The relationship between thrombophilic mutations and preeclampsia: A prospective case-control study

Annals of Saudi Medicine

Volumn 26, Issue 2, 2006, Pages 105-109

  Yalinkaya, Ahmet ^a   Erdemoglu, Mahmut ^a   Akdeniz, Nurten ^a   Kale, Ahmet ^a   Kale, Ebru ^a  

^a DICLE UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN III; BLOOD CLOTTING FACTOR 5 LEIDEN; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PROTEIN C; PROTEIN S; PROTHROMBIN;

ADULT; ANTITHROMBIN III DEFICIENCY; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DELIVERY; FEMALE; GENE MUTATION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; PREECLAMPSIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; RISK ASSESSMENT; STATISTICAL SIGNIFICANCE; THROMBOPHILIA; TURKEY (REPUBLIC);

EID: 33646818342     PISSN: 02564947     EISSN: None     Source Type: Journal    
DOI: 10.5144/0256-4947.2006.105     Document Type: Article

References (24)

1. Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet 2001;357:53-6.
2. British Committee for Standards in Haematology (1990) Guidelines on investigation and management of thrombophilia. Journal of Clinical Pathology. Clin Pathol 1990;43:703-9.
3. Many A, Elad R, Yaron Y, Eldor A, Lessing JB, Kupferminc MJ. Third-trimester unexplained intrauterine fetal death is associated with inherited thrombophilia. Obstet Gynecol 2002;99:684-7.
4. Foka ZJ, Lambropoulos AF, Saravelos H, Karas GB, Karavida A, Agorastos T, Zournatzi V, Makris PE, Bontis J, Kotsis A: Factor V leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages. Hum Reprod 2000; 15:458-62.
5. Hefler L, Jirecek S, Heim K, Grimm C, Antensteiner G, Zeillinger R, Husslein P, Tempfer C: Genetic polymorphisms associated with thrombaphilia and vascular disease in women with unexplained late intrauterine fetal death: a multicenter study. J Soc Gynecol Investig. 2004;11:42-4.
6. Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, Fait G, Lessing JB. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999; 340:9-13.
7. Von Tempelhoff GF, Heilmann L, Spanuth E, Kunzmann E, Hommel G. Incidence of the factor V Leiden-mutation, coagulation inhibitor deficiency, and elevated antiphospholipid-antibodies in patients with preeclampsia or HELLP-syndrome. Hemolysis, elevated liver-enzymes, low platelets. Thromb Res. 2000; 100:363-5.
8. American College of Obstetricians and Gynecologists. Hypertension in pregnancy. ACOG technical bulletin no. 219, Americon College of Obstetricians and Gynecologists, Washington DC (1996)
9. Brown MA, Hague WM, Higgins J, Lowe S, McCowan L, Oats J, Peek MJ, Rowan JA, Walters BN. The detection, investigation and management of hypertension in pregnancy, Aust N Z J Obstet Gynaecol 2000;40:139-55.
10. Kupferminc MJ, Fait G, Many A, Gordon D, Eldor A, Lessing JB: Severe preeclampsia and high frequency of genetic thrombophilic mutations. Obstet Gynecol 2000; 96: 45-49.
11. Lindqvist PG, Svensson PJ, Dahlback B, Marsal K: Factor V Q506 mutation (activated protein C resistance) associated with reduced intrapartum blood loss a possible evolutionary selection mechanism. Thromb Haemost 1998;79:69-73.
12. Livingston JC, Barton JR, Park V, Haddad B, Phillips O, Sibai BM: Maternal and fetal inherited thrombophilia are not related to the development of severe preeclampsia. Am J Obstet Gynecol 2001; 185: 153-157.
13. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-7.
14. Rees DC, Cox M, Clegg JB, World distribution of factor V Leiden. Lancet 1995;346:1133-4.
15. Kodaira H, Ishida F, Shimodaira S, Takamiya O, Furihata K, Kitano K. Resistance to activated protein C and Arg 504 Gln factor V mutation are uncommon in eastern Asian populations. Acta Haemato 1997;98:22-5.
16. Driul L, Damante G, D'Elia A, Ianni A, Springolo F, Marchesoni D. Genetic thrombophilia and uterine artery Doppler velocimetry and preeclampsia Int J Gynaecol Obstet 2005;88:265-70.
17. Antsaklis A, Daskalakis G, Tzortzis E, Michalas S. The effect of gestational age and placental location on the prediction of pre-eclampsia by uterine artery Doppler velocimetry in low-risk nulliparous women, Ultrasound Obstet Gyneco 2000;16:635-9.
18. Dizon-Townson DS, Nelson LM, Easton K, Ward K. The factor V Leiden mutation may predispose women to severe preeclampsia. Am J Obstet Gynecol. 1996;175:902-5.
19. Livingston JC, Barton JR, Park V, Haddad B, Phillips O, Sibai BM. Livingston JC, Barton JR, Park V, Haddad B, Phillips O, Sibai BM. Maternal and fetal inherited thrombophilia are not related to the development of severe preeclampsia. Am J Obstet Gynecol 2001; 185:153-7.
20. Grandone E, Margaglione M, Colaizzo D, Cappucci G, Scianname N, Montanaro S, Paladini D, Martinelli P, Di Minno G. Prothrombotic genetic risk factors and the occurrence of gestational hypertension with or without proteinuria. Thromb Haemost 1999;81:349-52.
21. Sohda S, Arinami T, Hamada H, Yamada N, Hamaguchi H, Kubo T. Methylenetetrahydrofolate reductase polymorphism and preeclampsia. J Med Genet 1997; 34:525-6.
22. O'Shaughnessy KM, Fu B, Ferraro F, Lewis I, Downing S, Morris NH. Factor V Leiden and thermolabile methylenetetrahydrofolate reductase gene variants in an East Anglian preeclampsia cohort. Hypertension 1999;33:1338-41.
23. Davalos IP, Moran MC, Martinez-Abundis E, Gonzalez-Ortiz M, Flores-Martinez SE, Machorro V, Sandoval L, Figuera LE, Mena JP, Oliva JM, Tlacuilo-Parra JA, Sanchez-Corona J, Salazar-Paramo M. Methylenetetrahydrofolate reductase C677T polymorphism and Factor V Leiden variant in Mexican women with preeclampsia/eclampsia. Blood Cells Mol Dis. 2005; 17: [Epub ahead of print]
24. Sayin M, Varol FG, Sayin NC. Evaluation of natural coagulation inhibitor levels in various hypertensive states of pregnancy. Eur J Obstet Gynecol Reprod Biol. 2005; [Epub ahead of print]