indexed keywords

ADENINE; CD28 ANTIGEN; CYTOSINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GENOMIC DNA; GUANINE; INDUCIBLE COSTIMULATOR; REGULATOR PROTEIN; RESTRICTION ENDONUCLEASE; THYMINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BRAZIL; CASE CONTROL STUDY; CD28 GENE; CONTROLLED STUDY; CTLA4 GENE; DNA EXTRACTION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; ICOS GENE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PREECLAMPSIA; PREGNANCY; REGULATOR GENE;

ADULT; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BRAZIL; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, GENETIC; PRE-ECLAMPSIA; PREGNANCY; YOUNG ADULT;

EID: 79952423162     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2010.247     Document Type: Article

References (35)

1. Khan KS, Wojdyla D, Say L, Gulmezoglu AM, Van Look PF. WHO analysis of causes of maternal death: a systematic review. Lancet 2006;367: 1066-1074.
2. Redman CW, Sargent IL. Pre-eclampsia, the placenta and the maternal systemic inflammatory response-a review. Placenta 2003;24(Suppl A): S21-S27. (Pubitemid 37184731)
3. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005;365: 785-799. (Pubitemid 40311367)
4. Hirashima C, Ohkuchi A, Matsubara S, Suzuki H, Takahashi K, Usui R, Suzuki M. Alteration of serum soluble endoglin levels after the onset of preeclampsia is more pronounced in women with early-onset. Hypertens Res 2008;31: 1541-1548.
5. Ohkuchi A, Hirashima C, Matsubara S, Suzuki H, Takahashi K, Arai F, Watanabe T, Kario K, Suzuki M. Alterations in placental growth factor levels before and after the onset of preeclampsia are more pronounced in women with early onset severe preeclampsia. Hypertens Res 2007;30: 151-159. (Pubitemid 46541789)
6. Allaire AD, Ballenger KA, Wells SR, McMahon MJ, Lessey BA. Placental apoptosis in preeclampsia. Obstet Gynecol 2000;96: 271-276. (Pubitemid 30447352)
7. Huppertz B. Placental origins of preeclampsia: challenging the current hypothesis. Hypertension 2008;51: 970-975. (Pubitemid 351398986)
8. Guerin LR, Prins JR, Robertson SA. Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum Reprod Update 2009;15: 517-535.
9. Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, Mak TW, Sakaguchi S. Immunologic self-tolerance maintained by CD25(+) CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000;192: 303-310.
10. Fitzpatrick E, Goring HH, Liu H, Borg A, Forrest S, Cooper DW, Brennecke SP, Moses EK. Fine mapping and SNP analysis of positional candidates at the preeclampsia susceptibility locus (PREG1) on chromosome 2. Hum Biol 2004;76: 849-862. (Pubitemid 40705526)
11. Harper K, Balzano C, Rouvier E, Mattei MG, Luciani MF, Golstein P. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. J Immunol 1991;147: 1037-1044.
12. Guzman VB, Morgun A, Shulzhenko N, Mine KL, Goncalves-Primo A, Musatti CC, Gerbase-Delima M. Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups. Hum Immunol 2005;66: 773-776. (Pubitemid 41169767)
13. Kristiansen OP, Larsen ZM, Pociot F. CTLA-4 in autoimmune diseases-a general susceptibility gene to autoimmunity? Genes Immun 2000;1: 170-184.
14. Cunninghame Graham DS, Wong AK, McHugh NJ, Whittaker JC, Vyse TJ. Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study. Hum Mol Genet 2006;15: 3195-3205. (Pubitemid 44605499)
15. de Reuver P, Pravica V, Hop W, Boor P, Metselaar HJ, Hutchinson IV, Tilanus HW, Kwekkeboom J. Recipient ctla-4 +49 G/G genotype is associated with reduced incidence of acute rejection after liver transplantation. Am J Transplant 2003;3: 1587-1594. (Pubitemid 37541518)
