Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women

American Journal of Medical Genetics

Volumn 93, Issue 2, 2000, Pages 122-125

  Kobashi, Gen ^a   Yamada, Hideto ^a   Asano, Toshimichi ^a   Nagano, Shunsuke ^a   Hata, Akira ^a   Kishi, Reiko ^a   Fujimoto, Seiichiro ^a   Kondo, Kiyotaro ^b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b OPEN UNIVERSITY OF JAPAN   (Japan)

Author keywords

Genetic factor; Hypertension; Polymorphism; Pregnancy

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; HOMOZYGOTE; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MATERNAL HYPERTENSION; MISSENSE MUTATION; PREECLAMPSIA; PRIORITY JOURNAL;

ADULT; ALLELES; AMINO ACID SUBSTITUTION; ANGIOTENSINOGEN; BODY MASS INDEX; DNA; FEMALE; GENE FREQUENCY; HUMANS; HYPERTENSION; JAPAN; MATERNAL AGE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MUTATION; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PARITY; POINT MUTATION; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PREGNANCY OUTCOME; SEVERITY OF ILLNESS INDEX; STATISTICS;

EID: 0034679870     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-8628(20000717)93:2<122::AID-AJMG8>3.0.CO;2-Z     Document Type: Article

References (26)

1. Abbate R, Sardi I, Pepe G, Marcucci R, Brunelli T, Prisco D, Fatini C, Capanni M, Simonetti I, Gensini GF. 1998. The high prevalence of thermolabile 5-10 methylenetetrahydrofolate reductase (MTHFR) in Italians is not associated to an increased risk for coronary artery disease (CAD). Thromb Haemost 79:727-730.
2. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. 1995. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 274:1049-1057.
3. Chesley LC, Annito JE, Cosgrove RA. 1968. The familial factor in toxemia of pregnancy. Obstet Gynaecol 32:303-311.
4. de Groot CJ, Taylor RN. 1993. New insights into the etiology of preeclampsia. Ann Med 25:243-249.
5. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van der Heuvel LP, Rozen R. 1995. A candidate genetic risk factor for vascular disease: a common mutation in methylentetrahydrofolate reductase. Nat Genet 10:111-113.
6. Fujimoto S, Makinoda S, Hoshi N. 1994. Elderly pregnancy and labor. Asian Med J 37:117-130.
7. Grandone E, Margaglione M, Colaizzo D, Cappucci G, Paladini D, Martinelli P, Montanaro S, Pavone G, Di Minno G. 1997. Factor V Leiden, C > T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thromb Haemost 77:1052-1054.
8. Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. 1990. National High Blood Pressure Education Program Working Group report on high blood pressure in pregnancy. Am J Obstet Gynecol 163:1689-1712.
9. Kang SS, Zhou J, Wong PW, Kowalisyn J, Strokosch G. 1988. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet 43:414-421.
10. Kobashi G, Hata A, Shido K, Kato EH, Yamada H, Fujimoto S, Kishi R, Kondo K. 1999. Association of a variant of the angiotensinogen gene with pure type of hypertension in pregnancy in the Japanese: implication of a racial difference and significance of an age factor. Am J Med Genet 86:232-236.
11. Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, Fait G, Lessing JB. 1999. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 340:9-13.
12. Maccario M, Ramunni J, Oleandri SE, Procopio M, Grottoli S, Rossetto R, Savio P, Aimaretti G, Camanni F, Ghigo E. 1999. Relationships between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients. Int J Obes Relat Metab Disord 23:612-618.
13. Markus HS, Ali N, Swaminathan R, Sankaralingam A, Molloy J, Powell J. 1997. A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease. Stroke 28:1739-1743.
14. McCully KS. 1996. Homocysteine and vascular disease. Nat Med 2:386-389.
15. Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurijara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y. 1997. Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease. Circulation 95:2032-2036.
16. Morita H, Kurihara H, Tsubaki S, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Kitamura K, Yazaki Y. 1998. Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese. Arterioscler Thromb Vasc Biol 18:1465-1469.
17. Nelen WL, Steegers EA, Eskes TK, Blom HJ. 1997. Genetic risk factor for unexplained recurrent early pregnancy loss. Lancet 350:861.
18. O'Shaughnessy KM, Fu B, Ferraro F, Lewis I, Downing S, Morris NH. 1999. Factor V Leiden and thermolabile methylenetetrahydrofolate reductase gene variants in an East Anglian preeclampsia cohort. Hypertension 33:1338-1341.
19. Quere I, Bellet H, Hoffet M, Janbon C, Mares P, Gris JC. 1998. A woman with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages. Fertil Steril 69:152-154.
20. Ray JG, Laskin CA. 1999. Folic acid and homocysteine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review. Placenta 20:519-529.
21. Roberts JM, Redman CW. 1993. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet 341:1447-1451.
22. Reinhardt D, Sigusch HH, Vogt SF, Farker K, Muller S, Hoffmann A. 1998. Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and the risk of coronary artery disease. Eur J Clin Invest 28:20-23.
23. Russ AP, Maerz W, Ruzicka V, Stein U, Gross W. 1993. Rapid detection of the hypertension-associated Met235→Thr allele of the human angiotensinogen gene. Hum Mol Genet 2:609-610.
24. Sohda S, Arinami T, Hamada H, Yamada N, Hamaguchi H, Kubo T. 1997. Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. J Med Genet 34:525-526.
25. Verhoef P, Kok FJ, Kluijtmans LA, Blom HJ, Refsum H, Ueland PM, Kruyssen DA. 1997. The 677C→T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease. Atherosclerosis 132: 105-113.
26. Ward K, Hata A, Jeunemaitre X, Helin C, Nelson L, Namikawa C, Farrington PF, Ogasawara M, Suzumori K, Tomoda S, Berrebi S, Sasaki M, Corvol P, Lifton RP, Lalouel JM. 1993. A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet 4:59-61.