-
1
-
-
84865152223
-
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
-
Abdel-Wahab O., Adli M., Lafave L.M., Gao J., Hricik T., Shih A.H., et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell 2012, 22:180-193.
-
(2012)
Cancer Cell
, vol.22
, pp. 180-193
-
-
Abdel-Wahab, O.1
Adli, M.2
Lafave, L.M.3
Gao, J.4
Hricik, T.5
Shih, A.H.6
-
2
-
-
76549109434
-
Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
-
Abdel-Wahab O., Manshouri T., Patel J., Harris K., Yao J., Hedvat C., et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Research 2010, 70:447-452.
-
(2010)
Cancer Research
, vol.70
, pp. 447-452
-
-
Abdel-Wahab, O.1
Manshouri, T.2
Patel, J.3
Harris, K.4
Yao, J.5
Hedvat, C.6
-
3
-
-
67651065502
-
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
-
Abdel-Wahab O., Mullally A., Hedvat C., Garcia-Manero G., Patel J., Wadleigh M., et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood 2009, 114:144-147.
-
(2009)
Blood
, vol.114
, pp. 144-147
-
-
Abdel-Wahab, O.1
Mullally, A.2
Hedvat, C.3
Garcia-Manero, G.4
Patel, J.5
Wadleigh, M.6
-
4
-
-
77957966270
-
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
-
Aggarwal P., Vaites L.P., Kim J.K., Mellert H., Gurung B., Nakagawa H., et al. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell 2010, 18:329-340.
-
(2010)
Cancer Cell
, vol.18
, pp. 329-340
-
-
Aggarwal, P.1
Vaites, L.P.2
Kim, J.K.3
Mellert, H.4
Gurung, B.5
Nakagawa, H.6
-
6
-
-
4043146501
-
Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
-
Balasubramanyam K., Altaf M., Varier R.A., Swaminathan V., Ravindran A., Sadhale P.P., et al. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. The Journal of Biological Chemistry 2004, 279:33716-33726.
-
(2004)
The Journal of Biological Chemistry
, vol.279
, pp. 33716-33726
-
-
Balasubramanyam, K.1
Altaf, M.2
Varier, R.A.3
Swaminathan, V.4
Ravindran, A.5
Sadhale, P.P.6
-
7
-
-
0020972981
-
Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia
-
Bartram C.R., de Klein A., Hagemeijer A., van Agthoven T., Geurts van Kessel A., Bootsma D., et al. Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature 1983, 306:277-280.
-
(1983)
Nature
, vol.306
, pp. 277-280
-
-
Bartram, C.R.1
de Klein, A.2
Hagemeijer, A.3
van Agthoven, T.4
Geurts van Kessel, A.5
Bootsma, D.6
-
8
-
-
84862738480
-
BET domain co-regulators in obesity, inflammation and cancer
-
Belkina A.C., Denis G.V. BET domain co-regulators in obesity, inflammation and cancer. Nature Reviews. Cancer 2012, 12:465-477.
-
(2012)
Nature Reviews. Cancer
, vol.12
, pp. 465-477
-
-
Belkina, A.C.1
Denis, G.V.2
-
9
-
-
84655162785
-
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains
-
Berman B.P., Weisenberger D.J., Aman J.F., Hinoue T., Ramjan Z., Liu Y., et al. Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nature Genetics 2012, 44:40-46.
-
(2012)
Nature Genetics
, vol.44
, pp. 40-46
-
-
Berman, B.P.1
Weisenberger, D.J.2
Aman, J.F.3
Hinoue, T.4
Ramjan, Z.5
Liu, Y.6
-
10
-
-
33646070846
-
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
-
Bernstein B.E., Mikkelsen T.S., Xie X., Kamal M., Huebert D.J., Cuff J., et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006, 125:315-326.
-
(2006)
Cell
, vol.125
, pp. 315-326
-
-
Bernstein, B.E.1
Mikkelsen, T.S.2
Xie, X.3
Kamal, M.4
Huebert, D.J.5
Cuff, J.6
-
12
-
-
79960044951
-
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
-
Bernt K.M., Zhu N., Sinha A.U., Vempati S., Faber J., Krivtsov A.V., et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell 2011, 20:66-78.
-
(2011)
Cancer Cell
, vol.20
, pp. 66-78
-
-
Bernt, K.M.1
Zhu, N.2
Sinha, A.U.3
Vempati, S.4
Faber, J.5
Krivtsov, A.V.6
-
13
-
-
78049402859
-
Molecular signals of epigenetic states
-
Bonasio R., Tu S., Reinberg D. Molecular signals of epigenetic states. Science 2010, 330:612-616.
-
(2010)
Science
, vol.330
, pp. 612-616
-
-
Bonasio, R.1
Tu, S.2
Reinberg, D.3
-
14
-
-
84861221693
-
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution
-
Booth M.J., Branco M.R., Ficz G., Oxley D., Krueger F., Reik W., et al. Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science 2012, 336:934-937.
-
(2012)
Science
, vol.336
, pp. 934-937
-
-
Booth, M.J.1
Branco, M.R.2
Ficz, G.3
Oxley, D.4
Krueger, F.5
Reik, W.6
-
15
-
-
9544220768
-
The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
-
Borrow J., Stanton V.P., Andresen J.M., Becher R., Behm F.G., Chaganti R.S., et al. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nature Genetics 1996, 14:33-41.
-
(1996)
Nature Genetics
, vol.14
, pp. 33-41
-
-
Borrow, J.1
Stanton, V.P.2
Andresen, J.M.3
Becher, R.4
Behm, F.G.5
Chaganti, R.S.6
-
16
-
-
70350500219
-
Polycomb group proteins: Navigators of lineage pathways led astray in cancer
-
Bracken A.P., Helin K. Polycomb group proteins: Navigators of lineage pathways led astray in cancer. Nature Reviews. Cancer 2009, 9:773-784.
-
(2009)
Nature Reviews. Cancer
, vol.9
, pp. 773-784
-
-
Bracken, A.P.1
Helin, K.2
-
17
-
-
0037114753
-
Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
-
Byrd J.C., Mrozek K., Dodge R.K., Carroll A.J., Edwards C.G., Arthur D.C., et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461). Blood 2002, 100:4325-4336.
-
(2002)
Blood
, vol.100
, pp. 4325-4336
-
-
Byrd, J.C.1
Mrozek, K.2
Dodge, R.K.3
Carroll, A.J.4
Edwards, C.G.5
Arthur, D.C.6
-
18
-
-
84555207349
-
Dnmt3a is essential for hematopoietic stem cell differentiation
-
Challen G.A., Sun D., Jeong M., Luo M., Jelinek J., Berg J.S., et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nature Genetics 2012, 44:23-31.
-
(2012)
Nature Genetics
, vol.44
, pp. 23-31
-
-
Challen, G.A.1
Sun, D.2
Jeong, M.3
Luo, M.4
Jelinek, J.5
Berg, J.S.6
-
19
-
-
0033215187
-
Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein
-
Champagne N., Bertos N.R., Pelletier N., Wang A.H., Vezmar M., Yang Y., et al. Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. The Journal of Biological Chemistry 1999, 274:28528-28536.
-
(1999)
The Journal of Biological Chemistry
, vol.274
, pp. 28528-28536
-
-
Champagne, N.1
Bertos, N.R.2
Pelletier, N.3
Wang, A.H.4
Vezmar, M.5
Yang, Y.6
-
20
-
-
65249093055
-
Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus
-
Chen H., Gu X., Su I.H., Bottino R., Contreras J.L., Tarakhovsky A., et al. Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes & Development 2009, 23:975-985.
-
(2009)
Genes & Development
, vol.23
, pp. 975-985
-
-
Chen, H.1
Gu, X.2
Su, I.H.3
Bottino, R.4
Contreras, J.L.5
Tarakhovsky, A.6
-
21
-
-
84862622207
-
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation
-
Chen S., Ma J., Wu F., Xiong L.J., Ma H., Xu W., et al. The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation. Genes & Development 2012, 26:1364-1375.
-
(2012)
Genes & Development
, vol.26
, pp. 1364-1375
-
-
Chen, S.1
Ma, J.2
Wu, F.3
Xiong, L.J.4
Ma, H.5
Xu, W.6
-
22
-
-
0242361142
-
Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia
-
Chessells J.M., Veys P., Kempski H., Henley P., Leiper A., Webb D., et al. Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia. British Journal of Haematology 2003, 123:396-405.
-
(2003)
British Journal of Haematology
, vol.123
, pp. 396-405
-
-
Chessells, J.M.1
Veys, P.2
Kempski, H.3
Henley, P.4
Leiper, A.5
Webb, D.6
-
23
-
-
77953995002
-
Covalent histone modifications-Miswritten, misinterpreted and mis-erased in human cancers
-
Chi P., Allis C.D., Wang G.G. Covalent histone modifications-Miswritten, misinterpreted and mis-erased in human cancers. Nature Reviews. Cancer 2010, 10:457-469.
