Curcumin in cancer chemoprevention: Molecular targets, pharmacokinetics, bioavailability, and clinical trials

Archiv der Pharmazie

Volumn 343, Issue 9, 2010, Pages 489-499

  Shehzad, Adeeb ^a   Wahid, Fazli ^a   Lee, Young Sup ^a  

^a Kyungpook National University   (South Korea)

Author keywords

Bioavailability; Cancer; Clinical trials; Curcumin; Inflammation

Indexed keywords

4 METHOXYAMPHETAMINE; APOPTOSIS INDUCING FACTOR; BCM 95; BETA CATENIN; BIOCURCUMAX; CASPASE; CASPASE 3; CELL ADHESION MOLECULE; COMPLEMENTARY DNA; CURCUMIN; CYCLIN D1; CYCLOOXYGENASE 2; CYTOCHROME C; DIPHENYLDIFLUOROKETONE; ENDONUCLEASE G; GELATINASE B; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STAT PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER CHEMOTHERAPY; CANCER PREVENTION; CELL ADHESION; CELL CYCLE ARREST; CELL PROLIFERATION; CELL SURVIVAL; CHROMATIN CONDENSATION; CLINICAL TRIAL; COLON CANCER; COLON CARCINOMA; COLORECTAL CANCER; DNA FRAGMENTATION; DOWN REGULATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG TISSUE LEVEL; GAMMA RADIATION; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; HUMAN; MICROARRAY ANALYSIS; MOUTH CANCER; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NONHUMAN; OSTEOSARCOMA; PANCREAS CANCER; PLEIOTROPY; PRIORITY JOURNAL; RECTUM CANCER; REVIEW; SIGNAL TRANSDUCTION; ULTRAVIOLET C RADIATION; UPREGULATION; UTERINE CERVIX CANCER;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; CHEMOPREVENTION; CLINICAL TRIALS AS TOPIC; CURCUMIN; DRUG DELIVERY SYSTEMS; HUMANS; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 77956863976     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200900319     Document Type: Review

References (100)