16. Roberts CT. Review: Complicated interactions between genes and the environment in placentation, pregnancy outcome and long term health. Placenta 2010;31(Suppl): S47-S53.
17. Samsami Dehaghani A, Doroudchi M, Kalantari T, Pezeshki AM, Ghaderi A. Heterozygosity in CTLA-4 gene and severe preeclampsia. Int J Gynaecol Obstet 2005;88: 19-24. (Pubitemid 40023089)
18. Jaaskelainen E, Toivonen S, Keski-Nisula L, Paattiniemi EL, Helisalmi S, Punnonen K, Heinonen S. CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women. Clin Chem Lab Med 2008;46: 169-173.
19. Chelbi ST, Vaiman D. Genetic and epigenetic factors contribute to the onset of preeclampsia. Mol Cell Endocrinol 2008;282: 120-129.
20. NHBPEP. Report of the National High Blood Pressure Education Program Working Group on high blood pressure in pregnancy. Am J Obstet Gynecol 2000;183: S1-S22.
21. Gustincich S, Manfioletti G, Del SG, Schneider C, Carninci P. A fast method for highquality genomic DNA extraction from whole human blood. Biotechniques 1991;11: 298-300, 302.
22. Dupont WD, Plummer Jr WD. Power and sample size calculations. A review and computer program. Control Clin Trials 1990;11: 116-128. (Pubitemid 20136185)
23. Bodnar LM, Catov JM, Roberts JM. Racial/ethnic differences in the monthly variation of preeclampsia incidence. Am J Obstet Gynecol 2007;196: 324-325.
24. Daher S, Sass N, Oliveira LG, Mattar R. Cytokine genotyping in preeclampsia. Am J Reprod Immunol 2006;55: 130-135. (Pubitemid 43329488)
25. Pena SDJ, Carvalho-Silva DR, Alves Silva J, Prado VF, Santos FR. Retrato Molecular do Brasil. Ciência Hoje 2000;159: 16-25.
26. Santos RV, Maio MC. Qual 'Retrato do Brasil'? Raça, Biologia, identidades e política na era da genômica. Mana 2004;10: 61-95.
27. Tsai AF, Kaufman KA, Walker MA, Karrison TG, Odem RR, Barnes RB, Scott JR, Schreiber JR, Stephenson MD, Ober C. Transmission disequilibrium of maternallyinherited CTLA-4 microsatellite alleles in idiopathic recurrent miscarriage. J Reprod Immunol 1998;40: 147-157. (Pubitemid 28552975)
28. Wang X, Ma Z, Hong Y, Lu P, Lin Q. Expression of CD28 and cytotoxic T lymphocyte antigen 4 at the maternal-fetal interface in women with unexplained pregnancy loss. Int J Gynaecol Obstet 2006;93: 123-129.
29. Shilling RA, Pinto JM, Decker DC, Schneider DH, Bandukwala HS, Schneider JR, Camoretti-Mercado B, Ober C, Sperling AI. Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production. J Immunol 2005;175: 2061-2065. (Pubitemid 41113810)
30. Douroudis K, Laine AP, Heinonen M, Hermann R, Lipponen K, Veijola R, Simell O, Knip M, Uibo R, Ilonen J, Kisand K. Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates. Hum Immunol 2009;70: 536-539.
31. Kaartinen T, Lappalainen J, Haimila K, Autero M, Partanen J. Genetic variation in ICOS regulates mRNA levels of ICOS and splicing isoforms of CTLA4. Mol Immunol 2007;44: 1644-1651.
32. Flores-Borja F, Jury EC, Mauri C, Ehrenstein MR. Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proc Natl Acad Sci USA 2008;105: 19396-19401.
33. Kouki T, Sawai Y, Gardine CA, Fisfalen ME, Alegre ML, DeGroot LJ. CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease. J Immunol 2000;165: 6606-6611.
34. Maurer M, Loserth S, Kolb-Maurer A, Ponath A, Wiese S, Kruse N, Rieckmann P. A polymorphism in the human cytotoxic T-lymphocyte antigen 4 (CTLA4) gene (exon 1. +49) alters T-cell activation. Immunogenetics 2002;54: 1-8. (Pubitemid 34492947)
35. Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol 2010;63: 601-610.