-
(2010)
Nature Reviews. Cancer
, vol.10
, pp. 457-469
-
-
Chi, P.1
Allis, C.D.2
Wang, G.G.3
-
24
-
-
80053558376
-
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells
-
Chiarle R., Zhang Y., Frock R.L., Lewis S.M., Molinie B., Ho Y.J., et al. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell 2011, 147:107-119.
-
(2011)
Cell
, vol.147
, pp. 107-119
-
-
Chiarle, R.1
Zhang, Y.2
Frock, R.L.3
Lewis, S.M.4
Molinie, B.5
Ho, Y.J.6
-
25
-
-
80052303426
-
TET family proteins and their role in stem cell differentiation and transformation
-
Cimmino L., Abdel-Wahab O., Levine R.L., Aifantis I. TET family proteins and their role in stem cell differentiation and transformation. Cell Stem Cell 2011, 9:193-204.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 193-204
-
-
Cimmino, L.1
Abdel-Wahab, O.2
Levine, R.L.3
Aifantis, I.4
-
28
-
-
84856593592
-
Hematological cancer in 2011: New therapeutic targets and treatment strategies
-
Cramer P., Hallek M. Hematological cancer in 2011: New therapeutic targets and treatment strategies. Nature Reviews. Clinical Oncology 2012, 9:72-74.
-
(2012)
Nature Reviews. Clinical Oncology
, vol.9
, pp. 72-74
-
-
Cramer, P.1
Hallek, M.2
-
29
-
-
79960058024
-
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
-
Daigle S.R., Olhava E.J., Therkelsen C.A., Majer C.R., Sneeringer C.J., Song J., et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell 2011, 20:53-65.
-
(2011)
Cancer Cell
, vol.20
, pp. 53-65
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.A.3
Majer, C.R.4
Sneeringer, C.J.5
Song, J.6
-
30
-
-
84859768494
-
Molecular targeted therapy in acute myeloid leukemia
-
Daver N., Cortes J. Molecular targeted therapy in acute myeloid leukemia. Hematology 2012, 17(Suppl. 1):S59-S62.
-
(2012)
Hematology
, vol.17
, Issue.SUPPL. 1
-
-
Daver, N.1
Cortes, J.2
-
31
-
-
84863621527
-
Cancer epigenetics: From mechanism to therapy
-
Dawson M.A., Kouzarides T. Cancer epigenetics: From mechanism to therapy. Cell 2012, 150:12-27.
-
(2012)
Cell
, vol.150
, pp. 12-27
-
-
Dawson, M.A.1
Kouzarides, T.2
-
33
-
-
80054984945
-
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
-
Dawson M.A., Prinjha R.K., Dittmann A., Giotopoulos G., Bantscheff M., Chan W.I., et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 2011, 478:529-533.
-
(2011)
Nature
, vol.478
, pp. 529-533
-
-
Dawson, M.A.1
Prinjha, R.K.2
Dittmann, A.3
Giotopoulos, G.4
Bantscheff, M.5
Chan, W.I.6
-
35
-
-
0034670036
-
The molecular biology of chronic myeloid leukemia
-
Deininger M.W., Goldman J.M., Melo J.V. The molecular biology of chronic myeloid leukemia. Blood 2000, 96:3343-3356.
-
(2000)
Blood
, vol.96
, pp. 3343-3356
-
-
Deininger, M.W.1
Goldman, J.M.2
Melo, J.V.3
-
36
-
-
66249137734
-
Mutation in TET2 in myeloid cancers
-
Delhommeau F., Dupont S., Della Valle V., James C., Trannoy S., Masse A., et al. Mutation in TET2 in myeloid cancers. The New England Journal of Medicine 2009, 360:2289-2301.
-
(2009)
The New England Journal of Medicine
, vol.360
, pp. 2289-2301
-
-
Delhommeau, F.1
Dupont, S.2
Della Valle, V.3
James, C.4
Trannoy, S.5
Masse, A.6
-
37
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
Delmore J.E., Issa G.C., Lemieux M.E., Rahl P.B., Shi J., Jacobs H.M., et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 2011, 146:904-917.
-
(2011)
Cell
, vol.146
, pp. 904-917
-
-
Delmore, J.E.1
Issa, G.C.2
Lemieux, M.E.3
Rahl, P.B.4
Shi, J.5
Jacobs, H.M.6
-
38
-
-
33746849256
-
Regulation of MLL1 H3K4 methyltransferase activity by its core components
-
Dou Y., Milne T.A., Ruthenburg A.J., Lee S., Lee J.W., Verdine G.L., et al. Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nature Structural and Molecular Biology 2006, 13:713-719.
-
(2006)
Nature Structural and Molecular Biology
, vol.13
, pp. 713-719
-
-
Dou, Y.1
Milne, T.A.2
Ruthenburg, A.J.3
Lee, S.4
Lee, J.W.5
Verdine, G.L.6
-
39
-
-
58149398623
-
Translation of the Philadelphia chromosome into therapy for CML
-
Druker B.J. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008, 112:4808-4817.
-
(2008)
Blood
, vol.112
, pp. 4808-4817
-
-
Druker, B.J.1
-
40
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
Druker B.J., Guilhot F., O'Brien S.G., Gathmann I., Kantarjian H., Gattermann N., et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. The New England Journal of Medicine 2006, 355:2408-2417.
-
(2006)
The New England Journal of Medicine
, vol.355
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
Gathmann, I.4
Kantarjian, H.5
Gattermann, N.6
-
41
-
-
0242584454
-
Chromosomal instability and tumors promoted by DNA hypomethylation
-
Eden A., Gaudet F., Waghmare A., Jaenisch R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003, 300:455.
-
(2003)
Science
, vol.300
, pp. 455
-
-
Eden, A.1
Gaudet, F.2
Waghmare, A.3
Jaenisch, R.4
-
42
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
-
Ernst T., Chase A.J., Score J., Hidalgo-Curtis C.E., Bryant C., Jones A.V., et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nature Genetics 2010, 42:722-726.
-
(2010)
Nature Genetics
, vol.42
, pp. 722-726
-
-
Ernst, T.1
Chase, A.J.2
Score, J.3
Hidalgo-Curtis, C.E.4
Bryant, C.5
Jones, A.V.6
-
43
-
-
1642281239
-
Definitive hematopoiesis requires the mixed-lineage leukemia gene
-
Ernst P., Fisher J.K., Avery W., Wade S., Foy D., Korsmeyer S.J. Definitive hematopoiesis requires the mixed-lineage leukemia gene. Developmental Cell 2004, 6:437-443.
-
(2004)
Developmental Cell
, vol.6
, pp. 437-443
-
-
Ernst, P.1
Fisher, J.K.2
Avery, W.3
Wade, S.4
Foy, D.5
Korsmeyer, S.J.6
-
44
-
-
78650747491
-
Discovery and characterization of chromatin states for systematic annotation of the human genome
-
Ernst J., Kellis M. Discovery and characterization of chromatin states for systematic annotation of the human genome. Nature Biotechnology 2010, 28:817-825.
-
(2010)
Nature Biotechnology
, vol.28
, pp. 817-825
-
-
Ernst, J.1
Kellis, M.2
-
45
-
-
79955583542
-
Mapping and analysis of chromatin state dynamics in nine human cell types
-
Ernst J., Kheradpour P., Mikkelsen T.S., Shoresh N., Ward L.D., Epstein C.B., et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 2011, 473:43-49.
-
(2011)
Nature
, vol.473
, pp. 43-49
-
-
Ernst, J.1
Kheradpour, P.2
Mikkelsen, T.S.3
Shoresh, N.4
Ward, L.D.5
Epstein, C.B.6
-
46
-
-
33947315736
-
Cancer epigenomics: DNA methylomes and histone-modification maps
-
Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nature Reviews. Genetics 2007, 8:286-298.
-
(2007)
Nature Reviews. Genetics
, vol.8
, pp. 286-298
-
-
Esteller, M.1
-
48
-
-
34250662288
-
An epigenetic approach to cancer etiology
-
Feinberg A.P. An epigenetic approach to cancer etiology. Cancer Journal 2007, 13:70-74.
-
(2007)
Cancer Journal
, vol.13
, pp. 70-74
-
-
Feinberg, A.P.1
-
49
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa M.E., Abdel-Wahab O., Lu C., Ward P.S., Patel J., Shih A., et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010, 18:553-567.
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
-
50
-
-
77957776228
-
Systematic protein location mapping reveals five principal chromatin types in Drosophila cells
-
Filion G.J., van Bemmel J.G., Braunschweig U., Talhout W., Kind J., Ward L.D., et al. Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. Cell 2010, 143:212-224.