1. B. B. Aggarwal, A. Kumar, A. C. Bharti, Anticancer Res. 2003, 23, 363-398.
2. S. Singh, Cell 2007, 130, 765-768.
3. W. P. Steward, A. J. Gescher, Mol. Nutr. Food Res. 2008, 52, 1005-1009.
4. J. Y. Liu, S. J. Lin, J. K. Lin, Carcinogenesis 1993, 14, 857-861.
5. T. S. Huang, S. C. Lee, J. K. Lin, Proc. Natl. Acad. Sci. U. S. A. 1991, 88, 5292-5296.
6. M. T. Huang, T. Lysz, T. Ferraro, T. F. Abidi, et al., Cancer Res. 1991, 51, 813-819.
7. S. Bhaumik, R. Anjum, N. Rangaraj, B. V. Pardhasaradhi, A. Khar, FEBS Lett. 1999, 456, 311-314.
8. F. Zhang, N. K. Altorki, J. R. Mestre, K. Subbaramaiah, A. J. Dannenberg, Carcinogenesis 1999, 20, 445-451.
9. K. Sugimoto, H. Hanai, K. Tozawa, T. Aoshi, et al., Gastroenterology. 2002, 123, 1912-1922.
10. L. Camacho-Barquero, I. Villegas, J. M. Sanchez-Calvo, E. Talero, et al., Int. Immunol. 2007, 7, 333-342.
11. A. John, G. Tuszynski, Pathol. Oncol. Res. 2001, 7, 14-23.
12. C. H. Park, E. R. Hahm, S. Park, H. K. Kim, C. H. Yang, FEBS Lett. 2005, 579, 2965-2971.
13. J. H. Woo, Y. H. Kim, Y. J. Choi, Y. J. Choi, et al., Carcinogenesis 2003, 24, 1199-1208.
14. A. Mukhopadhyay, S. Banerjee, L. J. Stafford, X. Xia, et al., Oncogene 2002, 21, 8852-8862.
15. E. Vogel, S. Pelletier, J. Pharm. 1815(2), 50.
16. J. V. Milobedzka, S. Kostanecki, V. Lampe, Ber. Dtsch. Chem. Ges. 1910, 43, 2163-2170.
17. I. Chattopadhyay, K. Biswas, U. Bandyopadhyay, R. K. Banerjee, Curr. Sci. 2004, 87, 44-53.
18. A. Goel, A. B. Kunnumakkara, B. B. Aggarwal, Biochem. Pharm. 2008, 75, 787-809.
19. L. D. Kapoor, in: Handbook of Ayurvedic Medicinal Plants, CRC Press, Boca Raton, Florida 1990, pp. 185.
20. C. M. Shih, W. C. Ko, J. S. Wu, Y. H. Wei, et al., J. Cell Biochem. 2004, 91, 383-397.
21. X. Wang, Genes Dev. 2001, 15, 2922-2933.
22. J. S. Armstrong, K. K. Steinauer, B. Hornung, J. M. Irish, et al., Cell Death Differ. 2002, 9, 252-263.
23. F. Thayyullathil, S. Chathoth, A. Hago, M. Patel, S. Galadari, Free Radical Biol. Med. 2008, 45, 1403-1412.
24. J. Ravindran, S. Prasad, B. B. Aggarwal, AAPS J. 2009. DOI: 10.1208/s12248-009-9128-x.
25. F. Sarkar, Y. Li, Mutat. Res. Fundam. Mol. Mech. Mutagen. 2004, 555, 53-64.
26. M. Grimmler, Y. Wang, T. Mund, Z. Cilensek, et al., Cell 2007, 128, 269-280.
27. G. Sa, T. Das, Cell Div. 2008, 3, 14.
28. R. Rashmi, T. R. Santhosh Kumar, D. Karunagaran, FEBS Lett. 2003, 538, 19-24.
29. S. S. Han, S. T. Chung, D. A. Robertson, D. Ranjan, S. Bondada, Clin. Immunol. 1999, 93, 152-161.
30. J. A. Bush, J. K.-J. Cheung, G. Li, Exp. Cell Res. 2001, 271, 305-314.
31. H. P. Ammon, M. A. Wahl, Planta Med. 1991, 57, 1-7.
32. M. T. Huang, T. Lysz, T. Ferraro, T. F. Abidi, et al., Cancer. Res. 1991, 51, 813-819.
33. A. Goel, C. R. Boland, D. P. Chauhan, Cancer Lett. 2001, 172, 111-118.
34. Y. J. Surh, K. S. Chun, H. H. Cha, S. S. Han, et al., Mutat. Res. Fundam. Mol. Mech. Mutagen. 2001, 480-481, 243-268.
