Preeclampsia is associated with a reduced response to activated protein C

American Journal of Obstetrics and Gynecology

Volumn 176, Issue 2, 1997, Pages 457-460

  Lindoff, C ^a   Ingemarsson, I ^a   Martinsson, G ^a   Segelmark, M ^a   Thysell, H ^a   Astedt, B ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Coagulation; preeclampsia; pregnancy; protein C

Indexed keywords

BLOOD CLOTTING FACTOR 5; PROTEIN C;

ARTICLE; BLOOD CLOTTING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; PATHOGENESIS; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; THROMBOEMBOLISM;

EID: 0031034899     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9378(97)70515-5     Document Type: Article

References (25)

1. BL Sheppard J. Bonnar The ultrastructure of the arterial supply of the human placenta in pregnancy complicated by fetal growth retardation Br J Obstet Gynaecol 83 1976 948 951
2. TY Khong JM Pearce WB. Robertson Acute atherosis in preeclampsia: maternal determinants and fetal outcome in the presence of the lesion Am J Obstet Gynecol 157 1987 360 363
3. B Dahlbäck M Carlsson PJ Svensson Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C Proc Natl Acad Sci U S A 90 1993 1004 1008
4. B Dahlbäck B Hildebrand Resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V Proc Natl Acad Sci U S A 91 1994 1396 1400
5. RM Bertina BPC Koeleman T Koster FR Rosendaal RJ Dirven H de Ronde Mutation in blood coagulation factor V associated with resistance to activated protein C Nature 369 1994 64 67
6. B Zöller B Dahlbäck Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis Lancet 343 1994 1536 1538
7. M Hellgren PJ Svensson B. Dahlback Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptives Am J Ostet Gynecol 173 1995 210 213
8. T Koster FR Rosendaal F de Ronde E Briët JP Vandenbroucke RM Bertina Venous thrombosis due to poor response to activated protein C: Leiden thrombophilia study Lancet 342 1993 1503 1506
9. PJ Svensson B Dahlbäck Resistance to activated protein C as a basis for venous thrombosis N Engl J Med 330 1994 517 521
10. W-M Halbmayer A Haushofer R Schön M Fischer The prevalence of poor anticoagulant response to activated protein C (APC resistance) among patients suffering from stroke or venous thrombosis and among healthy subjects Blood Coagul Fibrinolysis 5 1994 51 57
11. B Lindblad PJ Svensson B Dahlbäck Arterial and venous thromboembolism with fatal outcome in a young man with inherited resistance to activated protein C Lancet 343 1994 917
12. B Zöller PJ Svensson X He B Dahlbäck Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C J Clin Invest 94 1994 2521 2524
13. DC Rees M Cox JB. Clegg World distribution of factor V Leiden Lancet 346 1995 1133 1134
14. B Dahlbäck Inherited thrombophilia: resistance to activated protein C as a pathogenic factor of venous thromboembolism Blood 85 1995 607 614
15. J Holm B Zö11er E Bemtorp L Erhardt B Dahlbäck Prevalence of factor V gene mutation among myocardial infarction patients and healthy controls higher in Sweden than in other countries J Intern Med 239 1996 221 226
16. GA Dekker JI4 de Vries PM Doelitzsch PC Huijgens BME von Blomberg C Jakobs Underlying disorders associated with severe early-onset preeclampsia Am J Obstet Gynecol 173 1995 1042 1048
17. JH Griffin B Evatt C Wideman JA. Fernandez Anticoagulant protein C pathway defective in majority of thrombophilic patients Blood 82 1993 1989 1993
18. J Aznar J Gilabert A Estellé F Españia Fibrinolytic activity and protein C in preeclampsia Thromb Haemost 55 1986 314 317
19. JS Greengard X Sun X Xu JA Fernandez B. Evatt Activated protein C resistance caused by Arg506 Gln mutation in factor Va Lancet 343 1994 1362 1363
20. J Voorberg J Roelse R Koopman Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V Lancet 343 1994 1535 1536
21. 506-Gln mutation in factor V and risk of thrombosis during pregnancy Br J Haematol 92 1996 473 478
22. TY Khong C. Mott Immunohistologic demonstration of endothelial disruption in acute atherosis in pre-eclampsia Eur J Obstet Gynecol Reprod Biol 51 1993 193 197
23. CM Salafia JC Pezzullo JA López-Zeno S Simmens VK Minior AM Vintzileos Placental pathologic features of preterm preeclampsia Am J Obstet Gynecol 173 1995 1097 1105
24. JP Vandenbroucke T Koster E Briët PH Reitsma RM Bertina FR Rosendaal Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation Lancet 344 1994 1453 1457
25. 506to Gln mutation in the factor V gene, and venous thrombosis Thromb Haemost 73 1995 739 742