-
(2010)
Cell
, vol.143
, pp. 212-224
-
-
Filion, G.J.1
van Bemmel, J.G.2
Braunschweig, U.3
Talhout, W.4
Kind, J.5
Ward, L.D.6
-
51
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
Filippakopoulos P., Qi J., Picaud S., Shen Y., Smith W.B., Fedorov O., et al. Selective inhibition of BET bromodomains. Nature 2010, 468:1067-1073.
-
(2010)
Nature
, vol.468
, pp. 1067-1073
-
-
Filippakopoulos, P.1
Qi, J.2
Picaud, S.3
Shen, Y.4
Smith, W.B.5
Fedorov, O.6
-
52
-
-
70350494322
-
Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
-
Fiskus W., Wang Y., Sreekumar A., Buckley K.M., Shi H., Jillella A., et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood 2009, 114:2733-2743.
-
(2009)
Blood
, vol.114
, pp. 2733-2743
-
-
Fiskus, W.1
Wang, Y.2
Sreekumar, A.3
Buckley, K.M.4
Shi, H.5
Jillella, A.6
-
53
-
-
20144388146
-
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
-
Fraga M.F., Ballestar E., Villar-Garea A., Boix-Chornet M., Espada J., Schotta G., et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nature Genetics 2005, 37:391-400.
-
(2005)
Nature Genetics
, vol.37
, pp. 391-400
-
-
Fraga, M.F.1
Ballestar, E.2
Villar-Garea, A.3
Boix-Chornet, M.4
Espada, J.5
Schotta, G.6
-
54
-
-
0242584449
-
Induction of tumors in mice by genomic hypomethylation
-
Gaudet F., Hodgson J.G., Eden A., Jackson-Grusby L., Dausman J., Gray J.W., et al. Induction of tumors in mice by genomic hypomethylation. Science 2003, 300:489-492.
-
(2003)
Science
, vol.300
, pp. 489-492
-
-
Gaudet, F.1
Hodgson, J.G.2
Eden, A.3
Jackson-Grusby, L.4
Dausman, J.5
Gray, J.W.6
-
56
-
-
84859374915
-
New ways to use DNA methyltransferase inhibitors for the treatment of myelodysplastic syndrome
-
Gore S.D. New ways to use DNA methyltransferase inhibitors for the treatment of myelodysplastic syndrome. Hematology/The Education Program of the American Society of Hematology 2011, 2011:550-555.
-
(2011)
Hematology/The Education Program of the American Society of Hematology
, vol.2011
, pp. 550-555
-
-
Gore, S.D.1
-
57
-
-
84863723010
-
The mutational landscape of lethal castration-resistant prostate cancer
-
Grasso C.S., Wu Y.M., Robinson D.R., Cao X., Dhanasekaran S.M., Khan A.P., et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature 2012, 487:239-243.
-
(2012)
Nature
, vol.487
, pp. 239-243
-
-
Grasso, C.S.1
Wu, Y.M.2
Robinson, D.R.3
Cao, X.4
Dhanasekaran, S.M.5
Khan, A.P.6
-
58
-
-
75449119103
-
Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms
-
Green A., Beer P. Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms. The New England Journal of Medicine 2010, 362:369-370.
-
(2010)
The New England Journal of Medicine
, vol.362
, pp. 369-370
-
-
Green, A.1
Beer, P.2
-
59
-
-
30644474460
-
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9
-
Greiner D., Bonaldi T., Eskeland R., Roemer E., Imhof A. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nature Chemical Biology 2005, 1:143-145.
-
(2005)
Nature Chemical Biology
, vol.1
, pp. 143-145
-
-
Greiner, D.1
Bonaldi, T.2
Eskeland, R.3
Roemer, E.4
Imhof, A.5
-
60
-
-
0026496887
-
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
-
Gu Y., Nakamura T., Alder H., Prasad R., Canaani O., Cimino G., et al. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 1992, 71:701-708.
-
(1992)
Cell
, vol.71
, pp. 701-708
-
-
Gu, Y.1
Nakamura, T.2
Alder, H.3
Prasad, R.4
Canaani, O.5
Cimino, G.6
-
61
-
-
34447098370
-
A chromatin landmark and transcription initiation at most promoters in human cells
-
Guenther M.G., Levine S.S., Boyer L.A., Jaenisch R., Young R.A. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 2007, 130:77-88.
-
(2007)
Cell
, vol.130
, pp. 77-88
-
-
Guenther, M.G.1
Levine, S.S.2
Boyer, L.A.3
Jaenisch, R.4
Young, R.A.5
-
62
-
-
79955538247
-
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
-
Guo J.U., Su Y., Zhong C., Ming G.L., Song H. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 2011, 145:423-434.
-
(2011)
Cell
, vol.145
, pp. 423-434
-
-
Guo, J.U.1
Su, Y.2
Zhong, C.3
Ming, G.L.4
Song, H.5
-
63
-
-
77951118936
-
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
-
Gupta R.A., Shah N., Wang K.C., Kim J., Horlings H.M., Wong D.J., et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010, 464:1071-1076.
-
(2010)
Nature
, vol.464
, pp. 1071-1076
-
-
Gupta, R.A.1
Shah, N.2
Wang, K.C.3
Kim, J.4
Horlings, H.M.5
Wong, D.J.6
-
64
-
-
84859474968
-
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes
-
Hakim O., Resch W., Yamane A., Klein I., Kieffer-Kwon K.R., Jankovic M., et al. DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature 2012, 484:69-74.
-
(2012)
Nature
, vol.484
, pp. 69-74
-
-
Hakim, O.1
Resch, W.2
Yamane, A.3
Klein, I.4
Kieffer-Kwon, K.R.5
Jankovic, M.6
-
65
-
-
84862123313
-
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
-
Harris W.J., Huang X., Lynch J.T., Spencer G.J., Hitchin J.R., Li Y., et al. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 2012, 21:473-487.
-
(2012)
Cancer Cell
, vol.21
, pp. 473-487
-
-
Harris, W.J.1
Huang, X.2
Lynch, J.T.3
Spencer, G.J.4
Hitchin, J.R.5
Li, Y.6
-
66
-
-
79953815457
-
KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia
-
He J., Nguyen A.T., Zhang Y. KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia. Blood 2011, 117:3869-3880.
-
(2011)
Blood
, vol.117
, pp. 3869-3880
-
-
He, J.1
Nguyen, A.T.2
Zhang, Y.3
-
67
-
-
33847304609
-
Gene body-specific methylation on the active X chromosome
-
Hellman A., Chess A. Gene body-specific methylation on the active X chromosome. Science 2007, 315:1141-1143.
-
(2007)
Science
, vol.315
, pp. 1141-1143
-
-
Hellman, A.1
Chess, A.2
-
68
-
-
33646254136
-
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
-
Heltweg B., Gatbonton T., Schuler A.D., Posakony J., Li H., Goehle S., et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Research 2006, 66:4368-4377.
-
(2006)
Cancer Research
, vol.66
, pp. 4368-4377
-
-
Heltweg, B.1
Gatbonton, T.2
Schuler, A.D.3
Posakony, J.4
Li, H.5
Goehle, S.6
-
69
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
Herman J.G., Baylin S.B. Gene silencing in cancer in association with promoter hypermethylation. The New England Journal of Medicine 2003, 349:2042-2054.
-
(2003)
The New England Journal of Medicine
, vol.349
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
70
-
-
79958864954
-
Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: A report from the Children's Oncology Group
-
Ho P.A., Kutny M.A., Alonzo T.A., Gerbing R.B., Joaquin J., Raimondi S.C., et al. Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: A report from the Children's Oncology Group. Pediatric Blood & Cancer 2011, 57:204-209.
-
(2011)
Pediatric Blood & Cancer
, vol.57
, pp. 204-209
-
-
Ho, P.A.1
Kutny, M.A.2
Alonzo, T.A.3
Gerbing, R.B.4
Joaquin, J.5
Raimondi, S.C.6
-
71
-
-
26644444345
-
Global loss of imprinting leads to widespread tumorigenesis in adult mice
-
Holm T.M., Jackson-Grusby L., Brambrink T., Yamada Y., Rideout W.M., Jaenisch R. Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell 2005, 8:275-285.
-
(2005)
Cancer Cell
, vol.8
, pp. 275-285
-
-
Holm, T.M.1
Jackson-Grusby, L.2
Brambrink, T.3
Yamada, Y.4
Rideout, W.M.5
Jaenisch, R.6
-
72
-
-
20844463226
-
Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli
-
Holtz M.S., Forman S.J., Bhatia R. Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli. Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK 2005, 19:1034-1041.
-
(2005)
Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK
, vol.19
, pp. 1034-1041
-
-
Holtz, M.S.1
Forman, S.J.2
Bhatia, R.3
-
74
-
-
34548513035
-
P53 is regulated by the lysine demethylase LSD1
-
Huang J., Sengupta R., Espejo A.B., Lee M.G., Dorsey J.A., Richter M., et al. p53 is regulated by the lysine demethylase LSD1. Nature 2007, 449:105-108.