35. S. M. Plummer, K. A. Holloway, M. M. Manson, R. J. Munks, et al., Oncogene 1999, 18, 6013-6020.
36. A. Shehzad, S. Khan, O. Shehzad, Y. S. Lee, Drugs Today 2010. DOI: 10.1358/dot.2010.46.7.1509560
37. H. Hidaka, T. Ishiko, T. Furuhashi, H. Kamohara, et al., Cancer 2002, 95, 1206-1214.
38. J. W. Cho, K. S. Lee, C. W. Kim, Int. J. Mol. Med. 2007, 19, 469-474.
39. A. C. Bharti, N. Donato, B. B. Aggarwal, J. Immunol. 2003, 171, 3863-3871.
40. G. Niu, K. L. Wright, M. Huang, L. Song, et al., Oncogene 2002, 21, 2000-2008.
41. C. Natarajan, J. J. Bright, J. Immunol. 2002, 168, 6506-6513.
42. M. H. Cobb, E. J. Goldsmith, J. Biol. Chem. 1995, 270, 14843-14846.
43. E. Cano, L. C. Mahadevan, Trends Biochem. Sci. 1995, 20, 117-122.
44. J. M. Kyriakis, J. Avruch, Bioessays 1996, 18, 567-577.
45. Y. R. Chen, X. Wang, D. Templeton, R. J. Davis, T. H. Tan, J. Biol. Chem. 1996, 271, 31929-31936.
46. M. Karin, J. Biol. Chem. 1995, 270, 16483-16486.
47. K. W. Lee, J. H. Kim, H. J. Lee, Y. J. Surh, Antioxid. Redox. Signal. 2005, 7, 1612-1620.
48. Y. R. Chen, T. H. Tan, Oncogene 1998, 17, 173-178.
49. K. M. Dhandapani, V. B. Mahesh, D. W. Brann, J. Neurochem. 2007, 102, 522-538.
50. S. Zucker, J. Vacirca, Cancer Metastasis Rev. 2004, 23, 101-117.
51. M. S. Woo, S. H. Jung, S. Y. Kim, J. W. Hyun, et al., Biochem. Biophys. Res. Commun. 2005, 335, 1017-1025.
52. S. Philip, A. Bulbule, G. C. Kundu, Glycoconj. J. 2004, 21, 429-441.
53. G. J. Nabel, I. M. Verma, Genes Dev. 1993, 7, 2063. PMID 8224837.
54. C. Jobin, C. A. Bradham, M. P. Russo, B. Juma, et al., J. Immunol. 1999, 163, 3474-3483.
55. V. Bours, M. Bentires-Alj, A. C. Hellin, P. Viatour, et al., Biochem. Pharmacol. 2000, 60, 1085-1089.
56. P. Angel, M. Karin, Biochim. Biophys. Acta 1991, 1072, 129-157.
57. M. R. Young, J. J. Li, M. Rincon, R. A. Flavell, et al., Proc. Natl. Acad. Sci. U. S. A. 1999, 96, 9827-9832.
58. M. Funakoshi-Tago, K. Tago, Y. Sonoda, S. Tominaga, T. Kasahara, Eur. J. Biochem. 2003, 270, 1257-1268.
59. D. A. Dickinson, K. E. Iles, H. Zhang, V. Blank, H. J. Forman, FASEB. J. 2003, 17, 473-475.
60. S. S. Chin, J. J. Geng, L. T. Mao, C. J. Gung, et al., Anticancer Res. 2006, 26, 4379-4389.
61. S. Shishodia, H. M. Amin, R. Lai, B. B. Aggarwal, Biochem. Pharmacol. 2005, 70, 700-713.
62. B. Rubinfeld, I. Albert, E. Porfiri, C. Fiol, et al., Science 1996, 272, 1023-1026.
63. P. J. Morin, A. B. Sparks, V. Korinek, N. Barker, et al., Science 1997, 275, 1787-1790.
64. D. K. Woo, H. S. Kim, H. S. Lee, Y. H. Kang, et al., Int. J. Cancer 2001, 95, 108-113.
65. B. Mann, M. Gelos, A. Siedow, M. L. Hanski, et al., Proc. Natl. Acad. Sci. U. S. A. 1999, 96, 1603-1608.
66. A. Shehzad, Y. S. Lee, Drug Future 2010, 35, 113-119.
67. B. M. Gumbiner, J. Cell. Biol. 2000, 148, 399-404.
68. P. Polakis, Genes Dev. 2000, 14, 1837-1851.
69. G. Pawlak, D. M. Helfman, Curr. Opin. Genet. Dev. 2001, 11, 41-47.
70. A. S. Jaiswal, B. P. Marlow, N. Gupta, S. Narayan, Oncogene 2002, 21, 8414-8427.
