Maternal and neonatal outcome of preeclamptic pregnancies: The potential roles of Factor V Leiden mutation and 5,10 methylenetetrahydrofolate reductase

Hypertension in Pregnancy

Volumn 19, Issue 2, 2000, Pages 163-172

  Rigo Jr J ^a,d   Nagy, B ^a   Fintor, L ^c   Tanyi, J ^a   Beke, A ^a   Karadi I ^b   Papp, Z ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^d NONE   (Hungary)

Author keywords

5,10 methylenetetrahydrofolate reductase polymorphism; Factor V Leiden mutation; HELP syndrome; Polymerase chain reaction (PCR); Preeclampsia

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 5 LEIDEN; FOLIC ACID;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; HELLP SYNDROME; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INTRAUTERINE GROWTH RETARDATION; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PREECLAMPSIA; THROMBOGENESIS; TREATMENT OUTCOME;

EID: 0033932801     PISSN: 10641955     EISSN: None     Source Type: Journal    
DOI: 10.1081/PRG-100100132     Document Type: Article

References (20)

1. Dekker GA, deVries JI, Doelitzsch PM, Huijgens PC, von Blomberg BM, Jakobs C, et al. Underlying disorders associated with severe early-onset pre-eclampsia. Am J Obstet Gynecol 1995;173:1042-8.
2. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H., et al. Mutation in blood coagulation Factor V associated with resistance to activated protein C. Nature 1994;369:64-7.
3. Nagy B, Tóth T, Rigó J Jr, Karádi I, Romics L, Papp Z. Detection of factor V Leiden mutation in severe pre-eclamptic Hungarian women. Clin Genet 1998;53:478-81.
4. Peek MJ, Nelson-Piercy C, Manning RA, deSwiet M, Letsky EA. Activated protein C resistance in normal pregnancy. Br J Obstet Gynaecol 1997;104:1084-6.
5. Rotmensch S, Liberati M, Mittelmann M, Ben-Rafael Z. Activated protein C resistance and adverse pregnancy outcome. Am J Obstet Gynecol 1997;177:170-3.
6. Svensson PJ, Dahlback B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994;300:517-22.
7. Dizon-Towson DS, Nelson LM, Easton K, Ward K. The Factor V Leiden mutation may predispose women to severe pre-eclampsia. Am J Obstet Gynecol 1996;175:902-5.
8. Grandone E, Margaglione M, Colaizzo D, Cappucci G, Paladini D, Martinelli P, et al. Factor V Leiden, C > T MTHFR polymorphism and genetic susceptibility to pre-eclampsia. Thromb Hemost 1997;77:1052-4.
9. Rajkovic A, Catalano PM, Malinow MR. Elevated homocyst(e)ine levels with preeclampsia. Obstet Gynecol 1997;90:168-71.
10. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG. et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-3.
11. Sohda S, Arinami T, Hamada H, Yamada N, Hamaguchi H, Kubo T. Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. J Med Genet 1997;34:525-6.
12. Kupferminc JM, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, et al. Increased frequency of genetic thrombophylia in women with complications of pregnancy. N Engl J Med 1999;340:9-13.
13. Stankovics J, Melegh B, Nagy Á, Kis A, Molnár J, Losonczy H, et al. Frequency of Factor V G1691A (Leiden) mutation in Hungarian population [in Hungarian] Orv Hetil 1998;139:1161-3.
14. Thorp AJ, Zucker LM, Plapp VF, Rachel MJ, Hinkle C. Factor V Leiden mutation and preeclampsia. J Matern Fetal Invest 1997;7:19-20.
15. Rai RS, Regan L, Chitoloie A, Donald JG, Cohen H. Placental thrombosis and second trimester miscarriage associated with activated protein C resistance. Br J Obstet Gynaecol 1996;103:842-4.
16. Aries F, Romero R, Joist H, Kraus FT. Thrombophilia: A mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta. J Matern-Fetal Med 1998;7:277-86.
17. Brenner B, Lanir N, Thaler I. HELLP syndrome associated with Factor V R506Q mutation. Br J Haematol 1996;92:999-1001.
18. Seige M, Schweigart U, Moessmer G, Schneider KT, Classen M. Extensive hepatic infarction caused by thrombosis of right portal vein branches and arterial vasospasm in HELLP syndrome associated with homozygous Factor V Leiden. Am J Gastroenterol 1997;93:473-4.
19. Krauss T, Augustin HG, Osmers R, Meden H, Unterhalt M, Kuhn W. Activated protein C resistance and Factor V Leiden in patients with hemolysis, elevated liver enzymes, low platelets syndrome. Obstet Gynecol 1998;92:457-60.
20. Grandone E, Margaglione M, Colaizzo D, Montanaro S, Pavone G, Di-Minno G. Prevalence of FV Leiden and MTHFR mutation in a patient with complicated pregnancies [Letter]. Thromb Haemost 1997;77:1036-7.