-
(2007)
Nature
, vol.449
, pp. 105-108
-
-
Huang, J.1
Sengupta, R.2
Espejo, A.B.3
Lee, M.G.4
Dorsey, J.A.5
Richter, M.6
-
75
-
-
33947214077
-
Chaetocin: A promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress
-
Isham C.R., Tibodeau J.D., Jin W., Xu R., Timm M.M., Bible K.C. Chaetocin: A promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress. Blood 2007, 109:2579-2588.
-
(2007)
Blood
, vol.109
, pp. 2579-2588
-
-
Isham, C.R.1
Tibodeau, J.D.2
Jin, W.3
Xu, R.4
Timm, M.M.5
Bible, K.C.6
-
76
-
-
33847219608
-
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
-
Issaeva I., Zonis Y., Rozovskaia T., Orlovsky K., Croce C.M., Nakamura T., et al. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Molecular and Cellular Biology 2007, 27:1889-1903.
-
(2007)
Molecular and Cellular Biology
, vol.27
, pp. 1889-1903
-
-
Issaeva, I.1
Zonis, Y.2
Rozovskaia, T.3
Orlovsky, K.4
Croce, C.M.5
Nakamura, T.6
-
77
-
-
33947302685
-
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases
-
Iwase S., Lan F., Bayliss P., de la Torre-Ubieta L., Huarte M., Qi H.H., et al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell 2007, 128:1077-1088.
-
(2007)
Cell
, vol.128
, pp. 1077-1088
-
-
Iwase, S.1
Lan, F.2
Bayliss, P.3
de la Torre-Ubieta, L.4
Huarte, M.5
Qi, H.H.6
-
78
-
-
0035839136
-
Translating the histone code
-
Jenuwein T., Allis C.D. Translating the histone code. Science 2001, 293:1074-1080.
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
79
-
-
79951711112
-
Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains
-
Jiang H., Shukla A., Wang X., Chen W.Y., Bernstein B.E., Roeder R.G. Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell 2011, 144:513-525.
-
(2011)
Cell
, vol.144
, pp. 513-525
-
-
Jiang, H.1
Shukla, A.2
Wang, X.3
Chen, W.Y.4
Bernstein, B.E.5
Roeder, R.G.6
-
80
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones P.A., Baylin S.B. The fundamental role of epigenetic events in cancer. Nature Reviews. Genetics 2002, 3:415-428.
-
(2002)
Nature Reviews. Genetics
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
81
-
-
84867420094
-
Cancer and altered metabolism: Potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases
-
Kaelin W.G. Cancer and altered metabolism: Potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harbor Symposia on Quantitative Biology 2011, 76:335-345.
-
(2011)
Cold Spring Harbor Symposia on Quantitative Biology
, vol.76
, pp. 335-345
-
-
Kaelin, W.G.1
-
82
-
-
80053502216
-
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes
-
Klein I.A., Resch W., Jankovic M., Oliveira T., Yamane A., Nakahashi H., et al. Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell 2011, 147:95-106.
-
(2011)
Cell
, vol.147
, pp. 95-106
-
-
Klein, I.A.1
Resch, W.2
Jankovic, M.3
Oliveira, T.4
Yamane, A.5
Nakahashi, H.6
-
83
-
-
78650175023
-
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
-
Ko M., Huang Y., Jankowska A.M., Pape U.J., Tahiliani M., Bandukwala H.S., et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010, 468:839-843.
-
(2010)
Nature
, vol.468
, pp. 839-843
-
-
Ko, M.1
Huang, Y.2
Jankowska, A.M.3
Pape, U.J.4
Tahiliani, M.5
Bandukwala, H.S.6
-
84
-
-
0037275494
-
A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13)
-
Kojima K., Kaneda K., Yoshida C., Dansako H., Fujii N., Yano T., et al. A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13). British Journal of Haematology 2003, 120:271-273.
-
(2003)
British Journal of Haematology
, vol.120
, pp. 271-273
-
-
Kojima, K.1
Kaneda, K.2
Yoshida, C.3
Dansako, H.4
Fujii, N.5
Yano, T.6
-
85
-
-
84860215207
-
Molecular mechanisms and potential functions of histone demethylases
-
Kooistra S.M., Helin K. Molecular mechanisms and potential functions of histone demethylases. Nature Reviews. Molecular Cell Biology 2012, 13:297-311.
-
(2012)
Nature Reviews. Molecular Cell Biology
, vol.13
, pp. 297-311
-
-
Kooistra, S.M.1
Helin, K.2
-
86
-
-
77952426827
-
Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms
-
Kosmider O., Gelsi-Boyer V., Slama L., Dreyfus F., Beyne-Rauzy O., Quesnel B., et al. Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms. Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK 2010, 24:1094-1096.
-
(2010)
Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK
, vol.24
, pp. 1094-1096
-
-
Kosmider, O.1
Gelsi-Boyer, V.2
Slama, L.3
Dreyfus, F.4
Beyne-Rauzy, O.5
Quesnel, B.6
-
87
-
-
84865120905
-
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
-
Kruidenier L., Chung C.W., Cheng Z., Liddle J., Che K., Joberty G., et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012, 488:404-408.
-
(2012)
Nature
, vol.488
, pp. 404-408
-
-
Kruidenier, L.1
Chung, C.W.2
Cheng, Z.3
Liddle, J.4
Che, K.5
Joberty, G.6
-
88
-
-
0030459140
-
The role of DNA methylation in cancer genetic and epigenetics
-
Laird P.W., Jaenisch R. The role of DNA methylation in cancer genetic and epigenetics. Annual Review of Genetics 1996, 30:441-464.
-
(1996)
Annual Review of Genetics
, vol.30
, pp. 441-464
-
-
Laird, P.W.1
Jaenisch, R.2
-
89
-
-
35348993743
-
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination
-
Lee M.G., Villa R., Trojer P., Norman J., Yan K.P., Reinberg D., et al. Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science 2007, 318:447-450.
-
(2007)
Science
, vol.318
, pp. 447-450
-
-
Lee, M.G.1
Villa, R.2
Trojer, P.3
Norman, J.4
Yan, K.P.5
Reinberg, D.6
-
90
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
Ley T.J., Ding L., Walter M.J., McLellan M.D., Lamprecht T., Larson D.E., et al. DNMT3A mutations in acute myeloid leukemia. The New England Journal of Medicine 2010, 363:2424-2433.
-
(2010)
The New England Journal of Medicine
, vol.363
, pp. 2424-2433
-
-
Ley, T.J.1
Ding, L.2
Walter, M.J.3
McLellan, M.D.4
Lamprecht, T.5
Larson, D.E.6
-
91
-
-
80052285127
-
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
-
Li Z., Cai X., Cai C.L., Wang J., Zhang W., Petersen B.E., et al. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood 2011, 118:4509-4518.
-
(2011)
Blood
, vol.118
, pp. 4509-4518
-
-
Li, Z.1
Cai, X.2
Cai, C.L.3
Wang, J.4
Zhang, W.5
Petersen, B.E.6
-
92
-
-
84862908850
-
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
-
Li G., Ruan X., Auerbach R.K., Sandhu K.S., Zheng M., Wang P., et al. Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell 2012, 148:84-98.
-
(2012)
Cell
, vol.148
, pp. 84-98
-
-
Li, G.1
Ruan, X.2
Auerbach, R.K.3
Sandhu, K.S.4
Zheng, M.5
Wang, P.6
-
93
-
-
70349873824
-
Comprehensive mapping of long-range interactions reveals folding principles of the human genome
-
Lieberman-Aiden E., van Berkum N.L., Williams L., Imakaev M., Ragoczy T., Telling A., et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 2009, 326:289-293.
-
(2009)
Science
, vol.326
, pp. 289-293
-
-
Lieberman-Aiden, E.1
van Berkum, N.L.2
Williams, L.3
Imakaev, M.4
Ragoczy, T.5
Telling, A.6
-
94
-
-
79751486147
-
JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation
-
Liu F., Zhao X., Perna F., Wang L., Koppikar P., Abdel-Wahab O., et al. JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer Cell 2011, 19:283-294.
-
(2011)
Cancer Cell
, vol.19
, pp. 283-294
-
-
Liu, F.1
Zhao, X.2
Perna, F.3
Wang, L.4
Koppikar, P.5
Abdel-Wahab, O.6
-
95
-
-
0037350661
-
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)
-
Lorsbach R.B., Moore J., Mathew S., Raimondi S.C., Mukatira S.T., Downing J.R. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK 2003, 17:637-641.
-
(2003)
Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK
, vol.17
, pp. 637-641
-
-
Lorsbach, R.B.1
Moore, J.2
Mathew, S.3
Raimondi, S.C.4
Mukatira, S.T.5
Downing, J.R.6
-
96
-
-
84863534997
-
Metabolic regulation of epigenetics
-
Lu C., Thompson C.B. Metabolic regulation of epigenetics. Cell Metabolism 2012, 16:9-17.