71. A. R. Hussain, M. Al-Rasheed, P. S. Manogaran, K. A. Al-Hussein, et al., Apoptosis 2006, 11, 245-254.
72. M. Gururajan, T. Dasu, S. Shahidain, C. D. Jennings, et al., J. Immunol. 2007, 178, 111-121.
73. H. Hatcher, R. Planalp, J. Cho, F. M. Torti, S. V. Torti, Cell Mol. Life Sci. 2008, 65, 1631-1652.
74. M. S. Squires, E. A. Hudson, L. Howells, S. Sale, et al., Biochem. Pharmacol. 2003, 65, 361-376.
75. G. Sa, Y. Guo, D. W. Stacey, Cell Cycle 2005, 4, 618-627.
76. M. J. Park, E. H. Kim, I. C. Park, H. C. Lee, et al., Int. J. Oncol. 2002, 21, 379-383.
77. Y. Cheng, J. Ping, L. M. Xu, Chin. Med. J. 2007, 120, 794-801.
78. D. Hong, X. Zeng, W. Xu, J. Ma, et al., Pharmacol. Res. 2010, 61, 142-148.
79. M. H. Teiten, S. Eifes, S. Reuter, A. Duvoix, et al., Ann. N. Y. Acad. Sci. 2009, 1171, 391-398.
80. H. W. Chen, S. L. Yu, J. J. Chen, H. N. Li, et al., Mol. Pharmacol. 2004, 65, 99-110.
81. Evaluation of Certain Food Additives, WHO Technical Report Series, WHO, Geneva 2000, 891.
82. I. Villegas, S. Sánchez-Fidalgo, C. Alarcón de la Lastra, Mol. Nutr. Food Res. 2008, 52, 1040-1061.
83. G. M. Holder, J. L. Plummer, A. J. Ryan, Xenobiotica 1978, 8, 761-768.
84. V. Ravindranath, N. Chandrasekhara, Toxicology 1980, 16, 259-265.
85. M. H. Pan, T. M. Huang, J. K. Lin, Drug Metab. Dispos. 1999, 27, 486-494.
86. C. D. Lao, M. T. Ruffin, D. Normolle, D. D. Heath, et al., Altern. Med. Rev. 2006, 17, 6-10.
87. A. L. Cheng, C. H. Hsu, J. K. Lin, M. M. Hsu, et al., Anticancer Res. 2001, 21, 2895-2900.
88. R. A. Sharma, H. R. McLelland, K. A. Hill, C. R. Ireson, et al., Clin. Cancer Res. 2001, 7, 1894-1900.
89. G. Garcea, D. P. Berry, D. J. Jones, R. Singh, et al., Cancer Epidemiol. Biomarkers Prev. 2005, 14, 120-125.
90. R. A. Sharma, C. R. Ireson, R. D. Verschoyle, K. A. Hill, et al., Clin. Cancer Res. 2001, 7, 1452-1458.
91. C. Ireson, S. Orr, D. J. Jones, R. Verschoyle, et al., Cancer Res. 2001, 61, 1058-1064.
92. S. I. Hoehle, E. Pfeiffer, A. M. Solyom, M. Metzler, J. Agric. Food Chem. 2006, 54, 756-764.
93. C. R. Ireson, D. J. Jones, S. Orr, M. W. Coughtrie, et al., Cancer Epidemiol. Biomarkers Prev. 2002, 11, 105-111.
94. S. K. Sandur, M. K. Pandey, B. Sung, K. S. Ahn, et al., Carcinogenesis 2007, 28, 1765-1773.
95. E. Pfeiffer, S. I. Hoehle, S. G. Walch, A. Riess, et al., J. Agric. Food Chem. 2007, 55, 538-544.
96. K. Y. Yang, L. C. Lin, T. Y. Tseng, S. C. Wang, T. H. Tsai, J. Chromatogr., B. 2007, 853, 183-189.
97. K. Maiti, K. Mukherjee, A. Gantait, B. P. Saha, P. K. Mukherjee, Int. J. Pharm. 2007, 330, 155-163.
98. T. H. Marczylo, R. D. Verschoyle, D. N. Cooke, P. Morazzoni, et al., Cancer Chemother. Pharmacol. 2007, 60, 171-177.
99. S. Perkins, R. D. Verschoyle, K. Hill, I. Parveen, et al., Cancer Epidemiol. Biomarkers Prev. 2002, 11, 535-540.
100. D. Subramaniam, R. May, S. M. Sureban, K. B. Lee, et al., Cancer Res. 2008, 68, 1962-1969.