-
(2012)
Cell Metabolism
, vol.16
, pp. 9-17
-
-
Lu, C.1
Thompson, C.B.2
-
97
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu C., Ward P.S., Kapoor G.S., Rohle D., Turcan S., Abdel-Wahab O., et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 2012, 483:474-478.
-
(2012)
Nature
, vol.483
, pp. 474-478
-
-
Lu, C.1
Ward, P.S.2
Kapoor, G.S.3
Rohle, D.4
Turcan, S.5
Abdel-Wahab, O.6
-
98
-
-
34250321317
-
Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2
-
Lubitz S., Glaser S., Schaft J., Stewart A.F., Anastassiadis K. Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2. Molecular Biology of the Cell 2007, 18:2356-2366.
-
(2007)
Molecular Biology of the Cell
, vol.18
, pp. 2356-2366
-
-
Lubitz, S.1
Glaser, S.2
Schaft, J.3
Stewart, A.F.4
Anastassiadis, K.5
-
99
-
-
84864869260
-
Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia
-
Mar B.G., Bullinger L., Basu E., Schlis K., Silverman L.B., Dohner K., et al. Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia. Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK 2012, 26:1881-1883.
-
(2012)
Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK
, vol.26
, pp. 1881-1883
-
-
Mar, B.G.1
Bullinger, L.2
Basu, E.3
Schlis, K.4
Silverman, L.B.5
Dohner, K.6
-
100
-
-
84863116398
-
Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia
-
Marcucci G., Metzeler K.H., Schwind S., Becker H., Maharry K., Mrozek K., et al. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2012, 30:742-750.
-
(2012)
Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
, vol.30
, pp. 742-750
-
-
Marcucci, G.1
Metzeler, K.H.2
Schwind, S.3
Becker, H.4
Maharry, K.5
Mrozek, K.6
-
101
-
-
77949678340
-
Chromatin structure and the inheritance of epigenetic information
-
Margueron R., Reinberg D. Chromatin structure and the inheritance of epigenetic information. Nature Reviews. Genetics 2010, 11:285-296.
-
(2010)
Nature Reviews. Genetics
, vol.11
, pp. 285-296
-
-
Margueron, R.1
Reinberg, D.2
-
102
-
-
78751662908
-
The Polycomb complex PRC2 and its mark in life
-
Margueron R., Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature 2011, 469:343-349.
-
(2011)
Nature
, vol.469
, pp. 343-349
-
-
Margueron, R.1
Reinberg, D.2
-
103
-
-
79952229923
-
The role of HDACs inhibitors in childhood and adolescence acute leukemias
-
Masetti R., Serravalle S., Biagi C., Pession A. The role of HDACs inhibitors in childhood and adolescence acute leukemias. Journal of Biomedicine and Biotechnology 2011, 2011:148046.
-
(2011)
Journal of Biomedicine and Biotechnology
, vol.2011
, pp. 148046
-
-
Masetti, R.1
Serravalle, S.2
Biagi, C.3
Pession, A.4
-
104
-
-
84863165348
-
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
-
McCabe M.T., Graves A.P., Ganji G., Diaz E., Halsey W.S., Jiang Y., et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proceedings of the National Academy of Sciences of the United States of America 2012, 109:2989-2994.
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. 2989-2994
-
-
McCabe, M.T.1
Graves, A.P.2
Ganji, G.3
Diaz, E.4
Halsey, W.S.5
Jiang, Y.6
-
105
-
-
49649125042
-
Genome-scale DNA methylation maps of pluripotent and differentiated cells
-
Meissner A., Mikkelsen T.S., Gu H., Wernig M., Hanna J., Sivachenko A., et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 2008, 454:766-770.
-
(2008)
Nature
, vol.454
, pp. 766-770
-
-
Meissner, A.1
Mikkelsen, T.S.2
Gu, H.3
Wernig, M.4
Hanna, J.5
Sivachenko, A.6
-
106
-
-
84860772157
-
DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia
-
Metzeler K.H., Walker A., Geyer S., Garzon R., Klisovic R.B., Bloomfield C.D., et al. DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia. Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK 2012, 26:1106-1107.
-
(2012)
Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK
, vol.26
, pp. 1106-1107
-
-
Metzeler, K.H.1
Walker, A.2
Geyer, S.3
Garzon, R.4
Klisovic, R.B.5
Bloomfield, C.D.6
-
107
-
-
78649263390
-
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression
-
Miller S.A., Mohn S.E., Weinmann A.S. Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Molecular Cell 2010, 40:594-605.
-
(2010)
Molecular Cell
, vol.40
, pp. 594-605
-
-
Miller, S.A.1
Mohn, S.E.2
Weinmann, A.S.3
-
108
-
-
77957128551
-
Licensed to elongate: A molecular mechanism for MLL-based leukaemogenesis
-
Mohan M., Lin C., Guest E., Shilatifard A. Licensed to elongate: A molecular mechanism for MLL-based leukaemogenesis. Nature Reviews. Cancer 2010, 10:721-728.
-
(2010)
Nature Reviews. Cancer
, vol.10
, pp. 721-728
-
-
Mohan, M.1
Lin, C.2
Guest, E.3
Shilatifard, A.4
-
109
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
Moran-Crusio K., Reavie L., Shih A., Abdel-Wahab O., Ndiaye-Lobry D., Lobry C., et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 2011, 20:11-24.
-
(2011)
Cancer Cell
, vol.20
, pp. 11-24
-
-
Moran-Crusio, K.1
Reavie, L.2
Shih, A.3
Abdel-Wahab, O.4
Ndiaye-Lobry, D.5
Lobry, C.6
-
110
-
-
75749124332
-
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
-
Morin R.D., Johnson N.A., Severson T.M., Mungall A.J., An J., Goya R., et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nature Genetics 2010, 42:181-185.
-
(2010)
Nature Genetics
, vol.42
, pp. 181-185
-
-
Morin, R.D.1
Johnson, N.A.2
Severson, T.M.3
Mungall, A.J.4
An, J.5
Goya, R.6
-
111
-
-
79952381408
-
CREBBP mutations in relapsed acute lymphoblastic leukaemia
-
Mullighan C.G., Zhang J., Kasper L.H., Lerach S., Payne-Turner D., Phillips L.A., et al. CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature 2011, 471:235-239.
-
(2011)
Nature
, vol.471
, pp. 235-239
-
-
Mullighan, C.G.1
Zhang, J.2
Kasper, L.H.3
Lerach, S.4
Payne-Turner, D.5
Phillips, L.A.6
-
112
-
-
84859475727
-
Polycomb repressive complex 2 is required for MLL-AF9 leukemia
-
Neff T., Sinha A.U., Kluk M.J., Zhu N., Khattab M.H., Stein L., et al. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:5028-5033.
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. 5028-5033
-
-
Neff, T.1
Sinha, A.U.2
Kluk, M.J.3
Zhu, N.4
Khattab, M.H.5
Stein, L.6
-
113
-
-
16844384464
-
Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays
-
Nishigaki M., Aoyagi K., Danjoh I., Fukaya M., Yanagihara K., Sakamoto H., et al. Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. Cancer Research 2005, 65:2115-2124.
-
(2005)
Cancer Research
, vol.65
, pp. 2115-2124
-
-
Nishigaki, M.1
Aoyagi, K.2
Danjoh, I.3
Fukaya, M.4
Yanagihara, K.5
Sakamoto, H.6
-
114
-
-
84856747744
-
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
-
Ntziachristos P., Tsirigos A., Van Vlierberghe P., Nedjic J., Trimarchi T., Flaherty M.S., et al. Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nature Medicine 2012, 18:298-301.
-
(2012)
Nature Medicine
, vol.18
, pp. 298-301
-
-
Ntziachristos, P.1
Tsirigos, A.2
Van Vlierberghe, P.3
Nedjic, J.4
Trimarchi, T.5
Flaherty, M.S.6
-
115
-
-
84860364648
-
Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes
-
Oguro H., Yuan J., Tanaka S., Miyagi S., Mochizuki-Kashio M., Ichikawa H., et al. Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes. The Journal of Experimental Medicine 2012, 209:445-454.
-
(2012)
The Journal of Experimental Medicine
, vol.209
, pp. 445-454
-
-
Oguro, H.1
Yuan, J.2
Tanaka, S.3
Miyagi, S.4
Mochizuki-Kashio, M.5
Ichikawa, H.6
-
116
-
-
1042263110
-
Promoter methylation of cyclin D2 gene in gastric carcinoma
-
Oshimo Y., Nakayama H., Ito R., Kitadai Y., Yoshida K., Chayama K., et al. Promoter methylation of cyclin D2 gene in gastric carcinoma. International Journal of Oncology 2003, 23:1663-1670.
-
(2003)
International Journal of Oncology
, vol.23
, pp. 1663-1670
-
-
Oshimo, Y.1
Nakayama, H.2
Ito, R.3
Kitadai, Y.4
Yoshida, K.5
Chayama, K.6
-
117
-
-
0038349957
-
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
-
Park I.K., Qian D., Kiel M., Becker M.W., Pihalja M., Weissman I.L., et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003, 423:302-305.
-
(2003)
Nature
, vol.423
, pp. 302-305
-
-
Park, I.K.1
Qian, D.2
Kiel, M.3
Becker, M.W.4
Pihalja, M.5
Weissman, I.L.6
-
118
-
-
79251629946
-
The genetic landscape of the childhood cancer medulloblastoma
-
Parsons D.W., Li M., Zhang X., Jones S., Leary R.J., Lin J.C., et al. The genetic landscape of the childhood cancer medulloblastoma. Science 2011, 331:435-439.
-
(2011)
Science
, vol.331
, pp. 435-439
-
-
Parsons, D.W.1
Li, M.2
Zhang, X.3
Jones, S.4
Leary, R.J.5
Lin, J.C.6
-
119
-
-
79952430906
-
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
-
Pasqualucci L., Dominguez-Sola D., Chiarenza A., Fabbri G., Grunn A., Trifonov V., et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature 2011, 471:189-195.
-
(2011)
Nature
, vol.471
, pp. 189-195
-
-
Pasqualucci, L.1
Dominguez-Sola, D.2
Chiarenza, A.3
Fabbri, G.4
Grunn, A.5
Trifonov, V.6
-
120
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
Patel J.P., Gonen M., Figueroa M.E., Fernandez H., Sun Z., Racevskis J., et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. The New England Journal of Medicine 2012, 366:1079-1089.
-
(2012)
The New England Journal of Medicine
, vol.366
, pp. 1079-1089
-
-
Patel, J.P.1
Gonen, M.2
Figueroa, M.E.3
Fernandez, H.4
Sun, Z.5
Racevskis, J.6
-
121
-
-
33947693747
-
On the use of the word 'epigenetic'
-
Ptashne M. On the use of the word 'epigenetic'. Current Biology 2007, 17:R233-R236.
-
(2007)
Current Biology
, vol.17
-
-
Ptashne, M.1
-
123
-
-
84555171449
-
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
-
Quesada V., Conde L., Villamor N., Ordonez G.R., Jares P., Bassaganyas L., et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nature Genetics 2012, 44:47-52.
-
(2012)
Nature Genetics
, vol.44
, pp. 47-52
-
-
Quesada, V.1
Conde, L.2
Villamor, N.3
Ordonez, G.R.4
Jares, P.5
Bassaganyas, L.6
-
124
-
-
79960062301
-
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
-
Quivoron C., Couronne L., Della Valle V., Lopez C.K., Plo I., Wagner-Ballon O., et al. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell 2011, 20:25-38.
-
(2011)
Cancer Cell
, vol.20
, pp. 25-38
-
-
Quivoron, C.1
Couronne, L.2
Della Valle, V.3
Lopez, C.K.4
Plo, I.5
Wagner-Ballon, O.6
-
125
-
-
84455200582
-
Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells
-
Ram O., Goren A., Amit I., Shoresh N., Yosef N., Ernst J., et al. Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell 2011, 147:1628-1639.
-
(2011)
Cell
, vol.147
, pp. 1628-1639
-
-
Ram, O.1
Goren, A.2
Amit, I.3
Shoresh, N.4
Yosef, N.5
Ernst, J.6
-
126
-
-
84862502902
-
Mutant DNMT3A: A marker of poor prognosis in acute myeloid leukemia
-
Ribeiro A.F., Pratcorona M., Erpelinck-Verschueren C., Rockova V., Sanders M., Abbas S., et al. Mutant DNMT3A: A marker of poor prognosis in acute myeloid leukemia. Blood 2012, 119:5824-5831.
-
(2012)
Blood
, vol.119
, pp. 5824-5831
-
-
Ribeiro, A.F.1
Pratcorona, M.2
Erpelinck-Verschueren, C.3
Rockova, V.4
Sanders, M.5
Abbas, S.6
-
127
-
-
19944431781
-
Bone marrow recurrence after initial intensive treatment for childhood acute lymphoblastic leukemia
-
Rivera G.K., Zhou Y., Hancock M.L., Gajjar A., Rubnitz J., Ribeiro R.C., et al. Bone marrow recurrence after initial intensive treatment for childhood acute lymphoblastic leukemia. Cancer 2005, 103:368-376.
-
(2005)
Cancer
, vol.103
, pp. 368-376
-
-
Rivera, G.K.1
Zhou, Y.2
Hancock, M.L.3
Gajjar, A.4
Rubnitz, J.5
Ribeiro, R.C.6
-
128
-
-
0038054340
-
Spatial proximity of translocation-prone gene loci in human lymphomas
-
Roix J.J., McQueen P.G., Munson P.J., Parada L.A., Misteli T. Spatial proximity of translocation-prone gene loci in human lymphomas. Nature Genetics 2003, 34:287-291.
-
(2003)
Nature Genetics
, vol.34
, pp. 287-291
-
-
Roix, J.J.1
McQueen, P.G.2
Munson, P.J.3
Parada, L.A.4
Misteli, T.5
-
129
-
-
77956222562
-
Polycomb group proteins: Multi-faceted regulators of somatic stem cells and cancer
-
Sauvageau M., Sauvageau G. Polycomb group proteins: Multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 2010, 7:299-313.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 299-313
-
-
Sauvageau, M.1
Sauvageau, G.2
-
130
-
-
78149485776
-
Interpretation of developmental signaling at chromatin: The Polycomb perspective
-
Sawarkar R., Paro R. Interpretation of developmental signaling at chromatin: The Polycomb perspective. Developmental Cell 2010, 19:651-661.
-
(2010)
Developmental Cell
, vol.19
, pp. 651-661
-
-
Sawarkar, R.1
Paro, R.2
-
131
-
-
84862777766
-
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
-
Schenk T., Chen W.C., Gollner S., Howell L., Jin L., Hebestreit K., et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nature Medicine 2012, 18:605-611.
-
(2012)
Nature Medicine
, vol.18
, pp. 605-611
-
-
Schenk, T.1
Chen, W.C.2
Gollner, S.3
Howell, L.4
Jin, L.5
Hebestreit, K.6
-
132
-
-
77956863976
-
Curcumin in cancer chemoprevention: Molecular targets, pharmacokinetics, bioavailability, and clinical trials
-
Shehzad A., Wahid F., Lee Y.S. Curcumin in cancer chemoprevention: Molecular targets, pharmacokinetics, bioavailability, and clinical trials. Archiv der Pharmazie 2010, 343:489-499.
-
(2010)
Archiv der Pharmazie
, vol.343
, pp. 489-499
-
-
Shehzad, A.1
Wahid, F.2
Lee, Y.S.3
-
133
-
-
11144332565
-
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
-
Shi Y., Lan F., Matson C., Mulligan P., Whetstine J.R., Cole P.A., et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004, 119:941-953.
-
(2004)
Cell
, vol.119
, pp. 941-953
-
-
Shi, Y.1
Lan, F.2
Matson, C.3
Mulligan, P.4
Whetstine, J.R.5
Cole, P.A.6
-
134
-
-
84874106911
-
The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia
-
Shi J., Wang E., Zuber J., Rappaport A., Taylor M., Johns C., et al. The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia. Oncogene 2012, 32:930-938.
-
(2012)
Oncogene
, vol.32
, pp. 930-938
-
-
Shi, J.1
Wang, E.2
Zuber, J.3
Rappaport, A.4
Taylor, M.5
Johns, C.6
-
135
-
-
84866378702
-
The role of mutations in epigenetic regulators in myeloid malignancies
-
Shih A.H., Abdel-Wahab O., Patel J.P., Levine R.L. The role of mutations in epigenetic regulators in myeloid malignancies. Nature Reviews. Cancer 2012, 12:599-612.
-
(2012)
Nature Reviews. Cancer
, vol.12
, pp. 599-612
-
-
Shih, A.H.1
Abdel-Wahab, O.2
Patel, J.P.3
Levine, R.L.4
-
136
-
-
84859295400
-
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
-
Simon C., Chagraoui J., Krosl J., Gendron P., Wilhelm B., Lemieux S., et al. A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes & Development 2012, 26:651-656.
-
(2012)
Genes & Development
, vol.26
, pp. 651-656
-
-
Simon, C.1
Chagraoui, J.2
Krosl, J.3
Gendron, P.4
Wilhelm, B.5
Lemieux, S.6
-
138
-
-
79954552505
-
The super elongation complex (SEC) and MLL in development and disease
-
Smith E., Lin C., Shilatifard A. The super elongation complex (SEC) and MLL in development and disease. Genes & Development 2011, 25:661-672.
-
(2011)
Genes & Development
, vol.25
, pp. 661-672
-
-
Smith, E.1
Lin, C.2
Shilatifard, A.3
-
139
-
-
78650454078
-
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
-
Sneeringer C.J., Scott M.P., Kuntz K.W., Knutson S.K., Pollock R.M., Richon V.M., et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:20980-20985.
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, pp. 20980-20985
-
-
Sneeringer, C.J.1
Scott, M.P.2
Kuntz, K.W.3
Knutson, S.K.4
Pollock, R.M.5
Richon, V.M.6
-
140
-
-
66149147557
-
Developmental programming of CpG island methylation profiles in the human genome
-
Straussman R., Nejman D., Roberts D., Steinfeld I., Blum B., Benvenisty N., et al. Developmental programming of CpG island methylation profiles in the human genome. Nature Structural and Molecular Biology 2009, 16:564-571.
-
(2009)
Nature Structural and Molecular Biology
, vol.16
, pp. 564-571
-
-
Straussman, R.1
Nejman, D.2
Roberts, D.3
Steinfeld, I.4
Blum, B.5
Benvenisty, N.6
-
141
-
-
33746581782
-
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation
-
Sun Y., Jiang X., Chen S., Price B.D. Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Letters 2006, 580:4353-4356.
-
(2006)
FEBS Letters
, vol.580
, pp. 4353-4356
-
-
Sun, Y.1
Jiang, X.2
Chen, S.3
Price, B.D.4
-
142
-
-
34247337999
-
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells
-
Tadokoro Y., Ema H., Okano M., Li E., Nakauchi H. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. The Journal of Experimental Medicine 2007, 204:715-722.
-
(2007)
The Journal of Experimental Medicine
, vol.204
, pp. 715-722
-
-
Tadokoro, Y.1
Ema, H.2
Okano, M.3
Li, E.4
Nakauchi, H.5
-
143
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani M., Koh K.P., Shen Y., Pastor W.A., Bandukwala H., Brudno Y., et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009, 324:930-935.
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
Pastor, W.A.4
Bandukwala, H.5
Brudno, Y.6
-
144
-
-
81255192170
-
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
-
Tan J., Jones M., Koseki H., Nakayama M., Muntean A.G., Maillard I., et al. CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell 2011, 20:563-575.
-
(2011)
Cancer Cell
, vol.20
, pp. 563-575
-
-
Tan, J.1
Jones, M.2
Koseki, H.3
Nakayama, M.4
Muntean, A.G.5
Maillard, I.6
-
145
-
-
80052942443
-
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
-
Tan M., Luo H., Lee S., Jin F., Yang J.S., Montellier E., et al. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 2011, 146:1016-1028.
-
(2011)
Cell
, vol.146
, pp. 1016-1028
-
-
Tan, M.1
Luo, H.2
Lee, S.3
Jin, F.4
Yang, J.S.5
Montellier, E.6
-
146
-
-
67349124376
-
TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
-
Tefferi A., Pardanani A., Lim K.H., Abdel-Wahab O., Lasho T.L., Patel J., et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK 2009, 23:905-911.
-
(2009)
Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK
, vol.23
, pp. 905-911
-
-
Tefferi, A.1
Pardanani, A.2
Lim, K.H.3
Abdel-Wahab, O.4
Lasho, T.L.5
Patel, J.6
-
147
-
-
77957666255
-
Histone methyl transferases and demethylases; can they link metabolism and transcription?
-
Teperino R., Schoonjans K., Auwerx J. Histone methyl transferases and demethylases; can they link metabolism and transcription?. Cell Metabolism 2010, 12:321-327.
-
(2010)
Cell Metabolism
, vol.12
, pp. 321-327
-
-
Teperino, R.1
Schoonjans, K.2
Auwerx, J.3
-
148
-
-
82855177869
-
Rare occurrence of DNMT3A mutations in myelodysplastic syndromes
-
Thol F., Winschel C., Ludeking A., Yun H., Friesen I., Damm F., et al. Rare occurrence of DNMT3A mutations in myelodysplastic syndromes. Haematologica 2011, 96:1870-1873.
-
(2011)
Haematologica
, vol.96
, pp. 1870-1873
-
-
Thol, F.1
Winschel, C.2
Ludeking, A.3
Yun, H.4
Friesen, I.5
Damm, F.6
-
149
-
-
0026454451
-
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
-
Tkachuk D.C., Kohler S., Cleary M.L. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 1992, 71:691-700.
-
(1992)
Cell
, vol.71
, pp. 691-700
-
-
Tkachuk, D.C.1
Kohler, S.2
Cleary, M.L.3
-
150
-
-
77954572735
-
Long noncoding RNA as modular scaffold of histone modification complexes
-
Tsai M.C., Manor O., Wan Y., Mosammaparast N., Wang J.K., Lan F., et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science 2010, 329:689-693.
-
(2010)
Science
, vol.329
, pp. 689-693
-
-
Tsai, M.C.1
Manor, O.2
Wan, Y.3
Mosammaparast, N.4
Wang, J.K.5
Lan, F.6
-
151
-
-
32844454603
-
Histone demethylation by a family of JmjC domain-containing proteins
-
Tsukada Y., Fang J., Erdjument-Bromage H., Warren M.E., Borchers C.H., Tempst P., et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature 2006, 439:811-816.
-
(2006)
Nature
, vol.439
, pp. 811-816
-
-
Tsukada, Y.1
Fang, J.2
Erdjument-Bromage, H.3
Warren, M.E.4
Borchers, C.H.5
Tempst, P.6
-
152
-
-
84858796263
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
-
Turcan S., Rohle D., Goenka A., Walsh L.A., Fang F., Yilmaz E., et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 2012, 483:479-483.
-
(2012)
Nature
, vol.483
, pp. 479-483
-
-
Turcan, S.1
Rohle, D.2
Goenka, A.3
Walsh, L.A.4
Fang, F.5
Yilmaz, E.6
-
154
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
van Haaften G., Dalgliesh G.L., Davies H., Chen L., Bignell G., Greenman C., et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nature Genetics 2009, 41:521-523.
-
(2009)
Nature Genetics
, vol.41
, pp. 521-523
-
-
van Haaften, G.1
Dalgliesh, G.L.2
Davies, H.3
Chen, L.4
Bignell, G.5
Greenman, C.6
-
155
-
-
84862870008
-
The epigenetic promise for prostate cancer diagnosis
-
Van Neste L., Herman J.G., Otto G., Bigley J.W., Epstein J.I., Van Criekinge W. The epigenetic promise for prostate cancer diagnosis. The Prostate 2012, 72:1248-1261.
-
(2012)
The Prostate
, vol.72
, pp. 1248-1261
-
-
Van Neste, L.1
Herman, J.G.2
Otto, G.3
Bigley, J.W.4
Epstein, J.I.5
Van Criekinge, W.6
-
156
-
-
78650062951
-
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
-
Velichutina I., Shaknovich R., Geng H., Johnson N.A., Gascoyne R.D., Melnick A.M., et al. EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood 2010, 116:5247-5255.
-
(2010)
Blood
, vol.116
, pp. 5247-5255
-
-
Velichutina, I.1
Shaknovich, R.2
Geng, H.3
Johnson, N.A.4
Gascoyne, R.D.5
Melnick, A.M.6
-
157
-
-
23744440061
-
Common 4q24 deletion in four cases of hematopoietic malignancy: Early stem cell involvement?
-
Viguie F., Aboura A., Bouscary D., Ramond S., Delmer A., Tachdjian G., et al. Common 4q24 deletion in four cases of hematopoietic malignancy: Early stem cell involvement?. Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK 2005, 19:1411-1415.
-
(2005)
Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK
, vol.19
, pp. 1411-1415
-
-
Viguie, F.1
Aboura, A.2
Bouscary, D.3
Ramond, S.4
Delmer, A.5
Tachdjian, G.6
-
158
-
-
32844459336
-
The Polycomb group protein EZH2 directly controls DNA methylation
-
Vire E., Brenner C., Deplus R., Blanchon L., Fraga M., Didelot C., et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 2006, 439:871-874.
-
(2006)
Nature
, vol.439
, pp. 871-874
-
-
Vire, E.1
Brenner, C.2
Deplus, R.3
Blanchon, L.4
Fraga, M.5
Didelot, C.6
-
159
-
-
79960255863
-
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
-
Walter M.J., Ding L., Shen D., Shao J., Grillot M., McLellan M., et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK 2011, 25:1153-1158.
-
(2011)
Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK
, vol.25
, pp. 1153-1158
-
-
Walter, M.J.1
Ding, L.2
Shen, D.3
Shao, J.4
Grillot, M.5
McLellan, M.6
-
160
-
-
58149156264
-
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
-
Wang J., Hevi S., Kurash J.K., Lei H., Gay F., Bajko J., et al. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nature Genetics 2009, 41:125-129.
-
(2009)
Nature Genetics
, vol.41
, pp. 125-129
-
-
Wang, J.1
Hevi, S.2
Kurash, J.K.3
Lei, H.4
Gay, F.5
Bajko, J.6
-
161
-
-
71949107301
-
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II
-
Wang P., Lin C., Smith E.R., Guo H., Sanderson B.W., Wu M., et al. Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Molecular and Cellular Biology 2009, 29:6074-6085.
-
(2009)
Molecular and Cellular Biology
, vol.29
, pp. 6074-6085
-
-
Wang, P.1
Lin, C.2
Smith, E.R.3
Guo, H.4
Sanderson, B.W.5
Wu, M.6
-
162
-
-
67349266612
-
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
-
Wang G.G., Song J., Wang Z., Dormann H.L., Casadio F., Li H., et al. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature 2009, 459:847-851.
-
(2009)
Nature
, vol.459
, pp. 847-851
-
-
Wang, G.G.1
Song, J.2
Wang, Z.3
Dormann, H.L.4
Casadio, F.5
Li, H.6
-
163
-
-
79953748673
-
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
-
Wang K.C., Yang Y.W., Liu B., Sanyal A., Corces-Zimmerman R., Chen Y., et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature 2011, 472:120-124.
-
(2011)
Nature
, vol.472
, pp. 120-124
-
-
Wang, K.C.1
Yang, Y.W.2
Liu, B.3
Sanyal, A.4
Corces-Zimmerman, R.5
Chen, Y.6
-
164
-
-
69449102464
-
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
-
Wang Z., Zang C., Cui K., Schones D.E., Barski A., Peng W., et al. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 2009, 138:1019-1031.
-
(2009)
Cell
, vol.138
, pp. 1019-1031
-
-
Wang, Z.1
Zang, C.2
Cui, K.3
Schones, D.E.4
Barski, A.5
Peng, W.6
-
165
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward P.S., Patel J., Wise D.R., Abdel-Wahab O., Bennett B.D., Coller H.A., et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010, 17:225-234.
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
-
166
-
-
34047116826
-
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
-
Weber M., Hellmann I., Stadler M.B., Ramos L., Paabo S., Rebhan M., et al. Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nature Genetics 2007, 39:457-466.
-
(2007)
Nature Genetics
, vol.39
, pp. 457-466
-
-
Weber, M.1
Hellmann, I.2
Stadler, M.B.3
Ramos, L.4
Paabo, S.5
Rebhan, M.6
-
167
-
-
79959653996
-
SWI/SNF nucleosome remodellers and cancer
-
Wilson B.G., Roberts C.W. SWI/SNF nucleosome remodellers and cancer. Nature Reviews. Cancer 2011, 11:481-492.
-
(2011)
Nature Reviews. Cancer
, vol.11
, pp. 481-492
-
-
Wilson, B.G.1
Roberts, C.W.2
-
168
-
-
84862878624
-
Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma
-
Wolf J.L., Siegel D., Goldschmidt H., Hazell K., Bourquelot P.M., Bengoudifa B.R., et al. Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma. Leukemia & Lymphoma 2012, 53:1820-1823.
-
(2012)
Leukemia & Lymphoma
, vol.53
, pp. 1820-1823
-
-
Wolf, J.L.1
Siegel, D.2
Goldschmidt, H.3
Hazell, K.4
Bourquelot, P.M.5
Bengoudifa, B.R.6
-
170
-
-
79952599834
-
Methylation-mediated regulation of E2F1 in DNA damage-induced cell death
-
Xie Q., Bai Y., Wu J., Sun Y., Wang Y., Zhang Y., et al. Methylation-mediated regulation of E2F1 in DNA damage-induced cell death. Journal of Receptor and Signal Transduction Research 2011, 31:139-146.
-
(2011)
Journal of Receptor and Signal Transduction Research
, vol.31
, pp. 139-146
-
-
Xie, Q.1
Bai, Y.2
Wu, J.3
Sun, Y.4
Wang, Y.5
Zhang, Y.6
-
171
-
-
33646138230
-
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor
-
Yamane K., Toumazou C., Tsukada Y., Erdjument-Bromage H., Tempst P., Wong J., et al. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 2006, 125:483-495.
-
(2006)
Cell
, vol.125
, pp. 483-495
-
-
Yamane, K.1
Toumazou, C.2
Tsukada, Y.3
Erdjument-Bromage, H.4
Tempst, P.5
Wong, J.6
-
172
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H., Parsons D.W., Jin G., McLendon R., Rasheed B.A., Yuan W., et al. IDH1 and IDH2 mutations in gliomas. The New England Journal of Medicine 2009, 360:765-773.
-
(2009)
The New England Journal of Medicine
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
McLendon, R.4
Rasheed, B.A.5
Yuan, W.6
-
173
-
-
79953176952
-
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
-
Yan X.J., Xu J., Gu Z.H., Pan C.M., Lu G., Shen Y., et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nature Genetics 2011, 43:309-315.
-
(2011)
Nature Genetics
, vol.43
, pp. 309-315
-
-
Yan, X.J.1
Xu, J.2
Gu, Z.H.3
Pan, C.M.4
Lu, G.5
Shen, Y.6
-
174
-
-
34547895492
-
MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells
-
Yang X.J., Ullah M. MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells. Oncogene 2007, 26:5408-5419.
-
(2007)
Oncogene
, vol.26
, pp. 5408-5419
-
-
Yang, X.J.1
Ullah, M.2
-
175
-
-
79952167230
-
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
-
Yap D.B., Chu J., Berg T., Schapira M., Cheng S.W., Moradian A., et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 2011, 117:2451-2459.
-
(2011)
Blood
, vol.117
, pp. 2451-2459
-
-
Yap, D.B.1
Chu, J.2
Berg, T.3
Schapira, M.4
Cheng, S.W.5
Moradian, A.6
-
176
-
-
78649638594
-
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers
-
Yoshimatsu M., Toyokawa G., Hayami S., Unoki M., Tsunoda T., Field H.I., et al. Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers. International Journal of Cancer 2011, 128:562-573.
-
(2011)
International Journal of Cancer
, vol.128
, pp. 562-573
-
-
Yoshimatsu, M.1
Toyokawa, G.2
Hayami, S.3
Unoki, M.4
Tsunoda, T.5
Field, H.I.6
-
177
-
-
84861990517
-
Base-resolution analysis of 5-hydroxymethylcytosine in the Mammalian genome
-
Yu M., Hon G.C., Szulwach K.E., Song C.X., Zhang L., Kim A., et al. Base-resolution analysis of 5-hydroxymethylcytosine in the Mammalian genome. Cell 2012, 149:1368-1380.
-
(2012)
Cell
, vol.149
, pp. 1368-1380
-
-
Yu, M.1
Hon, G.C.2
Szulwach, K.E.3
Song, C.X.4
Zhang, L.5
Kim, A.6
-
178
-
-
84859226893
-
Disordered epigenetic regulation in the pathophysiology of myeloproliferative neoplasms
-
Zhang S.J., Abdel-Wahab O. Disordered epigenetic regulation in the pathophysiology of myeloproliferative neoplasms. Current Hematologic Malignancy Reports 2012, 7:34-42.
-
(2012)
Current Hematologic Malignancy Reports
, vol.7
, pp. 34-42
-
-
Zhang, S.J.1
Abdel-Wahab, O.2
-
179
-
-
84862907593
-
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
-
Zhang J., Ding L., Holmfeldt L., Wu G., Heatley S.L., Payne-Turner D., et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 2012, 481:157-163.
-
(2012)
Nature
, vol.481
, pp. 157-163
-
-
Zhang, J.1
Ding, L.2
Holmfeldt, L.3
Wu, G.4
Heatley, S.L.5
Payne-Turner, D.6
-
180
-
-
84862778059
-
Spatial organization of the mouse genome and its role in recurrent chromosomal translocations
-
Zhang Y., McCord R.P., Ho Y.J., Lajoie B.R., Hildebrand D.G., Simon A.C., et al. Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell 2012, 148:908-921.
-
(2012)
Cell
, vol.148
, pp. 908-921
-
-
Zhang, Y.1
McCord, R.P.2
Ho, Y.J.3
Lajoie, B.R.4
Hildebrand, D.G.5
Simon, A.C.6
-
181
-
-
78650304236
-
Charting histone modifications and the functional organization of mammalian genomes
-
Zhou V.W., Goren A., Bernstein B.E. Charting histone modifications and the functional organization of mammalian genomes. Nature Reviews. Genetics 2011, 12:7-18.
-
(2011)
Nature Reviews. Genetics
, vol.12
, pp. 7-18
-
-
Zhou, V.W.1
Goren, A.2
Bernstein, B.E.3
-
182
-
-
33845880624
-
Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription
-
Zilberman D., Gehring M., Tran R.K., Ballinger T., Henikoff S. Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription. Nature Genetics 2007, 39:61-69.
-
(2007)
Nature Genetics
, vol.39
, pp. 61-69
-
-
Zilberman, D.1
Gehring, M.2
Tran, R.K.3
Ballinger, T.4
Henikoff, S.5
|